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Annex II Entry 1762 15/01/2026

N,N’-methylenediacrylamide

N,N’-methylenediacrylamide is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1762

Chemical identity and properties

PubChem 2D chemical structure for CAS 110-26-9
CAS 110-26-9PubChem CID 8041

Methylenebisacrylamide

N,n'-methylenebisacrylamide is a white crystalline powder with a neutral odor. (NTP, 1992) — CAMEO Chemicals

IUPAC name
N-[(prop-2-enoylamino)methyl]prop-2-enamide
Molecular formula
C7H10N2O2
Molecular weight
154.17 g/mol
Exact mass
154.074227566 Da
XLogP3
0.1
Topological polar surface area
58.2 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
0

Also known as

N,N'-METHYLENEBISACRYLAMIDEMethylenediacrylamideN,N'-Methylenebis(acrylamide)2-Propenamide, N,N'-methylenebis-N,N'-MethylidenebisacrylamideAcrylamide, N,N'-methylenebis-N,N'-Methylenebis(2-propenamide)EDK4RIE19C
16 more reported names
N,N'-Methylenebis[acrylamide]RefChem:161037n,n'-methylene-bis(acrylamide)2-propenamide, N,N'-methyl-enebisN,N'-METHYLENEBIS-2-PROPENAMIDEmethylene bisacrylamideN,N'-Methylenediacrylamiden,n-methylenebisacrylamideN,N'-Methylene-bis-acrylamideBisacrylamideBis-acrylamideMBAAN-[(prop-2-enamido)methyl]prop-2-enamideNSC 406836NSC-406836Bisacrylamide; MBA;Methylenebisacrylamide
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match8041

Attributed physical-property, hazard, environmental and use annotations.

  • Melting Point: 365 °F (with decomposition) (NTP, 1992) Source: CAMEO Chemicals
  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) shou Source: CAMEO Chemicals
  • Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H340: May cause genetic defects [Danger Germ cell mutagenicity] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P203, P280, P318, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H301 (54.4%): Toxic if swallowed [Danger Acute toxicity, oral]; H302 (45.6%): Harmful if swallowed [Warning Acute toxicity, oral]; H312 (35.3%): Harmful in contact with skin [Warning Acute toxicity, dermal]; H317 (19.1%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H318 (19.1%): Causes serious eye damage [Danger Serious eye damage/eye irritation]; H332 (51.1%): Harmful if inhaled [Warning Acute toxicity, inhalation]; H340 (54.6%): May cause genetic defects [Danger Germ cell mutagenicity]; H350 (35.1%): May cause cancer [Danger Carcinogenicity]; H351 (19.3%): Suspected of causing cancer [Warning Carcinogenicity]; H360 (19.1%): May damage fertility or the unborn child [Danger Reproductive toxicity]; H361 (31.4%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]; H372 (54.4%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P260, P261, P264, P264+P265, P270, P271, P272, P280, P301+P316, P301+P317, P302+P352, P304+P340, P305+P354+P338, P317, P318, P319, P321, P330, P333+P317, P362+P364, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 544 reports by companies from 21 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H301: Toxic if swallowed [Danger Acute toxicity, oral]; H340: May cause genetic defects [Danger Germ cell mutagenicity]; H360: May damage fertility or the unborn child [Danger Reproductive toxicity]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P260, P264, P270, P280, P301+P316, P308+P316, P318, P321, P330, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

N,N’-methylenediacrylamide

Regulatory information

Regulation

(EU) 2026/78

See every entry this act set

Key data

CAS
110-26-9
EC
203-750-9
Annex
II
Entry number
1762

Inventory links for N,N’-methylenediacrylamide

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 1764
Nearby record in the same annex

Trimethyl borate

CAS: 121-43-7
EC: 204-468-9
Annex II 1754
Nearby record in the same annex

Acetone oxime

CAS: 127-06-0
EC: 204-820-1

What Annex II means for N,N’-methylenediacrylamide

N,N’-methylenediacrylamide is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. N,N’-methylenediacrylamide is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 110-26-9 is the unique numerical identifier assigned to N,N’-methylenediacrylamide by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record N,N’-methylenediacrylamide

This page summarizes one Annex II record for N,N’-methylenediacrylamide from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for N,N’-methylenediacrylamide, but confirm any final regulatory decision against the current official annex wording and source files.

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