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ProhibitedBinding ruleCNOfficial English translationOfficial-source import checked

1,2-苯基二羧酸支链和直链二戊基酯, 正戊基异戊基邻苯二甲酸酯, 双正戊 基邻苯二甲酸酯, 双异戊基邻苯二甲 酸酯 — 1,2-Benzenedicarboxylic acid, dipentylester, branched and linear （CAS No. 84777-06-0）,n-Pentyl-isopentylphthalate,di-n-Pentyl phthalate （CAS No. 131-18-0）, Diisopentylphthalate （CAS No. 605-50-5）

1,2-Benzenedicarboxylic acid, dipentylester, branched and linear （CAS No. 84777-06-0）,n-Pentyl-isopentylphthalate,di-n-Pentyl phthalate （CAS No. 131-18-0）, Diisopentylphthalate （CAS No. 605-50-5）

The NMPA binding 2021 catalogue prohibits this raw material in cosmetic formulas in China.

All China recordsCompare all marketsOpen official source

Regulatory decision and full conditions

Status
Prohibited
Legal role
Binding rule
Regulatory summary
The NMPA binding 2021 catalogue prohibits this raw material in cosmetic formulas in China.
Conditions and restrictions
Prohibited in cosmetic product formulas. Verify the cited Chinese source identity and any later NMPA amendment before use.

Substance identity

Official source name
1,2-苯基二羧酸支链和直链二戊基酯, 正戊基异戊基邻苯二甲酸酯, 双正戊 基邻苯二甲酸酯, 双异戊基邻苯二甲 酸酯 — 1,2-Benzenedicarboxylic acid, dipentylester, branched and linear （CAS No. 84777-06-0）,n-Pentyl-isopentylphthalate,di-n-Pentyl phthalate （CAS No. 131-18-0）, Diisopentylphthalate （CAS No. 605-50-5）
CAS
84777-06-0; 131-18-0; 605-50-5
EC
Not supplied in this source row
Identity mapping
standalone:official_nmpa_record
Search this identity across the siteCAS 84777-06-0CAS 131-18-0CAS 605-50-5

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

7 market datasets
PubChem 2D chemical structure for CAS 131-18-0
CAS 131-18-0PubChem CID 8561

Verified chemistry for CAS 131-18-0

Dipentyl phthalate

IUPAC name
dipentyl benzene-1,2-dicarboxylate
Molecular formula
C18H26O4
Molecular weight
306.4 g/mol
Exact mass
306.18310931 Da
Monoisotopic mass
306.18310931 Da
XLogP3
5.8
Topological polar surface area
52.6 Ų
Molecular complexity
295.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
4
Rotatable bonds
12
Heavy atoms
22
Covalent units
1

Names and synonyms reported to PubChem

DIAMYL PHTHALATEDi-n-pentyl phthalateAmyl phthalateAmoildi-n-Amyl phthalateDi-n-pentylphthalatePhthalic acid, dipentyl esterdiamylphthalate
16 more reported names
Phthalic Acid Diamyl EsterPhthalic acid, diamyl esterDPNPDipentyl 1,2-benzenedicarboxylateAI3-00363 (USDA)1,2-dipentyl benzene-1,2-dicarboxylateCHEBI:346805DC92K224XNSC-47201,2-Benzenedicarboxylic acid dipentyl esterRefChem:586287205-017-91,2-Benzenedicarboxylic acid, dipentyl esterPhthalic Acid Dipentyl Ester1,2-Benzenedicarboxylic acid, 1,2-dipentyl esterNSC 4720
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
5
3D rings
1
3D hydrophobes
2
3D acceptor features
2
3D donor features
0
3D anionic centres
0
3D cationic centres
0
3D conformers
10
Effective 3D rotors
12.0
Machine-readable structure identifiers
SMILES
CCCCCOC(=O)C1=CC=CC=C1C(=O)OCCCCC
InChI
InChI=1S/C18H26O4/c1-3-5-9-13-21-17(19)15-11-7-8-12-16(15)18(20)22-14-10-6-4-2/h7-8,11-12H,3-6,9-10,13-14H2,1-2H3
InChIKey
IPKKHRVROFYTEK-UHFFFAOYSA-N

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match8561

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) shou Source: CAMEO Chemicals
  • Health Effects: Phthalate esters are endocrine disruptors. Animal studies have shown that they disrupt reproductive development and can cause a number of malformations in affected young, such as reduced anogenital distance (AGD), cryptorchidism, hypospadias, and reduced fertility. The combination of effects associated with phthalates is called 'phthalate syndrome’. (A2883) Source: Toxin and Toxin Target Database (T3DB)
  • Toxicity Summary: Phthalate esters are endocrine disruptors. They decrease foetal testis testosterone production and reduce the expression of steroidogenic genes by decreasing mRNA expression. Some phthalates have also been shown to reduce the expression of insulin-like peptide 3 (insl3), an important hormone secreted by the Leydig cell necessary for development of the gubernacular ligament. Animal studies have shown that these effects disrupt reproductive development and can cause a number of malformations in affected young. (A2883) Source: Toxin and Toxin Target Database (T3DB)
  • Environmental Bioconcentration: An estimated BCF of 420 was calculated in fish for diamyl phthalate(SRC), using a log Kow of 5.62(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is high, provided the compound is not metabolized by the organism(SRC). However, bioconcentration studies on compounds which are structurally similar suggest that bioconcentration may be lower than that indicated by the regression-derived equations due to the ability of aquatic organisms to readily metabolize this class of compounds(4). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 27,000(SRC), determined from a log Kow values of 5.62(2), and a regression-derived equation(3), indicate that diamyl phthalate is expected to be immobile in soil(SRC). Volatilization of diamyl phthalate from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 8.9X10-7 atm-cu m/mole(SRC), using a fragment constant estimation method(4). Diamyl phthalate is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 2.0X10-4 mm Hg(SRC), determined from a fragment constant method(5). Biodegradation studies using pure cultures indicate that diamyl phthalate may biodegrade under aerobic conditions yielding phthalic acid and amyl alcohol(6). Although biodegradation data on diamyl phthalate are limited, biodegradation studies on a series of phthalate esters have demonstrated that, in general, phthalate esters are readily biodegraded(7). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 27,000(SRC), determined from a log Kow values of 5.62(2), and a regression-derived equation(3), indicate that diamyl phthalate is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 8.9X10-7 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). According to a classification scheme(5), an estimated BCF of 420(SRC), from its log Kow(2) and a regression-derived equation(6), suggests the potential for bioconcentration in aquatic organisms is high, provided the compound is not metabolized by the organism(SRC). However, bioconcentration studies on compounds which are structurally similar suggest that bioconcentration may be lower than that indicated by the regression-derived equations due to the ability of aquatic organisms to readily metabolize this class of compounds(7). Estimated hydrolysis half-lives of 3.4 years and 130 days at pHs 7 and 8, respectively, suggest that hydrolysis is not expected to be an important process(8). Biodegradation studies using pure cultures indicate th Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), diamyl phthalate, which has an estimated vapor pressure of 2.0X10-4 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase diamyl phthalate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 32 hours(SRC), calculated from its rate constant of 1.2X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Diamyl phthalate does contain chromophores that absorb at wavelengths >290 nm(4) and therefore may be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Sources/Uses: Used as plasticizer; [Hawley] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: Plasticizer Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Phthalate esters are mainly used as plasticizers, primarily used to soften polyvinyl chloride. They are found in a number of products, including glues, building materials, personal care products, detergents and surfactants, packaging, children's toys, paints, pharmaceuticals, food products, and textiles. Phthalates are used in a variety of household applications such as shower curtains, vinyl upholstery, adhesives, floor tiles, food containers and wrappers, and cleaning materials. Personal care items containing phthalates include perfume, eye shadow, moisturizer, nail polish, liquid soap, and hair spray. (L1903) Source: Toxin and Toxin Target Database (T3DB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 605-50-5
CAS 605-50-5PubChem CID 69059

Verified chemistry for CAS 605-50-5

Diisopentyl phthalate

IUPAC name
bis(3-methylbutyl) benzene-1,2-dicarboxylate
Molecular formula
C18H26O4
Molecular weight
306.4 g/mol
Exact mass
306.18310931 Da
Monoisotopic mass
306.18310931 Da
XLogP3
5.6
Topological polar surface area
52.6 Ų
Molecular complexity
315.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
4
Rotatable bonds
10
Heavy atoms
22
Covalent units
1

Names and synonyms reported to PubChem

Isoamyl phthalateBis(3-methylbutyl) phthalatePalatinol DIPPNSC 17070UNII-WPN6M4ZUIFWPN6M4ZUIFEINECS 210-088-4BRN 2134957
16 more reported names
AI3-04281NSC-17070ISOAMYL PHTHALATE [MI]EC 210-088-44-09-00-03179 (Beilstein Handbook Reference)1,2-Benzenedicarboxylic Acid 1,2-Bis(3-methylbutyl) EsterDiisopentyl phthalic acidRefChem:134061JANBFCARANRIKJ-UHFFFAOYSA-NDiisoamyl phthalateDisoamyl phthalatePhthalic acid, diisopentyl ester1,2-Benzenedicarboxylic acid, bis(3-methylbutyl) esterDiisopentylphthalateDiisopentyl phthalate, analytical standardPhthalic Acid Diisopentyl Ester
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
5
3D rings
1
3D hydrophobes
2
3D acceptor features
2
3D donor features
0
3D anionic centres
0
3D cationic centres
0
3D conformers
10
Effective 3D rotors
10.0
Machine-readable structure identifiers
SMILES
CC(C)CCOC(=O)C1=CC=CC=C1C(=O)OCCC(C)C
InChI
InChI=1S/C18H26O4/c1-13(2)9-11-21-17(19)15-7-5-6-8-16(15)18(20)22-12-10-14(3)4/h5-8,13-14H,9-12H2,1-4H3
InChIKey
JANBFCARANRIKJ-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 84777-06-0
CAS 84777-06-0PubChem CID 3020116

Verified chemistry for CAS 84777-06-0

1,2-Benzenedicarboxylic acid, dipentyl ester, branched and linear

IUPAC name
3,4-bis(3-methylbutyl)phthalate
Molecular formula
C18H24O4-2
Formula without charge
C18H24O4
Molecular weight
304.4 g/mol
Exact mass
304.16745924 Da
Monoisotopic mass
304.16745924 Da
XLogP3
6.5
Topological polar surface area
80.3 Ų
Molecular complexity
364.0
Formal charge
-2
Hydrogen-bond donors
0
Hydrogen-bond acceptors
4
Rotatable bonds
6
Heavy atoms
22
Covalent units
1

Names and synonyms reported to PubChem

RefChem:411195EINECS 284-032-2Dipentyl phthalate, branched and linear284-032-2MSK1148YRWFRHKQYQHUTP-UHFFFAOYSA-LPhthalic acid, n-pentyl-isopentyl (mixture of branched and linear isomers)
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
9
3D rings
1
3D hydrophobes
2
3D acceptor features
4
3D donor features
0
3D anionic centres
2
3D cationic centres
0
3D conformers
10
Effective 3D rotors
8.0
Machine-readable structure identifiers
SMILES
CC(C)CCC1=C(C(=C(C=C1)C(=O)[O-])C(=O)[O-])CCC(C)C
InChI
InChI=1S/C18H26O4/c1-11(2)5-7-13-8-10-15(17(19)20)16(18(21)22)14(13)9-6-12(3)4/h8,10-12H,5-7,9H2,1-4H3,(H,19,20)(H,21,22)/p-2
InChIKey
YRWFRHKQYQHUTP-UHFFFAOYSA-L

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
China NMPA banned raw-material catalogues (2021)
Source reference
NMPA 2021 Catalogue of Raw Materials Banned for Cosmetics, entry 14
Source record ID
chemical-14
Source version
NMPA Announcement No. 74 of 2021, effective 2021-05-26
Source language
Chinese with source English/Latin identity
Translation status
Official English translation · English translation
Effective date
2021-05-26
Source updated
2021-05-26
Snapshot checked
2026-08-31 14:13 UTC
Validation method
pdfplumber tables; exact 1,284 + 109 row counts and contiguous source numbering
SHA-256
8848aa3e0c7ac5e74f56fc27927336c4fc2e5bc80137da087c2ca9ba2d2c075e

Registered dataset notes

Dataset coverage
All 1,284 banned raw materials and 109 banned plant/animal raw materials effective from 26 May 2021
Authority note
Binding NMPA catalogues replacing Tables 1 and 2 of the 2015 Technical Specification
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

1393
current China records
1393
records marked Prohibited
1393
records from this source version
1249
market records with CAS identity

Status distribution

Prohibited: 1393

Condition text is present on 1393 of 1393 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

China market context

Complete prohibited catalogues plus official-source workflow

Coverage version: NMPA 2021 banned catalogues plus dynamic IECIC List I/List II system current since 2025

All 1,284 banned raw materials and 109 banned plant/animal raw materials, plus the official workflow for the dynamic existing-ingredient inventory, other technical restrictions and new ingredients.

Verification checklist

  1. Search the current NMPA IECIC List I and List II by Chinese name and identity.
  2. Check prohibited/restricted and positive lists in the current Safety and Technical Standards.
  3. Review technical purpose, use history and any monitoring period.
  4. Confirm Chinese labelling, safety assessment and filing/registration duties.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “1,2-苯基二羧酸支链和直链二戊基酯, 正戊基异戊基邻苯二甲酸酯, 双正戊 基邻苯二甲酸酯, 双异戊基邻苯二甲 酸酯 — 1,2-Benzenedicarboxylic acid, dipentylester, branched and linear （CAS No. 84777-06-0）,n-Pentyl-isopentylphthalate,di-n-Pentyl phthalate （CAS No. 131-18-0）, Diisopentylphthalate （CAS No. 605-50-5）” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Search the current NMPA IECIC List I and List II by Chinese name and identity.
  3. Check prohibited/restricted and positive lists in the current Safety and Technical Standards.
  4. Review technical purpose, use history and any monitoring period.
  5. Confirm Chinese labelling, safety assessment and filing/registration duties.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECNot supplied
  • Separate condition textAvailable
  • Effective dateAvailable
  • Snapshot hash and methodAvailable

Questions this page answers

This official record identifies the substance as prohibited for cosmetic use in the stated market scope. Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. IECIC listing is not blanket approval; absence may require the new cosmetic ingredient route, and restrictions are checked separately.

The record cites NMPA 2021 Catalogue of Raw Materials Banned for Cosmetics, entry 14, source version NMPA Announcement No. 74 of 2021, effective 2021-05-26. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

1,2-苯基二羧酸支链和直链二戊基酯, 正戊基异戊基邻苯二甲酸酯, 双正戊 基邻苯二甲酸酯, 双异戊基邻苯二甲 酸酯 — 1,2-Benzenedicarboxylic acid, dipentylester, branched and linear （CAS No. 84777-06-0）,n-Pentyl-isopentylphthalate,di-n-Pentyl phthalate （CAS No. 131-18-0）, Diisopentylphthalate （CAS No. 605-50-5）. NMPA 2021 Catalogue of Raw Materials Banned for Cosmetics, entry 14. China. Source version NMPA Announcement No. 74 of 2021, effective 2021-05-26. CosIng Checker regulatory record: https://cosingchecker.com/regulations/cn/records/11703/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for China

This official record identifies the substance as prohibited for cosmetic use in the stated market scope.

Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

How to interpret the legal role

The cited row forms part of a binding rule or legally incorporated list for this market.

Evidence on this page

  • Recorded outcome: Prohibited
  • Legal role: Binding rule
  • Source version: NMPA Announcement No. 74 of 2021, effective 2021-05-26
  • Effective date: 2021-05-26

What it does not prove

IECIC listing is not blanket approval; absence may require the new cosmetic ingredient route, and restrictions are checked separately.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity at the source

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity at the source

US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source