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Annex II Entry 1721 24/08/2023

Pentasodium (carboxylatomethyl)iminobis(ethylenenitrilo)tetraacetate; Pentasodium Pentetate (INCI)

Pentasodium (carboxylatomethyl)iminobis(ethylenenitrilo)tetraacetate; Pentasodium Pentetate (INCI) is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1721

Chemical identity and properties

PubChem 2D chemical structure for CAS 140-01-2
CAS 140-01-2PubChem CID 8779

Pentasodium Pentetate

IUPAC name
pentasodium;2-[bis[2-[bis(carboxylatomethyl)amino]ethyl]amino]acetate
Molecular formula
C14H18N3Na5O10
Molecular weight
503.26 g/mol
Exact mass
503.0480652 Da
Topological polar surface area
210.0 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
13
Covalent units
6
Defined stereocentres
0

Also known as

Pentasodium DTPAPentasodium diethylenetriaminepentaacetateTetralon BVersenex 80Diethylenetriaminepentaacetic acid pentasodium saltPlexene DSyntron CHamp-ex 80
16 more reported names
Trilon CPerma kleer 140Detarex pyKiresuto PChelest PDtpa pentasodium saltClewat DP 80Caswell No. 642BChel 330HSDB 5629Sodium diethylenetriaminepentaacetateEINECS 205-391-3UNII-961TOZ5L7TEPA Pesticide Chemical Code 039120961TOZ5L7TDISSOLVINE D 50
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Pentasodium (carboxylatomethyl)iminobis(ethylenenitrilo)tetraacetate; Pentasodium Pentetate (INCI)

Regulatory information

Regulation

(EU) 2023/1490

See every entry this act set

Identified ingredients

Key data

CAS
140-01-2
EC
205-391-3
Annex
II
Entry number
1721

Inventory links for Pentasodium (carboxylatomethyl)iminobis(ethylenenitrilo)tetraacetate; Pentasodium Pentetate (INCI)

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 1717
Nearby record in the same annex

Cumene

CAS: 98-82-8
EC: 202-704-5

What Annex II means for Pentasodium (carboxylatomethyl)iminobis(ethylenenitrilo)tetraacetate; Pentasodium Pentetate (INCI)

Pentasodium (carboxylatomethyl)iminobis(ethylenenitrilo)tetraacetate; Pentasodium Pentetate (INCI) is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. Pentasodium (carboxylatomethyl)iminobis(ethylenenitrilo)tetraacetate; Pentasodium Pentetate (INCI) is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 140-01-2 is the unique numerical identifier assigned to Pentasodium (carboxylatomethyl)iminobis(ethylenenitrilo)tetraacetate; Pentasodium Pentetate (INCI) by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Pentasodium (carboxylatomethyl)iminobis(ethylenenitrilo)tetraacetate; Pentasodium Pentetate (INCI)

This page summarizes one Annex II record for Pentasodium (carboxylatomethyl)iminobis(ethylenenitrilo)tetraacetate; Pentasodium Pentetate (INCI) from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Pentasodium (carboxylatomethyl)iminobis(ethylenenitrilo)tetraacetate; Pentasodium Pentetate (INCI), but confirm any final regulatory decision against the current official annex wording and source files.

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