Perfluorooctane sulfonic acid; heptadecafluorooctane-1-sulfonic acid [1]; Potassium perfluorooctanesulfonate; potassium heptadecafluorooctane-1-sulfonate [2]; Diethanolamine perfluorooctane sulfonate [3]; Ammonium perfluorooctane sulfonate; ammonium heptadecafluorooctanesulfonate [4]; Lithium perfluorooctane sulfonate; lithium heptadecafluorooctanesulfonate [5]
Perfluorooctane sulfonic acid; heptadecafluorooctane-1-sulfonic acid [1]; Potassium perfluorooctanesulfonate; potassium heptadecafluorooctane-1-sulfonate [2]; Diethanolamine perfluorooctane sulfonate [3]; Ammonium perfluorooctane sulfonate; ammonium heptadecafluorooctanesulfonate [4]; Lithium perfluorooctane sulfonate; lithium heptadecafluorooctanesulfonate [5] is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.
Chemical identity and properties
Perfluorooctanesulfonic acid
Perfluorooctane-1-sulfonic acid is a perfluoroalkanesulfonic acid that is octane-1-sulfonic acid in which all seventeen of the hydrogens that are attached to carbons hvae been replaced by fluorines. It has a role as an antilipemic drug and a persistent organic pollutant. It is functionally related to an octane-1-sulfonic acid. — ChEBI
- IUPAC name
- 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctane-1-sulfonic acid
- Molecular formula
- C8HF17O3S
- Molecular weight
- 500.13 g/mol
- Exact mass
- 499.9374938 Da
- XLogP3
- 5.0
- Topological polar surface area
- 62.8 Ų
- Hydrogen-bond donors
- 1
- Hydrogen-bond acceptors
- 20
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
16 more reported names
External database identifiers
- ChEBI:CHEBI:39421
- ChEMBL:CHEMBL1876554
- EPA DTXSID:DTXSID3031864
- PubMed:23109596
- PubMed:23032776
- PubMed:22964400
- PubMed:22959464
- PubMed:22953896
- PubMed:22946167
- PubMed:22946157
- PubMed:22941726
- PubMed:22935244
- PubMed:22922222
- PubMed:22897837
- PubMed:22879996
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Potassium perfluorooctanesulfonate
- IUPAC name
- potassium 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctane-1-sulfonate
- Molecular formula
- C8F17KO3S
- Molecular weight
- 538.22 g/mol
- Exact mass
- 537.8933753 Da
- Topological polar surface area
- 65.6 Ų
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 20
- Covalent units
- 2
- Defined stereocentres
- 0
Also known as
16 more reported names
External database identifiers
- ChEMBL:CHEMBL1902978
- EPA DTXSID:DTXSID8037706
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Ammonium heptadecafluorooctanesulphonate
- IUPAC name
- azane;1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctane-1-sulfonic acid
- Molecular formula
- C8H4F17NO3S
- Molecular weight
- 517.16 g/mol
- Exact mass
- 516.9640429 Da
- Topological polar surface area
- 63.8 Ų
- Hydrogen-bond donors
- 2
- Hydrogen-bond acceptors
- 21
- Covalent units
- 2
- Defined stereocentres
- 0
Also known as
10 more reported names
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Lithium (perfluorooctane)sulfonate
- IUPAC name
- lithium 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctane-1-sulfonate
- Molecular formula
- C8F17LiO3S
- Molecular weight
- 506.1 g/mol
- Exact mass
- 505.9456722 Da
- Topological polar surface area
- 65.6 Ų
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 20
- Covalent units
- 2
- Defined stereocentres
- 0
Also known as
16 more reported names
External database identifiers
- ChEMBL:CHEMBL3186076
- EPA DTXSID:DTXSID2032421
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Diethanolamine perfluoroctanesulfonate
- IUPAC name
- 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctane-1-sulfonic acid;2-(2-hydroxyethylamino)ethanol
- Molecular formula
- C12H12F17NO5S
- Molecular weight
- 605.27 g/mol
- Exact mass
- 605.0164724 Da
- Topological polar surface area
- 115.0 Ų
- Hydrogen-bond donors
- 4
- Hydrogen-bond acceptors
- 23
- Covalent units
- 2
- Defined stereocentres
- 0
Also known as
4 more reported names
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Record details
Chemical name
Perfluorooctane sulfonic acid; heptadecafluorooctane-1-sulfonic acid [1]; Potassium perfluorooctanesulfonate; potassium heptadecafluorooctane-1-sulfonate [2]; Diethanolamine perfluorooctane sulfonate [3]; Ammonium perfluorooctane sulfonate; ammonium heptadecafluorooctanesulfonate [4]; Lithium perfluorooctane sulfonate; lithium heptadecafluorooctanesulfonate [5]
Chemical / IUPAC name
Perfluorooctane sulfonic acid; heptadecafluorooctane-1-sulfonic acid [1]; Potassium perfluorooctanesulfonate; potassium heptadecafluorooctane-1-sulfonate [2]; Diethanolamine perfluorooctane sulfonate [3]; Ammonium perfluorooctane sulfonate; ammonium heptadecafluorooctanesulfonate [4]; Lithium perfluorooctane sulfonate; lithium heptadecafluorooctanesulfonate [5]
Regulatory information
CMR
| Category | Carcinogenic | Mutagenic | Reprotoxic |
|---|---|---|---|
| Cat. 1B | — | — | ✓ |
| Cat. 2 | ✓ | — | — |
Key data
Related records for Perfluorooctane sulfonic acid; heptadecafluorooctane-1-sulfonic acid [1]; Potassium perfluorooctanesulfonate; potassium heptadecafluorooctane-1-sulfonate [2]; Diethanolamine perfluorooctane sulfonate [3]; Ammonium perfluorooctane sulfonate; ammonium heptadecafluorooctanesulfonate [4]; Lithium perfluorooctane sulfonate; lithium heptadecafluorooctanesulfonate [5]
Direct matches are limited for this record, so nearby entries from Annex II are shown as well.
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What Annex II means for Perfluorooctane sulfonic acid; heptadecafluorooctane-1-sulfonic acid [1]; Potassium perfluorooctanesulfonate; potassium heptadecafluorooctane-1-sulfonate [2]; Diethanolamine perfluorooctane sulfonate [3]; Ammonium perfluorooctane sulfonate; ammonium heptadecafluorooctanesulfonate [4]; Lithium perfluorooctane sulfonate; lithium heptadecafluorooctanesulfonate [5]
Perfluorooctane sulfonic acid; heptadecafluorooctane-1-sulfonic acid [1]; Potassium perfluorooctanesulfonate; potassium heptadecafluorooctane-1-sulfonate [2]; Diethanolamine perfluorooctane sulfonate [3]; Ammonium perfluorooctane sulfonate; ammonium heptadecafluorooctanesulfonate [4]; Lithium perfluorooctane sulfonate; lithium heptadecafluorooctanesulfonate [5] is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.
Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.
The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.
Compliance checklist
- Verify this substance is absent from all raw materials and finished formulations.
- Request absence confirmation or CoA from raw material suppliers.
- Document the screening result in the Product Information File (PIF).
- This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.
Frequently asked questions
Source note for Annex II record Perfluorooctane sulfonic acid; heptadecafluorooctane-1-sulfonic acid [1]; Potassium perfluorooctanesulfonate; potassium heptadecafluorooctane-1-sulfonate [2]; Diethanolamine perfluorooctane sulfonate [3]; Ammonium perfluorooctane sulfonate; ammonium heptadecafluorooctanesulfonate [4]; Lithium perfluorooctane sulfonate; lithium heptadecafluorooctanesulfonate [5]
This page summarizes one Annex II record for Perfluorooctane sulfonic acid; heptadecafluorooctane-1-sulfonic acid [1]; Potassium perfluorooctanesulfonate; potassium heptadecafluorooctane-1-sulfonate [2]; Diethanolamine perfluorooctane sulfonate [3]; Ammonium perfluorooctane sulfonate; ammonium heptadecafluorooctanesulfonate [4]; Lithium perfluorooctane sulfonate; lithium heptadecafluorooctanesulfonate [5] from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.
Use this record page to review Annex II conditions for Perfluorooctane sulfonic acid; heptadecafluorooctane-1-sulfonic acid [1]; Potassium perfluorooctanesulfonate; potassium heptadecafluorooctane-1-sulfonate [2]; Diethanolamine perfluorooctane sulfonate [3]; Ammonium perfluorooctane sulfonate; ammonium heptadecafluorooctanesulfonate [4]; Lithium perfluorooctane sulfonate; lithium heptadecafluorooctanesulfonate [5], but confirm any final regulatory decision against the current official annex wording and source files.
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