CosIng Checker
CosIng Checker
EU cosmetic ingredients, restrictions and safety
Login
ProhibitedBinding ruleCNOfficial English translationOfficial-source import checked

吡蚜酮 — Pymetrozine （ISO） （CAS No. 123312-89-0）

Pymetrozine （ISO） （CAS No. 123312-89-0）

The NMPA binding 2021 catalogue prohibits this raw material in cosmetic formulas in China.

All China recordsCompare all marketsOpen official source

Regulatory decision and full conditions

Status
Prohibited
Legal role
Binding rule
Regulatory summary
The NMPA binding 2021 catalogue prohibits this raw material in cosmetic formulas in China.
Conditions and restrictions
Prohibited in cosmetic product formulas. Verify the cited Chinese source identity and any later NMPA amendment before use.

Substance identity

Official source name
吡蚜酮 — Pymetrozine （ISO） （CAS No. 123312-89-0）
CAS
123312-89-0
EC
Not supplied in this source row
Identity mapping
standalone:official_nmpa_record
Search this identity across the siteCAS 123312-89-0

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

9 market datasets
PubChem 2D chemical structure for CAS 123312-89-0
CAS 123312-89-0PubChem CID 9576037

Verified chemistry for CAS 123312-89-0

Pymetrozine

IUPAC name
6-methyl-4-[(E)-pyridin-3-ylmethylideneamino]-2,5-dihydro-1,2,4-triazin-3-one
Molecular formula
C10H11N5O
Molecular weight
217.23 g/mol
Exact mass
217.09635999 Da
Monoisotopic mass
217.09635999 Da
XLogP3
0.0
Topological polar surface area
70.0 Ų
Molecular complexity
325.0
Formal charge
0
Hydrogen-bond donors
1
Hydrogen-bond acceptors
4
Rotatable bonds
2
Heavy atoms
16
Covalent units
1

Names and synonyms reported to PubChem

F0G3V7874J1,2,4-Triazin-3(2H)-one, 4,5-dihydro-6-methyl-4-[(E)-(3-pyridinylmethylene)amino]-CHEBI:39311(E)-4,5-dihydro-6-methyl-4-((3-pyridinylmethylene)amino)-1,2,4-triazin-3(2H)-one1,2,4-Triazin-3(2H)-one, 4,5-dihydro-6-methyl-4-((E)-(3-pyridinylmethylene)amino)-(e)-4,5-dihydro-6-methyl-4-(3-pyridylmethyleneamino)-1,2,4-triazin-3(2h)-one6-methyl-4-{[(1E)-pyridin-3-ylmethylene]amino}-4,5-dihydro-1,2,4-triazin-3(2H)-one6-methyl-4-(((1E)-pyridin-3-ylmethylene)amino)-4,5-dihydro-1,2,4-triazin-3(2H)-one
16 more reported names
RefChem:1773796-methyl-4-((E)-(pyridin-3-ylmethylidene)amino)-2,3,4,5-tetrahydro-1,2,4-triazin-3-one602-927-1pymetrozine (ISO); (E)-4,5-dihydro-6-methyl-4-(3-pyridylmethyleneamino)-1,2,4-triazin-3(2H)-onePymetrozinFulfillPlenumCGA 215944HSDB 7054Pymetrozine [ISO:BSI]PymethrozineUNII-F0G3V7874JEINECS Annex I Index 613-202-00-4Pymetrozine (Standard)PYMETROZINE [MI]PYMETROZINE [ISO]
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
1
Undefined bond stereocentres
0
3D pharmacophore features
7
3D rings
2
3D hydrophobes
0
3D acceptor features
4
3D donor features
1
3D anionic centres
0
3D cationic centres
0
3D conformers
10
Effective 3D rotors
2.6
Machine-readable structure identifiers
SMILES
CC1=NNC(=O)N(C1)/N=C/C2=CN=CC=C2
InChI
InChI=1S/C10H11N5O/c1-8-7-15(10(16)14-13-8)12-6-9-3-2-4-11-5-9/h2-6H,7H2,1H3,(H,14,16)/b12-6+
InChIKey
QHMTXANCGGJZRX-WUXMJOGZSA-N

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match9576037

Attributed physical-property, hazard, environmental and use annotations.

  • Signal: Warning Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H351: Suspected of causing cancer [Warning Carcinogenicity]; H361fd: Suspected of damaging fertility; Suspected of damaging the unborn child [Warning Reproductive toxicity]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P203, P273, P280, P318, P391, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Signal: Warning Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H332 (19.5%): Harmful if inhaled [Warning Acute toxicity, inhalation]; H351 (100%): Suspected of causing cancer [Warning Carcinogenicity]; H361fd (76.4%): Suspected of damaging fertility; Suspected of damaging the unborn child [Warning Reproductive toxicity]; H410 (77.4%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]; H412 (22.6%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P261, P271, P273, P280, P304+P340, P317, P318, P391, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 195 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Warning Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
  • GHS Hazard Statements: H351: Suspected of causing cancer [Warning Carcinogenicity]; H361fd: Suspected of damaging fertility; Suspected of damaging the unborn child [Warning Reproductive toxicity]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
  • Precautionary Statement Codes: P203, P273, P280, P318, P391, P405, and P501 (click each P-code to see the statement) Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
  • Environmental Bioconcentration: An estimated BCF of 3 was calculated for pymetrozine(SRC), using a log Kow of -0.18(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Pymetrozine is expected to have slight mobility in soil(1). Volatilization of pymetrozine from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 3.0X10-11 atm-cu m/mole(SRC), derived from its vapor pressure, <3X10-8 mm Hg(1), and water solubility, 290 mg/l(1). Pymetrozine is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(1). Pymetrozine is rapidly degraded in soil with a half-life of 8 to 38 days(1). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Pymetrozine is expected to adsorb to suspended solids and sediment(SRC), based upon its slight mobility in soil(1). Volatilization from water surfaces is not expected(2) based upon an estimated Henry's Law constant of 3.0X10-11 atm-cu m/mole(SRC), derived from its vapor pressure, <3X10-8 mm Hg(1), and water solubility, 290 mg/l(1). According to a classification scheme(3), an estimated BCF of 3(SRC), from its log Kow (1) and a regression-derived equation(4), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Pymetrozine may undergo hydrolysis at low pH; the hydrolysis half-life is 25 days at pH 5(1). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), pymetrozine, which has a vapor pressure of <3X10-8 mm Hg at 25 °C(2), is expected to exist solely in the particulate phase in the ambient atmosphere(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Uses: For Pymetrozine (USEPA/OPP Pesticide Code: 101103) ACTIVE products with label matches. /SRP: Registered for use in the U.S. but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./ Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Control of aphids and whiteflies in vegetables, ornamentals, cotton, field crops, deciduous and citrus fruit; control of plant hoppers in rice. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: This is a man-made compound that is used as a pesticide. Source: Toxin and Toxin Target Database (T3DB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
China NMPA banned raw-material catalogues (2021)
Source reference
NMPA 2021 Catalogue of Raw Materials Banned for Cosmetics, entry 1073
Source record ID
chemical-1073
Source version
NMPA Announcement No. 74 of 2021, effective 2021-05-26
Source language
Chinese with source English/Latin identity
Translation status
Official English translation · English translation
Effective date
2021-05-26
Source updated
2021-05-26
Snapshot checked
2026-08-31 14:13 UTC
Validation method
pdfplumber tables; exact 1,284 + 109 row counts and contiguous source numbering
SHA-256
8848aa3e0c7ac5e74f56fc27927336c4fc2e5bc80137da087c2ca9ba2d2c075e

Registered dataset notes

Dataset coverage
All 1,284 banned raw materials and 109 banned plant/animal raw materials effective from 26 May 2021
Authority note
Binding NMPA catalogues replacing Tables 1 and 2 of the 2015 Technical Specification
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

1393
current China records
1393
records marked Prohibited
1393
records from this source version
1249
market records with CAS identity

Status distribution

Prohibited: 1393

Condition text is present on 1393 of 1393 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

China market context

Complete prohibited catalogues plus official-source workflow

Coverage version: NMPA 2021 banned catalogues plus dynamic IECIC List I/List II system current since 2025

All 1,284 banned raw materials and 109 banned plant/animal raw materials, plus the official workflow for the dynamic existing-ingredient inventory, other technical restrictions and new ingredients.

Verification checklist

  1. Search the current NMPA IECIC List I and List II by Chinese name and identity.
  2. Check prohibited/restricted and positive lists in the current Safety and Technical Standards.
  3. Review technical purpose, use history and any monitoring period.
  4. Confirm Chinese labelling, safety assessment and filing/registration duties.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “吡蚜酮 — Pymetrozine （ISO） （CAS No. 123312-89-0）” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Search the current NMPA IECIC List I and List II by Chinese name and identity.
  3. Check prohibited/restricted and positive lists in the current Safety and Technical Standards.
  4. Review technical purpose, use history and any monitoring period.
  5. Confirm Chinese labelling, safety assessment and filing/registration duties.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECNot supplied
  • Separate condition textAvailable
  • Effective dateAvailable
  • Snapshot hash and methodAvailable

Questions this page answers

This official record identifies the substance as prohibited for cosmetic use in the stated market scope. Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. IECIC listing is not blanket approval; absence may require the new cosmetic ingredient route, and restrictions are checked separately.

The record cites NMPA 2021 Catalogue of Raw Materials Banned for Cosmetics, entry 1073, source version NMPA Announcement No. 74 of 2021, effective 2021-05-26. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

吡蚜酮 — Pymetrozine （ISO） （CAS No. 123312-89-0）. NMPA 2021 Catalogue of Raw Materials Banned for Cosmetics, entry 1073. China. Source version NMPA Announcement No. 74 of 2021, effective 2021-05-26. CosIng Checker regulatory record: https://cosingchecker.com/regulations/cn/records/12762/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for China

This official record identifies the substance as prohibited for cosmetic use in the stated market scope.

Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

How to interpret the legal role

The cited row forms part of a binding rule or legally incorporated list for this market.

Evidence on this page

  • Recorded outcome: Prohibited
  • Legal role: Binding rule
  • Source version: NMPA Announcement No. 74 of 2021, effective 2021-05-26
  • Effective date: 2021-05-26

What it does not prove

IECIC listing is not blanket approval; absence may require the new cosmetic ingredient route, and restrictions are checked separately.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity at the source

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity at the source

US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source