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Annex II Entry 1719 24/08/2023

Pentapotassium 2,2’,2’’,2’’’,2’’’’-(ethane-1,2-diylnitrilo)pentaacetate

Pentapotassium 2,2’,2’’,2’’’,2’’’’-(ethane-1,2-diylnitrilo)pentaacetate is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1719

Chemical identity and properties

PubChem 2D chemical structure for CAS 7216-95-7
CAS 7216-95-7PubChem CID 10167209

Glycine, N,N-bis(2-(bis(carboxymethyl)amino)ethyl)-, potassium salt (1:5)

IUPAC name
pentapotassium;2-[bis[2-[bis(carboxylatomethyl)amino]ethyl]amino]acetate
Molecular formula
C14H18K5N3O10
Molecular weight
583.80 g/mol
Exact mass
582.9177512 Da
Topological polar surface area
210.0 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
13
Covalent units
6
Defined stereocentres
0

Also known as

Glycine, N,N-bis[2-[bis(carboxymethyl)amino]ethyl]-, potassium salt (1:5)RefChem:663686Potassium 2,2',2'',2'''-((((carboxylatomethyl)azanediyl)bis(ethane-2,1-diyl))bis(azanetriyl))tetraacetateLRNLJCBZAUJMIS-UHFFFAOYSA-IPentapotassium 2,2',2'',2''',2''''-(ethane-1,2-diylnitrilo)pentaacetate
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Pentapotassium 2,2’,2’’,2’’’,2’’’’-(ethane-1,2-diylnitrilo)pentaacetate

Regulatory information

Regulation

(EU) 2023/1490

See every entry this act set

Key data

CAS
7216-95-7
EC
404-290-3
Annex
II
Entry number
1719

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 1717
Nearby record in the same annex

Cumene

CAS: 98-82-8
EC: 202-704-5

What Annex II means for Pentapotassium 2,2’,2’’,2’’’,2’’’’-(ethane-1,2-diylnitrilo)pentaacetate

Pentapotassium 2,2’,2’’,2’’’,2’’’’-(ethane-1,2-diylnitrilo)pentaacetate is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. Pentapotassium 2,2’,2’’,2’’’,2’’’’-(ethane-1,2-diylnitrilo)pentaacetate is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 7216-95-7 is the unique numerical identifier assigned to Pentapotassium 2,2’,2’’,2’’’,2’’’’-(ethane-1,2-diylnitrilo)pentaacetate by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Pentapotassium 2,2’,2’’,2’’’,2’’’’-(ethane-1,2-diylnitrilo)pentaacetate

This page summarizes one Annex II record for Pentapotassium 2,2’,2’’,2’’’,2’’’’-(ethane-1,2-diylnitrilo)pentaacetate from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Pentapotassium 2,2’,2’’,2’’’,2’’’’-(ethane-1,2-diylnitrilo)pentaacetate, but confirm any final regulatory decision against the current official annex wording and source files.

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