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Annex II Entry 1758 15/01/2026

7-oxabicyclo[4.1.0]hept-3-ylmethyl 7-oxabicyclo[4.1.0]heptane-3-carboxylate

7-oxabicyclo[4.1.0]hept-3-ylmethyl 7-oxabicyclo[4.1.0]heptane-3-carboxylate is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1758

Chemical identity and properties

PubChem 2D chemical structure for CAS 2386-87-0
CAS 2386-87-0PubChem CID 16949

UT-632

IUPAC name
7-oxabicyclo[4.1.0]heptan-3-ylmethyl 7-oxabicyclo[4.1.0]heptane-3-carboxylate
Molecular formula
C14H20O4
Molecular weight
252.31 g/mol
Exact mass
252.13615911 Da
XLogP3
1.5
Topological polar surface area
51.4 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
4
Covalent units
1
Defined stereocentres
0

Also known as

3,4-Epoxycyclohexylmethyl 3,4-epoxycyclohexanecarboxylateChissonox 221 monomerERL-4221HSDB 58733,4-EPOXYCYCLOHEXYLMETHYL-3,4-EPOXYCYCLOHEXANECARBOXYLATE3,4-Epoxycyclohexylmethyl 3,4-epoxycyclohexane carboxylateEINECS 219-207-4CCRIS 8882
16 more reported names
3,4-Epoxycyclohexanecarboxylic acid (3,4-epoxycyclohexylmethyl) esterBRN 1381750(3,4-Epoxycyclohexyl)methyl 3,4-epoxycyclohexylcarboxylate3,4-Epoxycyclohexanemethyl 3,4-epoxycyclohexanecarboxylate7-Oxabicyclo(4.1.0)heptane-3-carboxylic acid, 7-oxabicyclo(4.1.0)hept-3-ylmethyl esterEC 219-207-4UVA 1500 MONOMER7-Oxabicyclo(4.1.0)hept-3-ylmethyl 7-oxabicyclo(4.1.0)heptane-3-carboxylate7-Oxabicyclo[4.1.0]heptane-3-carboxylic acid, 7-oxabicyclo[4.1.0]hept-3-ylmethyl ester3,4-EPOXYCYCLOHEXANEMETHYL 3,4-EPOXYCYCLOHEXANECARBOXYLATE [HSDB]7-Oxabicyclo[4.1.0]hept-3-ylmethyl 7-oxabicyclo[4.1.0]heptane-3-carboxylate7-oxabicyclo[4.1.0]hept-3-ylmethyl7-oxabicyclo[4.1.0]heptane-3-carboxylate7-oxabicyclo(4.1.0)hept-3-ylmethyl7-oxabicyclo(4.1.0)heptane-3-carboxylateRefChem:901511ERL42213,4Epoxycyclohexylmethyl3,4epoxycyclohexanecarboxylate
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

7-oxabicyclo[4.1.0]hept-3-ylmethyl 7-oxabicyclo[4.1.0]heptane-3-carboxylate

Regulatory information

Regulation

(EU) 2026/78

See every entry this act set

Key data

CAS
2386-87-0
EC
219-207-4
Annex
II
Entry number
1758

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 1754
Nearby record in the same annex

Acetone oxime

CAS: 127-06-0
EC: 204-820-1
Annex II 1764
Nearby record in the same annex

Trimethyl borate

CAS: 121-43-7
EC: 204-468-9

What Annex II means for 7-oxabicyclo[4.1.0]hept-3-ylmethyl 7-oxabicyclo[4.1.0]heptane-3-carboxylate

7-oxabicyclo[4.1.0]hept-3-ylmethyl 7-oxabicyclo[4.1.0]heptane-3-carboxylate is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. 7-oxabicyclo[4.1.0]hept-3-ylmethyl 7-oxabicyclo[4.1.0]heptane-3-carboxylate is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 2386-87-0 is the unique numerical identifier assigned to 7-oxabicyclo[4.1.0]hept-3-ylmethyl 7-oxabicyclo[4.1.0]heptane-3-carboxylate by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record 7-oxabicyclo[4.1.0]hept-3-ylmethyl 7-oxabicyclo[4.1.0]heptane-3-carboxylate

This page summarizes one Annex II record for 7-oxabicyclo[4.1.0]hept-3-ylmethyl 7-oxabicyclo[4.1.0]heptane-3-carboxylate from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for 7-oxabicyclo[4.1.0]hept-3-ylmethyl 7-oxabicyclo[4.1.0]heptane-3-carboxylate, but confirm any final regulatory decision against the current official annex wording and source files.

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