Nickel hydrogen phosphate [1]; Nickel bis(dihydrogen phosphate) [2]; Trinickel bis(orthophosphate) [3]; Dinickel diphosphate [4]; Nickel bis(phosphinate) [5]; Nickel phosphinate [6]; Phosphoric acid, calcium nickel salt [7]; Diphosphoric acid, nickel(II) salt [8]
Nickel hydrogen phosphate [1]; Nickel bis(dihydrogen phosphate) [2]; Trinickel bis(orthophosphate) [3]; Dinickel diphosphate [4]; Nickel bis(phosphinate) [5]; Nickel phosphinate [6]; Phosphoric acid, calcium nickel salt [7]; Diphosphoric acid, nickel(II) salt [8] is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.
Chemical identity and properties
Nickel phosphate
Nickel phosphate is a phosphate of nickel. Nickel is a chemical compound with the atomic number 28. It is found abundantly in nature in laterite ore minerals, such as limonite, garnierite, and pentlandite. Nickel has a biological role and is found in certain enzymes, including urease, hydrogenase, methylcoenzyme M reductase, and carbon monoxide dehydrogenase. (L40, L41) — Toxin and Toxin Target Database (T3DB)
- IUPAC name
- tris(nickel(2+)) diphosphate
- Molecular formula
- Ni3O8P2
- Molecular weight
- 366.02 g/mol
- Exact mass
- 365.708309 Da
- Topological polar surface area
- 173.0 Ų
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 8
- Covalent units
- 5
- Defined stereocentres
- 0
Also known as
16 more reported names
External database identifiers
- EPA DTXSID:DTXSID20889591
Evidence from additional scientific databases
NIH PubChem PUG-View
Attributed physical-property, hazard, environmental and use annotations.
- Physical Description: Liquid Source: EPA Chemical Data Reporting (CDR)
- Physical Description: Light green solid, insoluble in water; [Merck Index] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Carcinogen Classification: 1, carcinogenic to humans. (L135) Source: Toxin and Toxin Target Database (T3DB)
- Exposure Routes: Oral (L41) ; inhalation (L41) ; dermal (L41) Source: Toxin and Toxin Target Database (T3DB)
- Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- GHS Hazard Statements: H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]; H350i: May cause cancer by inhalation [Danger Carcinogenicity]; H372 **: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Precautionary Statement Codes: P203, P233, P260, P261, P264, P270, P271, P272, P273, P280, P284, P302+P352, P304+P340, P318, P319, P321, P333+P317, P342+P316, P362+P364, P391, P403, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Signal: Danger Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H334 (100%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]; H350 (100%): May cause cancer [Danger Carcinogenicity]; H372 (100%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P203, P233, P260, P261, P264, P270, P271, P272, P273, P280, P284, P302+P352, P304+P340, P318, P319, P321, P333+P317, P342+P316, P362+P364, P391, P403, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 73 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Health Effects: The most common harmful health effect of nickel in humans is an allergic reaction. This usually manifests as a skin rash, although some people experience asthma attacks. Long term inhahation of nickel causes chronic bronchitis and reduced lung function, as well as damage to the naval cavity. Ingestion of excess nickel results in damage to the stomach, blood, liver, kidneys, and immune system, as well as having adverse effects on reproduction and development. (L41) Source: Toxin and Toxin Target Database (T3DB)
- Toxicity Summary: Nickel is known to substitute for other essential elements in certain enzmes, such as calcineurin. It is genotoxic, and some nickel compounds have been shown to promote cell proliferation. Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. Nickel has also been shown to alter several transcription factors, including hypoxia-inducible transcription factor, activating transcription factor, and NF-KB transcription factor. There is also evidence that nickel ions inhibit DNA repair, either by directly inhibiting DNA repair enzymes or competing with zinc ions for binding to zinc-finger DNA binding proteins, resulting in structural changes in DNA that prevent repair enzymes from binding. Nickel ions can also complex with a number of cellular ligands including amino acids, peptides, and proteins resulting in the generation of oxygen radicals, which induce base damage, DNA strand breaks, and DNA protein crosslinks. (L41, Source: Toxin and Toxin Target Database (T3DB)
- Consumer Uses: Plating agent; Other Source: EPA Chemical Data Reporting (CDR)
- Industry Uses: Adhesion/cohesion promoter; Plating agent; Other Source: EPA Chemical Data Reporting (CDR)
- Sources/Uses: Yields on ignition nickel yellow, a pigment in oil and water-color paints; [Merck Index] Used in electroplating; [Hawley] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Industrial Processes with risk of exposure: Electroplating [Category: Plate]; Painting (Pigments, Binders, and Biocides) [Category: Paint] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| EMBL-EBI ChEBI | No exact record | 2026-08-31 |
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Nickel hydrogen phosphate
- IUPAC name
- hydrogen phosphate;nickel(2+)
- Molecular formula
- HNiO4P
- Molecular weight
- 154.673 g/mol
- Exact mass
- 153.896587 Da
- Topological polar surface area
- 83.4 Ų
- Hydrogen-bond donors
- 1
- Hydrogen-bond acceptors
- 4
- Covalent units
- 2
- Defined stereocentres
- 0
Also known as
External database identifiers
- EPA DTXSID:DTXSID90931819
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Diphosphoric acid, nickel(2+) salt (1:2)
- IUPAC name
- bis(nickel(2+));phosphonato phosphate
- Molecular formula
- Ni2O7P2
- Molecular weight
- 291.33 g/mol
- Exact mass
- 289.782610 Da
- Topological polar surface area
- 136.0 Ų
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 7
- Covalent units
- 3
- Defined stereocentres
- 0
Also known as
External database identifiers
- EPA DTXSID:DTXSID80889633
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Phosphinic acid, nickel(2+) salt (2:1)
- Molecular formula
- NiO2P+
- Molecular weight
- 121.666 g/mol
- Exact mass
- 120.898933 Da
- Topological polar surface area
- 40.1 Ų
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 2
- Covalent units
- 2
- Defined stereocentres
- 0
Also known as
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Phosphoric acid, calcium nickel salt (1:?:?)
- IUPAC name
- calcium;nickel(2+);phosphate
- Molecular formula
- CaNiO4P+
- Molecular weight
- 193.74 g/mol
- Exact mass
- 192.851353 Da
- Topological polar surface area
- 86.3 Ų
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 4
- Covalent units
- 3
- Defined stereocentres
- 0
Also known as
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Phosphoric acid, nickel(2+) salt (2:1)
- IUPAC name
- bis(dihydrogen phosphate);nickel(2+)
- Molecular formula
- H4NiO8P2
- Molecular weight
- 252.67 g/mol
- Exact mass
- 251.873483 Da
- Topological polar surface area
- 161.0 Ų
- Hydrogen-bond donors
- 4
- Hydrogen-bond acceptors
- 8
- Covalent units
- 3
- Defined stereocentres
- 0
Also known as
External database identifiers
- EPA DTXSID:DTXSID401029291
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Diphosphoric acid, nickel(2+) salt (1:?)
- IUPAC name
- nickel(2+);phosphonato phosphate
- Molecular formula
- NiO7P2-2
- Molecular weight
- 232.64 g/mol
- Exact mass
- 231.847268 Da
- Topological polar surface area
- 136.0 Ų
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 7
- Covalent units
- 2
- Defined stereocentres
- 0
Also known as
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Record details
Chemical name
Nickel hydrogen phosphate [1]; Nickel bis(dihydrogen phosphate) [2]; Trinickel bis(orthophosphate) [3]; Dinickel diphosphate [4]; Nickel bis(phosphinate) [5]; Nickel phosphinate [6]; Phosphoric acid, calcium nickel salt [7]; Diphosphoric acid, nickel(II) salt [8]
Chemical / IUPAC name
Nickel hydrogen phosphate [1]; Nickel bis(dihydrogen phosphate) [2]; Trinickel bis(orthophosphate) [3]; Dinickel diphosphate [4]; Nickel bis(phosphinate) [5]; Nickel phosphinate [6]; Phosphoric acid, calcium nickel salt [7]; Diphosphoric acid, nickel(II) salt [8]
Regulatory information
CMR
| Category | Carcinogenic | Mutagenic | Reprotoxic |
|---|---|---|---|
| Cat. 1A | ✓ | — | — |
Key data
Related records for Nickel hydrogen phosphate [1]; Nickel bis(dihydrogen phosphate) [2]; Trinickel bis(orthophosphate) [3]; Dinickel diphosphate [4]; Nickel bis(phosphinate) [5]; Nickel phosphinate [6]; Phosphoric acid, calcium nickel salt [7]; Diphosphoric acid, nickel(II) salt [8]
Direct matches are limited for this record, so nearby entries from Annex II are shown as well.
Nickel hexafluorosilicate
Nickel difluoride [1]; Nickel dibromide [2]; Nickel diiodide [3]; Nickel potassium fluoride [4]
Nickel(II) silicate [1]; Dinickel orthosilicate [2]; Nickel silicate (3:4) [3]; Silicic acid, nicke…
Dinickel hexacyanoferrate
Nickel(II) stearate; nickel(II) octadecanoate
Trinickel bis(arsenate); nickel(II) arsenate
What Annex II means for Nickel hydrogen phosphate [1]; Nickel bis(dihydrogen phosphate) [2]; Trinickel bis(orthophosphate) [3]; Dinickel diphosphate [4]; Nickel bis(phosphinate) [5]; Nickel phosphinate [6]; Phosphoric acid, calcium nickel salt [7]; Diphosphoric acid, nickel(II) salt [8]
Nickel hydrogen phosphate [1]; Nickel bis(dihydrogen phosphate) [2]; Trinickel bis(orthophosphate) [3]; Dinickel diphosphate [4]; Nickel bis(phosphinate) [5]; Nickel phosphinate [6]; Phosphoric acid, calcium nickel salt [7]; Diphosphoric acid, nickel(II) salt [8] is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.
Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.
The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.
Compliance checklist
- Verify this substance is absent from all raw materials and finished formulations.
- Request absence confirmation or CoA from raw material suppliers.
- Document the screening result in the Product Information File (PIF).
- This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.
Frequently asked questions
Source note for Annex II record Nickel hydrogen phosphate [1]; Nickel bis(dihydrogen phosphate) [2]; Trinickel bis(orthophosphate) [3]; Dinickel diphosphate [4]; Nickel bis(phosphinate) [5]; Nickel phosphinate [6]; Phosphoric acid, calcium nickel salt [7]; Diphosphoric acid, nickel(II) salt [8]
This page summarizes one Annex II record for Nickel hydrogen phosphate [1]; Nickel bis(dihydrogen phosphate) [2]; Trinickel bis(orthophosphate) [3]; Dinickel diphosphate [4]; Nickel bis(phosphinate) [5]; Nickel phosphinate [6]; Phosphoric acid, calcium nickel salt [7]; Diphosphoric acid, nickel(II) salt [8] from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.
Use this record page to review Annex II conditions for Nickel hydrogen phosphate [1]; Nickel bis(dihydrogen phosphate) [2]; Trinickel bis(orthophosphate) [3]; Dinickel diphosphate [4]; Nickel bis(phosphinate) [5]; Nickel phosphinate [6]; Phosphoric acid, calcium nickel salt [7]; Diphosphoric acid, nickel(II) salt [8], but confirm any final regulatory decision against the current official annex wording and source files.
Tools & next steps
Check your formula
Paste a full INCI list to detect Nickel hydrogen phosphate [1]; Nickel bis(dihydrogen phosphate) [2]; Trinickel bis(orthophosphate) [3]; Dinickel diphosphate [4]; Nickel bis(phosphinate) [5]; Nickel phosphinate [6]; Phosphoric acid, calcium nickel salt [7]; Diphosphoric acid, nickel(II) salt [8] and other flagged EU annex records in one pass.
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Compare Nickel hydrogen phosphate [1]; Nickel bis(dihydrogen phosphate) [2]; Trinickel bis(orthophosphate) [3]; Dinickel diphosphate [4]; Nickel bis(phosphinate) [5]; Nickel phosphinate [6]; Phosphoric acid, calcium nickel salt [7]; Diphosphoric acid, nickel(II) salt [8] side by side with another annex record to review differences in restrictions, concentrations and annex placement.
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