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ProhibitedBinding ruleCNOfficial English translationOfficial-source import checked

肾上腺素受体激动药，包括但不限于麻 黄碱及其盐类、肾上腺素、异丙肾上腺 素、萘甲唑啉及其盐类、去甲肾上腺素 及其盐类、奥托君及其盐类等 — Adrenergic agents, including but not limited to Ephedrine （CAS No. 299-42-3） and its salts, Epinephrine （INN） （CAS No. 51-43-4）, Isoprenaline （INN） （CAS No. 7683-59-2）, Naphazoline （INN） （CAS No. 835-31-4） and its salts, Noradrenaline（CAS No. 51-41-2） and its salts, Octodrine （INN） （CAS No. 543-82-8） and its salts

Adrenergic agents, including but not limited to Ephedrine （CAS No. 299-42-3） and its salts, Epinephrine （INN） （CAS No. 51-43-4）, Isoprenaline （INN） （CAS No. 7683-59-2）, Naphazoline （INN） （CAS No. 835-31-4） and its salts, Noradrenaline（CAS No. 51-41-2） and

The NMPA binding 2021 catalogue prohibits this raw material in cosmetic formulas in China.

All China recordsCompare all marketsOpen official source

Regulatory decision and full conditions

Status
Prohibited
Legal role
Binding rule
Regulatory summary
The NMPA binding 2021 catalogue prohibits this raw material in cosmetic formulas in China.
Conditions and restrictions
Prohibited in cosmetic product formulas. Verify the cited Chinese source identity and any later NMPA amendment before use.

Substance identity

Official source name
肾上腺素受体激动药，包括但不限于麻 黄碱及其盐类、肾上腺素、异丙肾上腺 素、萘甲唑啉及其盐类、去甲肾上腺素 及其盐类、奥托君及其盐类等 — Adrenergic agents, including but not limited to Ephedrine （CAS No. 299-42-3） and its salts, Epinephrine （INN） （CAS No. 51-43-4）, Isoprenaline （INN） （CAS No. 7683-59-2）, Naphazoline （INN） （CAS No. 835-31-4） and its salts, Noradrenaline（CAS No. 51-41-2） and its salts, Octodrine （INN） （CAS No. 543-82-8） and its salts
CAS
299-42-3; 51-43-4; 7683-59-2; 835-31-4; 51-41-2; 543-82-8
EC
Not supplied in this source row
Identity mapping
standalone:official_nmpa_record
Search this identity across the siteCAS 299-42-3CAS 51-43-4CAS 7683-59-2CAS 835-31-4CAS 51-41-2CAS 543-82-8

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

10 market datasets
PubChem 2D chemical structure for CAS 299-42-3
CAS 299-42-3PubChem CID 9294

Verified chemistry for CAS 299-42-3

Ephedrine

(-)-ephedrine is a phenethylamine alkaloid that is 2-phenylethanamine substituted by a methyl group at the amino nitrogen and a methyl and a hydroxy group at position 2 and 1 respectively. It has a role as a sympathomimetic agent, a xenobiotic, a vasoconstrictor agent, a plant metabolite, a bacterial metabolite, a nasal decongestant and an environmental contaminant. It is a member of phenylethanolamines and a phenethylamine alkaloid. It is a conjugate base of a (-)-ephedrinium. — ChEBI

IUPAC name
(1R,2S)-2-(methylamino)-1-phenylpropan-1-ol
Molecular formula
C10H15NO
Molecular weight
165.23 g/mol
Exact mass
165.115364102 Da
Monoisotopic mass
165.115364102 Da
XLogP3
0.9
Topological polar surface area
32.3 Ų
Molecular complexity
121.0
Formal charge
0
Hydrogen-bond donors
2
Hydrogen-bond acceptors
2
Rotatable bonds
3
Heavy atoms
12
Covalent units
1

Names and synonyms reported to PubChem

l-Ephedrine(-)-EphedrineEphedrinMandrinEphedrolSanedrineL(-)-Ephedrine1-Sedrin
16 more reported names
BiophedrinEphedremalEphedritalEphedrosanEphedrotalEphendronalEciphinEfedrinEphedralEphedsolEphoxaminKratedynManadrinVenciponZephrolNasol
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
2
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
5
3D rings
1
3D hydrophobes
0
3D acceptor features
1
3D donor features
2
3D anionic centres
0
3D cationic centres
1
3D conformers
7
Effective 3D rotors
3.0
Machine-readable structure identifiers
SMILES
C[C@@H]([C@@H](C1=CC=CC=C1)O)NC
InChI
InChI=1S/C10H15NO/c1-8(11-2)10(12)9-6-4-3-5-7-9/h3-8,10-12H,1-2H3/t8-,10-/m0/s1
InChIKey
KWGRBVOPPLSCSI-WPRPVWTQSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 51-41-2
CAS 51-41-2PubChem CID 439260

Verified chemistry for CAS 51-41-2

Norepinephrine

IUPAC name
4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol
Molecular formula
C8H11NO3
Molecular weight
169.18 g/mol
Exact mass
169.07389321 Da
Monoisotopic mass
169.07389321 Da
XLogP3
-1.2
Topological polar surface area
86.7 Ų
Molecular complexity
142.0
Formal charge
0
Hydrogen-bond donors
4
Hydrogen-bond acceptors
4
Rotatable bonds
2
Heavy atoms
12
Covalent units
1

Names and synonyms reported to PubChem

L-NoradrenalineLevarterenolArterenolL-Norepinephrine(R)-Noradrenaline(-)-Norepinephrine(-)-NORADRENALINEL-arterenol
16 more reported names
(-)-Arterenol(R)-NorepinephrineLevonoradrenalineSympathin ELevonorepinephrine(R)-(-)-NorepinephrineNorepirenamine(R)-4-(2-Amino-1-hydroxyethyl)-1,2-benzenediolNoradrenalinnorepinephrinumNoradrenalinumNorartrinalNor adrenalinNor-EpirenannorepinefrinaNoradrenalina
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
1
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
7
3D rings
1
3D hydrophobes
0
3D acceptor features
1
3D donor features
4
3D anionic centres
0
3D cationic centres
1
3D conformers
8
Effective 3D rotors
2.0
Machine-readable structure identifiers
SMILES
C1=CC(=C(C=C1[C@H](CN)O)O)O
InChI
InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/t8-/m0/s1
InChIKey
SFLSHLFXELFNJZ-QMMMGPOBSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 51-43-4
CAS 51-43-4PubChem CID 5816

Verified chemistry for CAS 51-43-4

Epinephrine

IUPAC name
4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
Molecular formula
C9H13NO3
Molecular weight
183.20 g/mol
Exact mass
183.08954328 Da
Monoisotopic mass
183.08954328 Da
XLogP3
-1.4
Topological polar surface area
72.7 Ų
Molecular complexity
154.0
Formal charge
0
Hydrogen-bond donors
4
Hydrogen-bond acceptors
4
Rotatable bonds
3
Heavy atoms
13
Covalent units
1

Names and synonyms reported to PubChem

l-AdrenalineadrenalineAdrenalinLevoepinephrineNephridineEpinefrinaEpipen(-)-Adrenaline
16 more reported names
AdnephrineChelafrinEpinephranEpirenanRenoform(R)-AdrenalineHypernephrinRenostypticinAdrenineHemisineHemostasinLevoreninLevorenineMucidrinaNieralineParanephrin
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
1
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
7
3D rings
1
3D hydrophobes
0
3D acceptor features
1
3D donor features
4
3D anionic centres
0
3D cationic centres
1
3D conformers
10
Effective 3D rotors
3.0
Machine-readable structure identifiers
SMILES
CNC[C@@H](C1=CC(=C(C=C1)O)O)O
InChI
InChI=1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3/t9-/m0/s1
InChIKey
UCTWMZQNUQWSLP-VIFPVBQESA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 543-82-8
CAS 543-82-8PubChem CID 10982

Verified chemistry for CAS 543-82-8

Octodrine

Octodrine is an alkylamine. — ChEBI

IUPAC name
6-methylheptan-2-amine
Molecular formula
C8H19N
Molecular weight
129.24 g/mol
Exact mass
129.151749610 Da
Monoisotopic mass
129.151749610 Da
XLogP3
2.3
Topological polar surface area
26.0 Ų
Molecular complexity
59.0
Formal charge
0
Hydrogen-bond donors
1
Hydrogen-bond acceptors
1
Rotatable bonds
4
Heavy atoms
9
Covalent units
1

Names and synonyms reported to PubChem

2-Amino-6-methylheptane1,5-Dimethylhexylamine6-Methyl-2-heptylamineOctodrinaOctodrinumOttodrinaSK&F 51HEXYLAMINE, 1,5-DIMETHYL-
16 more reported names
SKF-51SK&F-51NSC-7598131,5-DMHA3GQ9E911BIRefChem:856055208-851-1227-796-42-Heptanamine, 6-methyl-VaporpacOctodrinSKF 512-Methyl-6-aminoheptane6-Amino-2-methylheptane2-Heptylamine, 6-methyl-2-Metil-6-amino-eptano
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
1
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
4
3D rings
0
3D hydrophobes
2
3D acceptor features
0
3D donor features
1
3D anionic centres
0
3D cationic centres
1
3D conformers
10
Effective 3D rotors
4.0
Machine-readable structure identifiers
SMILES
CC(C)CCCC(C)N
InChI
InChI=1S/C8H19N/c1-7(2)5-4-6-8(3)9/h7-8H,4-6,9H2,1-3H3
InChIKey
QNIVIMYXGGFTAK-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 7683-59-2
CAS 7683-59-2PubChem CID 3779

Verified chemistry for CAS 7683-59-2

Isoproterenol

Isoprenaline is a secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders. It has a role as a beta-adrenergic agonist, a bronchodilator agent, a sympathomimetic agent and a cardiotonic drug. It is a member of catechols, a secondary alcohol and a secondary amino compound. — ChEBI

IUPAC name
4-[1-hydroxy-2-(propan-2-ylamino)ethyl]benzene-1,2-diol
Molecular formula
C11H17NO3
Molecular weight
211.26 g/mol
Exact mass
211.12084340 Da
Monoisotopic mass
211.12084340 Da
XLogP3
-0.6
Topological polar surface area
72.7 Ų
Molecular complexity
187.0
Formal charge
0
Hydrogen-bond donors
4
Hydrogen-bond acceptors
4
Rotatable bonds
4
Heavy atoms
15
Covalent units
1

Names and synonyms reported to PubChem

IsoprenalineIsopropydrinAludrineNovodrinAsiprenolAssiprenolBellasthmanIsoprenalin
16 more reported names
RespifralAsmalarNeodrenalProternolneo-EpinineIsonorinIsoreninSaventrineIsopropylarterenolN-IsopropylnoradrenalineIsopropyladrenalineN-IsopropylnorepinephrineIsuprenIsopropylnorepinephrineVapo-N-isoIsopropylnoradrenaline
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
1
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
8
3D rings
1
3D hydrophobes
1
3D acceptor features
1
3D donor features
4
3D anionic centres
0
3D cationic centres
1
3D conformers
10
Effective 3D rotors
4.0
Machine-readable structure identifiers
SMILES
CC(C)NCC(C1=CC(=C(C=C1)O)O)O
InChI
InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3
InChIKey
JWZZKOKVBUJMES-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 835-31-4
CAS 835-31-4PubChem CID 4436

Verified chemistry for CAS 835-31-4

Naphazoline

2-(1-naphthalenylmethyl)-4,5-dihydro-1H-imidazole is a member of naphthalenes. — ChEBI

IUPAC name
2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole
Molecular formula
C14H14N2
Molecular weight
210.27 g/mol
Exact mass
210.115698455 Da
Monoisotopic mass
210.115698455 Da
XLogP3
2.1
Topological polar surface area
24.4 Ų
Molecular complexity
272.0
Formal charge
0
Hydrogen-bond donors
1
Hydrogen-bond acceptors
1
Rotatable bonds
2
Heavy atoms
16
Covalent units
1

Names and synonyms reported to PubChem

NafazolinaClearineNafazolinNaphazolinum2-(1-Naphthylmethyl)-2-imidazolineCiba 2020/Ralpha-Naphthylmethyl imidazoline1H-Imidazole, 4,5-dihydro-2-(1-naphthalenylmethyl)-
16 more reported names
H231GF11BVTele StullnAK ConVasoconstrictor PensaPensa, VasoconstrictorRefChem:56335naphthizinum (for the nitrate)R01AA08R01AB02S01GA01212-641-5NaphthizineAntan2-(1-Naphthylmethyl)-4,5-dihydro-1H-imidazole2-(Naphthyl-(1')-methyl)imidazolinNaphazoline (INN)
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
5
3D rings
3
3D hydrophobes
0
3D acceptor features
0
3D donor features
1
3D anionic centres
0
3D cationic centres
1
3D conformers
10
Effective 3D rotors
2.6
Machine-readable structure identifiers
SMILES
C1CN=C(N1)CC2=CC=CC3=CC=CC=C32
InChI
InChI=1S/C14H14N2/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14/h1-7H,8-10H2,(H,15,16)
InChIKey
CNIIGCLFLJGOGP-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
China NMPA banned raw-material catalogues (2021)
Source reference
NMPA 2021 Catalogue of Raw Materials Banned for Cosmetics, entry 1281
Source record ID
chemical-1281
Source version
NMPA Announcement No. 74 of 2021, effective 2021-05-26
Source language
Chinese with source English/Latin identity
Translation status
Official English translation · English translation
Effective date
2021-05-26
Source updated
2021-05-26
Snapshot checked
2026-08-31 14:13 UTC
Validation method
pdfplumber tables; exact 1,284 + 109 row counts and contiguous source numbering
SHA-256
8848aa3e0c7ac5e74f56fc27927336c4fc2e5bc80137da087c2ca9ba2d2c075e

Registered dataset notes

Dataset coverage
All 1,284 banned raw materials and 109 banned plant/animal raw materials effective from 26 May 2021
Authority note
Binding NMPA catalogues replacing Tables 1 and 2 of the 2015 Technical Specification
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

1393
current China records
1393
records marked Prohibited
1393
records from this source version
1249
market records with CAS identity

Status distribution

Prohibited: 1393

Condition text is present on 1393 of 1393 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

China market context

Complete prohibited catalogues plus official-source workflow

Coverage version: NMPA 2021 banned catalogues plus dynamic IECIC List I/List II system current since 2025

All 1,284 banned raw materials and 109 banned plant/animal raw materials, plus the official workflow for the dynamic existing-ingredient inventory, other technical restrictions and new ingredients.

Verification checklist

  1. Search the current NMPA IECIC List I and List II by Chinese name and identity.
  2. Check prohibited/restricted and positive lists in the current Safety and Technical Standards.
  3. Review technical purpose, use history and any monitoring period.
  4. Confirm Chinese labelling, safety assessment and filing/registration duties.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “肾上腺素受体激动药，包括但不限于麻 黄碱及其盐类、肾上腺素、异丙肾上腺 素、萘甲唑啉及其盐类、去甲肾上腺素 及其盐类、奥托君及其盐类等 — Adrenergic agents, including but not limited to Ephedrine （CAS No. 299-42-3） and its salts, Epinephrine （INN） （CAS No. 51-43-4）, Isoprenaline （INN） （CAS No. 7683-59-2）, Naphazoline （INN） （CAS No. 835-31-4） and its salts, Noradrenaline（CAS No. 51-41-2） and its salts, Octodrine （INN） （CAS No. 543-82-8） and its salts” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Search the current NMPA IECIC List I and List II by Chinese name and identity.
  3. Check prohibited/restricted and positive lists in the current Safety and Technical Standards.
  4. Review technical purpose, use history and any monitoring period.
  5. Confirm Chinese labelling, safety assessment and filing/registration duties.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECNot supplied
  • Separate condition textAvailable
  • Effective dateAvailable
  • Snapshot hash and methodAvailable

Questions this page answers

This official record identifies the substance as prohibited for cosmetic use in the stated market scope. Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. IECIC listing is not blanket approval; absence may require the new cosmetic ingredient route, and restrictions are checked separately.

The record cites NMPA 2021 Catalogue of Raw Materials Banned for Cosmetics, entry 1281, source version NMPA Announcement No. 74 of 2021, effective 2021-05-26. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

肾上腺素受体激动药，包括但不限于麻 黄碱及其盐类、肾上腺素、异丙肾上腺 素、萘甲唑啉及其盐类、去甲肾上腺素 及其盐类、奥托君及其盐类等 — Adrenergic agents, including but not limited to Ephedrine （CAS No. 299-42-3） and its salts, Epinephrine （INN） （CAS No. 51-43-4）, Isoprenaline （INN） （CAS No. 7683-59-2）, Naphazoline （INN） （CAS No. 835-31-4） and its salts, Noradrenaline（CAS No. 51-41-2） and its salts, Octodrine （INN） （CAS No. 543-82-8） and its salts. NMPA 2021 Catalogue of Raw Materials Banned for Cosmetics, entry 1281. China. Source version NMPA Announcement No. 74 of 2021, effective 2021-05-26. CosIng Checker regulatory record: https://cosingchecker.com/regulations/cn/records/12970/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for China

This official record identifies the substance as prohibited for cosmetic use in the stated market scope.

Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

How to interpret the legal role

The cited row forms part of a binding rule or legally incorporated list for this market.

Evidence on this page

  • Recorded outcome: Prohibited
  • Legal role: Binding rule
  • Source version: NMPA Announcement No. 74 of 2021, effective 2021-05-26
  • Effective date: 2021-05-26

What it does not prove

IECIC listing is not blanket approval; absence may require the new cosmetic ingredient route, and restrictions are checked separately.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity at the source

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity at the source

US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source