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Annex II Entry 1238 21/10/2010

HC Green No 1

HC Green No 1 is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1238

Chemical identity and properties

PubChem 2D chemical structure for CAS 52136-25-1
CAS 52136-25-1PubChem CID 104094

HC Green No. 1

IUPAC name
2-[4-[bis(2-hydroxyethyl)amino]anilino]-5-(2-hydroxyethylamino)cyclohexa-2,5-diene-1,4-dione
Molecular formula
C18H23N3O5
Molecular weight
361.4 g/mol
Exact mass
361.16377084 Da
XLogP3
0.0
Topological polar surface area
122.0 Ų
Hydrogen-bond donors
5
Hydrogen-bond acceptors
8
Covalent units
1
Defined stereocentres
0

Also known as

UNII-578544UDFJIMEXINE IKEINECS 257-687-72,5-CYCLOHEXADIENE-1,4-DIONE, 2-((4-(BIS(2-HYDROXYETHYL)AMINO)PHENYL)AMINO)-5-((2-HYDROXYETHYL)AMINO)-2-((4-(BIS(2-HYDROXYETHYL)AMINO)PHENYL)AMINO)-5-((2-HYDROXYETHYL)AMINO)-2,5-CYCLOHEXADIENE-1,4-DIONERefChem:145368HC GREEN NO. 1 [INCI]2-((4-(Bis(2-hydroxyethyl)amino)phenyl)amino)-5-((2-hydroxyethyl)-amino)-2,5-cyclohexadiene-1,4-dione
15 more reported names
2-beta-Hydroxyethylamino-5-(4'-bis-(beta-hydroxyethyl)-amino)anil-ino-1,4-benzoquinone2,5-Cyclohexadiene-1,4-dione, 2-((4-(bis(2-hydroxyethyl)amino)phenyl)amino)-5-((2-hydroxyethyl)-amino)-2-.BETA.-HYDROXYETHYLAMINO-5-(4'-BIS-(.BETA.-HYDROXYETHYL)-AMINO)ANILINO-1,4-BENZOQUINONE2-BETA-HYDROXYETHYLAMINO-5-(4'-BIS-(BETA-HYDROXYETHYL)-AMINO)ANILINO-1,4-BENZOQUINONE257-687-72-((4-(Bis(2-hydroxyethyl)amino)phenyl)amino)-5-((2-hydroxyethyl)- amino)-2,5-cyclohexadiene-1,4-dione2-((4-(Bis(2-hydroxyethyl)amino)phenyl)amino)-5-((2-hydroxyethyl)amino)cyclohexa-2,5-diene-1,4-dione1,8-naphthaolactamBZYZOJIGZUACMS-UHFFFAOYSA-NDB-2605412-beta-Hydroxyethylamino-5-(4'-bis-(beta-hydroxyethyl)-amino)anil- ino-1,4- benzoquinone2,5-Cyclohexadiene-1,4-dione, 2-((4-(bis(2-hydroxyethyl)amino)phenyl)amino)-5-((2-hydroxyethyl)- amino)-2-.BETA.-HYDROXYETHYLAMINO-5-(4'-BIS-(.BETA.-HYDROXYETHYL)-AMINO)ANILINO-1,4- BENZOQUINONE2-[[4-[Bis(2-hydroxyethyl)amino]phenyl ]amino]-5-[(2-hydroxyethyl)amino]cyclohexa-2,5-diene-1,4-dione2-{4-[Bis(2-hydroxyethyl)amino]anilino}-5-[(2-hydroxyethyl)amino]cyclohexa-2,5-diene-1,4-dione
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External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

HC Green No 1

Regulatory information

Regulation

(EC) 2009/1223

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SCCS opinions

Identified ingredients

Key data

CAS
52136-25-1
EC
257-687-7
Annex
II
Entry number
1238

Inventory links for HC Green No 1

Inventory Restriction reference
Ref 34200

HC GREEN NO. 1

CAS: 52136-25-1
EC: 257-687-7

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

What Annex II means for HC Green No 1

HC Green No 1 is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. HC Green No 1 is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 52136-25-1 is the unique numerical identifier assigned to HC Green No 1 by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record HC Green No 1

This page summarizes one Annex II record for HC Green No 1 from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for HC Green No 1, but confirm any final regulatory decision against the current official annex wording and source files.

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