1,3-Diphenylguanidine
New Zealand Cosmetic Products Group Standard Schedule 4, reference 993.
Regulatory decision and full conditions
- Status
- Prohibited
- Legal role
- Binding rule
- Regulatory summary
- New Zealand Cosmetic Products Group Standard Schedule 4, reference 993.
- Conditions and restrictions
- A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. Open the cited source and apply the market-wide requirements below.
Substance identity
- Official source name
- 1,3-Diphenylguanidine
- CAS
- 102-06-7
- EC
- Not supplied in this source row
- Identity mapping
- standalone:official_nz_schedule
Cross-market snapshot for this identity
Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.
European Union
1 linked record
Open supporting recordGreat Britain
1 linked record
Open supporting recordNew Zealand
Current record1 linked record
Open supporting recordASEAN
1 linked record
Open supporting recordChina
1 linked record · 1 with specific conditions
Open supporting recordSouth Korea
1 linked record
Open supporting recordBrazil
1 linked record · 1 with specific conditions
Open supporting recordIndia
1 linked record · 1 with specific conditions
Open supporting recordSaudi Arabia
1 linked record
Open supporting recordVerified chemistry for CAS 102-06-7
Diphenylguanidine
- IUPAC name
- 1,2-diphenylguanidine
- Molecular formula
- C13H13N3
- Molecular weight
- 211.26 g/mol
- Exact mass
- 211.110947427 Da
- Monoisotopic mass
- 211.110947427 Da
- XLogP3
- 2.4
- Topological polar surface area
- 50.4 Ų
- Molecular complexity
- 225.0
- Formal charge
- 0
- Hydrogen-bond donors
- 2
- Hydrogen-bond acceptors
- 1
- Rotatable bonds
- 3
- Heavy atoms
- 16
- Covalent units
- 1
Names and synonyms reported to PubChem
16 more reported names
External database identifiers
- ChEBI:CHEBI:144319
- ChEMBL:CHEMBL77675
- EPA DTXSID:DTXSID3025178
- PubMed:22998617
- PubMed:22762249
- PubMed:21365105
- PubMed:20855699
- PubMed:20646676
- PubMed:20137737
- PubMed:19345756
- PubMed:19220004
- PubMed:18376821
- PubMed:17928183
- PubMed:16426298
- PubMed:15840103
Advanced structure statistics
- Defined atom stereocentres
- 0
- Undefined atom stereocentres
- 0
- Defined bond stereocentres
- 0
- Undefined bond stereocentres
- 0
- 3D pharmacophore features
- 5
- 3D rings
- 2
- 3D hydrophobes
- 0
- 3D acceptor features
- 0
- 3D donor features
- 2
- 3D anionic centres
- 0
- 3D cationic centres
- 1
- 3D conformers
- 6
- Effective 3D rotors
- 3.0
Machine-readable structure identifiers
- SMILES
C1=CC=C(C=C1)NC(=NC2=CC=CC=C2)N- InChI
InChI=1S/C13H13N3/c14-13(15-11-7-3-1-4-8-11)16-12-9-5-2-6-10-12/h1-10H,(H3,14,15,16)- InChIKey
OWRCNXZUPFZXOS-UHFFFAOYSA-N
Evidence from additional scientific databases
EMBL-EBI ChEBI
1,3-diphenylguanidine
Guanidine carrying a phenyl substituent on each of the two amino groups. It is used as an accelerator in the rubber industry.
- Formula
- C13H13N3
- Average mass
- 211.268 g/mol
- Monoisotopic mass
- 211.11095 Da
- Formal charge
- 0
- guanidines — is a (CHEBI:24436)
- allergen — has role (CHEBI:50904)
- allergen — has role (CHEBI:50904)
- guanidines — is a (CHEBI:24436)
Additional curated names
Cross-references from this source
- CAS: 102-06-7 — ChemIDplus
Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2019-07-25. Retrieved: 2026-08-31. Open source record
NIH PubChem PUG-View
Attributed physical-property, hazard, environmental and use annotations.
- Boiling Point: Decomposes >338 °F (NTP, 1992) Source: CAMEO Chemicals
- Boiling Point: 170 °C (decomposes) Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: Monoclinic needles (crystalized from alcohol and toluene) Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: White powder Source: Hazardous Substances Data Bank (HSDB)
- Density: 1.13 at 68 °F (NTP, 1992) - Denser than water; will sink Source: CAMEO Chemicals
- Density: 1.13 g/cu cm at 20 °C Source: Hazardous Substances Data Bank (HSDB)
- Density: 1.19 g/cm³ Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Density: 1.13 @ 20°C Source: PAC Chemical Database, U.S. Department of Energy
- Dissociation Constants: pKa = 10.12 (conjugate acid) Source: Hazardous Substances Data Bank (HSDB)
- Flash Point: 388 °F (NTP, 1992) Source: CAMEO Chemicals
- Flash Point: 170 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- LogP: log Kow = 2.89 /Estimated/ Source: Hazardous Substances Data Bank (HSDB)
- LogP: 1.69 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Melting Point: 302 °F (NTP, 1992) Source: CAMEO Chemicals
- Melting Point: 150 °C Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: 150 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Melting Point: 150 °C Source: PAC Chemical Database, U.S. Department of Energy
- Odor: Slight odor Source: Hazardous Substances Data Bank (HSDB)
- Physical Description: 1,3-diphenylguanidine is a white to cream-colored chalky powder. Bitter taste and slight odor. Source: CAMEO Chemicals
- Physical Description: Dry Powder; Large Crystals; Dry Powder; Other Solid; Dry Powder; Large Crystals Source: EPA Chemical Data Reporting (CDR)
- Physical Description: Colorless or white solid; [ICSC] White powder; [MSDSonline] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Physical Description: COLOURLESS OR WHITE CRYSTALLINE POWDER OR NEEDLES Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Solubility: less than 1 mg/mL at 70 °F (NTP, 1992) Source: CAMEO Chemicals
- Solubility: Soluble in ethanol, carbon tetrachloride, chloroform, toluene; very soluble in ethyl ether. Source: Hazardous Substances Data Bank (HSDB)
- Solubility: In water, 1,000 mg/L at 25 °C Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Solubility in water at 20 °C: poor Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Solubility: 29.5 [ug/mL] (The mean of the results at pH 7.4) Source: Sanford-Burnham Center for Chemical Genomics
- Vapor Pressure: Negligible (NTP, 1992) Source: CAMEO Chemicals
- Vapor Pressure: 0.00000845 [mmHg] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Vapor Pressure: 4.0X10-6 mm Hg at 25 °C /Estimated/ Source: Hazardous Substances Data Bank (HSDB)
- Vapor Pressure: Vapor pressure, kPa at 20 °C: 0.17 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- pH: Aq soln is strongly alkaline Source: Hazardous Substances Data Bank (HSDB)
- Exposure Routes: The substance can be absorbed into the body by inhalation and by ingestion. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) shou Source: CAMEO Chemicals
- Signal: Warning Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H361f ***: Suspected of damaging fertility [Warning Reproductive toxicity]; H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Precautionary Statement Codes: P203, P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P318, P319, P321, P330, P332+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Signal: Danger Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H301 (34%): Toxic if swallowed [Danger Acute toxicity, oral]; H302 (66%): Harmful if swallowed [Warning Acute toxicity, oral]; H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]; H319 (98.2%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335 (99.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H361 (70.8%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]; H361f (29.2%): Suspected of damaging fertility [Warning Reproductive toxicity]; H411 (100%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P203, P261, P264, P264+P265, P270, P271, P273, P280, P301+P316, P301+P317, P302+P352, P304+P340, P305+P351+P338, P318, P319, P321, P330, P332+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 562 reports by companies from 24 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Signal: Danger Source: NITE-CMC
- GHS Hazard Statements: H301: Toxic if swallowed [Danger Acute toxicity, oral]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]; H360: May damage fertility or the unborn child [Danger Reproductive toxicity]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] Source: NITE-CMC
- Precautionary Statement Codes: P203, P260, P261, P264, P264+P265, P270, P271, P272, P280, P301+P316, P302+P352, P304+P340, P305+P354+P338, P317, P318, P319, P321, P330, P333+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
- GHS Hazard Statements: H401: Toxic to aquatic life [Hazardous to the aquatic environment, acute hazard]; H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
- Precautionary Statement Codes: P273, P391, and P501 (click each P-code to see the statement) Source: NITE-CMC
- Environmental Bioconcentration: BCFs of <2 and <20 were measured for N,N'-diphenylguanidine(SRC) using orange-red killifish (Oryzias latipes) which were exposed over a 6-week period(1). According to a classification scheme(2), these BCFs suggest the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 5,900(SRC), determined from a structure estimation method(2), indicates that N,N'-diphenylguanidine is expected to be immobile in soil(SRC). Volatilization of N,N'-diphenylguanidine from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 7.1X10-12 atm-cu m/mole(SRC), using a fragment constant estimation method(3). N,N'-Diphenylguanidine is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 8.4X10-6 mm Hg(SRC), determined from a fragment constant method(4). N,N'-diphenylguanidine reached 0% of its theoretical BOD in 2 weeks using an activated sludge and the Japanese MITI test(5), indicating that biodegradation in soil is not an important environmental fate process(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 5,900(SRC), determined from a structure estimation method(2), indicates that N,N'-diphenylguanidine is expected to adsorb to suspended solids and sediment(SRC). The pKa of N,N'-diphenylguanidine is 10.12(3), indicating that this compound will primarily exist in cation form in the environment and cations generally adsorb more strongly to suspended solids and sediment than their neutral counterparts(4). N,N'-Diphenylguanidine will exist almost entirely as a cation at pH values of 5 to 9 and therefore volatilization from water surfaces is not expected to be an important fate process. According to a classification scheme(5), BCFs of <2 and <20(6) suggest the potential for bioconcentration in aquatic organisms is low(SRC). Biodegradation rates of 18% and 9% in river water and sea water, respectively, after a 3-day cultivation period(7), indicates that biodegradation in water may not be an important environmental fate process(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), N,N'-diphenylguanidine, which has an estimated vapor pressure 8.4X10-6 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), will exist in both the vapor and particulate phases. Vapor-phase N,N'-diphenylguanidine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 4.5 hours(SRC), calculated from its rate constant of 8.5X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Particulate-phase N,N'-diphenylguanidine may be removed from the air by wet and dry deposition(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Consumer Uses: Not Known or Reasonably Ascertainable; Filler; Chemical reaction regulator; Processing aids not otherwise specified; Other; Polymerization promoter Source: EPA Chemical Data Reporting (CDR)
- Industry Uses: Processing aids not otherwise specified; Chemical reaction regulator; Polymerization promoter; Other; Intermediate; Dye; Filler Source: EPA Chemical Data Reporting (CDR)
- Sources/Uses: Used as a vulcanization accelerator, an activator for other rubber accelerators, and a primary material for standardizing acids; [HSDB] Formerly was contained in Carbamix used to patch test for allergic contact dermatitis; Workers may be exposed to rubber items in homemaking and in the metal, health, laboratory, and building industries; [Kanerva, p. 1789] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Uses: Primary material for standardizing acids; free base and phthalate as accelerators for vulcanization of rubber. Source: Hazardous Substances Data Bank (HSDB)
- Uses: Vulcanization accelerator for natural and synthetic rubbers. Source: Hazardous Substances Data Bank (HSDB)
- Uses: Activator for other rubber accelerators. Source: Hazardous Substances Data Bank (HSDB)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| EMBL-EBI ChEBI | Exact match | 2026-08-31 |
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Official source and provenance
- Registered source
- New Zealand cosmetic product schedules 4–8
- Source reference
- Schedule 4, reference 993, source row 1020
- Source record ID
S4-1020- Source version
- effective-2026-01-01
- Source language
- English
- Translation status
- Original is English
- Effective date
- 2026-01-01
- Source updated
- 2024-01-01
- Snapshot checked
- 2026-08-30 04:54 UTC
- Validation method
- openpyxl extraction; reviewed per-schedule counts
- SHA-256
4e62e372fb0aad7ac630af8c41fa50b38b52a793fd51b99697a65f8ecce1ae8a
Registered dataset notes
- Dataset coverage
- Prohibited and restricted substances, permitted colorants, preservatives and UV filters
- Authority note
- Official EPA group standard schedules; current market-specific rule source
How this record fits the market dataset
Status distribution
Condition text is present on 747 of 2913 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.
New Zealand market context
Complete schedules dataset
Coverage version: Cosmetic Products Group Standard schedules effective 1 January 2026
Schedules 4–8: prohibited, restricted, colourant, preservative and UV-filter entries.
Verification checklist
- Search exact identity across Schedules 4–8.
- Apply use, concentration and warning conditions.
- Check hazardous-substance classification and Group Standard scope.
- Confirm the latest legal instrument, not only the spreadsheet.
Official market sources
- New Zealand cosmetic product schedules 4–8Official EPA group standard schedules; current market-specific rule source
Verification workflow and record completeness
Before using this result in a compliance decision
- Confirm that “1,3-Diphenylguanidine” and every CAS/EC identifier refer to the material in your supplier specification.
- Search exact identity across Schedules 4–8.
- Apply use, concentration and warning conditions.
- Check hazardous-substance classification and Group Standard scope.
- Confirm the latest legal instrument, not only the spreadsheet.
- Document the source version and recheck the regulator before manufacture, notification or market placement.
Fields available in this record
- Official substance nameAvailable
- CASAvailable
- ECNot supplied
- Separate condition textNot present in source row
- Effective dateAvailable
- Snapshot hash and methodAvailable
Questions this page answers
Stable citation
1,3-Diphenylguanidine. Schedule 4, reference 993, source row 1020. New Zealand. Source version effective-2026-01-01. CosIng Checker regulatory record: https://cosingchecker.com/regulations/nz/records/7690/
Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.
Interpretation and limits for New Zealand
This official record identifies the substance as prohibited for cosmetic use in the stated market scope.
Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.
How to interpret the legal role
The cited row forms part of a binding rule or legally incorporated list for this market.
Evidence on this page
- Recorded outcome: Prohibited
- Legal role: Binding rule
- Source version: effective-2026-01-01
- Effective date: 2026-01-01
What it does not prove
The searchable spreadsheet is an aid; the legal Group Standard and incorporated notices remain authoritative.
Further authoritative substance research
These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.
Cosmetic Ingredient Review safety assessments
Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents
Independent expert review considered by FDA; not a government approval or binding market rule
Research this identity at the sourceFDA Global Substance Registration System
UNII identifiers, preferred names, substance types, codes and public substance relationships
Identity registry only; UNII availability does not imply FDA review or approval
Research this identity at the sourceILO/WHO International Chemical Safety Cards
Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals
International occupational chemical-safety reference; not cosmetic-use approval
Research this identity at the sourceJapan NITE-CHRIP
Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information
Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules
Research this identity at the sourceNIOSH Pocket Guide to Chemical Hazards
REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals
US occupational-health guidance and limits; not a cosmetic ingredient decision
Research this identity at the sourceOECD eChemPortal
Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records
Discovery gateway; each linked authority remains responsible for its data
Research this identity at the sourceUS EPA CompTox CTX APIs
API key required for importDTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data
Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality
Research this identity at the source