Skip to main content
CosIng Checker
CosIng Checker
EU cosmetic ingredients, restrictions and safety
Login
Annex II Entry 1490 CMR30/07/2020

Trisodium nitrilotriacetate

Trisodium nitrilotriacetate is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

Search similar Back to annex Compare
Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1490
CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 5064-31-3
CAS 5064-31-3PubChem CID 21152

Trisodium Nitrilotriacetate

Sodium nitrilotriacetate is an organic sodium salt composed of sodium and nitrilotriacetate ions in a 3:1 ratio. It has a role as a carcinogenic agent and a nephrotoxic agent. It contains a nitrilotriacetate(3-). — ChEBI

IUPAC name
trisodium;2-[bis(carboxylatomethyl)amino]acetate
Molecular formula
C6H6NNa3O6
Molecular weight
257.08 g/mol
Exact mass
256.98881976 Da
Topological polar surface area
124.0 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
7
Covalent units
4
Defined stereocentres
0

Also known as

Nitrilotriacetic acid trisodium saltTrisodium NTAHampshire NTANtana3Sodium nitrilotriacetateNTA Trisodium saltSyntron ATrisodium aminotriacetate
16 more reported names
Masquol np 140Versene NTA 150Versene NTA 335Hampshire NTA 150Chemcolox 365 powderNitrilotriacetic acid, trisodium saltTrisodium 2,2',2''-nitrilotriacetateTrisodium nitrilotriacetic acidNitrilotriacetate trisodium saltTrisodium N,N-bis(carboxymethyl)glycinateE3C8R2M0XDGlycine, N,N-bis(carboxymethyl)-, trisodium saltAcetic acid, nitrilotri-, trisodium saltN,N-Bis(carboxymethyl)glycine, trisodium saltCHEBI:132766RefChem:192175
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Trisodium nitrilotriacetate

Chemical / IUPAC name

Trisodium nitrilotriacetate

Regulatory information

Regulation

(EU) 2019/831

See every entry this act set

SCCS opinions

Identified ingredients

CMR

CategoryCarcinogenicMutagenicReprotoxic
Cat. 2✓——

Key data

CAS
5064-31-3
EC
225-768-6
Annex
II
Entry number
1490

Inventory links for Trisodium nitrilotriacetate

Inventory Restriction reference
Ref 38775

TRISODIUM NTA

CAS: 5064-31-3
EC: 225-768-6

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

What Annex II means for Trisodium nitrilotriacetate

Trisodium nitrilotriacetate is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).
  • This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.

Frequently asked questions

Yes. Trisodium nitrilotriacetate is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 5064-31-3 is the unique numerical identifier assigned to Trisodium nitrilotriacetate by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Trisodium nitrilotriacetate has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
Open INCI Checker

Source note for Annex II record Trisodium nitrilotriacetate

This page summarizes one Annex II record for Trisodium nitrilotriacetate from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Trisodium nitrilotriacetate, but confirm any final regulatory decision against the current official annex wording and source files.

View sourcesView updates

Tools & next steps

Check your formula

Paste a full INCI list to detect Trisodium nitrilotriacetate and other flagged EU annex records in one pass.

INCI Checker

Compare entries

Compare Trisodium nitrilotriacetate side by side with another annex record to review differences in restrictions, concentrations and annex placement.

Compare

Browse the annex

See all records in Annex II and compare regulatory conditions across substances in this annex.

Open Annex II