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Annex II Entry 1240 15/10/2010

Tetrahydro-6-nitroquinoxaline and its salts

Tetrahydro-6-nitroquinoxaline and its salts is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1240

Chemical identity and properties

PubChem 2D chemical structure for CAS 158006-54-3
CAS 158006-54-3PubChem CID 23213043

Quinoxaline, 1,2,3,4-tetrahydro-6-nitro-, monohydrochloride

IUPAC name
6-nitro-1,2,3,4-tetrahydroquinoxaline;hydrochloride
Molecular formula
C8H10ClN3O2
Molecular weight
215.64 g/mol
Exact mass
215.0461543 Da
Topological polar surface area
69.9 Ų
Hydrogen-bond donors
3
Hydrogen-bond acceptors
4
Covalent units
2
Defined stereocentres
0
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External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 41959-35-7
CAS 41959-35-7PubChem CID 10197942

1,2,3,4-Tetrahydro-6-nitroquinoxaline

IUPAC name
6-nitro-1,2,3,4-tetrahydroquinoxaline
Molecular formula
C8H9N3O2
Molecular weight
179.18 g/mol
Exact mass
179.069476538 Da
XLogP3
1.5
Topological polar surface area
69.9 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
4
Covalent units
1
Defined stereocentres
0

Also known as

RefChem:4105456-NITRO-1,2,3,4-TETRAHYDRO QUINOXALINETetrahydro-6-nitroquinoxaline1,2,3,4-tetrahydro-6-nitro-quinoxalineQuinoxaline, 1,2,3,4-tetrahydro-6-nitro-Quinoxaline, 1,2,3,4-tetrahydro-6-nitro- (9CI)6-Nitro-1234-tetrahydroquinoxalineCS-W022513
3 more reported names
DS-0870DB-070239AE-562/43292921
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 73855-45-5
CAS 73855-45-5PubChem CID 3056886

Quinoxaline, 1,2,3,4-tetrahydro-6-chloro-

IUPAC name
6-chloro-1,2,3,4-tetrahydroquinoxaline
Molecular formula
C8H9ClN2
Molecular weight
168.62 g/mol
Exact mass
168.0454260 Da
XLogP3
2.3
Topological polar surface area
24.1 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
0

Also known as

BRN 0135422Quinoxaline, 6-chloro-1,2,3,4-tetrahydro-5-23-06-00027 (Beilstein Handbook Reference)RefChem:3788686-Chloro-1,2,3,4-tetrahydro-quinoxalineClC1=CC=C2NCCNC2=C1MS-20013DB-359333
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Tetrahydro-6-nitroquinoxaline and its salts

Chemical / IUPAC name

Quinoxaline, 1,2,3,4-tetrahydro-6-chloro-

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

SCCS opinions

Identified ingredients

Key data

CAS
158006-54-3 / 41959-35-7 / 73855-45-5
EC
- / - / -
Annex
II
Entry number
1240

Inventory links for Tetrahydro-6-nitroquinoxaline and its salts

Inventory Shared CAS number
Ref 34210

HC RED NO. 8

CAS: 13556-29-1 / 97404-14-3 / 41959-35-7
EC: - / 306-778-0 / -

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 1238
Nearby record in the same annex

HC Green No 1

CAS: 52136-25-1
EC: 257-687-7

What Annex II means for Tetrahydro-6-nitroquinoxaline and its salts

Tetrahydro-6-nitroquinoxaline and its salts is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

This record is linked to 2 CosIng inventory ingredients for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. Tetrahydro-6-nitroquinoxaline and its salts is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 158006-54-3 / 41959-35-7 / 73855-45-5 is the unique numerical identifier assigned to Tetrahydro-6-nitroquinoxaline and its salts by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Tetrahydro-6-nitroquinoxaline and its salts

This page summarizes one Annex II record for Tetrahydro-6-nitroquinoxaline and its salts from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Tetrahydro-6-nitroquinoxaline and its salts, but confirm any final regulatory decision against the current official annex wording and source files.

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