Nickel hydrogen phosphate [1]; Nickel bis(dihydrogen phosphate) [2]; Trinickel bis(orthophosphate) [3]; Dinickel diphosphate [4]; Nickel bis(phosphinate) [5]; Nickel phosphinate [6]; Phosphoric acid, calcium nickel salt [7]; Diphosphoric acid, nickel(II) salt [8]
Nickel hydrogen phosphate [1]; Nickel bis(dihydrogen phosphate) [2]; Trinickel bis(orthophosphate) [3]; Dinickel diphosphate [4]; Nickel bis(phosphinate) [5]; Nickel phosphinate [6]; Phosphoric acid, calcium nickel salt [7]; Diphosphoric acid, nickel(II)
Listed by the Saudi Food and Drug Authority as prohibited in cosmetic products.
Regulatory decision and full conditions
- Status
- Prohibited
- Legal role
- Binding rule
- Regulatory summary
- Listed by the Saudi Food and Drug Authority as prohibited in cosmetic products.
- Conditions and restrictions
- A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. Open the cited source and apply the market-wide requirements below.
Substance identity
- Official source name
- Nickel hydrogen phosphate [1]; Nickel bis(dihydrogen phosphate) [2]; Trinickel bis(orthophosphate) [3]; Dinickel diphosphate [4]; Nickel bis(phosphinate) [5]; Nickel phosphinate [6]; Phosphoric acid, calcium nickel salt [7]; Diphosphoric acid, nickel(II) salt [8]
- CAS
- 14332-34-4; 18718-11-1; 10381-36-9; 14448-18-1; 14507-36-9; 36026-88-7; 17169-61-8; 19372-20-4
- EC
- Not supplied in this source row
- Identity mapping
- standalone:official_sfda_record
Cross-market snapshot for this identity
Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.
European Union
1 linked record
Open supporting recordNew Zealand
8 linked records
Open supporting recordIndia
2 linked records · 2 with specific conditions
Open supporting recordSaudi Arabia
Current record1 linked record
Open supporting recordVerified chemistry for CAS 10381-36-9
Nickel phosphate
- IUPAC name
- tris(nickel(2+)) diphosphate
- Molecular formula
- Ni3O8P2
- Molecular weight
- 366.02 g/mol
- Exact mass
- 365.708309 Da
- Monoisotopic mass
- 363.71287 Da
- Topological polar surface area
- 173.0 Ų
- Molecular complexity
- 36.0
- Formal charge
- 0
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 8
- Rotatable bonds
- 0
- Heavy atoms
- 13
- Covalent units
- 5
Names and synonyms reported to PubChem
16 more reported names
External database identifiers
- EPA DTXSID:DTXSID20889591
Advanced structure statistics
- Defined atom stereocentres
- 0
- Undefined atom stereocentres
- 0
- Defined bond stereocentres
- 0
- Undefined bond stereocentres
- 0
- 3D conformers
- 0
Machine-readable structure identifiers
- SMILES
[O-]P(=O)([O-])[O-].[O-]P(=O)([O-])[O-].[Ni+2].[Ni+2].[Ni+2]- InChI
InChI=1S/3Ni.2H3O4P/c;;;2*1-5(2,3)4/h;;;2*(H3,1,2,3,4)/q3*+2;;/p-6- InChIKey
AFYAQDWVUWAENU-UHFFFAOYSA-H
Evidence from additional scientific databases
NIH PubChem PUG-View
Attributed physical-property, hazard, environmental and use annotations.
- Physical Description: Liquid Source: EPA Chemical Data Reporting (CDR)
- Physical Description: Light green solid, insoluble in water; [Merck Index] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Carcinogen Classification: 1, carcinogenic to humans. (L135) Source: Toxin and Toxin Target Database (T3DB)
- Exposure Routes: Oral (L41) ; inhalation (L41) ; dermal (L41) Source: Toxin and Toxin Target Database (T3DB)
- Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- GHS Hazard Statements: H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]; H350i: May cause cancer by inhalation [Danger Carcinogenicity]; H372 **: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Precautionary Statement Codes: P203, P233, P260, P261, P264, P270, P271, P272, P273, P280, P284, P302+P352, P304+P340, P318, P319, P321, P333+P317, P342+P316, P362+P364, P391, P403, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Signal: Danger Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H334 (100%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]; H350 (100%): May cause cancer [Danger Carcinogenicity]; H372 (100%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P203, P233, P260, P261, P264, P270, P271, P272, P273, P280, P284, P302+P352, P304+P340, P318, P319, P321, P333+P317, P342+P316, P362+P364, P391, P403, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 73 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Health Effects: The most common harmful health effect of nickel in humans is an allergic reaction. This usually manifests as a skin rash, although some people experience asthma attacks. Long term inhahation of nickel causes chronic bronchitis and reduced lung function, as well as damage to the naval cavity. Ingestion of excess nickel results in damage to the stomach, blood, liver, kidneys, and immune system, as well as having adverse effects on reproduction and development. (L41) Source: Toxin and Toxin Target Database (T3DB)
- Toxicity Summary: Nickel is known to substitute for other essential elements in certain enzmes, such as calcineurin. It is genotoxic, and some nickel compounds have been shown to promote cell proliferation. Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. Nickel has also been shown to alter several transcription factors, including hypoxia-inducible transcription factor, activating transcription factor, and NF-KB transcription factor. There is also evidence that nickel ions inhibit DNA repair, either by directly inhibiting DNA repair enzymes or competing with zinc ions for binding to zinc-finger DNA binding proteins, resulting in structural changes in DNA that prevent repair enzymes from binding. Nickel ions can also complex with a number of cellular ligands including amino acids, peptides, and proteins resulting in the generation of oxygen radicals, which induce base damage, DNA strand breaks, and DNA protein crosslinks. (L41, Source: Toxin and Toxin Target Database (T3DB)
- Consumer Uses: Plating agent; Other Source: EPA Chemical Data Reporting (CDR)
- Industry Uses: Adhesion/cohesion promoter; Plating agent; Other Source: EPA Chemical Data Reporting (CDR)
- Sources/Uses: Yields on ignition nickel yellow, a pigment in oil and water-color paints; [Merck Index] Used in electroplating; [Hawley] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Industrial Processes with risk of exposure: Electroplating [Category: Plate]; Painting (Pigments, Binders, and Biocides) [Category: Paint] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| EMBL-EBI ChEBI | No exact record | 2026-08-31 |
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Verified chemistry for CAS 14332-34-4
Nickel hydrogen phosphate
- IUPAC name
- hydrogen phosphate;nickel(2+)
- Molecular formula
- HNiO4P
- Molecular weight
- 154.673 g/mol
- Exact mass
- 153.896587 Da
- Monoisotopic mass
- 153.896587 Da
- Topological polar surface area
- 83.4 Ų
- Molecular complexity
- 46.0
- Formal charge
- 0
- Hydrogen-bond donors
- 1
- Hydrogen-bond acceptors
- 4
- Rotatable bonds
- 0
- Heavy atoms
- 6
- Covalent units
- 2
Names and synonyms reported to PubChem
External database identifiers
- EPA DTXSID:DTXSID90931819
Advanced structure statistics
- Defined atom stereocentres
- 0
- Undefined atom stereocentres
- 0
- Defined bond stereocentres
- 0
- Undefined bond stereocentres
- 0
- 3D conformers
- 0
Machine-readable structure identifiers
- SMILES
OP(=O)([O-])[O-].[Ni+2]- InChI
InChI=1S/Ni.H3O4P/c;1-5(2,3)4/h;(H3,1,2,3,4)/q+2;/p-2- InChIKey
OLYKGFYCSAJGKT-UHFFFAOYSA-L
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Verified chemistry for CAS 14448-18-1
Diphosphoric acid, nickel(2+) salt (1:2)
- IUPAC name
- bis(nickel(2+));phosphonato phosphate
- Molecular formula
- Ni2O7P2
- Molecular weight
- 291.33 g/mol
- Exact mass
- 289.782610 Da
- Monoisotopic mass
- 289.782610 Da
- Topological polar surface area
- 136.0 Ų
- Molecular complexity
- 124.0
- Formal charge
- 0
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 7
- Rotatable bonds
- 0
- Heavy atoms
- 11
- Covalent units
- 3
Names and synonyms reported to PubChem
External database identifiers
- EPA DTXSID:DTXSID80889633
Advanced structure statistics
- Defined atom stereocentres
- 0
- Undefined atom stereocentres
- 0
- Defined bond stereocentres
- 0
- Undefined bond stereocentres
- 0
- 3D conformers
- 0
Machine-readable structure identifiers
- SMILES
[O-]P(=O)([O-])OP(=O)([O-])[O-].[Ni+2].[Ni+2]- InChI
InChI=1S/2Ni.H4O7P2/c;;1-8(2,3)7-9(4,5)6/h;;(H2,1,2,3)(H2,4,5,6)/q2*+2;/p-4- InChIKey
OHPFZXJAABILIK-UHFFFAOYSA-J
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Verified chemistry for CAS 14507-36-9
Phosphinic acid, nickel(2+) salt (2:1)
- Molecular formula
- NiO2P+
- Formula without charge
- NiO2P
- Molecular weight
- 121.666 g/mol
- Exact mass
- 120.898933 Da
- Monoisotopic mass
- 120.898933 Da
- Topological polar surface area
- 40.1 Ų
- Molecular complexity
- 7.0
- Formal charge
- 1
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 2
- Rotatable bonds
- 0
- Heavy atoms
- 4
- Covalent units
- 2
Names and synonyms reported to PubChem
Advanced structure statistics
- Defined atom stereocentres
- 0
- Undefined atom stereocentres
- 0
- Defined bond stereocentres
- 0
- Undefined bond stereocentres
- 0
- 3D conformers
- 0
Machine-readable structure identifiers
- SMILES
[O-]P=O.[Ni+2]- InChI
InChI=1S/Ni.HO2P/c;1-3-2/h;(H,1,2)/q+2;/p-1- InChIKey
FHWOHHDDVAYSLG-UHFFFAOYSA-M
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Verified chemistry for CAS 17169-61-8
Phosphoric acid, calcium nickel salt (1:?:?)
- IUPAC name
- calcium;nickel(2+);phosphate
- Molecular formula
- CaNiO4P+
- Formula without charge
- CaNiO4P
- Molecular weight
- 193.74 g/mol
- Exact mass
- 192.851353 Da
- Monoisotopic mass
- 192.851353 Da
- Topological polar surface area
- 86.3 Ų
- Molecular complexity
- 36.0
- Formal charge
- 1
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 4
- Rotatable bonds
- 0
- Heavy atoms
- 7
- Covalent units
- 3
Names and synonyms reported to PubChem
Advanced structure statistics
- Defined atom stereocentres
- 0
- Undefined atom stereocentres
- 0
- Defined bond stereocentres
- 0
- Undefined bond stereocentres
- 0
- 3D conformers
- 0
Machine-readable structure identifiers
- SMILES
[O-]P(=O)([O-])[O-].[Ca+2].[Ni+2]- InChI
InChI=1S/Ca.Ni.H3O4P/c;;1-5(2,3)4/h;;(H3,1,2,3,4)/q2*+2;/p-3- InChIKey
FIQNIRPYLPNUDK-UHFFFAOYSA-K
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Verified chemistry for CAS 18718-11-1
Phosphoric acid, nickel(2+) salt (2:1)
- IUPAC name
- bis(dihydrogen phosphate);nickel(2+)
- Molecular formula
- H4NiO8P2
- Molecular weight
- 252.67 g/mol
- Exact mass
- 251.873483 Da
- Monoisotopic mass
- 251.873483 Da
- Topological polar surface area
- 161.0 Ų
- Molecular complexity
- 49.0
- Formal charge
- 0
- Hydrogen-bond donors
- 4
- Hydrogen-bond acceptors
- 8
- Rotatable bonds
- 0
- Heavy atoms
- 11
- Covalent units
- 3
Names and synonyms reported to PubChem
External database identifiers
- EPA DTXSID:DTXSID401029291
Advanced structure statistics
- Defined atom stereocentres
- 0
- Undefined atom stereocentres
- 0
- Defined bond stereocentres
- 0
- Undefined bond stereocentres
- 0
- 3D conformers
- 0
Machine-readable structure identifiers
- SMILES
OP(=O)(O)[O-].OP(=O)(O)[O-].[Ni+2]- InChI
InChI=1S/Ni.2H3O4P/c;2*1-5(2,3)4/h;2*(H3,1,2,3,4)/q+2;;/p-2- InChIKey
LCFKXCNZLIBDOX-UHFFFAOYSA-L
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Verified chemistry for CAS 19372-20-4
Diphosphoric acid, nickel(2+) salt (1:?)
- IUPAC name
- nickel(2+);phosphonato phosphate
- Molecular formula
- NiO7P2-2
- Formula without charge
- NiO7P2
- Molecular weight
- 232.64 g/mol
- Exact mass
- 231.847268 Da
- Monoisotopic mass
- 231.847268 Da
- Topological polar surface area
- 136.0 Ų
- Molecular complexity
- 124.0
- Formal charge
- -2
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 7
- Rotatable bonds
- 0
- Heavy atoms
- 10
- Covalent units
- 2
Names and synonyms reported to PubChem
Advanced structure statistics
- Defined atom stereocentres
- 0
- Undefined atom stereocentres
- 0
- Defined bond stereocentres
- 0
- Undefined bond stereocentres
- 0
- 3D conformers
- 0
Machine-readable structure identifiers
- SMILES
[O-]P(=O)([O-])OP(=O)([O-])[O-].[Ni+2]- InChI
InChI=1S/Ni.H4O7P2/c;1-8(2,3)7-9(4,5)6/h;(H2,1,2,3)(H2,4,5,6)/q+2;/p-4- InChIKey
QAFJCFNEKICMDN-UHFFFAOYSA-J
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Official source and provenance
- Registered source
- Saudi SFDA prohibited and restricted ingredient lists
- Source reference
- SFDA prohibited list, page 145, row 1
- Source record ID
prohibited-144-1- Source version
- live-snapshot-2026-08-30
- Source language
- English
- Translation status
- Original is English
- Snapshot checked
- 2026-08-30 05:18 UTC
- Validation method
- complete SFDA paginated HTML snapshot; strict page/row counts
- SHA-256
ceb6cc636e6b1f4b3013f88ce0297217b49d6194342c6ece5c03b1e04256d71a
Registered dataset notes
- Dataset coverage
- Prohibited and restricted substances with CAS, EC and conditions
- Authority note
- Official SFDA dated lists; version and hash each release
How this record fits the market dataset
Status distribution
Condition text is present on 0 of 2090 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.
Saudi Arabia market context
Complete official list index
Coverage version: SFDA live prohibited/restricted lists, snapshot 30 August 2026
Every page and entry in the public SFDA prohibited and restricted ingredient indexes; restricted detail pages remain the source for conditions.
Verification checklist
- Search names and CAS across both SFDA lists.
- Open the cited restricted-entry detail and apply every condition.
- Check current SFDA/GSO technical regulations and updates.
- Complete eCosma notification, label and responsible-party requirements.
Official market sources
- Saudi SFDA prohibited and restricted ingredient listsOfficial SFDA dated lists; version and hash each release
Verification workflow and record completeness
Before using this result in a compliance decision
- Confirm that “Nickel hydrogen phosphate [1]; Nickel bis(dihydrogen phosphate) [2]; Trinickel bis(orthophosphate) [3]; Dinickel diphosphate [4]; Nickel bis(phosphinate) [5]; Nickel phosphinate [6]; Phosphoric acid, calcium nickel salt [7]; Diphosphoric acid, nickel(II) salt [8]” and every CAS/EC identifier refer to the material in your supplier specification.
- Search names and CAS across both SFDA lists.
- Open the cited restricted-entry detail and apply every condition.
- Check current SFDA/GSO technical regulations and updates.
- Complete eCosma notification, label and responsible-party requirements.
- Document the source version and recheck the regulator before manufacture, notification or market placement.
Fields available in this record
- Official substance nameAvailable
- CASAvailable
- ECNot supplied
- Separate condition textNot present in source row
- Effective dateNot supplied
- Snapshot hash and methodAvailable
Questions this page answers
Stable citation
Nickel hydrogen phosphate [1]; Nickel bis(dihydrogen phosphate) [2]; Trinickel bis(orthophosphate) [3]; Dinickel diphosphate [4]; Nickel bis(phosphinate) [5]; Nickel phosphinate [6]; Phosphoric acid, calcium nickel salt [7]; Diphosphoric acid, nickel(II) salt [8]. SFDA prohibited list, page 145, row 1. Saudi Arabia. Source version live-snapshot-2026-08-30. CosIng Checker regulatory record: https://cosingchecker.com/regulations/sa/records/11020/
Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.
Interpretation and limits for Saudi Arabia
This official record identifies the substance as prohibited for cosmetic use in the stated market scope.
Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.
How to interpret the legal role
The cited row forms part of a binding rule or legally incorporated list for this market.
Evidence on this page
- Recorded outcome: Prohibited
- Legal role: Binding rule
- Source version: live-snapshot-2026-08-30
What it does not prove
No list match is not permission; Gulf/SFDA product, claim, notification and technical requirements still apply.
Further authoritative substance research
These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.
Cosmetic Ingredient Review safety assessments
Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents
Independent expert review considered by FDA; not a government approval or binding market rule
Research this identity at the sourceFDA Global Substance Registration System
UNII identifiers, preferred names, substance types, codes and public substance relationships
Identity registry only; UNII availability does not imply FDA review or approval
Research this identity at the sourceILO/WHO International Chemical Safety Cards
Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals
International occupational chemical-safety reference; not cosmetic-use approval
Research this identity at the sourceJapan NITE-CHRIP
Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information
Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules
Research this identity at the sourceNIOSH Pocket Guide to Chemical Hazards
REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals
US occupational-health guidance and limits; not a cosmetic ingredient decision
Research this identity at the sourceOECD eChemPortal
Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records
Discovery gateway; each linked authority remains responsible for its data
Research this identity at the sourceUS EPA CompTox CTX APIs
API key required for importDTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data
Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality
Research this identity at the source