1,4-bis(p-Tolylamino)anthraquinone (Solvent Green 3; CI 61565) when used as a substance in hair dye products
Listed by the Saudi Food and Drug Authority as prohibited in cosmetic products.
Regulatory decision and full conditions
- Status
- Prohibited
- Legal role
- Binding rule
- Regulatory summary
- Listed by the Saudi Food and Drug Authority as prohibited in cosmetic products.
- Conditions and restrictions
- A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. Open the cited source and apply the market-wide requirements below.
Substance identity
- Official source name
- 1,4-bis(p-Tolylamino)anthraquinone (Solvent Green 3; CI 61565) when used as a substance in hair dye products
- CAS
- 128-80-3
- EC
- Not supplied in this source row
- Identity mapping
- standalone:official_sfda_record
Cross-market snapshot for this identity
Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.
European Union
2 linked records
Open supporting recordGreat Britain
1 linked record
Open supporting recordNew Zealand
2 linked records · 1 with specific conditions
Open supporting recordASEAN
1 linked record
Open supporting recordBrazil
1 linked record · 1 with specific conditions
Open supporting recordIndia
1 linked record · 1 with specific conditions
Open supporting recordSaudi Arabia
Current record1 linked record
Open supporting recordVerified chemistry for CAS 128-80-3
Cyanine Green G Base
- IUPAC name
- 1,4-bis(4-methylanilino)anthracene-9,10-dione
- Molecular formula
- C28H22N2O2
- Molecular weight
- 418.5 g/mol
- Exact mass
- 418.168127949 Da
- Monoisotopic mass
- 418.168127949 Da
- XLogP3
- 7.8
- Topological polar surface area
- 58.2 Ų
- Molecular complexity
- 619.0
- Formal charge
- 0
- Hydrogen-bond donors
- 2
- Hydrogen-bond acceptors
- 4
- Rotatable bonds
- 4
- Heavy atoms
- 32
- Covalent units
- 1
Names and synonyms reported to PubChem
16 more reported names
External database identifiers
- EPA DTXSID:DTXSID9044376
- PubMed:8669891
Advanced structure statistics
- Defined atom stereocentres
- 0
- Undefined atom stereocentres
- 0
- Defined bond stereocentres
- 0
- Undefined bond stereocentres
- 0
- 3D pharmacophore features
- 11
- 3D rings
- 5
- 3D hydrophobes
- 0
- 3D acceptor features
- 2
- 3D donor features
- 2
- 3D anionic centres
- 0
- 3D cationic centres
- 2
- 3D conformers
- 8
- Effective 3D rotors
- 4.0
Machine-readable structure identifiers
- SMILES
CC1=CC=C(C=C1)NC2=C3C(=C(C=C2)NC4=CC=C(C=C4)C)C(=O)C5=CC=CC=C5C3=O- InChI
InChI=1S/C28H22N2O2/c1-17-7-11-19(12-8-17)29-23-15-16-24(30-20-13-9-18(2)10-14-20)26-25(23)27(31)21-5-3-4-6-22(21)28(26)32/h3-16,29-30H,1-2H3- InChIKey
TVRGPOFMYCMNRB-UHFFFAOYSA-N
Evidence from additional scientific databases
NIH PubChem PUG-View
Attributed physical-property, hazard, environmental and use annotations.
- Color/Form: Dark burgundy Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: Dark violet needles Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: Solid at 20 °C Source: Hazardous Substances Data Bank (HSDB)
- Density: 0.45 g/mL Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: 218 °C Source: Hazardous Substances Data Bank (HSDB)
- Physical Description: Dark violet solid; [Merck Index] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Solubility: In 2-methoxymethanol, 2 mg/mL; in ethanol 0.3 mg/mL Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Soluble in 3.4 g/100 mL alcohol at 25 °C. Soluble in hydrochloric and sulfuric acid. Sparingly soluble in methanol, ethyl ether. Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Slightly soluble in acetone, ethyl acetate, mineral oil, oleic acid, stearic acid. Soluble in benzene, toluene. Source: Hazardous Substances Data Bank (HSDB)
- Note: This chemical does not meet GHS hazard criteria for 97.8% (2848 of 2913) of all reports. Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: Not Classified; Reported as not meeting GHS hazard criteria by 2848 of 2913 companies (only 2.2% companies provided GHS information). For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 2913 reports by companies from 14 notifications to the ECHA C&L Inventory.; Reported as not meeting GHS hazard criteria per 2848 of 2913 reports by companies.; There are 11 notifications provided by 65 of 2913 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Environmental Bioconcentration: An estimated BCF of 500 was calculated in fish for D&C Green No. 6(SRC), using an estimated log Kow of 8.69(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is high(SRC), provided the compound is not metabolized by the organism(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 4.8X10+6(SRC), determined from a structure estimation method(2), indicates that D&C Green No. 6 is expected to be immobile in soil(SRC). Volatilization of D&C Green No. 6 from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.5X10-16 atm-cu m/mole(SRC), using a fragment constant estimation method(3). D&C Green No. 6 is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 7.0X10-13 mm Hg at 25 °C(SRC), determined from a fragment constant method(4). D&C Green No. 6 was shown to be susceptible to photolysis on soil, with two photoproducts detected, not identified(5). Biodegradation data in soil were not available(SRC, 2011). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 4.8X10+6(SRC), determined from a structure estimation method(2), indicates that D&C Green No. 6 is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 1.5X10-16 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). According to a classification scheme(5), an estimated BCF of 500(SRC), from an estimated log Kow of 8.69(6) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is high, provided the compound is not metabolized by the organism(SRC). Biodegradation data in water were not available(SRC, 2011). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), D&C Green No. 6, which has an estimated vapor pressure of 7.0X10-13 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely in the particulate phase in the ambient atmosphere. Particulate-phase D&C Green No. 6 may be removed from the air by wet or dry deposition(SRC). D&C Green No. 6 absorbs light at wavelengths 644 nm(3), and therefore may be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Sources/Uses: Used for sutures; Approved for external drugs and cosmetics; [Merck Index] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Uses: Coloring fats, oils, waxes, hydrocarbon solvents, hydrocarbon-base wood stains, cellulose acetate, polystyrene and soap, and in the preparation of oleic or stearic rotogravure inks. Source: Hazardous Substances Data Bank (HSDB)
- Uses: Coloring contact lenses; ... coloring polyethylene terephthalate surgical sutures, including sutures for ophthalmic use; ... coloring polyglycolic acid surgical sutures with diameter greater than U.S.P. size 8-0, including sutures for ophthalmic use; ... coloring poly(glycolic acid-co-trimethylene carbonate) sutures (also referred to as 1,4-dioxan-2,5-dione polymer with 1,3-dioxan-2-one) for general surgical use; and ... coloring polymethylmethacrylate support haptics of intraocular lenses. Source: Hazardous Substances Data Bank (HSDB)
- Uses: Military smoke dye grenades used for communication Source: Hazardous Substances Data Bank (HSDB)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Official source and provenance
- Registered source
- Saudi SFDA prohibited and restricted ingredient lists
- Source reference
- SFDA prohibited list, page 136, row 10
- Source record ID
prohibited-135-10- Source version
- live-snapshot-2026-08-30
- Source language
- English
- Translation status
- Original is English
- Snapshot checked
- 2026-08-30 05:18 UTC
- Validation method
- complete SFDA paginated HTML snapshot; strict page/row counts
- SHA-256
ceb6cc636e6b1f4b3013f88ce0297217b49d6194342c6ece5c03b1e04256d71a
Registered dataset notes
- Dataset coverage
- Prohibited and restricted substances with CAS, EC and conditions
- Authority note
- Official SFDA dated lists; version and hash each release
How this record fits the market dataset
Status distribution
Condition text is present on 0 of 2090 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.
Saudi Arabia market context
Complete official list index
Coverage version: SFDA live prohibited/restricted lists, snapshot 30 August 2026
Every page and entry in the public SFDA prohibited and restricted ingredient indexes; restricted detail pages remain the source for conditions.
Verification checklist
- Search names and CAS across both SFDA lists.
- Open the cited restricted-entry detail and apply every condition.
- Check current SFDA/GSO technical regulations and updates.
- Complete eCosma notification, label and responsible-party requirements.
Official market sources
- Saudi SFDA prohibited and restricted ingredient listsOfficial SFDA dated lists; version and hash each release
Verification workflow and record completeness
Before using this result in a compliance decision
- Confirm that “1,4-bis(p-Tolylamino)anthraquinone (Solvent Green 3; CI 61565) when used as a substance in hair dye products” and every CAS/EC identifier refer to the material in your supplier specification.
- Search names and CAS across both SFDA lists.
- Open the cited restricted-entry detail and apply every condition.
- Check current SFDA/GSO technical regulations and updates.
- Complete eCosma notification, label and responsible-party requirements.
- Document the source version and recheck the regulator before manufacture, notification or market placement.
Fields available in this record
- Official substance nameAvailable
- CASAvailable
- ECNot supplied
- Separate condition textNot present in source row
- Effective dateNot supplied
- Snapshot hash and methodAvailable
Questions this page answers
Stable citation
1,4-bis(p-Tolylamino)anthraquinone (Solvent Green 3; CI 61565) when used as a substance in hair dye products. SFDA prohibited list, page 136, row 10. Saudi Arabia. Source version live-snapshot-2026-08-30. CosIng Checker regulatory record: https://cosingchecker.com/regulations/sa/records/10939/
Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.
Interpretation and limits for Saudi Arabia
This official record identifies the substance as prohibited for cosmetic use in the stated market scope.
Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.
How to interpret the legal role
The cited row forms part of a binding rule or legally incorporated list for this market.
Evidence on this page
- Recorded outcome: Prohibited
- Legal role: Binding rule
- Source version: live-snapshot-2026-08-30
What it does not prove
No list match is not permission; Gulf/SFDA product, claim, notification and technical requirements still apply.
Further authoritative substance research
These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.
Cosmetic Ingredient Review safety assessments
Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents
Independent expert review considered by FDA; not a government approval or binding market rule
Research this identity at the sourceFDA Global Substance Registration System
UNII identifiers, preferred names, substance types, codes and public substance relationships
Identity registry only; UNII availability does not imply FDA review or approval
Research this identity at the sourceILO/WHO International Chemical Safety Cards
Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals
International occupational chemical-safety reference; not cosmetic-use approval
Research this identity at the sourceJapan NITE-CHRIP
Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information
Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules
Research this identity at the sourceNIOSH Pocket Guide to Chemical Hazards
REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals
US occupational-health guidance and limits; not a cosmetic ingredient decision
Research this identity at the sourceOECD eChemPortal
Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records
Discovery gateway; each linked authority remains responsible for its data
Research this identity at the sourceUS EPA CompTox CTX APIs
API key required for importDTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data
Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality
Research this identity at the source