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Annex II Entry 281 15/10/2010

Physostigma venenosum Balf.

Physostigma venenosum Balf. is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 281

Record details

Chemical name

Physostigma venenosum Balf.

Regulatory information

Regulation

(EC) 2009/1223

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Key data

CAS
89958-15-6
EC
289-638-0
Annex
II
Entry number
281

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 282
Nearby record in the same annex

Picrotoxin

CAS: 124-87-8
EC: 204-716-6

What Annex II means for Physostigma venenosum Balf.

Physostigma venenosum Balf. is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. Physostigma venenosum Balf. is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 89958-15-6 is the unique numerical identifier assigned to Physostigma venenosum Balf. by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Physostigma venenosum Balf.

This page summarizes one Annex II record for Physostigma venenosum Balf. from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Physostigma venenosum Balf., but confirm any final regulatory decision against the current official annex wording and source files.

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