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ProhibitedBinding ruleKRNo English translationOfficial-source import checked

에톡시에탄올아세테이트

Listed by the Korean MFDS as a substance that may not be used in cosmetics.

All South Korea recordsOpen ingredient profileCompare all marketsOpen official source

Regulatory decision and full conditions

Status
Prohibited
Legal role
Binding rule
Regulatory summary
Listed by the Korean MFDS as a substance that may not be used in cosmetics.
Conditions and restrictions
A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. Open the cited source and apply the market-wide requirements below.

Substance identity

Official source name
에톡시에탄올아세테이트
CAS
111-15-9
EC
203-839-2
Identity mapping
cas_number
Linked ingredient
ETHOXYETHANOL ACETATE
Search this identity across the siteCAS 111-15-9EC 203-839-2

Linked CosIng identity data

Names and aliases

ETHOXYETHANOL ACETATE

EU inventory restriction note: II/666

Recorded cosmetic function: SOLVENT

Function pages:SOLVENT

View the complete ingredient profile

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

10 market datasets
PubChem 2D chemical structure for CAS 111-15-9
CAS 111-15-9PubChem CID 8095

Verified chemistry for CAS 111-15-9

Glycol monoethyl ether acetate

Ethylene Glycol Monoethyl Ether Acetate can cause developmental toxicity and male reproductive toxicity according to The National Institute for Occupational Safety and Health (NIOSH). — California Office of Environmental Health Hazard Assessment (OEHHA)

IUPAC name
2-ethoxyethyl acetate
Molecular formula
C6H12O3
Molecular weight
132.16 g/mol
Exact mass
132.078644241 Da
Monoisotopic mass
132.078644241 Da
XLogP3
0.3
Topological polar surface area
35.5 Ų
Molecular complexity
80.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
3
Rotatable bonds
5
Heavy atoms
9
Covalent units
1

Names and synonyms reported to PubChem

ETHYLENE GLYCOL MONOETHYL ETHER ACETATECellosolve acetateOxitol acetateOxytol acetate2-Ethoxyethanol acetateEthyl cellosolve acetate1-Acetoxy-2-ethoxyethaneEthylglycol acetate
16 more reported names
EthylglykolacetatOctan etoksyetylu2-Aethoxy-aethylacetatGlycol ether ee acetateCelosolvacetat2-Ethoxyethylacetate2-Etossietil-acetatoAcetate d'ethylglycolAcetate de cellosolveAcetato di cellosolve2-Ethoxy-ethylacetaatEktasolve EE acetate solventEthyl cellosolve acetaatAethylenglykolaetheracetatEthanol, 2-ethoxy-, acetateEthylene glycol ethyl ether acetate
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
2
3D rings
0
3D hydrophobes
0
3D acceptor features
2
3D donor features
0
3D anionic centres
0
3D cationic centres
0
3D conformers
10
Effective 3D rotors
5.0
Machine-readable structure identifiers
SMILES
CCOCCOC(=O)C
InChI
InChI=1S/C6H12O3/c1-3-8-4-5-9-6(2)7/h3-5H2,1-2H3
InChIKey
SVONRAPFKPVNKG-UHFFFAOYSA-N

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match8095

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) shou Source: CAMEO Chemicals
  • ERG2024, Guide 129 (Ethylene glycol monoethyl ether acetate): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)
  • First Aid: (General first aid procedures); Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.; Skin: Water flush promptly - If this chemical contacts the skin, flush the contaminated skin with water promptly. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water promptly. If irritation persists after washing, get medical attention.; Breathing: Respiratory support; Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately. Source: The National Institute for Occupational Safety and Health (NIOSH)
  • Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H226: Flammable liquid and vapor [Warning Flammable liquids]; H302: Harmful if swallowed [Warning Acute toxicity, oral]; H312: Harmful in contact with skin [Warning Acute toxicity, dermal]; H332: Harmful if inhaled [Warning Acute toxicity, inhalation]; H360FD: May damage fertility; May damage the unborn child [Danger Reproductive toxicity] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P261, P264, P270, P271, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P317, P318, P321, P330, P362+P364, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Note: This chemical does not meet GHS hazard criteria for 8.8% (36 of 410) of reports. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H226 (90.5%): Flammable liquid and vapor [Warning Flammable liquids]; H302 (91.2%): Harmful if swallowed [Warning Acute toxicity, oral]; H312 (91.2%): Harmful in contact with skin [Warning Acute toxicity, dermal]; H332 (91.2%): Harmful if inhaled [Warning Acute toxicity, inhalation]; H360 (91%): May damage fertility or the unborn child [Danger Reproductive toxicity] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P261, P264, P270, P271, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P317, P318, P321, P330, P362+P364, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 410 reports by companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 36 of 410 reports by companies.; There are 12 notifications provided by 374 of 410 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H226: Flammable liquid and vapor [Warning Flammable liquids]; H332: Harmful if inhaled [Warning Acute toxicity, inhalation]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]; H360: May damage fertility or the unborn child [Danger Reproductive toxicity]; H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H402: Harmful to aquatic life [Hazardous to the aquatic environment, acute hazard] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P273, P280, P303+P361+P353, P304+P340, P308+P316, P317, P318, P319, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • GHS Hazard Statements: H226: Flammable liquid and vapor [Warning Flammable liquids]; H320: Causes eye irritation [Warning Serious eye damage/eye irritation]; H332: Harmful if inhaled [Warning Acute toxicity, inhalation]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]; H360: May damage fertility or the unborn child [Danger Reproductive toxicity]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] Source: NITE-CMC
  • NFPA Health Rating: 1 - Materials that, under emergency conditions, can cause significant irritation. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Fire Rating: 2 - Materials that must be moderately heated or exposed to relatively high ambient temperatures before ignition can occur. Materials would not under normal conditions form hazardous atmospheres with air, but under high ambient temperatures or under moderate heating could release vapor in sufficient quantities to produce hazardous atmospheres with air. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Instability Rating: 0 - Materials that in themselves are normally stable, even under fire conditions. Source: Hazardous Substances Data Bank (HSDB)
  • Cosmetic Ingredient Review Conclusion: On the basis of the animal and clinical data included in this report, the CIR Expert Panel concludes that Ethoxyethanol and Ethoxyethanol Acetate are unsafe for use in cosmetic products. Source: Cosmetic Ingredient Review (CIR)
  • Cosmetic Ingredient Review Finding(s): The ingredient is unsafe for use in cosmetics Source: Cosmetic Ingredient Review (CIR)
  • Toxicity Summary: ... The methyl and ethyl ethers of ethylene glycol, ie 2- methoxyethanol (2-ME) esters, 2-methoxyethyl acetate (2-MEA) and 2-ethoxyethyl acetate (2- EEA) ... are all stable, and are all miscible with (or in the case of 2-EEA very soluble in) water and miscible with a large number of organic solvents. ... The solubility of these glycol ethers in water and their relatively low vapor pressure could result in their build-up in water in the absence of degradation. However, degradation by microorganisms in soil, sewage sludge, and water appears to prevent this possibility. Atmospheric emissions resulting from the use of glycol ethers as evaporative solvents result in the greatest environmental exposure.... Effects on Organisms in the Environment: The toxicity of 2-ME and 2-EE to microorganisms and aquatic animals appears to be low. ... The glycol ether acetates (2-MEA and 2-EEA) are far more toxic to fish. The LC50 of 2-EEA for fathead minnows is 46 mg/L and that of 2-MEA for tidewater silverfish and bluegills is 45 mg/L. ... Effects on Experimental Animals and In Vitro Test Systems: Systemic toxicity: The toxicity of 2-ME and 2-EE to experimental animals has been much more widely studie Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: An estimated BCF value of 3.0 was calculated for ethylene glycol monoethyl ether acetate(SRC), using a measured log Kow of 0.24(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF value suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 32(SRC), determined from a measured Kow of 0.24(2) and a regression-derived equation(3), indicates that ethylene glycol monoethyl ether acetate will have very high mobility in soil(SRC). Volatilization of ethylene glycol monoethyl ether acetate from moist soil surfaces may be an important fate process(SRC) given its Henry's Law constant of 3.2X10-6 atm-cu m/mole(4). Ethylene glycol monoethyl ether acetate is expected to volatilize from dry soil surfaces(SRC) based on its vapor pressure of 2.00 mm Hg(5). Several screening biodegradation tests have demonstrated that ethylene glycol monoethyl ether acetate is readily biodegradable(6-9); 80% biodegradation was measured for ethylene glycol monoethyl ether acetate in a 20 day screening test(7) suggesting that biodegradation may be an important fate process in soil(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a recommended classification scheme(1), an estimated Koc value of 32(SRC), using a log Kow of 0.24(2) and a regression-derived equation(1), indicates that ethylene glycol monoethyl ether acetate should not adsorb to suspended solids and sediment in water(SRC). Volatilization from water surfaces may occur(1) based on a Henry's Law constant of 3.2X10-11 atm-cu m/mole(3). Using this Henry's Law constant and an estimation method(1), volatilization half-lives for a model river and model lake are 13 and 100 days, respectively(SRC). According to a classification scheme(4),an estimated BCF value of 3.0(SRC), determined from its log Kow(2), suggests that bioconcentration in aquatic organisms is low(SRC). Biodegradation of ethylene glycol monoethyl ether acetate in a 28 day river die-away test resulted in classification as easily degraded(5) and 80% biodegradation occurred in a 20 day screening test(6) which suggest biodegradation as an important environmental fate process in water(SRC). This compound is expected to hydrolyze with estimated half-lives of 305 and 30 days at pH values of 7 and 8, respectively(7). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), ethylene glycol monoethyl ether acetate, which has a measured vapor pressure of 2.00 mm Hg at 25 °C(2), will exist solely as a vapor in the ambient atmosphere. Vapor-phase ethylene glycol monoethyl ether acetate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be about 0.7 days(SRC), calculated from its measured rate constant of 1.3X10-11 cu cm/molecule-sec at 25 °C(3). Ethylene glycol monoethyl ether acetate does not contain chromophores that absorb at wavelengths >290 nm(4) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
South Korea MFDS cosmetic ingredient data
Source reference
화장품 안전기준 등에 관한 규정, 별표 1, record 1-752
Source record ID
1-752
Source version
2026-19
Source language
Korean
Translation status
No English translation
Effective date
2026-03-18
Source updated
2026-03-18
Snapshot checked
2026-08-30 04:33 UTC
Validation method
MFDS JSON appendices 1–2 parse; 1077 prohibited, 243 restricted
SHA-256
056de35b843a5e31f709073f9e79d5e6e18f7c9164eb537bb099b185a37ef7d8

Registered dataset notes

Dataset coverage
Ingredient identity and separate restriction/regulation data endpoints
Authority note
Korean source is canonical; English materials alone are not complete enough for certification
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

1320
current South Korea records
1077
records marked Prohibited
1320
records from this source version
1252
market records with CAS identity

Status distribution

Prohibited: 1077Restricted: 243

Condition text is present on 638 of 1320 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

South Korea market context

Complete current appendix dataset

Coverage version: MFDS Notice 2026-19, effective 18 March 2026

All rows in official Appendix 1 (prohibited) and Appendix 2 (restricted) of the Safety Standards for Cosmetics.

Verification checklist

  1. Match the Korean canonical substance name and identifiers.
  2. Review all Appendix 1 and 2 matches and conditions.
  3. Check functional-cosmetic and positive-list requirements where applicable.
  4. Confirm current MFDS notice, responsible seller and label obligations.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “에톡시에탄올아세테이트” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Match the Korean canonical substance name and identifiers.
  3. Review all Appendix 1 and 2 matches and conditions.
  4. Check functional-cosmetic and positive-list requirements where applicable.
  5. Confirm current MFDS notice, responsible seller and label obligations.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECAvailable
  • Separate condition textNot present in source row
  • Effective dateAvailable
  • Snapshot hash and methodAvailable

Questions this page answers

This official record identifies the substance as prohibited for cosmetic use in the stated market scope. Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. Korean source wording is canonical and other positive lists/notices may still apply to the formulation.

The record cites 화장품 안전기준 등에 관한 규정, 별표 1, record 1-752, source version 2026-19. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

에톡시에탄올아세테이트. 화장품 안전기준 등에 관한 규정, 별표 1, record 1-752. South Korea. Source version 2026-19. CosIng Checker regulatory record: https://cosingchecker.com/regulations/kr/records/1429/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for South Korea

This official record identifies the substance as prohibited for cosmetic use in the stated market scope.

Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

How to interpret the legal role

The cited row forms part of a binding rule or legally incorporated list for this market.

Evidence on this page

  • Recorded outcome: Prohibited
  • Legal role: Binding rule
  • Source version: 2026-19
  • Effective date: 2026-03-18

What it does not prove

Korean source wording is canonical and other positive lists/notices may still apply to the formulation.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity at the source

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity at the source

US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source