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CAS 1 record

CAS 124-87-8

CAS 124-87-8 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 124-87-8
CAS 124-87-8PubChem CID 31304

Picrotoxin

Cocculus appears as a poisonous berry, the dried fruit of Anamirta cocculus L. Contains several substances including about one percent picrotoxin. Pure picrotoxin occurs as shiny leaflets with an intensely bitter taste or as a microcrystalline powder. Very poisonous!. Used in medicine as a central nervous system stimulant and antidote for barbiturate poisoning. Not currently regarded as a useful therapeutic agent. — CAMEO Chemicals

IUPAC name
(1R,3R,5S,8S,13R,14S)-1-hydroxy-14-(2-hydroxypropan-2-yl)-13-methyl-4,7,10-trioxapentacyclo[6.4.1.19,12.03,5.05,13]tetradecane-6,11-dione;(1R,5S,8S,13R,14R)-1-hydroxy-13-methyl-14-prop-1-en-2-yl-4,7,10-trioxapentacyclo[6.4.1.19,12.03,5.05,13]tetradecane-6,11-dione
Molecular formula
C30H34O13
Molecular weight
602.6 g/mol
Exact mass
602.19994113 Da
Topological polar surface area
191.0 Ų
Hydrogen-bond donors
3
Hydrogen-bond acceptors
13
Covalent units
2
Defined stereocentres
11

Also known as

CocculinCocculusPicrotoxinumOriental berryIndian berryPicrotoxinePicrotoxCoques du levant
16 more reported names
Picrotin, compound with picrotoxinin (1:1)EPA Pesticide Chemical Code 002301AI3-17689ZLT174DL7UNSC-403139RefChem:174201CHEBI:134126204-716-6Coques du levant [French]Caswell No. 663APicrotoxinin - picrotinPicrotoxin [NF]HSDB 6385EINECS 204-716-6UNII-ZLT174DL7UNSC 403139
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External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match31304

Attributed physical-property, hazard, environmental and use annotations.

  • Physical Description: Cocculus appears as a poisonous berry, the dried fruit of Anamirta cocculus L. Contains several substances including about one percent picrotoxin. Pure picrotoxin occurs as shiny leaflets with an intensely bitter taste or as a microcrystalline powder. Very poisonous!. Used in medicine as a central nervous system stimulant and antidote for barbiturate poisoning. Not currently regarded as a useful therapeutic agent. Source: CAMEO Chemicals
  • First Aid: Warning: Picrotoxin is a powerful stimulant and affects all portions of the central nervous system. Picrotoxin is a highly toxic alkaloid convulsant poison. Epileptics may be more sensitive to picrotoxin.; Signs and Symptoms of Picrotoxin Exposure: Signs and symptoms of acute exposure to picrotoxin may include slowing of pulse followed by increased pulse rate, tachycardia, and arrhythmias. Headache, salivation, sweating, dilation of pupils, loss of vision, muscle rigidity, excitement, hyperactivity, delirium, hallucinations, and convulsions may be observed. Nausea, vomiting, diarrhea, hyperpnea (excessive respiration), pulmonary edema, respiratory failure, and coma may also be noted.; Emergency Life-Support Procedures: Acute exposure to picrotoxin may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.; Inhalation Exposure:; 1. Move victims to fresh Source: CAMEO Chemicals
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P264, P270, P301+P316, P321, P330, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 43 reports by companies from 1 notifications to the ECHA C&L Inventory.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 124-87-8

1 total

How CAS 124-87-8 is used on this site

CAS 124-87-8 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 124-87-8 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 124-87-8 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

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