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Annex II Entry 1237 21/10/2010

HC Orange No 3

HC Orange No 3 is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1237

Chemical identity and properties

PubChem 2D chemical structure for CAS 81612-54-6
CAS 81612-54-6PubChem CID 21909542

HC Orange No. 3

IUPAC name
3-[4-(2-hydroxyethylamino)-3-nitrophenoxy]propane-1,2-diol
Molecular formula
C11H16N2O6
Molecular weight
272.25 g/mol
Exact mass
272.10083623 Da
XLogP3
0.3
Topological polar surface area
128.0 Ų
Hydrogen-bond donors
4
Hydrogen-bond acceptors
7
Covalent units
1
Defined stereocentres
0

Also known as

Imexine FACHC ORANGE 3UNII-428754S94Z1,2-Propanediol, 3-(4-((2-hydroxyethyl)amino)-3-nitrophenoxy)-RefChem:145371HC ORANGE NO. 3 [INCI](+-)-HC ORANGE NO. 3HC Orange 3
7 more reported names
HC Orange no. 3(+/-)-HC Orange no. 33-(4-((2-Hydroxyethyl)amino)-3-nitrophenoxy)propane-1,2-diol3-{4-[(2-HYDROXYETHYL)AMINO]-3-NITROPHENOXY}PROPANE-1,2-DIOLSZWQTBKBBNGUAB-UHFFFAOYSA-N(+/-)-HC ORANGE NO. 33-nitro-4-[N-(beta-hydroxyethyl)-amino]-phenyl beta,gamma-dihydroxypropyl ether
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

HC Orange No 3

Regulatory information

Regulation

(EC) 2009/1223

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SCCS opinions

Identified ingredients

Key data

CAS
81612-54-6
EC
—
Annex
II
Entry number
1237

Inventory links for HC Orange No 3

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 1238
Nearby record in the same annex

HC Green No 1

CAS: 52136-25-1
EC: 257-687-7

What Annex II means for HC Orange No 3

HC Orange No 3 is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. HC Orange No 3 is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 81612-54-6 is the unique numerical identifier assigned to HC Orange No 3 by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record HC Orange No 3

This page summarizes one Annex II record for HC Orange No 3 from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for HC Orange No 3, but confirm any final regulatory decision against the current official annex wording and source files.

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