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Annex II Entry 1198 CMR24/10/2016

Pymetrozine (ISO)

Pymetrozine (ISO) is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1198
CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 123312-89-0
CAS 123312-89-0PubChem CID 9576037

Pymetrozine

Pymetrozine is a member of the class of 1,2,4-triazines that is 4,5-dihydro-1,2,4-triazin-3(2H)-one substituted by a methyl group at position 6 and a (pyridin-3-ylmethylidene)amino group at position 4. It has a role as a TRPV channel modulator, an antifeedant, a xenobiotic and an environmental contaminant. It is a member of pyridines and a member of 1,2,4-triazines. — ChEBI

IUPAC name
6-methyl-4-[(E)-pyridin-3-ylmethylideneamino]-2,5-dihydro-1,2,4-triazin-3-one
Molecular formula
C10H11N5O
Molecular weight
217.23 g/mol
Exact mass
217.09635999 Da
XLogP3
0.0
Topological polar surface area
70.0 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
4
Covalent units
1
Defined stereocentres
0

Also known as

F0G3V7874J1,2,4-Triazin-3(2H)-one, 4,5-dihydro-6-methyl-4-[(E)-(3-pyridinylmethylene)amino]-CHEBI:39311(E)-4,5-dihydro-6-methyl-4-((3-pyridinylmethylene)amino)-1,2,4-triazin-3(2H)-one1,2,4-Triazin-3(2H)-one, 4,5-dihydro-6-methyl-4-((E)-(3-pyridinylmethylene)amino)-(e)-4,5-dihydro-6-methyl-4-(3-pyridylmethyleneamino)-1,2,4-triazin-3(2h)-one6-methyl-4-{[(1E)-pyridin-3-ylmethylene]amino}-4,5-dihydro-1,2,4-triazin-3(2H)-one6-methyl-4-(((1E)-pyridin-3-ylmethylene)amino)-4,5-dihydro-1,2,4-triazin-3(2H)-one
16 more reported names
RefChem:1773796-methyl-4-((E)-(pyridin-3-ylmethylidene)amino)-2,3,4,5-tetrahydro-1,2,4-triazin-3-one602-927-1pymetrozine (ISO); (E)-4,5-dihydro-6-methyl-4-(3-pyridylmethyleneamino)-1,2,4-triazin-3(2H)-onePymetrozinFulfillPlenumCGA 215944HSDB 7054Pymetrozine [ISO:BSI]PymethrozineUNII-F0G3V7874JEINECS Annex I Index 613-202-00-4Pymetrozine (Standard)PYMETROZINE [MI]PYMETROZINE [ISO]
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match9576037

Attributed physical-property, hazard, environmental and use annotations.

  • Signal: Warning Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H351: Suspected of causing cancer [Warning Carcinogenicity]; H361fd: Suspected of damaging fertility; Suspected of damaging the unborn child [Warning Reproductive toxicity]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P203, P273, P280, P318, P391, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Signal: Warning Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H332 (19.5%): Harmful if inhaled [Warning Acute toxicity, inhalation]; H351 (100%): Suspected of causing cancer [Warning Carcinogenicity]; H361fd (76.4%): Suspected of damaging fertility; Suspected of damaging the unborn child [Warning Reproductive toxicity]; H410 (77.4%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]; H412 (22.6%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P261, P271, P273, P280, P304+P340, P317, P318, P391, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 195 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Warning Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
  • GHS Hazard Statements: H351: Suspected of causing cancer [Warning Carcinogenicity]; H361fd: Suspected of damaging fertility; Suspected of damaging the unborn child [Warning Reproductive toxicity]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
  • Precautionary Statement Codes: P203, P273, P280, P318, P391, P405, and P501 (click each P-code to see the statement) Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
  • Environmental Bioconcentration: An estimated BCF of 3 was calculated for pymetrozine(SRC), using a log Kow of -0.18(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Pymetrozine is expected to have slight mobility in soil(1). Volatilization of pymetrozine from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 3.0X10-11 atm-cu m/mole(SRC), derived from its vapor pressure, <3X10-8 mm Hg(1), and water solubility, 290 mg/l(1). Pymetrozine is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(1). Pymetrozine is rapidly degraded in soil with a half-life of 8 to 38 days(1). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Pymetrozine is expected to adsorb to suspended solids and sediment(SRC), based upon its slight mobility in soil(1). Volatilization from water surfaces is not expected(2) based upon an estimated Henry's Law constant of 3.0X10-11 atm-cu m/mole(SRC), derived from its vapor pressure, <3X10-8 mm Hg(1), and water solubility, 290 mg/l(1). According to a classification scheme(3), an estimated BCF of 3(SRC), from its log Kow (1) and a regression-derived equation(4), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Pymetrozine may undergo hydrolysis at low pH; the hydrolysis half-life is 25 days at pH 5(1). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), pymetrozine, which has a vapor pressure of <3X10-8 mm Hg at 25 °C(2), is expected to exist solely in the particulate phase in the ambient atmosphere(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Uses: For Pymetrozine (USEPA/OPP Pesticide Code: 101103) ACTIVE products with label matches. /SRP: Registered for use in the U.S. but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./ Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Control of aphids and whiteflies in vegetables, ornamentals, cotton, field crops, deciduous and citrus fruit; control of plant hoppers in rice. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: This is a man-made compound that is used as a pesticide. Source: Toxin and Toxin Target Database (T3DB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Pymetrozine (ISO)

Chemical / IUPAC name

(E)-4,5-dihydro-6-methyl-4-(3-pyridylmethyleneamino)1,2,4-triazin-3(2H)-one

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

SCCS opinions

CMR

CategoryCarcinogenicMutagenicReprotoxic
Cat. 2✓——

Key data

CAS
123312-89-0
EC
602-927-1
Annex
II
Entry number
1198

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 1199
Nearby record in the same annex

Oxadiargyl (ISO)

CAS: 39807-15-3
EC: 254-637-6

What Annex II means for Pymetrozine (ISO)

Pymetrozine (ISO) is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).
  • This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.

Frequently asked questions

Yes. Pymetrozine (ISO) is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 123312-89-0 is the unique numerical identifier assigned to Pymetrozine (ISO) by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Pymetrozine (ISO) has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Pymetrozine (ISO)

This page summarizes one Annex II record for Pymetrozine (ISO) from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Pymetrozine (ISO), but confirm any final regulatory decision against the current official annex wording and source files.

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