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ProhibitedBinding ruleGBOriginal is EnglishOfficial-source import checked

2-(2-Aminoethylamino)ethanol; (AEEA)

The consolidated GB Cosmetics Regulation lists this record in Annex II.

All Great Britain recordsOpen ingredient profileCompare all marketsOpen official source

Regulatory decision and full conditions

Status
Prohibited
Legal role
Binding rule
Regulatory summary
The consolidated GB Cosmetics Regulation lists this record in Annex II.
Conditions and restrictions
A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. Open the cited source and apply the market-wide requirements below.

Substance identity

Official source name
2-(2-Aminoethylamino)ethanol; (AEEA)
CAS
111-41-1
EC
203-867-5
Identity mapping
cas_number
Linked ingredient
AMINOETHYLETHANOLAMINE
Search this identity across the siteCAS 111-41-1EC 203-867-5

Linked CosIng identity data

Names and aliases

AMINOETHYLETHANOLAMINE

CosIng description: Ethanol, 2-[(2-aminoethyl)amino]-,Hydroxyethyl Ethylenediamine

EU inventory restriction note: II/1471

Recorded cosmetic function: NOT REPORTED

Function pages:NOT REPORTED

View the complete ingredient profile

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

6 market datasets
PubChem 2D chemical structure for CAS 111-41-1
CAS 111-41-1PubChem CID 8112

Verified chemistry for CAS 111-41-1

N-(2-Hydroxyethyl)ethylenediamine

IUPAC name
2-(2-aminoethylamino)ethanol
Molecular formula
C4H12N2O
Molecular weight
104.15 g/mol
Exact mass
104.094963011 Da
Monoisotopic mass
104.094963011 Da
XLogP3
-1.7
Topological polar surface area
58.3 Ų
Molecular complexity
32.0
Formal charge
0
Hydrogen-bond donors
3
Hydrogen-bond acceptors
3
Rotatable bonds
4
Heavy atoms
7
Covalent units
1

Names and synonyms reported to PubChem

monoethanol ethylenediamineRefChem:112035Aminoethylethanolamine2-((2-Aminoethyl)amino)ethanolN-(Hydroxyethyl)ethylenediamineN-(2-Aminoethyl)ethanolamineN-(Aminoethyl)ethanolamine(2-Hydroxyethyl)ethylenediamine
16 more reported names
MonoethanolethylenediamineEthanol, 2-[(2-aminoethyl)amino]-(2-Aminoethyl)ethanolamine2-[(2-Aminoethyl)amino]ethanolEthanolethylene diamineN-Hydroxyethyl-1,2-ethanediamineN-Hydroxyethylethylenediamine2-[(2-aminoethyl)amino]ethan-1-olN-(2-Hydroxyethyl)-1,2-ethanediamineNSC 461Ethanol, 2-((2-aminoethyl)amino)-2-((Aminoethyl)amino)ethanol2-[2-Aminoethylamino]ethanolTrimetazidine Impurity PRC78W6NPXT1-(2-(Hydroxyethyl)amino)-2-aminoethane
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
6
3D rings
0
3D hydrophobes
0
3D acceptor features
1
3D donor features
3
3D anionic centres
0
3D cationic centres
2
3D conformers
10
Effective 3D rotors
4.0
Machine-readable structure identifiers
SMILES
C(CNCCO)N
InChI
InChI=1S/C4H12N2O/c5-1-2-6-3-4-7/h6-7H,1-5H2
InChIKey
LHIJANUOQQMGNT-UHFFFAOYSA-N

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match8112

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) shou Source: CAMEO Chemicals
  • Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H360Df: May damage the unborn child; Suspected of damaging fertility [Danger Reproductive toxicity] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P203, P260, P261, P264, P272, P280, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P318, P321, P333+P317, P362+P364, P363, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H290 (13.6%): May be corrosive to metals [Warning Corrosive to Metals]; H314 (99.4%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]; H317 (> 99.9%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H318 (19%): Causes serious eye damage [Danger Serious eye damage/eye irritation]; H335 (17.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H360 (99.8%): May damage fertility or the unborn child [Danger Reproductive toxicity] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P234, P260, P261, P264, P264+P265, P271, P272, P280, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P318, P319, P321, P333+P317, P362+P364, P363, P390, P403+P233, P405, P406, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 3278 reports by companies from 41 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H402: Harmful to aquatic life [Hazardous to the aquatic environment, acute hazard]; H412: Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
  • Precautionary Statement Codes: P273, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]; H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]; H360: May damage fertility or the unborn child [Danger Reproductive toxicity]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]; H402: Harmful to aquatic life [Hazardous to the aquatic environment, acute hazard]; H412: Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P233, P260, P261, P264, P264+P265, P271, P272, P273, P280, P284, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P318, P319, P321, P333+P317, P342+P316, P362+P364, P363, P403, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • NFPA Health Rating: 2 - Materials that, under emergency conditions, can cause temporary incapacitation or residual injury. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Fire Rating: 1 - Materials that must be preheated before ignition can occur. Materials require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Instability Rating: 0 - Materials that in themselves are normally stable, even under fire conditions. Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: Based upon an estimated log Kow of -1.39(1), the BCF for aminoethyl ethanolamine can be estimated to be 0.05 from a recommended regression-derived equation(2,SRC). This estimated BCF value indicates that bioconcentration in aquatic organisms is not important. Aminoethyl ethanolamine is miscible in water(3) which also indicates that bioconcentration is not important(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: The results of one biodegradation screening study have indicated that aminoethyl ethanolamine biodegrades readily(1); therefore, biodegradation may be an important transformation process in soil(SRC). Aminoethyl ethanolamine has a pKa of 7.21(2) that indicates it can exist in both the protonated and neutral forms in environmental media; neutral aminoethyl ethanolamine is expected to leach readily. However, the mobility of protonated aminoethyl ethanolamine in soil can not be predicted without additional experimental data(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: The results of one biodegradation screening study have indicated that aminoethyl ethanolamine biodegrades readily(1); therefore, biodegradation may be an important transformation process in water. Aquatic bioconcentration and volatilization are not expected to be important because of the high solubility of aminoethyl ethanolamine(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: Based upon a vapor pressure of 8.19X10-4 mm Hg at 25 °C(1), aminoethyl ethanolamine is expected to exist primarily in the vapor-phase in the ambient atmosphere(2,SRC). It will degrade rapidly in the atmosphere by the vapor-phase reaction with photochemically produced hydroxyl radicals with an estimated half-life of 3.3 hr(3,SRC). Aminoethyl ethanolamine is miscible with water(4), therefore, physical removal from air by wet deposition (dissolution in clouds, rainfall, etc) is possible(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Sources/Uses: Used as a chemical intermediate, textile finishing compound, and additive to oils in metal cutting; [HSDB] Occupational asthma reported in solderer and cable jointer; [Malo] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Industrial Processes with risk of exposure: Metal Machining [Category: Heat or Machine]; Soldering [Category: Heat or Machine]; Semiconductor Manufacturing [Category: Industry]; Textiles (Printing, Dyeing, or Finishing) [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: CHEM INT FOR CHELATING AGENTS, DETERGENTS & EMULSIFIERS, CORROSION INHIBITORS, MINING CHEMICALS, GASOLINE STABILIZERS, DYEING ASSISTANTS, MODIFYING AGENTS (TEXTILES), 2,4-D HERBICIDE SALTS, OILS USED IN TEXTILE PROCESSING, OILS USED IN METAL CUTTING, AND GAS PROCESSING CHEMICALS Source: Hazardous Substances Data Bank (HSDB)
  • Uses: TEXTILE FINISHING CMPD (ANTIFUMING AGENTS, DYESTUFFS, CATIONIC SURFACTANTS); RESINS, RUBBER PRODUCTS; INSECTICIDES, CERTAIN MEDICINALS Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
Great Britain Cosmetics Regulation — consolidated Annexes II–VI and amendments
Source reference
GB Cosmetics Regulation, Annex II, entry 1471
Source record ID
II-1471
Source version
2026-08-15
Source language
English
Translation status
Original is English
Effective date
2026-08-15
Source updated
2026-08-19
Snapshot checked
2026-08-30 04:51 UTC
Validation method
legislation.gov.uk XML table parse; {'II': 1758, 'III': 326, 'IV': 154, 'V': 57, 'VI': 34}
SHA-256
e3a386d950f54c6e7a7f9e784d1bd46e52de725137e89d5630709824475215d8

Registered dataset notes

Dataset coverage
Complete consolidated GB Annexes II–VI, with later amendments versioned separately
Authority note
Binding GB schedules and versioned amendments to retained Regulation 1223/2009; applies to England, Wales and Scotland, not Northern Ireland
Source licence
Open Government Licence v3.0 / Crown copyright
Attribution
Contains public sector information licensed under the Open Government Licence v3.0.
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

2329
current Great Britain records
1758
records marked Prohibited
2329
records from this source version
2015
market records with CAS identity

Status distribution

Permitted list with conditions: 245Prohibited: 1758Restricted: 326

Condition text is present on 517 of 2329 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

Great Britain market context

Complete consolidated annex dataset

Coverage version: GB retained Regulation 1223/2009 schedules, effective 15 August 2026

Current consolidated Annexes II–VI for England, Scotland and Wales.

Verification checklist

  1. Confirm INCI/CAS/EC identity.
  2. Review every current GB Annex II–VI match.
  3. Check commencement dates and later statutory instruments.
  4. Verify SCPN, responsible-person, safety-report and labelling duties.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “2-(2-Aminoethylamino)ethanol; (AEEA)” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Confirm INCI/CAS/EC identity.
  3. Review every current GB Annex II–VI match.
  4. Check commencement dates and later statutory instruments.
  5. Verify SCPN, responsible-person, safety-report and labelling duties.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECAvailable
  • Separate condition textNot present in source row
  • Effective dateAvailable
  • Snapshot hash and methodAvailable

Questions this page answers

This official record identifies the substance as prohibited for cosmetic use in the stated market scope. Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. No annex match is not approval and does not cover Northern Ireland, which follows the applicable EU framework.

The record cites GB Cosmetics Regulation, Annex II, entry 1471, source version 2026-08-15. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

2-(2-Aminoethylamino)ethanol; (AEEA). GB Cosmetics Regulation, Annex II, entry 1471. Great Britain. Source version 2026-08-15. CosIng Checker regulatory record: https://cosingchecker.com/regulations/gb/records/5826/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for Great Britain

This official record identifies the substance as prohibited for cosmetic use in the stated market scope.

Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

How to interpret the legal role

The cited row forms part of a binding rule or legally incorporated list for this market.

Evidence on this page

  • Recorded outcome: Prohibited
  • Legal role: Binding rule
  • Source version: 2026-08-15
  • Effective date: 2026-08-15

What it does not prove

No annex match is not approval and does not cover Northern Ireland, which follows the applicable EU framework.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity at the source

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity at the source

US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source