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Annex II Entry 278 15/10/2010

Psilocybine (INN)

Psilocybine (INN) is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 278

Chemical identity and properties

PubChem 2D chemical structure for CAS 520-52-5
CAS 520-52-5PubChem CID 10624

Psilocybin

Psilocybin is a tryptamine alkaloid that is N,N-dimethyltryptamine carrying an additional phosphoryloxy substituent at position 4. The major hallucinogenic alkaloid isolated from Psilocybe mushrooms (also known as Teonancatl or "magic mushrooms"). It has a role as a hallucinogen, a serotonergic agonist, a prodrug and a fungal metabolite. It is an organic phosphate, a tryptamine alkaloid and a tertiary amino compound. It is functionally related to a psilocin. It is a conjugate acid of a psilocybin(1-). — ChEBI

IUPAC name
[3-[2-(dimethylamino)ethyl]-1H-indol-4-yl] dihydrogen phosphate
Molecular formula
C12H17N2O4P
Molecular weight
284.25 g/mol
Exact mass
284.09259403 Da
XLogP3
-1.6
Topological polar surface area
85.8 Ų
Hydrogen-bond donors
3
Hydrogen-bond acceptors
5
Covalent units
1
Defined stereocentres
0

Also known as

PsilocybineIndocybinPsilocibinTeonanacatlPsilocin phosphate esterPsilocibinaPsilotsibinPsilocybinum
16 more reported names
CY-39O-Phosphoryl-4-hydroxy-N,N-dimethyltryptamine4-Phosphoryloxy-N,N-dimethyltryptamine3-2'-Dimethylaminoethylindol-4-phosphate3-(2-(Dimethylamino)ethyl)-1H-indol-4-ol dihydrogen phosphate ester3-(2-Dimethylaminoethyl)indol-4-yl dihydrogen phosphateCOMP360COMP-360CY392RV7212BP04-Phosphoryloxy-omega-N,N-dimethyltryptamine3-[2-(Dimethylamino)ethyl]-1H-indol-4-yl dihydrogen phosphate1H-Indol-4-ol, 3-(2-(dimethylamino)ethyl)-, dihydrogen phosphate (ester)CHEBI:8614({3-[2-(dimethylamino)ethyl]-1H-indol-4-yl}oxy)phosphonic acid3-(2-(dimethylamino)ethyl)-1H-indol-4-yl dihydrogen phosphate
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External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Psilocybine (INN)

Chemical / IUPAC name

1H-Indol-4-ol, 3-(2-(dimethylamino)ethyl)-, dihydrogen phosphate (ester)

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

Key data

CAS
520-52-5
EC
208-294-4
Annex
II
Entry number
278

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 282
Nearby record in the same annex

Picrotoxin

CAS: 124-87-8
EC: 204-716-6

What Annex II means for Psilocybine (INN)

Psilocybine (INN) is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. Psilocybine (INN) is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 520-52-5 is the unique numerical identifier assigned to Psilocybine (INN) by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Psilocybine (INN)

This page summarizes one Annex II record for Psilocybine (INN) from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Psilocybine (INN), but confirm any final regulatory decision against the current official annex wording and source files.

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