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Annex II Entry 1246 21/10/2010

5-Hydroxy-1,4-benzodioxane and its salts, when used as a substance in hair dye products

5-Hydroxy-1,4-benzodioxane and its salts, when used as a substance in hair dye products is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1246

Chemical identity and properties

PubChem 2D chemical structure for CAS 10288-36-5
CAS 10288-36-5PubChem CID 82520

2,3-Dihydro-1,4-benzodioxin-5-ol

IUPAC name
2,3-dihydro-1,4-benzodioxin-5-ol
Molecular formula
C8H8O3
Molecular weight
152.15 g/mol
Exact mass
152.047344113 Da
XLogP3
1.3
Topological polar surface area
38.7 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
3
Covalent units
1
Defined stereocentres
0

Also known as

2,3-DIHYDROBENZO[B][1,4]DIOXIN-5-OL5-hydroxy-1,4-benzodioxane2,3-EthylenedioxyphenolEINECS 233-639-02,3-dihydro-5-hydroxy-1,4-benzodioxin5-Hydroxy-1,4-benzodioxanUNII-7SES1T8T441,4-BENZODIOXIN-5-OL, 2,3-DIHYDRO-
16 more reported names
7SES1T8T445-Hydroxy-2,3-dihydro-1,4-benzodioxin1,4-BENZODIOXAN-5-OL1,4-BENZODIOXAN, 5-HYDROXY-2,3-DIHYDROBENZO(1,4)DIOXINE-5-OL2,3-DIHYDROBENZO(B)(1,4)DIOXIN-5-OL2,3-Dihydrobenzo[1,4]dioxine-5-olRefChem:81653233-639-02,3-Dihydro-benzo[1,4]dioxin-5-olCS-W0056502H,3H-benzo[e]1,4-dioxin-5-olSpectrum35-hydroxybenzodioxane1-Phenylcyclopropanamine, HClDS-0384
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match82520

Attributed physical-property, hazard, environmental and use annotations.

  • Signal: Warning Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]; H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]; H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]; H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation]; H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory. Source: European Chemicals Agency (ECHA)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBINo exact record2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

5-Hydroxy-1,4-benzodioxane and its salts, when used as a substance in hair dye products

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

SCCS opinions

Key data

CAS
10288-36-5
EC
233-639-0
Annex
II
Entry number
1246

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

What Annex II means for 5-Hydroxy-1,4-benzodioxane and its salts, when used as a substance in hair dye products

5-Hydroxy-1,4-benzodioxane and its salts, when used as a substance in hair dye products is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. 5-Hydroxy-1,4-benzodioxane and its salts, when used as a substance in hair dye products is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 10288-36-5 is the unique numerical identifier assigned to 5-Hydroxy-1,4-benzodioxane and its salts, when used as a substance in hair dye products by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record 5-Hydroxy-1,4-benzodioxane and its salts, when used as a substance in hair dye products

This page summarizes one Annex II record for 5-Hydroxy-1,4-benzodioxane and its salts, when used as a substance in hair dye products from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for 5-Hydroxy-1,4-benzodioxane and its salts, when used as a substance in hair dye products, but confirm any final regulatory decision against the current official annex wording and source files.

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