Why does CAS 299-42-3 appear in more than one EU cosmetic annex?

A substance identified by CAS 299-42-3 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 299-42-3?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 299-42-3 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 299-42-3

Q: How do I use CAS 299-42-3 for compliance screening?

Cross-reference CAS 299-42-3 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 299-42-3 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 299-42-3

CAS 299-42-3PubChem CID 9294

Ephedrine

(-)-ephedrine is a phenethylamine alkaloid that is 2-phenylethanamine substituted by a methyl group at the amino nitrogen and a methyl and a hydroxy group at position 2 and 1 respectively. It has a role as a sympathomimetic agent, a xenobiotic, a vasoconstrictor agent, a plant metabolite, a bacterial metabolite, a nasal decongestant and an environmental contaminant. It is a member of phenylethanolamines and a phenethylamine alkaloid. It is a conjugate base of a (-)-ephedrinium. — ChEBI

IUPAC name: (1R,2S)-2-(methylamino)-1-phenylpropan-1-ol

Molecular formula: C10H15NO
Molecular weight: 165.23 g/mol
Exact mass: 165.115364102 Da
XLogP3: 0.9
Topological polar surface area: 32.3 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 2
Covalent units: 1
Defined stereocentres: 2

Also known as

l-Ephedrine(-)-EphedrineEphedrinMandrinEphedrolSanedrineL(-)-Ephedrine1-Sedrin

16 more reported names

BiophedrinEphedremalEphedritalEphedrosanEphedrotalEphendronalEciphinEfedrinEphedralEphedsolEphoxaminKratedynManadrinVenciponZephrolNasol

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:15407
ChEMBL:CHEMBL211456
EPA DTXSID:DTXSID0022985
PubMed:23117432
PubMed:23066006
PubMed:23060984
PubMed:23035903
PubMed:23023353
PubMed:23019939
PubMed:22991817
PubMed:22991810
PubMed:22973381
PubMed:22971501
PubMed:22965529
PubMed:22945558

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 299-42-3

1 total

Annex

Entry

164

Ephedrine and its salts

206-080-5

How CAS 299-42-3 is used on this site

CAS 299-42-3 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 299-42-3 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 299-42-3 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.

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