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Annex II Entry 1491 CMR30/07/2020

2-Ethylhexyl-2-ethylhexanoate

2-Ethylhexyl-2-ethylhexanoate is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1491
CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 7425-14-1
CAS 7425-14-1PubChem CID 23906

2-Ethylhexyl 2-ethylhexanoate

The Panel concluded that the alkyl ethylhexanoates, listed below, are safe in the present practices of use and concentration described in the safety assessment when formulated to be non-irritating...Ethylhexyl Ethylhexanoate... — Cosmetic Ingredient Review (CIR)

IUPAC name
2-ethylhexyl 2-ethylhexanoate
Molecular formula
C16H32O2
Molecular weight
256.42 g/mol
Exact mass
256.240230259 Da
XLogP3
6.1
Topological polar surface area
26.3 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
0

Also known as

2-Ethylhexyl-2-ethylhexanoateETHYLHEXYL ETHYLHEXANOATEEINECS 231-057-1BRN 1777190UNII-430RJA6715430RJA6715OCTYL OCTANOATE (RIFM)4-02-00-01005 (Beilstein Handbook Reference)
16 more reported names
HEXANOIC ACID, 2-ETHYL, 2-ETHYLHEXYL ESTERRefChem:86968ETHYLHEXYL ETHYLHEXANOATE [INCI]OUCGJMIVSYHBEC-UHFFFAOYSA-NHEXANOIC ACID, 2-ETHYL-, 2-ETHYLHEXYL ESTER2-Ethylhexyl -2-ethylhexanoateHexanoic acid,2-ethyl-, 2-ethylhexyl ester2-Ethylhexanoic acid, 2-ethylhexyl esteroctyloctanoate2-Ethylhexylester kyseliny 2-ethylkapronove2-Ethylhexylester kyseliny 2-ethylkapronove [Czech]2-Ethylhexanoic acid 2-ethylhexyl ester(2-ethylhexyl) 2-ethylhexanoate2-ethyl-hexanoic acid 2-ethyl-hexyl esterDB-251498W-110219
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External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

2-Ethylhexyl-2-ethylhexanoate

Chemical / IUPAC name

2-Ethylhexyl-2-ethylhexanoate

Regulatory information

Regulation

(EU) 2019/831

See every entry this act set

Identified ingredients

CMR

CategoryCarcinogenicMutagenicReprotoxic
Cat. 2——✓

Key data

CAS
7425-14-1
EC
231-057-1
Annex
II
Entry number
1491

Inventory links for 2-Ethylhexyl-2-ethylhexanoate

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

What Annex II means for 2-Ethylhexyl-2-ethylhexanoate

2-Ethylhexyl-2-ethylhexanoate is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).
  • This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.

Frequently asked questions

Yes. 2-Ethylhexyl-2-ethylhexanoate is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 7425-14-1 is the unique numerical identifier assigned to 2-Ethylhexyl-2-ethylhexanoate by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

2-Ethylhexyl-2-ethylhexanoate has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record 2-Ethylhexyl-2-ethylhexanoate

This page summarizes one Annex II record for 2-Ethylhexyl-2-ethylhexanoate from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for 2-Ethylhexyl-2-ethylhexanoate, but confirm any final regulatory decision against the current official annex wording and source files.

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