EU cosmetic ingredients, restrictions and safety

Annex II Entry 1720 24/08/2023

N-carboxymethyliminobis(ethylenenitrilo)tetra(acetic acid); Pentetic Acid (INCI)

N-carboxymethyliminobis(ethylenenitrilo)tetra(acetic acid); Pentetic Acid (INCI) is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

Search similar Back to annex Compare

Prohibited substance— Annex II, EU Regulation 1223/2009

Entry: 1720

Chemical identity and properties

PubChem 2D chemical structure for CAS 67-43-6

CAS 67-43-6PubChem CID 3053

Diethylenetriaminepentaacetic acid

Pentetic acid is a pentacarboxylic acid. It has a role as a copper chelator. It is a conjugate acid of a pentetate(1-). — ChEBI

IUPAC name: 2-[bis[2-[bis(carboxymethyl)amino]ethyl]amino]acetic acid

Molecular formula: C14H23N3O10
Molecular weight: 393.35 g/mol
Exact mass: 393.13834394 Da
XLogP3: -8.5
Topological polar surface area: 196.0 Å²
Hydrogen-bond donors: 5
Hydrogen-bond acceptors: 13
Covalent units: 1
Defined stereocentres: 0

Also known as

Pentetic acidDTPADetapacDetarexTitriplex VMonaquest CAIPerma kleerDabeersen 503

16 more reported names

CHEL 330 acidPenthanilPenthamilChel DTPADissolvine DPentacarboxymethyldiethylenetriamineDiethylenetriamine Pentaacetic AcidAcido penteticoAcide pentetique(Diethylenetrinitrilo)pentaacetic acidDiethylenetriamine-N,N,N',N'',N''-pentaacetic acidPentaindAcidum penteticumDTP-A1,1,4,7,7-Diethylenetriaminepentaacetic acidGlycine, N,N-bis(2-(bis(carboxymethyl)amino)ethyl)-

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:35739
ChEMBL:CHEMBL780
EPA DTXSID:DTXSID2023434
PubMed:24047113
PubMed:23073590
PubMed:23063854
PubMed:23015126
PubMed:23007687
PubMed:23007610
PubMed:23001305
PubMed:22975238
PubMed:22951173
PubMed:22919017
PubMed:22912733
PubMed:22893970

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

N-carboxymethyliminobis(ethylenenitrilo)tetra(acetic acid); Pentetic Acid (INCI)

Regulatory information

Regulation

See every entry this act set

Key data

CAS

EC

Annex

Entry number

1720

Inventory links for N-carboxymethyliminobis(ethylenenitrilo)tetra(acetic acid); Pentetic Acid (INCI)

Inventory Shared CAS number

Ref 36487

PENTETIC ACID

CAS: 67-43-6

EC: 200-652-8

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 1719

Nearby record in the same annex

Pentapotassium 2,2’,2’’,2’’’,2’’’’-(ethane-1,2-diylnitrilo)pentaacetate

CAS: 7216-95-7

EC: 404-290-3

Annex II 1721

Nearby record in the same annex

Pentasodium (carboxylatomethyl)iminobis(ethylenenitrilo)tetraacetate; Pentasodium Pentetate (INCI)

CAS: 140-01-2

EC: 205-391-3

Annex II 1718

Nearby record in the same annex

2-ethyl-2-[[(1-oxoallyl)oxy]methyl]-1,3-propanediyl diacrylate; 2,2-bis(acryloyloxymethyl)butyl acr…

CAS: 15625-89-5

EC: 239-701-3

Annex II 1722

Nearby record in the same annex

Acetamiprid (ISO); (1E)-N-[(6-chloropyridin-3-yl)methyl]-N'-cyano-N-methylethanimidamide; (E)-N1-[(…

CAS: 135410-20-7/ 160430-64-8

EC: 603-921-1/ 682-791-8

Annex II 1717

Nearby record in the same annex

Cumene

CAS: 98-82-8

EC: 202-704-5

Annex II 1723

Nearby record in the same annex

Pendimethalin (ISO); N-(1-ethylpropyl)-2,6-dinitro-3,4-xylidene

CAS: 40487-42-1

EC: 254-938-2

Annex II 1716

Nearby record in the same annex

Margosa, ext. [from the kernels of Azadirachta indica extracted with water and further processed wi…

CAS: 84696-25-3

EC: 283-644-7

Annex II 1724

Nearby record in the same annex

Bentazone (ISO); 3-isopropyl-2,1,3-benzothiadiazine-4-one-2,2-dioxide

CAS: 25057-89-0

EC: 246-585-8

Annex II 1715

Nearby record in the same annex

Reaction mass of 3-(difluoromethyl)-1-methyl-N-[(1RS,4SR,9RS)-1,2,3,4-tetrahydro-9-isopropyl-1,4-me…

CAS: 881685-58-1

EC: 632-619-2

Annex II 1725

Nearby record in the same annex

Styrene/Acrylates copolymer (nano) [INCI] Sodium Styrene/Acrylates copolymer (nano) [INCI]

CAS: 9010-92-8

EC: 927-710-1

Annex II 1714

Nearby record in the same annex

N-(5-chloro-2-isopropylbenzyl)-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-car…

CAS: 1255734-28-1

EC: 811-438-4

Annex II 1726

Nearby record in the same annex

Copper (nano) [INCI] Colloidal Copper (nano) [INCI]

CAS: 7440-50-8

EC: 231-159-6

What Annex II means for N-carboxymethyliminobis(ethylenenitrilo)tetra(acetic acid); Pentetic Acid (INCI)

N-carboxymethyliminobis(ethylenenitrilo)tetra(acetic acid); Pentetic Acid (INCI) is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

Verify this substance is absent from all raw materials and finished formulations.
Request absence confirmation or CoA from raw material suppliers.
Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. N-carboxymethyliminobis(ethylenenitrilo)tetra(acetic acid); Pentetic Acid (INCI) is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 67-43-6 is the unique numerical identifier assigned to N-carboxymethyliminobis(ethylenenitrilo)tetra(acetic acid); Pentetic Acid (INCI) by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.

Open INCI Checker

Source note for Annex II record N-carboxymethyliminobis(ethylenenitrilo)tetra(acetic acid); Pentetic Acid (INCI)

This page summarizes one Annex II record for N-carboxymethyliminobis(ethylenenitrilo)tetra(acetic acid); Pentetic Acid (INCI) from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for N-carboxymethyliminobis(ethylenenitrilo)tetra(acetic acid); Pentetic Acid (INCI), but confirm any final regulatory decision against the current official annex wording and source files.

View sources View updates

Tools & next steps

Check your formula

Paste a full INCI list to detect N-carboxymethyliminobis(ethylenenitrilo)tetra(acetic acid); Pentetic Acid (INCI) and other flagged EU annex records in one pass.

Compare entries

Compare N-carboxymethyliminobis(ethylenenitrilo)tetra(acetic acid); Pentetic Acid (INCI) side by side with another annex record to review differences in restrictions, concentrations and annex placement.

Browse the annex

See all records in Annex II and compare regulatory conditions across substances in this annex.