CAS 123312-89-0PubChem CID 9576037
Pymetrozine
Pymetrozine is a member of the class of 1,2,4-triazines that is 4,5-dihydro-1,2,4-triazin-3(2H)-one substituted by a methyl group at position 6 and a (pyridin-3-ylmethylidene)amino group at position 4. It has a role as a TRPV channel modulator, an antifeedant, a xenobiotic and an environmental contaminant. It is a member of pyridines and a member of 1,2,4-triazines. — ChEBI
- IUPAC name
- 6-methyl-4-[(E)-pyridin-3-ylmethylideneamino]-2,5-dihydro-1,2,4-triazin-3-one
- Molecular formula
- C10H11N5O
- Molecular weight
- 217.23 g/mol
- Exact mass
- 217.09635999 Da
- XLogP3
- 0.0
- Topological polar surface area
- 70.0 Ų
- Hydrogen-bond donors
- 1
- Hydrogen-bond acceptors
- 4
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
F0G3V7874J1,2,4-Triazin-3(2H)-one, 4,5-dihydro-6-methyl-4-[(E)-(3-pyridinylmethylene)amino]-CHEBI:39311(E)-4,5-dihydro-6-methyl-4-((3-pyridinylmethylene)amino)-1,2,4-triazin-3(2H)-one1,2,4-Triazin-3(2H)-one, 4,5-dihydro-6-methyl-4-((E)-(3-pyridinylmethylene)amino)-(e)-4,5-dihydro-6-methyl-4-(3-pyridylmethyleneamino)-1,2,4-triazin-3(2h)-one6-methyl-4-{[(1E)-pyridin-3-ylmethylene]amino}-4,5-dihydro-1,2,4-triazin-3(2H)-one6-methyl-4-(((1E)-pyridin-3-ylmethylene)amino)-4,5-dihydro-1,2,4-triazin-3(2H)-one
16 more reported names
RefChem:1773796-methyl-4-((E)-(pyridin-3-ylmethylidene)amino)-2,3,4,5-tetrahydro-1,2,4-triazin-3-one602-927-1pymetrozine (ISO); (E)-4,5-dihydro-6-methyl-4-(3-pyridylmethyleneamino)-1,2,4-triazin-3(2H)-onePymetrozinFulfillPlenumCGA 215944HSDB 7054Pymetrozine [ISO:BSI]PymethrozineUNII-F0G3V7874JEINECS Annex I Index 613-202-00-4Pymetrozine (Standard)PYMETROZINE [MI]PYMETROZINE [ISO]
External database identifiers
- ChEBI:CHEBI:39311
- ChEMBL:CHEMBL1906026
- EPA DTXSID:DTXSID2032637
- PubMed:35568224
- PubMed:28973306
- PubMed:20416315
- PubMed:15536055
Evidence from additional scientific databases
NIH PubChem PUG-View
Exact identifier match9576037
Attributed physical-property, hazard, environmental and use annotations.
- Color/Form: Colorless crystals Source: Hazardous Substances Data Bank (HSDB)
- Density: 1.36 @ 20 °C Source: Hazardous Substances Data Bank (HSDB)
- LogP: log Kow = -0.18 Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: 217 °C Source: Hazardous Substances Data Bank (HSDB)
- Solubility: In ethanol, 2.25; in hexane <0.001 (both g/l @ 20 °C) Source: Hazardous Substances Data Bank (HSDB)
- Solubility: In water, 290 mg/l @ 25 °C Source: Hazardous Substances Data Bank (HSDB)
- Vapor Pressure: <3X10-8 mm Hg @ 25 °C Source: Hazardous Substances Data Bank (HSDB)
- Carcinogen Classification: No indication of carcinogenicity to humans (not listed by IARC). Source: Toxin and Toxin Target Database (T3DB)
- Signal: Warning Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- GHS Hazard Statements: H351: Suspected of causing cancer [Warning Carcinogenicity]; H361fd: Suspected of damaging fertility; Suspected of damaging the unborn child [Warning Reproductive toxicity]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Precautionary Statement Codes: P203, P273, P280, P318, P391, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Signal: Warning Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H332 (19.5%): Harmful if inhaled [Warning Acute toxicity, inhalation]; H351 (100%): Suspected of causing cancer [Warning Carcinogenicity]; H361fd (76.4%): Suspected of damaging fertility; Suspected of damaging the unborn child [Warning Reproductive toxicity]; H410 (77.4%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]; H412 (22.6%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P203, P261, P271, P273, P280, P304+P340, P317, P318, P391, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 195 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Signal: Warning Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- GHS Hazard Statements: H351: Suspected of causing cancer [Warning Carcinogenicity]; H361fd: Suspected of damaging fertility; Suspected of damaging the unborn child [Warning Reproductive toxicity]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- Precautionary Statement Codes: P203, P273, P280, P318, P391, P405, and P501 (click each P-code to see the statement) Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- Environmental Bioconcentration: An estimated BCF of 3 was calculated for pymetrozine(SRC), using a log Kow of -0.18(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: TERRESTRIAL FATE: Pymetrozine is expected to have slight mobility in soil(1). Volatilization of pymetrozine from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 3.0X10-11 atm-cu m/mole(SRC), derived from its vapor pressure, <3X10-8 mm Hg(1), and water solubility, 290 mg/l(1). Pymetrozine is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(1). Pymetrozine is rapidly degraded in soil with a half-life of 8 to 38 days(1). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: AQUATIC FATE: Pymetrozine is expected to adsorb to suspended solids and sediment(SRC), based upon its slight mobility in soil(1). Volatilization from water surfaces is not expected(2) based upon an estimated Henry's Law constant of 3.0X10-11 atm-cu m/mole(SRC), derived from its vapor pressure, <3X10-8 mm Hg(1), and water solubility, 290 mg/l(1). According to a classification scheme(3), an estimated BCF of 3(SRC), from its log Kow (1) and a regression-derived equation(4), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Pymetrozine may undergo hydrolysis at low pH; the hydrolysis half-life is 25 days at pH 5(1). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), pymetrozine, which has a vapor pressure of <3X10-8 mm Hg at 25 °C(2), is expected to exist solely in the particulate phase in the ambient atmosphere(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Uses: For Pymetrozine (USEPA/OPP Pesticide Code: 101103) ACTIVE products with label matches. /SRP: Registered for use in the U.S. but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./ Source: Hazardous Substances Data Bank (HSDB)
- Uses: Control of aphids and whiteflies in vegetables, ornamentals, cotton, field crops, deciduous and citrus fruit; control of plant hoppers in rice. Source: Hazardous Substances Data Bank (HSDB)
- Uses: This is a man-made compound that is used as a pesticide. Source: Toxin and Toxin Target Database (T3DB)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.