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ProhibitedBinding ruleBROfficial English translationOfficial-source import checked

1,3-difenilguanidina

ANVISA lists this substance among materials that may not be used in personal-hygiene products, cosmetics or perfumes in Brazil.

All Brazil recordsCompare all marketsOpen official source

Regulatory decision and full conditions

Status
Prohibited
Legal role
Binding rule
Regulatory summary
ANVISA lists this substance among materials that may not be used in personal-hygiene products, cosmetics or perfumes in Brazil.
Conditions and restrictions
1,3-difenilguanidina

Substance identity

Official source name
1,3-difenilguanidina
CAS
102-06-7
EC
203-002-1
Identity mapping
standalone:official_anvisa_record
Search this identity across the siteCAS 102-06-7EC 203-002-1

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

9 market datasets
PubChem 2D chemical structure for CAS 102-06-7
CAS 102-06-7PubChem CID 7594

Verified chemistry for CAS 102-06-7

Diphenylguanidine

IUPAC name
1,2-diphenylguanidine
Molecular formula
C13H13N3
Molecular weight
211.26 g/mol
Exact mass
211.110947427 Da
Monoisotopic mass
211.110947427 Da
XLogP3
2.4
Topological polar surface area
50.4 Ų
Molecular complexity
225.0
Formal charge
0
Hydrogen-bond donors
2
Hydrogen-bond acceptors
1
Rotatable bonds
3
Heavy atoms
16
Covalent units
1

Names and synonyms reported to PubChem

1,3-DiphenylguanidineN,N'-DIPHENYLGUANIDINEVulkazitMelanilineAccelerator DNocceler DDenaxs-Diphenylguanidine
16 more reported names
Vulkacite DVulcafor DPGVulkacit DDenax DPGDPG acceleratorVulkacit D/CDwufenyloguanidynaSoxinol DGuanidine, 1,3-diphenyl-Guanidine, N,N'-diphenyl-USAF EK-1270Sanceler DUSAF B-19Vulcacid DNCI-C609246MRZ85RNHQ
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
5
3D rings
2
3D hydrophobes
0
3D acceptor features
0
3D donor features
2
3D anionic centres
0
3D cationic centres
1
3D conformers
6
Effective 3D rotors
3.0
Machine-readable structure identifiers
SMILES
C1=CC=C(C=C1)NC(=NC2=CC=CC=C2)N
InChI
InChI=1S/C13H13N3/c14-13(15-11-7-3-1-4-8-11)16-12-9-5-2-6-10-12/h1-10H,(H3,14,15,16)
InChIKey
OWRCNXZUPFZXOS-UHFFFAOYSA-N

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:144319

1,3-diphenylguanidine

Guanidine carrying a phenyl substituent on each of the two amino groups. It is used as an accelerator in the rubber industry.

Formula
C13H13N3
Average mass
211.268 g/mol
Monoisotopic mass
211.11095 Da
Formal charge
0
  • guanidines — is a (CHEBI:24436)
  • allergen — has role (CHEBI:50904)
  • allergen — has role (CHEBI:50904)
  • guanidines — is a (CHEBI:24436)
Additional curated names
N,N'-diphenylguanidine1,3-Diphenylguanidines-Diphenylguanidine
Cross-references from this source

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2019-07-25. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match7594

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) shou Source: CAMEO Chemicals
  • Signal: Warning Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H361f ***: Suspected of damaging fertility [Warning Reproductive toxicity]; H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P203, P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P318, P319, P321, P330, P332+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H301 (34%): Toxic if swallowed [Danger Acute toxicity, oral]; H302 (66%): Harmful if swallowed [Warning Acute toxicity, oral]; H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]; H319 (98.2%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335 (99.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H361 (70.8%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]; H361f (29.2%): Suspected of damaging fertility [Warning Reproductive toxicity]; H411 (100%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P261, P264, P264+P265, P270, P271, P273, P280, P301+P316, P301+P317, P302+P352, P304+P340, P305+P351+P338, P318, P319, P321, P330, P332+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 562 reports by companies from 24 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H301: Toxic if swallowed [Danger Acute toxicity, oral]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]; H360: May damage fertility or the unborn child [Danger Reproductive toxicity]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P260, P261, P264, P264+P265, P270, P271, P272, P280, P301+P316, P302+P352, P304+P340, P305+P354+P338, P317, P318, P319, P321, P330, P333+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • GHS Hazard Statements: H401: Toxic to aquatic life [Hazardous to the aquatic environment, acute hazard]; H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
  • Precautionary Statement Codes: P273, P391, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Environmental Bioconcentration: BCFs of <2 and <20 were measured for N,N'-diphenylguanidine(SRC) using orange-red killifish (Oryzias latipes) which were exposed over a 6-week period(1). According to a classification scheme(2), these BCFs suggest the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 5,900(SRC), determined from a structure estimation method(2), indicates that N,N'-diphenylguanidine is expected to be immobile in soil(SRC). Volatilization of N,N'-diphenylguanidine from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 7.1X10-12 atm-cu m/mole(SRC), using a fragment constant estimation method(3). N,N'-Diphenylguanidine is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 8.4X10-6 mm Hg(SRC), determined from a fragment constant method(4). N,N'-diphenylguanidine reached 0% of its theoretical BOD in 2 weeks using an activated sludge and the Japanese MITI test(5), indicating that biodegradation in soil is not an important environmental fate process(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 5,900(SRC), determined from a structure estimation method(2), indicates that N,N'-diphenylguanidine is expected to adsorb to suspended solids and sediment(SRC). The pKa of N,N'-diphenylguanidine is 10.12(3), indicating that this compound will primarily exist in cation form in the environment and cations generally adsorb more strongly to suspended solids and sediment than their neutral counterparts(4). N,N'-Diphenylguanidine will exist almost entirely as a cation at pH values of 5 to 9 and therefore volatilization from water surfaces is not expected to be an important fate process. According to a classification scheme(5), BCFs of <2 and <20(6) suggest the potential for bioconcentration in aquatic organisms is low(SRC). Biodegradation rates of 18% and 9% in river water and sea water, respectively, after a 3-day cultivation period(7), indicates that biodegradation in water may not be an important environmental fate process(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), N,N'-diphenylguanidine, which has an estimated vapor pressure 8.4X10-6 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), will exist in both the vapor and particulate phases. Vapor-phase N,N'-diphenylguanidine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 4.5 hours(SRC), calculated from its rate constant of 8.5X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Particulate-phase N,N'-diphenylguanidine may be removed from the air by wet and dry deposition(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Consumer Uses: Not Known or Reasonably Ascertainable; Filler; Chemical reaction regulator; Processing aids not otherwise specified; Other; Polymerization promoter Source: EPA Chemical Data Reporting (CDR)
  • Industry Uses: Processing aids not otherwise specified; Chemical reaction regulator; Polymerization promoter; Other; Intermediate; Dye; Filler Source: EPA Chemical Data Reporting (CDR)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
Brazil ANVISA consolidated prohibited substances — RDC 529/2021 through RDC 1.030/2026
Source reference
RDC 529/2021 consolidated annex, entry 993 (through RDC 1.030/2026)
Source record ID
annex:993
Source version
RDC 529/2021 consolidated through RDC 1.030/2026
Source language
Portuguese with official English identity where published
Translation status
Official English translation · English translation
Effective date
2026-06-15
Source updated
2026-06-15
Snapshot checked
2026-08-31 15:26 UTC
Validation method
pdfplumber government baseline + 4 RDC 1.030 exclusions + 15 additions; 1,387 substantive rows
SHA-256
a212e85540a186a842664fbdd4f351af0b1b4baeeb0c4765b9b52c6ce91c1e84

Registered dataset notes

Dataset coverage
All 1,387 substantive current prohibited rows after applying RDC 1.030/2026 additions, amendments and exclusions to RDC 529/2021
Authority note
Binding consolidated prohibited list for personal-hygiene products, cosmetics and perfumes
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

1387
current Brazil records
1387
records marked Prohibited
1387
records from this source version
1335
market records with CAS identity

Status distribution

Prohibited: 1387

Condition text is present on 1387 of 1387 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

Brazil market context

Complete prohibited dataset plus current restricted-list workflow

Coverage version: ANVISA RDC 1.029/2026 and RDC 1.030/2026, published 15 June 2026

All 1,387 substantive current prohibited rows in RDC 529/2021 consolidated through RDC 1.030/2026, plus the current RDC 1.029 restricted-list and identity workflow.

Verification checklist

  1. Resolve Portuguese, INCI and CAS identity with the ANVISA crosswalk.
  2. Check the consolidated prohibited list including RDC 1.030/2026 changes.
  3. Apply RDC 1.029/2026 restrictions and the still-effective complementary rules.
  4. Verify Mercosur incorporation, regularisation, labelling and transition periods.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “1,3-difenilguanidina” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Resolve Portuguese, INCI and CAS identity with the ANVISA crosswalk.
  3. Check the consolidated prohibited list including RDC 1.030/2026 changes.
  4. Apply RDC 1.029/2026 restrictions and the still-effective complementary rules.
  5. Verify Mercosur incorporation, regularisation, labelling and transition periods.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECAvailable
  • Separate condition textAvailable
  • Effective dateAvailable
  • Snapshot hash and methodAvailable

Questions this page answers

This official record identifies the substance as prohibited for cosmetic use in the stated market scope. Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. RDC 1.030/2026 amends rather than replaces the prohibited baseline, and the second restricted-list revision was still under consultation in July 2026.

The record cites RDC 529/2021 consolidated annex, entry 993 (through RDC 1.030/2026), source version RDC 529/2021 consolidated through RDC 1.030/2026. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

1,3-difenilguanidina. RDC 529/2021 consolidated annex, entry 993 (through RDC 1.030/2026). Brazil. Source version RDC 529/2021 consolidated through RDC 1.030/2026. CosIng Checker regulatory record: https://cosingchecker.com/regulations/br/records/14193/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for Brazil

This official record identifies the substance as prohibited for cosmetic use in the stated market scope.

Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

How to interpret the legal role

The cited row forms part of a binding rule or legally incorporated list for this market.

Evidence on this page

  • Recorded outcome: Prohibited
  • Legal role: Binding rule
  • Source version: RDC 529/2021 consolidated through RDC 1.030/2026
  • Effective date: 2026-06-15

What it does not prove

RDC 1.030/2026 amends rather than replaces the prohibited baseline, and the second restricted-list revision was still under consultation in July 2026.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity at the source

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity at the source

US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source