CAS 10381-36-9PubChem CID 165868
Nickel phosphate
- IUPAC name
- tris(nickel(2+)) diphosphate
- Molecular formula
- Ni3O8P2
- Molecular weight
- 366.02 g/mol
- Exact mass
- 365.708309 Da
- Topological polar surface area
- 173.0 Ų
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 8
- Covalent units
- 5
- Defined stereocentres
- 0
Also known as
Nickel(II) phosphateNickel orthophosphatePhosphoric acid, nickel(2+) salt (2:3)Trinickel bis(orthophosphate)UNII-S0S2HKR70LS0S2HKR70LEINECS 233-844-5Phosphoric acid, nickel salt
16 more reported names
VSB 5VSB-5NICKEL PHOSPHATE [MI]NICKEL(2+) PHOSPHATEPHOSPHORIC ACID NICKEL(2+) SALT (2:3)Nickel phosphic acidRefChem:165675trinickel(2+) ion diphosphateNICKEL (II) PHOSPHATENickelous phosphatenickel(ii)phosphateTrinickel diphosphatenickel(2+);diphosphateNickel phosphate (Ni3P2O8)Nickel phosphate (Ni3(PO4)2)Nickel(2+) phosphate (3/2)
External database identifiers
- EPA DTXSID:DTXSID20889591
Evidence from additional scientific databases
NIH PubChem PUG-View
Exact identifier match165868
Attributed physical-property, hazard, environmental and use annotations.
- Physical Description: Liquid Source: EPA Chemical Data Reporting (CDR)
- Physical Description: Light green solid, insoluble in water; [Merck Index] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Carcinogen Classification: 1, carcinogenic to humans. (L135) Source: Toxin and Toxin Target Database (T3DB)
- Exposure Routes: Oral (L41) ; inhalation (L41) ; dermal (L41) Source: Toxin and Toxin Target Database (T3DB)
- Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- GHS Hazard Statements: H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]; H350i: May cause cancer by inhalation [Danger Carcinogenicity]; H372 **: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Precautionary Statement Codes: P203, P233, P260, P261, P264, P270, P271, P272, P273, P280, P284, P302+P352, P304+P340, P318, P319, P321, P333+P317, P342+P316, P362+P364, P391, P403, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Signal: Danger Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H334 (100%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]; H350 (100%): May cause cancer [Danger Carcinogenicity]; H372 (100%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P203, P233, P260, P261, P264, P270, P271, P272, P273, P280, P284, P302+P352, P304+P340, P318, P319, P321, P333+P317, P342+P316, P362+P364, P391, P403, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 73 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Health Effects: The most common harmful health effect of nickel in humans is an allergic reaction. This usually manifests as a skin rash, although some people experience asthma attacks. Long term inhahation of nickel causes chronic bronchitis and reduced lung function, as well as damage to the naval cavity. Ingestion of excess nickel results in damage to the stomach, blood, liver, kidneys, and immune system, as well as having adverse effects on reproduction and development. (L41) Source: Toxin and Toxin Target Database (T3DB)
- Toxicity Summary: Nickel is known to substitute for other essential elements in certain enzmes, such as calcineurin. It is genotoxic, and some nickel compounds have been shown to promote cell proliferation. Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. Nickel has also been shown to alter several transcription factors, including hypoxia-inducible transcription factor, activating transcription factor, and NF-KB transcription factor. There is also evidence that nickel ions inhibit DNA repair, either by directly inhibiting DNA repair enzymes or competing with zinc ions for binding to zinc-finger DNA binding proteins, resulting in structural changes in DNA that prevent repair enzymes from binding. Nickel ions can also complex with a number of cellular ligands including amino acids, peptides, and proteins resulting in the generation of oxygen radicals, which induce base damage, DNA strand breaks, and DNA protein crosslinks. (L41, Source: Toxin and Toxin Target Database (T3DB)
- Consumer Uses: Plating agent; Other Source: EPA Chemical Data Reporting (CDR)
- Industry Uses: Adhesion/cohesion promoter; Plating agent; Other Source: EPA Chemical Data Reporting (CDR)
- Sources/Uses: Yields on ignition nickel yellow, a pigment in oil and water-color paints; [Merck Index] Used in electroplating; [Hawley] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Industrial Processes with risk of exposure: Electroplating [Category: Plate]; Painting (Pigments, Binders, and Biocides) [Category: Paint] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| EMBL-EBI ChEBI | No exact record | 2026-08-31 |
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.