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Annex II Entry 996 CMR15/10/2010

Carbendazim

Carbendazim is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 996
CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 10605-21-7
CAS 10605-21-7PubChem CID 25429

Carbendazim

Carbendazim is a member of the class of benzimidazoles that is 2-aminobenzimidazole in which the primary amino group is substituted by a methoxycarbonyl group. A fungicide, carbendazim controls Ascomycetes, Fungi Imperfecti, and Basidiomycetes on a wide variety of crops, including bananas, cereals, cotton, fruits, grapes, mushrooms, ornamentals, peanuts, sugarbeet, soybeans, tobacco, and vegetables. It has a role as a metabolite, an antinematodal drug, a microtubule-destabilising agent and an antifungal agrochemical. It is a member of benzimidazoles, a carbamate ester, a benzimidazole fungicide and a benzimidazolylcarbamate fungicide. It is functionally related to a 2-aminobenzimidazole. — ChEBI

IUPAC name
methyl N-(1H-benzimidazol-2-yl)carbamate
Molecular formula
C9H9N3O2
Molecular weight
191.19 g/mol
Exact mass
191.069476538 Da
XLogP3
1.5
Topological polar surface area
67.0 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
3
Covalent units
1
Defined stereocentres
0

Also known as

CarbendazoleMecarzoleBavistinThicoperCarbendazimeDerosalBavistanCarbendazol
16 more reported names
FunabenSupercarbDelseneKolfugoMedamineBattalMycoMethyl 2-benzimidazolecarbamateCarbendazymEquitdazinGarbendaKemdazinAgrizimBavistin 3460BengardBitosen
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:3392

carbendazim

A member of the class of benzimidazoles that is 2-aminobenzimidazole in which the primary amino group is substituted by a methoxycarbonyl group. A fungicide, carbendazim controls Ascomycetes, Fungi Imperfecti, and Basidiomycetes on a wide variety of crops, including bananas, cereals, cotton, fruits, grapes, mushrooms, ornamentals, peanuts, sugarbeet, soybeans, tobacco, and vegetables.

Formula
C9H9N3O2
Average mass
191.190 g/mol
Monoisotopic mass
191.06948 Da
Formal charge
0
  • benzimidazoles — is a (CHEBI:22715)
  • benzimidazolylcarbamate fungicide — is a (CHEBI:87064)
  • benzimidazole fungicide — is a (CHEBI:87036)
  • carbamate ester — is a (CHEBI:23003)
  • antineoplastic agent — has role (CHEBI:35610)
  • antinematodal drug — has role (CHEBI:35444)
  • microtubule-destabilising agent — has role (CHEBI:61951)
  • metabolite — has role (CHEBI:25212)
  • antifungal agrochemical — has role (CHEBI:86328)
  • 2-aminobenzimidazole — has functional parent (CHEBI:27822)
  • antineoplastic agent — has role (CHEBI:35610)
  • antinematodal drug — has role (CHEBI:35444)
  • microtubule-destabilising agent — has role (CHEBI:61951)
  • metabolite — has role (CHEBI:25212)
  • antifungal agrochemical — has role (CHEBI:86328)
  • benzimidazoles — is a (CHEBI:22715)
  • benzimidazolylcarbamate fungicide — is a (CHEBI:87064)
  • benzimidazole fungicide — is a (CHEBI:87036)
  • carbamate ester — is a (CHEBI:23003)
Additional curated names
methyl 1H-benzimidazol-2-ylcarbamate1H-benzimidazol-2-ylcarbamic acid methyl ester2-benzimidazolecarbamic acid methyl ester2-(Methoxy-carbonylamino)-benzimidazol2-(methoxycarbonylamino)-benzimidazole2-(methoxycarbonylamino)benzimidazoleA 118A118BAS-67054FBavistinBMCCarbendazimcarbendazimeDerropreneEK-578FB-642Fenbendazole related compound aLignasanMBCMecarzolemethyl 2-benzimidazolecarbamatemethyl benzimidazol-2-ylcarbamateNSC-109874Thicoper
Cross-references from this source
  • CAS: 10605-21-7 — ChemIDplus
  • CAS: 10605-21-7 — KEGG COMPOUND
  • MANUAL_X_REF: 116 — PPDB
  • MANUAL_X_REF: C10897 — KEGG COMPOUND
  • MANUAL_X_REF: carbendazim — Alan Wood's Pesticides
  • MANUAL_X_REF: Carbendazim — Wikipedia
  • MANUAL_X_REF: HMDB0031769 — HMDB
  • MANUAL_X_REF: US3010968 — Patent
  • REGISTRY_NUMBER: 649044 — Reaxys

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2023-11-22. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match25429

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. If symptoms (such as redness or irritation) develop, immediately transport the victim to a hospital.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not availabl Source: CAMEO Chemicals
  • Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H340: May cause genetic defects [Danger Germ cell mutagenicity]; H360FD: May damage fertility; May damage the unborn child [Danger Reproductive toxicity]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P203, P261, P272, P273, P280, P302+P352, P318, P321, P333+P317, P362+P364, P391, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Note: This chemical does not meet GHS hazard criteria for 0.3% (2 of 692) of reports. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H317 (27.9%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H340 (99.6%): May cause genetic defects [Danger Germ cell mutagenicity]; H360 (74%): May damage fertility or the unborn child [Danger Reproductive toxicity]; H360FD (25.6%): May damage fertility; May damage the unborn child [Danger Reproductive toxicity]; H400 (98.1%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410 (99.7%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P261, P272, P273, P280, P302+P352, P318, P321, P333+P317, P362+P364, P391, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 692 reports by companies from 27 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 2 of 692 reports by companies.; There are 26 notifications provided by 690 of 692 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H340: May cause genetic defects [Danger Germ cell mutagenicity]; H360: May damage fertility or the unborn child [Danger Reproductive toxicity]; H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P260, P261, P264, P270, P272, P280, P302+P352, P308+P316, P318, P319, P321, P333+P317, P362+P364, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Signal: Warning Source: NITE-CMC
  • Health Effects: Carbendazim is a suspected endocrine disruptor. It is also a developmental toxin. Animals exposed to carbendazim in the womb to have serious deformities such as lack of eyes and hydrocephalus (water on the brain). Carbendazim can disrupt the development of sperm and damage testicular development in adult rats. Source: Toxin and Toxin Target Database (T3DB)
  • Toxicity Summary: IDENTIFICATION AND USE: Carbendazim is a white powder. it is a systemic leaf and soil fungicide, absorbed through the roots and green tissues. HUMAN EXPOSURE AND TOXICITY: Six human chromosomes were investigated in pairs (1 and 8, 11 and 18, and X and 17). Abnormalities were classified as chromosome loss (including centromeric positive micronuclei), chromosome gain, non-disjunction, or polyploidy. ANIMAL STUDIES: Previous studies indicate that carbendazim may interfere with mitosis and thus may disrupt or inhibit microtubule function resulting in apoptosis. Carbendazim even at low dose exhibited toxicity, affected the liver and also caused specific changes in hematological and biochemical parameters in the rat. Male rats (6 per dose level) were gavaged with 200, 3400 and 5000 mg/kg 5 days/wk for 2 wk. Two out of the 6 rats died at the dose level of 3400 mg/kg per day. At all dose levels, gross and microscopic evidence of adverse effects on the testes and reduction or absence of sperm in the epididymides was seen. The testes were small and discolored, with tubular degeneration and evidence of aspermatogenesis. At the dose level of 3400 mg/kg per day, there were also morphological ch Source: Hazardous Substances Data Bank (HSDB)
  • Toxicity Summary: Carbendazim targets beta tubulin in actively dividing cells. It binds to microtubules, interfering with cell functions, such as meiosis and intracellular transportation (A15332). Source: Toxin and Toxin Target Database (T3DB)
  • Environmental Bioconcentration: BCFs of <1.5-3.5 and 0.6-1.1 were measured using carp (Cyprinus carpio) exposed to 2 and 20 ug/L, respectively, carbendazim over a 6-week period(1). Carbendazim was not bioconcentrated in perch (Perca fluviatilis) and carp exposed to food pellets containing a mixture of 13 pesticides(2). According to a classification scheme(3), these BCF values suggest bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), Koc values of 122.3-2805(2-3), indicate that carbendazim is expected to have high mobility in some soils with decreasing mobility as the amount of clay and organic carbon content increases, pH will have a lesser effect on mobility. Volatilization of carbendazim from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.5X10-12 atm-cu m/mole(SRC), using a fragment constant estimation method(4). Carbendazim is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 7.5X10-10 mm Hg at 25 °C(5). Measured soil biodegradation rates of 45% in 21 days and 45% in 14 days suggest that carbendazim is expected to biodegrade slowly under normal environmental conditions(6). However, biodegradation rates of 100% in 5 days and 97% in 9 days suggest that biodegradation of carbendazim will be enhanced in pretreated soils(6). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Carbendazim is absorbed through the roots and green tissues of plants, with translocation acropetally. Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), Koc values of 122.3-2805(2-3), indicate that carbendazim is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(4) based upon an estimated Henry's Law constant of 1.5X10-12 atm-cu m/mole(SRC), developed using a fragment constant estimation method(5). Measured hydrolysis half-lives for carbendazim at 22 °C were >350 days at pH 5-7 and 124 days at pH 9(6). According to a classification scheme(7), BCFs of <1.5-3.5 measured in carp(8), suggest bioconcentration in aquatic organisms is low(SRC). A 0% of Theoretical BOD using activated sludge in the Japanese MITI test(8) suggests that biodegradation is not an important environmental fate process in water(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), carbendazim, which has a vapor pressure of 7.5X10-10 mm Hg at 25 °C(2), is expected to exist solely in the particulate phase in the ambient atmosphere. Particulate-phase carbendazim may be removed from the air by wet and dry deposition(SRC). Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Carbendazim

Chemical / IUPAC name

methyl benzimidazol-2-ylcarbamate

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

SCCS opinions

CMR

CategoryCarcinogenicMutagenicReprotoxic
Cat. 1B—✓✓

Key data

CAS
10605-21-7
EC
234-232-0
Annex
II
Entry number
996

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 995
Nearby record in the same annex

4-Nitrosophenol

CAS: 104-91-6
EC: 203-251-6
Annex II 999
Nearby record in the same annex

Hexane

CAS: 110-54-3
EC: 203-777-6

What Annex II means for Carbendazim

Carbendazim is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).
  • This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.

Frequently asked questions

Yes. Carbendazim is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 10605-21-7 is the unique numerical identifier assigned to Carbendazim by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Carbendazim has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Carbendazim

This page summarizes one Annex II record for Carbendazim from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Carbendazim, but confirm any final regulatory decision against the current official annex wording and source files.

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