Why does CAS 5064-31-3 appear in more than one EU cosmetic annex?

A substance identified by CAS 5064-31-3 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

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Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 5064-31-3 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 5064-31-3

Q: How do I use CAS 5064-31-3 for compliance screening?

Cross-reference CAS 5064-31-3 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 5064-31-3 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 5064-31-3

CAS 5064-31-3PubChem CID 21152

Trisodium Nitrilotriacetate

Sodium nitrilotriacetate is an organic sodium salt composed of sodium and nitrilotriacetate ions in a 3:1 ratio. It has a role as a carcinogenic agent and a nephrotoxic agent. It contains a nitrilotriacetate(3-). — ChEBI

IUPAC name: trisodium;2-[bis(carboxylatomethyl)amino]acetate

Molecular formula: C6H6NNa3O6
Molecular weight: 257.08 g/mol
Exact mass: 256.98881976 Da
Topological polar surface area: 124.0 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 7
Covalent units: 4
Defined stereocentres: 0

Also known as

Nitrilotriacetic acid trisodium saltTrisodium NTAHampshire NTANtana3Sodium nitrilotriacetateNTA Trisodium saltSyntron ATrisodium aminotriacetate

16 more reported names

Masquol np 140Versene NTA 150Versene NTA 335Hampshire NTA 150Chemcolox 365 powderNitrilotriacetic acid, trisodium saltTrisodium 2,2',2''-nitrilotriacetateTrisodium nitrilotriacetic acidNitrilotriacetate trisodium saltTrisodium N,N-bis(carboxymethyl)glycinateE3C8R2M0XDGlycine, N,N-bis(carboxymethyl)-, trisodium saltAcetic acid, nitrilotri-, trisodium saltN,N-Bis(carboxymethyl)glycine, trisodium saltCHEBI:132766RefChem:192175

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:132766
EPA DTXSID:DTXSID8027587

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 5064-31-3

1 total

Annex

Entry

1490

Trisodium nitrilotriacetate

225-768-6

CMR

How CAS 5064-31-3 is used on this site

CAS 5064-31-3 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 5064-31-3 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 5064-31-3 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.

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