CosIng Checker
CosIng Checker
EU cosmetic ingredients, restrictions and safety
Login
ProhibitedBinding ruleSAOriginal is EnglishOfficial-source import checked

Carbendazim

Listed by the Saudi Food and Drug Authority as prohibited in cosmetic products.

All Saudi Arabia recordsCompare all marketsOpen official source

Regulatory decision and full conditions

Status
Prohibited
Legal role
Binding rule
Regulatory summary
Listed by the Saudi Food and Drug Authority as prohibited in cosmetic products.
Conditions and restrictions
A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. Open the cited source and apply the market-wide requirements below.

Substance identity

Official source name
Carbendazim
CAS
10605-21-7
EC
Not supplied in this source row
Identity mapping
standalone:official_sfda_record
Search this identity across the siteCAS 10605-21-7

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

9 market datasets
PubChem 2D chemical structure for CAS 10605-21-7
CAS 10605-21-7PubChem CID 25429

Verified chemistry for CAS 10605-21-7

Carbendazim

Carbendazim is a member of the class of benzimidazoles that is 2-aminobenzimidazole in which the primary amino group is substituted by a methoxycarbonyl group. A fungicide, carbendazim controls Ascomycetes, Fungi Imperfecti, and Basidiomycetes on a wide variety of crops, including bananas, cereals, cotton, fruits, grapes, mushrooms, ornamentals, peanuts, sugarbeet, soybeans, tobacco, and vegetables. It has a role as a metabolite, an antinematodal drug, a microtubule-destabilising agent and an antifungal agrochemical. It is a member of benzimidazoles, a carbamate ester, a benzimidazole fungicide and a benzimidazolylcarbamate fungicide. It is functionally related to a 2-aminobenzimidazole. — ChEBI

IUPAC name
methyl N-(1H-benzimidazol-2-yl)carbamate
Molecular formula
C9H9N3O2
Molecular weight
191.19 g/mol
Exact mass
191.069476538 Da
Monoisotopic mass
191.069476538 Da
XLogP3
1.5
Topological polar surface area
67.0 Ų
Molecular complexity
222.0
Formal charge
0
Hydrogen-bond donors
2
Hydrogen-bond acceptors
3
Rotatable bonds
2
Heavy atoms
14
Covalent units
1

Names and synonyms reported to PubChem

CarbendazoleMecarzoleBavistinThicoperCarbendazimeDerosalBavistanCarbendazol
16 more reported names
FunabenSupercarbDelseneKolfugoMedamineBattalMycoMethyl 2-benzimidazolecarbamateCarbendazymEquitdazinGarbendaKemdazinAgrizimBavistin 3460BengardBitosen
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
5
3D rings
2
3D hydrophobes
0
3D acceptor features
1
3D donor features
2
3D anionic centres
0
3D cationic centres
0
3D conformers
2
Effective 3D rotors
3.0
Machine-readable structure identifiers
SMILES
COC(=O)NC1=NC2=CC=CC=C2N1
InChI
InChI=1S/C9H9N3O2/c1-14-9(13)12-8-10-6-4-2-3-5-7(6)11-8/h2-5H,1H3,(H2,10,11,12,13)
InChIKey
TWFZGCMQGLPBSX-UHFFFAOYSA-N

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:3392

carbendazim

A member of the class of benzimidazoles that is 2-aminobenzimidazole in which the primary amino group is substituted by a methoxycarbonyl group. A fungicide, carbendazim controls Ascomycetes, Fungi Imperfecti, and Basidiomycetes on a wide variety of crops, including bananas, cereals, cotton, fruits, grapes, mushrooms, ornamentals, peanuts, sugarbeet, soybeans, tobacco, and vegetables.

Formula
C9H9N3O2
Average mass
191.190 g/mol
Monoisotopic mass
191.06948 Da
Formal charge
0
  • benzimidazoles — is a (CHEBI:22715)
  • benzimidazolylcarbamate fungicide — is a (CHEBI:87064)
  • benzimidazole fungicide — is a (CHEBI:87036)
  • carbamate ester — is a (CHEBI:23003)
  • antineoplastic agent — has role (CHEBI:35610)
  • antinematodal drug — has role (CHEBI:35444)
  • microtubule-destabilising agent — has role (CHEBI:61951)
  • metabolite — has role (CHEBI:25212)
  • antifungal agrochemical — has role (CHEBI:86328)
  • 2-aminobenzimidazole — has functional parent (CHEBI:27822)
  • antineoplastic agent — has role (CHEBI:35610)
  • antinematodal drug — has role (CHEBI:35444)
  • microtubule-destabilising agent — has role (CHEBI:61951)
  • metabolite — has role (CHEBI:25212)
  • antifungal agrochemical — has role (CHEBI:86328)
  • benzimidazoles — is a (CHEBI:22715)
  • benzimidazolylcarbamate fungicide — is a (CHEBI:87064)
  • benzimidazole fungicide — is a (CHEBI:87036)
  • carbamate ester — is a (CHEBI:23003)
Additional curated names
methyl 1H-benzimidazol-2-ylcarbamate1H-benzimidazol-2-ylcarbamic acid methyl ester2-benzimidazolecarbamic acid methyl ester2-(Methoxy-carbonylamino)-benzimidazol2-(methoxycarbonylamino)-benzimidazole2-(methoxycarbonylamino)benzimidazoleA 118A118BAS-67054FBavistinBMCCarbendazimcarbendazimeDerropreneEK-578FB-642Fenbendazole related compound aLignasanMBCMecarzolemethyl 2-benzimidazolecarbamatemethyl benzimidazol-2-ylcarbamateNSC-109874Thicoper
Cross-references from this source
  • CAS: 10605-21-7 — ChemIDplus
  • CAS: 10605-21-7 — KEGG COMPOUND
  • MANUAL_X_REF: 116 — PPDB
  • MANUAL_X_REF: C10897 — KEGG COMPOUND
  • MANUAL_X_REF: carbendazim — Alan Wood's Pesticides
  • MANUAL_X_REF: Carbendazim — Wikipedia
  • MANUAL_X_REF: HMDB0031769 — HMDB
  • MANUAL_X_REF: US3010968 — Patent
  • REGISTRY_NUMBER: 649044 — Reaxys

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2023-11-22. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match25429

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. If symptoms (such as redness or irritation) develop, immediately transport the victim to a hospital.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not availabl Source: CAMEO Chemicals
  • Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H340: May cause genetic defects [Danger Germ cell mutagenicity]; H360FD: May damage fertility; May damage the unborn child [Danger Reproductive toxicity]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P203, P261, P272, P273, P280, P302+P352, P318, P321, P333+P317, P362+P364, P391, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Note: This chemical does not meet GHS hazard criteria for 0.3% (2 of 692) of reports. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H317 (27.9%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H340 (99.6%): May cause genetic defects [Danger Germ cell mutagenicity]; H360 (74%): May damage fertility or the unborn child [Danger Reproductive toxicity]; H360FD (25.6%): May damage fertility; May damage the unborn child [Danger Reproductive toxicity]; H400 (98.1%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410 (99.7%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P261, P272, P273, P280, P302+P352, P318, P321, P333+P317, P362+P364, P391, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 692 reports by companies from 27 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 2 of 692 reports by companies.; There are 26 notifications provided by 690 of 692 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H340: May cause genetic defects [Danger Germ cell mutagenicity]; H360: May damage fertility or the unborn child [Danger Reproductive toxicity]; H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P260, P261, P264, P270, P272, P280, P302+P352, P308+P316, P318, P319, P321, P333+P317, P362+P364, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Signal: Warning Source: NITE-CMC
  • Health Effects: Carbendazim is a suspected endocrine disruptor. It is also a developmental toxin. Animals exposed to carbendazim in the womb to have serious deformities such as lack of eyes and hydrocephalus (water on the brain). Carbendazim can disrupt the development of sperm and damage testicular development in adult rats. Source: Toxin and Toxin Target Database (T3DB)
  • Toxicity Summary: IDENTIFICATION AND USE: Carbendazim is a white powder. it is a systemic leaf and soil fungicide, absorbed through the roots and green tissues. HUMAN EXPOSURE AND TOXICITY: Six human chromosomes were investigated in pairs (1 and 8, 11 and 18, and X and 17). Abnormalities were classified as chromosome loss (including centromeric positive micronuclei), chromosome gain, non-disjunction, or polyploidy. ANIMAL STUDIES: Previous studies indicate that carbendazim may interfere with mitosis and thus may disrupt or inhibit microtubule function resulting in apoptosis. Carbendazim even at low dose exhibited toxicity, affected the liver and also caused specific changes in hematological and biochemical parameters in the rat. Male rats (6 per dose level) were gavaged with 200, 3400 and 5000 mg/kg 5 days/wk for 2 wk. Two out of the 6 rats died at the dose level of 3400 mg/kg per day. At all dose levels, gross and microscopic evidence of adverse effects on the testes and reduction or absence of sperm in the epididymides was seen. The testes were small and discolored, with tubular degeneration and evidence of aspermatogenesis. At the dose level of 3400 mg/kg per day, there were also morphological ch Source: Hazardous Substances Data Bank (HSDB)
  • Toxicity Summary: Carbendazim targets beta tubulin in actively dividing cells. It binds to microtubules, interfering with cell functions, such as meiosis and intracellular transportation (A15332). Source: Toxin and Toxin Target Database (T3DB)
  • Environmental Bioconcentration: BCFs of <1.5-3.5 and 0.6-1.1 were measured using carp (Cyprinus carpio) exposed to 2 and 20 ug/L, respectively, carbendazim over a 6-week period(1). Carbendazim was not bioconcentrated in perch (Perca fluviatilis) and carp exposed to food pellets containing a mixture of 13 pesticides(2). According to a classification scheme(3), these BCF values suggest bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), Koc values of 122.3-2805(2-3), indicate that carbendazim is expected to have high mobility in some soils with decreasing mobility as the amount of clay and organic carbon content increases, pH will have a lesser effect on mobility. Volatilization of carbendazim from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.5X10-12 atm-cu m/mole(SRC), using a fragment constant estimation method(4). Carbendazim is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 7.5X10-10 mm Hg at 25 °C(5). Measured soil biodegradation rates of 45% in 21 days and 45% in 14 days suggest that carbendazim is expected to biodegrade slowly under normal environmental conditions(6). However, biodegradation rates of 100% in 5 days and 97% in 9 days suggest that biodegradation of carbendazim will be enhanced in pretreated soils(6). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Carbendazim is absorbed through the roots and green tissues of plants, with translocation acropetally. Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), Koc values of 122.3-2805(2-3), indicate that carbendazim is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(4) based upon an estimated Henry's Law constant of 1.5X10-12 atm-cu m/mole(SRC), developed using a fragment constant estimation method(5). Measured hydrolysis half-lives for carbendazim at 22 °C were >350 days at pH 5-7 and 124 days at pH 9(6). According to a classification scheme(7), BCFs of <1.5-3.5 measured in carp(8), suggest bioconcentration in aquatic organisms is low(SRC). A 0% of Theoretical BOD using activated sludge in the Japanese MITI test(8) suggests that biodegradation is not an important environmental fate process in water(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), carbendazim, which has a vapor pressure of 7.5X10-10 mm Hg at 25 °C(2), is expected to exist solely in the particulate phase in the ambient atmosphere. Particulate-phase carbendazim may be removed from the air by wet and dry deposition(SRC). Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
Saudi SFDA prohibited and restricted ingredient lists
Source reference
SFDA prohibited list, page 100, row 4
Source record ID
prohibited-99-4
Source version
live-snapshot-2026-08-30
Source language
English
Translation status
Original is English
Snapshot checked
2026-08-30 05:18 UTC
Validation method
complete SFDA paginated HTML snapshot; strict page/row counts
SHA-256
ceb6cc636e6b1f4b3013f88ce0297217b49d6194342c6ece5c03b1e04256d71a

Registered dataset notes

Dataset coverage
Prohibited and restricted substances with CAS, EC and conditions
Authority note
Official SFDA dated lists; version and hash each release
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

2090
current Saudi Arabia records
1726
records marked Prohibited
2090
records from this source version
1991
market records with CAS identity

Status distribution

Prohibited: 1726Restricted: 364

Condition text is present on 0 of 2090 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

Saudi Arabia market context

Complete official list index

Coverage version: SFDA live prohibited/restricted lists, snapshot 30 August 2026

Every page and entry in the public SFDA prohibited and restricted ingredient indexes; restricted detail pages remain the source for conditions.

Verification checklist

  1. Search names and CAS across both SFDA lists.
  2. Open the cited restricted-entry detail and apply every condition.
  3. Check current SFDA/GSO technical regulations and updates.
  4. Complete eCosma notification, label and responsible-party requirements.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “Carbendazim” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Search names and CAS across both SFDA lists.
  3. Open the cited restricted-entry detail and apply every condition.
  4. Check current SFDA/GSO technical regulations and updates.
  5. Complete eCosma notification, label and responsible-party requirements.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECNot supplied
  • Separate condition textNot present in source row
  • Effective dateNot supplied
  • Snapshot hash and methodAvailable

Questions this page answers

This official record identifies the substance as prohibited for cosmetic use in the stated market scope. Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. No list match is not permission; Gulf/SFDA product, claim, notification and technical requirements still apply.

The record cites SFDA prohibited list, page 100, row 4, source version live-snapshot-2026-08-30. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

Carbendazim. SFDA prohibited list, page 100, row 4. Saudi Arabia. Source version live-snapshot-2026-08-30. CosIng Checker regulatory record: https://cosingchecker.com/regulations/sa/records/10593/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for Saudi Arabia

This official record identifies the substance as prohibited for cosmetic use in the stated market scope.

Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

How to interpret the legal role

The cited row forms part of a binding rule or legally incorporated list for this market.

Evidence on this page

  • Recorded outcome: Prohibited
  • Legal role: Binding rule
  • Source version: live-snapshot-2026-08-30

What it does not prove

No list match is not permission; Gulf/SFDA product, claim, notification and technical requirements still apply.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity at the source

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity at the source

US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source