What does the restriction note for ISOBUTYLPARABEN mean?

The restriction field for ISOBUTYLPARABEN reads: II/1375. This is the restriction note from the CosIng inventory. For authoritative conditions and limits, always refer to the linked annex entries.

What other records share CAS 4247-02-3?

CAS 4247-02-3 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains ISOBUTYLPARABEN?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 3461220/03/2017

ISOBUTYLPARABEN

Isobutyl 4-hydroxybenzoate

ISOBUTYLPARABEN is linked to 1 EU annex record on this page. Inventory note: II/1375.

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Regulatory evidence by market

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Market	Evidence status	Records	Source language
European Union	Evidence linked Prohibited entry found Open this evidence	1	English and EU languages
Great Britain	Evidence linked Prohibited Open this evidence	1	English
Canada	Source mapped Official source mapped; ingredient rule not imported	0	English and French
New Zealand	Evidence linked Prohibited Open this evidence	1	English
ASEAN	Evidence linked Prohibited Open this evidence	1	English and national languages
China	Evidence linked Prohibited Open this evidence	1	Chinese with selected English material
Japan	Source mapped Official source mapped; ingredient rule not imported	0	Japanese; official English translation available
South Korea	Source mapped Official source mapped; ingredient rule not imported	0	Korean with some English names
United States	Source mapped Official source mapped; ingredient rule not imported	0	English
Australia	Source mapped Official source mapped; ingredient rule not imported	0	English
Brazil	Evidence linked Prohibited Open this evidence	1	Portuguese with INCI crosswalks
India	Evidence linked Prohibited Open this evidence	1	English and Hindi
Saudi Arabia	Evidence linked Prohibited Open this evidence	1	Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 4247-02-3

CAS 4247-02-3PubChem CID 20240

Isobutylparaben

Isobutylparaben is a 4-hydroxybenzoate ester. — ChEBI

IUPAC name: 2-methylpropyl 4-hydroxybenzoate

Molecular formula: C11H14O3
Molecular weight: 194.23 g/mol
Exact mass: 194.094294304 Da
XLogP3: 3.4
Topological polar surface area: 46.5 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 3
Covalent units: 1
Defined stereocentres: 0

Also known as

Isobutyl 4-hydroxybenzoateisobutyl parabenIsobutyl p-hydroxybenzoateIsobutyl-4-hydroxybenzoateIsobutyl parahydroxybenzoateBenzoic acid, 4-hydroxy-, 2-methylpropyl esterisobutyl-p-hydroxybenzoateBENZOIC ACID, p-HYDROXY-, ISOBUTYL ESTER

16 more reported names

0QQJ25X58Gi-BHBRefChem:923642224-208-84-Hydroxybenzoic Acid Isobutyl Esterp-Hydroxybenzoic acid isobutyl esterChemDiv2_000057p-OxybenzoesaureisobutylesterCHEBI:1782564-Hydroxybenzoic acid-isobutyl esterISOBUTYL PARA HYDROXY BENZOATEp-Hydroxybenzoic acid sec-butyl ester3-10-00-00308 (Beilstein Handbook Reference)SR-01000389342-12-Methylpropyl 4-Hydroxybenzoate (Isobutyl Parahydroxybenzoate)CCRIS 2463

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:178256
ChEMBL:CHEMBL3182006
EPA DTXSID:DTXSID4020749
PubMed:31472229
PubMed:29945225
PubMed:28927721
PubMed:23567241
PubMed:23211298
PubMed:22961055
PubMed:22690157
PubMed:22648813
PubMed:22237600
PubMed:22076563
PubMed:22051549
PubMed:22027501

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for ISOBUTYLPARABEN

INCI name

ISOBUTYLPARABEN

Description

Isobutyl 4-hydroxybenzoate

Record provenance

Inventory reference: 34612
Imported identity: ISOBUTYLPARABEN
Source update: 20/03/2017

European Commission CosIng source notes

Annex records for ISOBUTYLPARABEN

Annex II Restriction reference

Entry 1375

Isobutyl 4-hydroxybenzoate (INCI: Isobutylparaben) /Sodium salt or Salts of Isobutylparaben

CAS: 4247-02-3 / 224-208-8

EC: 84930-15-4 / 284-595-4

Key data

CAS

4247-02-3

224-208-8

Restriction

II/1375

Function

ANTIMICROBIAL: Preventing and/or slowing down microbial growth.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#13702 · ISOBUTYLPARABEN

Ingredients with overlapping formulation functions

ICHTHAMMOLANTIMICROBIAL

ICTASOLANTI-SEBORRHEIC, ANTIMICROBIAL

IODOFORMANTIMICROBIAL

IPOMOEA BATATAS MERISTEM CELL EXTRACTANTI-SEBORRHEIC; ANTIMICROBIAL; ANTIOXIDANT; SKIN PROTECTING

ISODECYLPARABENANTIMICROBIAL

ISOPROPYL SORBATEANTIMICROBIAL

ISOPROPYLBENZYL BUTYLNORBERBERINE IODIDEANTI-SEBORRHEIC, ANTIMICROBIAL, HAIR CONDITIONING

ITACONIC ACIDANTIMICROBIAL, BUFFERING, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How ISOBUTYLPARABEN appears in the CosIng inventory

The CosIng inventory lists ISOBUTYLPARABEN as a cosmetic ingredient and this page links it to 1 annex record. The inventory entry captures names and identifiers, while the annex record shows where the substance is prohibited, restricted or positively listed in EU cosmetics law.

ISOBUTYLPARABEN is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

ISOBUTYLPARABEN appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

The restriction field for ISOBUTYLPARABEN reads: "II/1375". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.

According to the EU CosIng inventory, ISOBUTYLPARABEN carries the following function designation(s):

ANTIMICROBIAL

CAS 4247-02-3 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for ISOBUTYLPARABEN

This page combines the CosIng inventory entry for ISOBUTYLPARABEN with 1 linked Annex II–VI record from the local dataset built from public European Commission cosmetic ingredient materials.

Use this inventory page to research ISOBUTYLPARABEN and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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