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CAS 1 record

CAS 10605-21-7

CAS 10605-21-7 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 10605-21-7
CAS 10605-21-7PubChem CID 25429

Carbendazim

Carbendazim is a member of the class of benzimidazoles that is 2-aminobenzimidazole in which the primary amino group is substituted by a methoxycarbonyl group. A fungicide, carbendazim controls Ascomycetes, Fungi Imperfecti, and Basidiomycetes on a wide variety of crops, including bananas, cereals, cotton, fruits, grapes, mushrooms, ornamentals, peanuts, sugarbeet, soybeans, tobacco, and vegetables. It has a role as a metabolite, an antinematodal drug, a microtubule-destabilising agent and an antifungal agrochemical. It is a member of benzimidazoles, a carbamate ester, a benzimidazole fungicide and a benzimidazolylcarbamate fungicide. It is functionally related to a 2-aminobenzimidazole. — ChEBI

IUPAC name
methyl N-(1H-benzimidazol-2-yl)carbamate
Molecular formula
C9H9N3O2
Molecular weight
191.19 g/mol
Exact mass
191.069476538 Da
XLogP3
1.5
Topological polar surface area
67.0 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
3
Covalent units
1
Defined stereocentres
0

Also known as

CarbendazoleMecarzoleBavistinThicoperCarbendazimeDerosalBavistanCarbendazol
16 more reported names
FunabenSupercarbDelseneKolfugoMedamineBattalMycoMethyl 2-benzimidazolecarbamateCarbendazymEquitdazinGarbendaKemdazinAgrizimBavistin 3460BengardBitosen
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:3392

carbendazim

A member of the class of benzimidazoles that is 2-aminobenzimidazole in which the primary amino group is substituted by a methoxycarbonyl group. A fungicide, carbendazim controls Ascomycetes, Fungi Imperfecti, and Basidiomycetes on a wide variety of crops, including bananas, cereals, cotton, fruits, grapes, mushrooms, ornamentals, peanuts, sugarbeet, soybeans, tobacco, and vegetables.

Formula
C9H9N3O2
Average mass
191.190 g/mol
Monoisotopic mass
191.06948 Da
Formal charge
0
  • benzimidazoles — is a (CHEBI:22715)
  • benzimidazolylcarbamate fungicide — is a (CHEBI:87064)
  • benzimidazole fungicide — is a (CHEBI:87036)
  • carbamate ester — is a (CHEBI:23003)
  • antineoplastic agent — has role (CHEBI:35610)
  • antinematodal drug — has role (CHEBI:35444)
  • microtubule-destabilising agent — has role (CHEBI:61951)
  • metabolite — has role (CHEBI:25212)
  • antifungal agrochemical — has role (CHEBI:86328)
  • 2-aminobenzimidazole — has functional parent (CHEBI:27822)
  • antineoplastic agent — has role (CHEBI:35610)
  • antinematodal drug — has role (CHEBI:35444)
  • microtubule-destabilising agent — has role (CHEBI:61951)
  • metabolite — has role (CHEBI:25212)
  • antifungal agrochemical — has role (CHEBI:86328)
  • benzimidazoles — is a (CHEBI:22715)
  • benzimidazolylcarbamate fungicide — is a (CHEBI:87064)
  • benzimidazole fungicide — is a (CHEBI:87036)
  • carbamate ester — is a (CHEBI:23003)
Additional curated names
methyl 1H-benzimidazol-2-ylcarbamate1H-benzimidazol-2-ylcarbamic acid methyl ester2-benzimidazolecarbamic acid methyl ester2-(Methoxy-carbonylamino)-benzimidazol2-(methoxycarbonylamino)-benzimidazole2-(methoxycarbonylamino)benzimidazoleA 118A118BAS-67054FBavistinBMCCarbendazimcarbendazimeDerropreneEK-578FB-642Fenbendazole related compound aLignasanMBCMecarzolemethyl 2-benzimidazolecarbamatemethyl benzimidazol-2-ylcarbamateNSC-109874Thicoper
Cross-references from this source
  • CAS: 10605-21-7 — ChemIDplus
  • CAS: 10605-21-7 — KEGG COMPOUND
  • MANUAL_X_REF: 116 — PPDB
  • MANUAL_X_REF: C10897 — KEGG COMPOUND
  • MANUAL_X_REF: carbendazim — Alan Wood's Pesticides
  • MANUAL_X_REF: Carbendazim — Wikipedia
  • MANUAL_X_REF: HMDB0031769 — HMDB
  • MANUAL_X_REF: US3010968 — Patent
  • REGISTRY_NUMBER: 649044 — Reaxys

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2023-11-22. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match25429

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. If symptoms (such as redness or irritation) develop, immediately transport the victim to a hospital.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not availabl Source: CAMEO Chemicals
  • Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H340: May cause genetic defects [Danger Germ cell mutagenicity]; H360FD: May damage fertility; May damage the unborn child [Danger Reproductive toxicity]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P203, P261, P272, P273, P280, P302+P352, P318, P321, P333+P317, P362+P364, P391, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Note: This chemical does not meet GHS hazard criteria for 0.3% (2 of 692) of reports. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H317 (27.9%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H340 (99.6%): May cause genetic defects [Danger Germ cell mutagenicity]; H360 (74%): May damage fertility or the unborn child [Danger Reproductive toxicity]; H360FD (25.6%): May damage fertility; May damage the unborn child [Danger Reproductive toxicity]; H400 (98.1%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410 (99.7%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P261, P272, P273, P280, P302+P352, P318, P321, P333+P317, P362+P364, P391, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 692 reports by companies from 27 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 2 of 692 reports by companies.; There are 26 notifications provided by 690 of 692 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H340: May cause genetic defects [Danger Germ cell mutagenicity]; H360: May damage fertility or the unborn child [Danger Reproductive toxicity]; H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P260, P261, P264, P270, P272, P280, P302+P352, P308+P316, P318, P319, P321, P333+P317, P362+P364, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Signal: Warning Source: NITE-CMC
  • Health Effects: Carbendazim is a suspected endocrine disruptor. It is also a developmental toxin. Animals exposed to carbendazim in the womb to have serious deformities such as lack of eyes and hydrocephalus (water on the brain). Carbendazim can disrupt the development of sperm and damage testicular development in adult rats. Source: Toxin and Toxin Target Database (T3DB)
  • Toxicity Summary: IDENTIFICATION AND USE: Carbendazim is a white powder. it is a systemic leaf and soil fungicide, absorbed through the roots and green tissues. HUMAN EXPOSURE AND TOXICITY: Six human chromosomes were investigated in pairs (1 and 8, 11 and 18, and X and 17). Abnormalities were classified as chromosome loss (including centromeric positive micronuclei), chromosome gain, non-disjunction, or polyploidy. ANIMAL STUDIES: Previous studies indicate that carbendazim may interfere with mitosis and thus may disrupt or inhibit microtubule function resulting in apoptosis. Carbendazim even at low dose exhibited toxicity, affected the liver and also caused specific changes in hematological and biochemical parameters in the rat. Male rats (6 per dose level) were gavaged with 200, 3400 and 5000 mg/kg 5 days/wk for 2 wk. Two out of the 6 rats died at the dose level of 3400 mg/kg per day. At all dose levels, gross and microscopic evidence of adverse effects on the testes and reduction or absence of sperm in the epididymides was seen. The testes were small and discolored, with tubular degeneration and evidence of aspermatogenesis. At the dose level of 3400 mg/kg per day, there were also morphological ch Source: Hazardous Substances Data Bank (HSDB)
  • Toxicity Summary: Carbendazim targets beta tubulin in actively dividing cells. It binds to microtubules, interfering with cell functions, such as meiosis and intracellular transportation (A15332). Source: Toxin and Toxin Target Database (T3DB)
  • Environmental Bioconcentration: BCFs of <1.5-3.5 and 0.6-1.1 were measured using carp (Cyprinus carpio) exposed to 2 and 20 ug/L, respectively, carbendazim over a 6-week period(1). Carbendazim was not bioconcentrated in perch (Perca fluviatilis) and carp exposed to food pellets containing a mixture of 13 pesticides(2). According to a classification scheme(3), these BCF values suggest bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), Koc values of 122.3-2805(2-3), indicate that carbendazim is expected to have high mobility in some soils with decreasing mobility as the amount of clay and organic carbon content increases, pH will have a lesser effect on mobility. Volatilization of carbendazim from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.5X10-12 atm-cu m/mole(SRC), using a fragment constant estimation method(4). Carbendazim is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 7.5X10-10 mm Hg at 25 °C(5). Measured soil biodegradation rates of 45% in 21 days and 45% in 14 days suggest that carbendazim is expected to biodegrade slowly under normal environmental conditions(6). However, biodegradation rates of 100% in 5 days and 97% in 9 days suggest that biodegradation of carbendazim will be enhanced in pretreated soils(6). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Carbendazim is absorbed through the roots and green tissues of plants, with translocation acropetally. Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), Koc values of 122.3-2805(2-3), indicate that carbendazim is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(4) based upon an estimated Henry's Law constant of 1.5X10-12 atm-cu m/mole(SRC), developed using a fragment constant estimation method(5). Measured hydrolysis half-lives for carbendazim at 22 °C were >350 days at pH 5-7 and 124 days at pH 9(6). According to a classification scheme(7), BCFs of <1.5-3.5 measured in carp(8), suggest bioconcentration in aquatic organisms is low(SRC). A 0% of Theoretical BOD using activated sludge in the Japanese MITI test(8) suggests that biodegradation is not an important environmental fate process in water(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), carbendazim, which has a vapor pressure of 7.5X10-10 mm Hg at 25 °C(2), is expected to exist solely in the particulate phase in the ambient atmosphere. Particulate-phase carbendazim may be removed from the air by wet and dry deposition(SRC). Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 10605-21-7

1 total

How CAS 10605-21-7 is used on this site

CAS 10605-21-7 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 10605-21-7 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

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A substance identified by CAS 10605-21-7 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

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