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Annex II Entry 1299 21/10/2010

Ethanaminium, N-(4-[(4-(diethylamino)phenyl)phenylmethylene]-2,5-cyclohexadien-1-ylidine)-N-ethyl- and its salts, when used as a substance in hair dye products

Ethanaminium, N-(4-[(4-(diethylamino)phenyl)phenylmethylene]-2,5-cyclohexadien-1-ylidine)-N-ethyl- and its salts, when used as a substance in hair dye products is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1299

Chemical identity and properties

PubChem 2D chemical structure for CAS 633-03-4
CAS 633-03-4PubChem CID 12449

Brilliant Green

Brilliant green is an organic hydrogensulfate salt having 4-{[4-(diethylamino)phenyl](phenyl)methylidene}-N,N-diethylcyclohexa-2,5-dien-1-iminium as the counterion. It has a role as an antibacterial agent, an antiseptic drug, a fluorochrome, a poison, a histological dye and an environmental contaminant. It contains a brilliant green cation. — ChEBI

IUPAC name
[4-[[4-(diethylamino)phenyl]-phenylmethylidene]cyclohexa-2,5-dien-1-ylidene]-diethylazanium;hydrogen sulfate
Molecular formula
C27H34N2O4S
Molecular weight
482.6 g/mol
Exact mass
482.22392874 Da
Topological polar surface area
92.1 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
5
Covalent units
2
Defined stereocentres
0

Also known as

Basic green 1Malachite Green GDiamond Green GC.I. Basic Green 1Fast Green JSolid GreenBasic Brilliant GreenBasic Green V
16 more reported names
Green ENBrilliant Green BBrilliant Green GBrilliant Green PBrilliant Green YFast Green JJOBasic Bright GreenBrilliant Green GXBrilliant Green YNDeorlene Green JJOBrilliant Green BPCBrilliant Green DSCBrilliant Green LakeBrilliant Green YNSHidaco Brilliant GreenAstrazon Green D
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Ethanaminium, N-(4-[(4-(diethylamino)phenyl)phenylmethylene]-2,5-cyclohexadien-1-ylidine)-N-ethyl- and its salts, when used as a substance in hair dye products

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

SCCS opinions

  • Opinion concerning Use of Permanent Hair Dyes and Bladder Cancer - Updated 2004
  • Opinion concerning Hair Dyes without File submitted
  • Opinion on Personal Use of Hair Dyes and Cancer Risk
  • Opinion on the Use of Permanent Hair Dyes and Bladder Cancer Risk
  • Assessment Strategies for Hair Dyes

Identified ingredients

Key data

CAS
633-03-4
EC
211-190-1
Annex
II
Entry number
1299

Inventory links for Ethanaminium, N-(4-[(4-(diethylamino)phenyl)phenylmethylene]-2,5-cyclohexadien-1-ylidine)-N-ethyl- and its salts, when used as a substance in hair dye products

Inventory Restriction reference
Ref 32073

BASIC GREEN 1

CAS: 633-03-4
EC: 211-190-1

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

What Annex II means for Ethanaminium, N-(4-[(4-(diethylamino)phenyl)phenylmethylene]-2,5-cyclohexadien-1-ylidine)-N-ethyl- and its salts, when used as a substance in hair dye products

Ethanaminium, N-(4-[(4-(diethylamino)phenyl)phenylmethylene]-2,5-cyclohexadien-1-ylidine)-N-ethyl- and its salts, when used as a substance in hair dye products is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. Ethanaminium, N-(4-[(4-(diethylamino)phenyl)phenylmethylene]-2,5-cyclohexadien-1-ylidine)-N-ethyl- and its salts, when used as a substance in hair dye products is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 633-03-4 is the unique numerical identifier assigned to Ethanaminium, N-(4-[(4-(diethylamino)phenyl)phenylmethylene]-2,5-cyclohexadien-1-ylidine)-N-ethyl- and its salts, when used as a substance in hair dye products by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Ethanaminium, N-(4-[(4-(diethylamino)phenyl)phenylmethylene]-2,5-cyclohexadien-1-ylidine)-N-ethyl- and its salts, when used as a substance in hair dye products

This page summarizes one Annex II record for Ethanaminium, N-(4-[(4-(diethylamino)phenyl)phenylmethylene]-2,5-cyclohexadien-1-ylidine)-N-ethyl- and its salts, when used as a substance in hair dye products from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Ethanaminium, N-(4-[(4-(diethylamino)phenyl)phenylmethylene]-2,5-cyclohexadien-1-ylidine)-N-ethyl- and its salts, when used as a substance in hair dye products, but confirm any final regulatory decision against the current official annex wording and source files.

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