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磷酸三（2-氯乙）酯 — Tris（2-chloroethyl） phosphate （CAS No. 115-96-8）

Tris（2-chloroethyl） phosphate （CAS No. 115-96-8）

The NMPA binding 2021 catalogue prohibits this raw material in cosmetic formulas in China.

All China recordsCompare all marketsOpen official source

Regulatory decision and full conditions

Status
Prohibited
Legal role
Binding rule
Regulatory summary
The NMPA binding 2021 catalogue prohibits this raw material in cosmetic formulas in China.
Conditions and restrictions
Prohibited in cosmetic product formulas. Verify the cited Chinese source identity and any later NMPA amendment before use.

Substance identity

Official source name
磷酸三（2-氯乙）酯 — Tris（2-chloroethyl） phosphate （CAS No. 115-96-8）
CAS
115-96-8
EC
Not supplied in this source row
Identity mapping
standalone:official_nmpa_record
Search this identity across the siteCAS 115-96-8

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

9 market datasets
PubChem 2D chemical structure for CAS 115-96-8
CAS 115-96-8PubChem CID 8295

Verified chemistry for CAS 115-96-8

Tris(2-chloroethyl) phosphate

IUPAC name
tris(2-chloroethyl) phosphate
Molecular formula
C6H12Cl3O4P
Molecular weight
285.5 g/mol
Exact mass
283.953879 Da
Monoisotopic mass
283.953879 Da
XLogP3
1.3
Topological polar surface area
44.8 Ų
Molecular complexity
152.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
4
Rotatable bonds
9
Heavy atoms
14
Covalent units
1

Names and synonyms reported to PubChem

Tris(2-chloroethyl)phosphateCelluflexDisflamoll TCACelluflex CEFFyrol CEFNiax 3CFNiax Flame Retardant 3CFTrichlorethyl phosphate
16 more reported names
TRI(2-CHLOROETHYL) PHOSPHATE2-Chloroethanol phosphateTris(2-chloroethyl) orthophosphateTris(chloroethyl)phosphateTris(beta-chloroethyl) phosphateEthanol, 2-chloro-, phosphate (3:1)Fyrol CFNCI-C60128Tri-beta-chloroethyl phosphatePhosphoric acid, tris(2-chloroethyl)esterTris-(2-chloroethyl)fosfatAI3-1502332IVO568B0NSC-3213CHEBI:35037tri(chloroethyl)phosphate
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
1
3D rings
0
3D hydrophobes
0
3D acceptor features
1
3D donor features
0
3D anionic centres
0
3D cationic centres
0
3D conformers
10
Effective 3D rotors
9.0
Machine-readable structure identifiers
SMILES
C(CCl)OP(=O)(OCCCl)OCCCl
InChI
InChI=1S/C6H12Cl3O4P/c7-1-4-11-14(10,12-5-2-8)13-6-3-9/h1-6H2
InChIKey
HQUQLFOMPYWACS-UHFFFAOYSA-N

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match8295

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) shou Source: CAMEO Chemicals
  • Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H351: Suspected of causing cancer [Warning Carcinogenicity]; H360F ***: May damage fertility [Danger Reproductive toxicity]; H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P203, P264, P270, P273, P280, P301+P317, P318, P330, P391, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H302 (97.3%): Harmful if swallowed [Warning Acute toxicity, oral]; H351 (100%): Suspected of causing cancer [Warning Carcinogenicity]; H360 (86.5%): May damage fertility or the unborn child [Danger Reproductive toxicity]; H360F (13%): May damage fertility [Danger Reproductive toxicity]; H411 (99.9%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P264, P270, P273, P280, P301+P317, P318, P330, P391, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 801 reports by companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H320: Causes eye irritation [Warning Serious eye damage/eye irritation]; H351: Suspected of causing cancer [Warning Carcinogenicity]; H360: May damage fertility or the unborn child [Danger Reproductive toxicity]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]; H401: Toxic to aquatic life [Hazardous to the aquatic environment, acute hazard]; H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P260, P264, P264+P265, P270, P273, P280, P301+P317, P305+P351+P338, P308+P316, P318, P319, P321, P330, P337+P317, P391, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H316: Causes mild skin irritation [Warning Skin corrosion/irritation]; H320: Causes eye irritation [Warning Serious eye damage/eye irritation]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]; H340: May cause genetic defects [Danger Germ cell mutagenicity]; H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P304+P340, P305+P351+P338, P308+P316, P318, P319, P321, P330, P332+P317, P337+P317, P403+P233, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Toxicity Summary: IDENTIFICATION AND USE: (Tris(2-chloroethyl) phosphate is a Clear, transparent liquid. It is used primarily as an additive plasticizer and viscosity regulator with flame-retarding properties for polyurethane, polyesters, polyvinyl chloride and other polymers. HUMAN EXPOSURE AND TOXICITY: Tris(2-chloroethyl) phosphate did not consistently demonstrate detectable unscheduled DNA synthesis with and without metabolic activation and failed to show a dose-response relationship in human WI-38 cells. ANIMAL STUDIES: In repeat dose studies Tris(2-chloroethyl) phosphate caused adverse effects on the brain (hippocampal lesions in rats), liver and kidneys. Non-irritant to eyes, but conflicting reports in the literature on skin irritation, has not been tested for sensitization potential. Not teratogenic. It adversely affects the fertility of male rats and mice. In vitro mutagenicity test results were inconsistent and an in vivo micronucleus test gave equivocal results. Tris(2-chloroethyl) phosphate causes benign and malignant tumors at various organ sites in rats and mice. A very high oral dose caused some inhibition of plasma cholinesterase and brain neuropathy target esterase, but did not caus Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: A BCF of 2.2 was determined for tris(2-chloroethyl) phosphate using killifish (Oryzias latipes) exposed to the chemical in static water for 72 hr(1). A BCF of 0.9 was obtained for goldfish (Carassius auratus) under identical conditions(1). BCFs of 1.1 and 1.3 were determined using killifish exposed to 12.7 ppm of tris(2-chloroethyl) phosphate for 5 days and 2.3 ppm for 11 days, respectively, in a continuous flow water system(2). BCFs of <1.2-5.1 and 0.6-0.8 were reported in carp (Cyprinus carpio) which were exposed to tris(2-chloroethyl) phosphate at 0.1 and 1 ppm, respectively, over a 6-week period(3). According to a classification scheme(4), these BCF values suggest bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 390(SRC), determined from a structure estimation method(2), indicates that tris(2-chloroethyl) phosphate is expected to have moderate mobility in soil(SRC). Volatilization of tris(2-chloroethyl) phosphate from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 3.3X10-6 atm-cu m/mole(SRC), based upon its vapor pressure, 6.13X10-2 mm Hg(3), and water solubility, 7000 mg/L(4). Tris(2-chloroethyl) phosphate is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(3). A 4% of theoretical BOD using activated sludge in the Japanese MITI test(5) suggests that biodegradation is not an important environmental fate process in soil(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 390(SRC), determined from a structure estimation method(2), indicates that tris(2-chloroethyl) phosphate is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 3.3X10-6 atm-cu m/mole(SRC), derived from its vapor pressure, 6.13X10-2 mm Hg(4), and water solubility, 7000 mg/L(5). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 19 and 140 days, respectively(SRC). Tris(2-chloroethyl) phosphate may undergo hydrolysis in the environment based on an estimated hydrolysis half-life of 20 days at pH 5 to 9(2). According to a classification scheme(6), measured BCF values of 0.6-5.1 in fish(7-9), suggest bioconcentration in aquatic organisms is low(SRC). A 4% of theoretical BOD using activated sludge in the Japanese MITI test(7) suggests that biodegradation is not an important environmental fate process in water(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), tris(2-chloroethyl) phosphate, which has a vapor pressure of 6.13X10-2 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase tris(2-chloroethyl) phosphate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 16 hours(SRC), calculated from its rate constant of 2.2X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Tris(2-chloroethyl) phosphate does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Sources/Uses: Flame retardant in plastics, especially in flexible foams used in automobiles and furniture, and in rigid foams used for building insulation. [IARC] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Industrial Processes with risk of exposure: Plastic Composites Manufacturing [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: ... Used primarily as an additive plasticiser and viscosity regulator with flame-retarding properties for polyurethane, polyesters, polyvinyl chloride and other polymers. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Flame-retardant plasticizer Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Used in rigid polyurethane and polyisocyanurate foams, carpet backing, flame-laminated and rebonded flexible foam, flame-retardant coatings, most classes of thermosets, adhesives (gv), cast acrylic sheet, and wood-resin composites such as particle board. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Emulsions of tris(2-chloroethyl) phosphate, blended with a binder such as a vinyl or acrylic emulsion, can be used for applications such as the backcoating of upholstery. It can be used as a secondary plasticizer in polyvinyl chloride to suppress the flammability resulting from plasticizers such as phthalates. Where a particularly high degree of flame retardancy is required, it can be used in combination with the aromatic phosphate plasticizers. Such formulations can serve as an alternative to the use of antimony oxide in plasticized vinyl polymers. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: For more Uses (Complete) data for TRIS(2-CHLOROETHYL) PHOSPHATE (7 total), please visit the HSDB record page. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Tris(2-chloroethyl) phosphate is used as a flame retardant, plasticizer, and viscosity regulator in various types of polymers including polyurethanes, polyester resins, and polyacrylates. Source: Toxin and Toxin Target Database (T3DB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
China NMPA banned raw-material catalogues (2021)
Source reference
NMPA 2021 Catalogue of Raw Materials Banned for Cosmetics, entry 1240
Source record ID
chemical-1240
Source version
NMPA Announcement No. 74 of 2021, effective 2021-05-26
Source language
Chinese with source English/Latin identity
Translation status
Official English translation · English translation
Effective date
2021-05-26
Source updated
2021-05-26
Snapshot checked
2026-08-31 14:13 UTC
Validation method
pdfplumber tables; exact 1,284 + 109 row counts and contiguous source numbering
SHA-256
8848aa3e0c7ac5e74f56fc27927336c4fc2e5bc80137da087c2ca9ba2d2c075e

Registered dataset notes

Dataset coverage
All 1,284 banned raw materials and 109 banned plant/animal raw materials effective from 26 May 2021
Authority note
Binding NMPA catalogues replacing Tables 1 and 2 of the 2015 Technical Specification
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

1393
current China records
1393
records marked Prohibited
1393
records from this source version
1249
market records with CAS identity

Status distribution

Prohibited: 1393

Condition text is present on 1393 of 1393 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

China market context

Complete prohibited catalogues plus official-source workflow

Coverage version: NMPA 2021 banned catalogues plus dynamic IECIC List I/List II system current since 2025

All 1,284 banned raw materials and 109 banned plant/animal raw materials, plus the official workflow for the dynamic existing-ingredient inventory, other technical restrictions and new ingredients.

Verification checklist

  1. Search the current NMPA IECIC List I and List II by Chinese name and identity.
  2. Check prohibited/restricted and positive lists in the current Safety and Technical Standards.
  3. Review technical purpose, use history and any monitoring period.
  4. Confirm Chinese labelling, safety assessment and filing/registration duties.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “磷酸三（2-氯乙）酯 — Tris（2-chloroethyl） phosphate （CAS No. 115-96-8）” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Search the current NMPA IECIC List I and List II by Chinese name and identity.
  3. Check prohibited/restricted and positive lists in the current Safety and Technical Standards.
  4. Review technical purpose, use history and any monitoring period.
  5. Confirm Chinese labelling, safety assessment and filing/registration duties.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECNot supplied
  • Separate condition textAvailable
  • Effective dateAvailable
  • Snapshot hash and methodAvailable

Questions this page answers

This official record identifies the substance as prohibited for cosmetic use in the stated market scope. Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. IECIC listing is not blanket approval; absence may require the new cosmetic ingredient route, and restrictions are checked separately.

The record cites NMPA 2021 Catalogue of Raw Materials Banned for Cosmetics, entry 1240, source version NMPA Announcement No. 74 of 2021, effective 2021-05-26. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

磷酸三（2-氯乙）酯 — Tris（2-chloroethyl） phosphate （CAS No. 115-96-8）. NMPA 2021 Catalogue of Raw Materials Banned for Cosmetics, entry 1240. China. Source version NMPA Announcement No. 74 of 2021, effective 2021-05-26. CosIng Checker regulatory record: https://cosingchecker.com/regulations/cn/records/12929/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for China

This official record identifies the substance as prohibited for cosmetic use in the stated market scope.

Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

How to interpret the legal role

The cited row forms part of a binding rule or legally incorporated list for this market.

Evidence on this page

  • Recorded outcome: Prohibited
  • Legal role: Binding rule
  • Source version: NMPA Announcement No. 74 of 2021, effective 2021-05-26
  • Effective date: 2021-05-26

What it does not prove

IECIC listing is not blanket approval; absence may require the new cosmetic ingredient route, and restrictions are checked separately.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity at the source

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity at the source

US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source