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Annex II Entry 1151 CMR12/08/2019

1,2-Benzenedicarboxylic acid, dipentylester, branched and linear [1]; n-Pentyl-isopentylphthalate [2]; di-n-Pentyl phthalate [3]; Diisopentylphthalate [4]

1,2-Benzenedicarboxylic acid, dipentylester, branched and linear [1]; n-Pentyl-isopentylphthalate [2]; di-n-Pentyl phthalate [3]; Diisopentylphthalate [4] is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1151
CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 131-18-0
CAS 131-18-0PubChem CID 8561

Dipentyl phthalate

Dipentyl phthalate is a phthalate ester that is the dipentyl ester of benzene-1,2-dicarboxylic acid. It has a role as a plasticiser. It is a phthalate ester and a diester. It is functionally related to a pentan-1-ol. — ChEBI

IUPAC name
dipentyl benzene-1,2-dicarboxylate
Molecular formula
C18H26O4
Molecular weight
306.4 g/mol
Exact mass
306.18310931 Da
XLogP3
5.8
Topological polar surface area
52.6 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
4
Covalent units
1
Defined stereocentres
0

Also known as

DIAMYL PHTHALATEDi-n-pentyl phthalateAmyl phthalateAmoildi-n-Amyl phthalateDi-n-pentylphthalatePhthalic acid, dipentyl esterdiamylphthalate
16 more reported names
Phthalic Acid Diamyl EsterPhthalic acid, diamyl esterDPNPDipentyl 1,2-benzenedicarboxylateAI3-00363 (USDA)1,2-dipentyl benzene-1,2-dicarboxylateCHEBI:346805DC92K224XNSC-47201,2-Benzenedicarboxylic acid dipentyl esterRefChem:586287205-017-91,2-Benzenedicarboxylic acid, dipentyl esterPhthalic Acid Dipentyl Ester1,2-Benzenedicarboxylic acid, 1,2-dipentyl esterNSC 4720
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match8561

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) shou Source: CAMEO Chemicals
  • Health Effects: Phthalate esters are endocrine disruptors. Animal studies have shown that they disrupt reproductive development and can cause a number of malformations in affected young, such as reduced anogenital distance (AGD), cryptorchidism, hypospadias, and reduced fertility. The combination of effects associated with phthalates is called 'phthalate syndrome’. (A2883) Source: Toxin and Toxin Target Database (T3DB)
  • Toxicity Summary: Phthalate esters are endocrine disruptors. They decrease foetal testis testosterone production and reduce the expression of steroidogenic genes by decreasing mRNA expression. Some phthalates have also been shown to reduce the expression of insulin-like peptide 3 (insl3), an important hormone secreted by the Leydig cell necessary for development of the gubernacular ligament. Animal studies have shown that these effects disrupt reproductive development and can cause a number of malformations in affected young. (A2883) Source: Toxin and Toxin Target Database (T3DB)
  • Environmental Bioconcentration: An estimated BCF of 420 was calculated in fish for diamyl phthalate(SRC), using a log Kow of 5.62(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is high, provided the compound is not metabolized by the organism(SRC). However, bioconcentration studies on compounds which are structurally similar suggest that bioconcentration may be lower than that indicated by the regression-derived equations due to the ability of aquatic organisms to readily metabolize this class of compounds(4). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 27,000(SRC), determined from a log Kow values of 5.62(2), and a regression-derived equation(3), indicate that diamyl phthalate is expected to be immobile in soil(SRC). Volatilization of diamyl phthalate from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 8.9X10-7 atm-cu m/mole(SRC), using a fragment constant estimation method(4). Diamyl phthalate is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 2.0X10-4 mm Hg(SRC), determined from a fragment constant method(5). Biodegradation studies using pure cultures indicate that diamyl phthalate may biodegrade under aerobic conditions yielding phthalic acid and amyl alcohol(6). Although biodegradation data on diamyl phthalate are limited, biodegradation studies on a series of phthalate esters have demonstrated that, in general, phthalate esters are readily biodegraded(7). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 27,000(SRC), determined from a log Kow values of 5.62(2), and a regression-derived equation(3), indicate that diamyl phthalate is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 8.9X10-7 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). According to a classification scheme(5), an estimated BCF of 420(SRC), from its log Kow(2) and a regression-derived equation(6), suggests the potential for bioconcentration in aquatic organisms is high, provided the compound is not metabolized by the organism(SRC). However, bioconcentration studies on compounds which are structurally similar suggest that bioconcentration may be lower than that indicated by the regression-derived equations due to the ability of aquatic organisms to readily metabolize this class of compounds(7). Estimated hydrolysis half-lives of 3.4 years and 130 days at pHs 7 and 8, respectively, suggest that hydrolysis is not expected to be an important process(8). Biodegradation studies using pure cultures indicate th Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), diamyl phthalate, which has an estimated vapor pressure of 2.0X10-4 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase diamyl phthalate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 32 hours(SRC), calculated from its rate constant of 1.2X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Diamyl phthalate does contain chromophores that absorb at wavelengths >290 nm(4) and therefore may be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Sources/Uses: Used as plasticizer; [Hawley] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: Plasticizer Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Phthalate esters are mainly used as plasticizers, primarily used to soften polyvinyl chloride. They are found in a number of products, including glues, building materials, personal care products, detergents and surfactants, packaging, children's toys, paints, pharmaceuticals, food products, and textiles. Phthalates are used in a variety of household applications such as shower curtains, vinyl upholstery, adhesives, floor tiles, food containers and wrappers, and cleaning materials. Personal care items containing phthalates include perfume, eye shadow, moisturizer, nail polish, liquid soap, and hair spray. (L1903) Source: Toxin and Toxin Target Database (T3DB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 605-50-5
CAS 605-50-5PubChem CID 69059

Diisopentyl phthalate

isoamyl phthalate has been reported in Cryptotaenia canadensis with data available. — LOTUS - the natural products occurrence database

IUPAC name
bis(3-methylbutyl) benzene-1,2-dicarboxylate
Molecular formula
C18H26O4
Molecular weight
306.4 g/mol
Exact mass
306.18310931 Da
XLogP3
5.6
Topological polar surface area
52.6 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
4
Covalent units
1
Defined stereocentres
0

Also known as

Isoamyl phthalateBis(3-methylbutyl) phthalatePalatinol DIPPNSC 17070UNII-WPN6M4ZUIFWPN6M4ZUIFEINECS 210-088-4BRN 2134957
16 more reported names
AI3-04281NSC-17070ISOAMYL PHTHALATE [MI]EC 210-088-44-09-00-03179 (Beilstein Handbook Reference)1,2-Benzenedicarboxylic Acid 1,2-Bis(3-methylbutyl) EsterDiisopentyl phthalic acidRefChem:134061JANBFCARANRIKJ-UHFFFAOYSA-NDiisoamyl phthalateDisoamyl phthalatePhthalic acid, diisopentyl ester1,2-Benzenedicarboxylic acid, bis(3-methylbutyl) esterDiisopentylphthalateDiisopentyl phthalate, analytical standardPhthalic Acid Diisopentyl Ester
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 776297-69-9
CAS 776297-69-9PubChem CID 71307505

1-(3-Methylbutyl) 2-pentyl 1,2-benzenedicarboxylate

IUPAC name
2-O-(3-methylbutyl) 1-O-pentyl benzene-1,2-dicarboxylate
Molecular formula
C18H26O4
Molecular weight
306.4 g/mol
Exact mass
306.18310931 Da
XLogP3
5.7
Topological polar surface area
52.6 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
4
Covalent units
1
Defined stereocentres
0

Also known as

RefChem:424031Isopentyl pentyl phthalaten-pentyl isopentyl phthalateIsopentylpentylphthalatePhthalic acid, n-pentyl-isopentyl esterPhthalic acid, 3-methylbutyl pentyl estern-Pentyl iso-pentyl phthalate (n-Pentyl 3-methlybutyl phthalate)3-Methylbutyl pentyl phthalate
10 more reported names
Isopentyl pentan-2-yl phthalateN-Pentyl- Isopentyl PhthalateIsopentyl pentyl phthalate, 97%MSK11561,2-Benzenedicarboxylic Acid-d4 1-(3-Methylbutyl) 2-pentyl EsterCS-W022765AS-19170DB-2876593-Methylbutyl pentyl benzene-1,2-dicarboxylateO2-isopentyl O1-pentyl benzene-1,2-dicarboxylate
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 84777-06-0
CAS 84777-06-0PubChem CID 3020116

1,2-Benzenedicarboxylic acid, dipentyl ester, branched and linear

IUPAC name
3,4-bis(3-methylbutyl)phthalate
Molecular formula
C18H24O4-2
Molecular weight
304.4 g/mol
Exact mass
304.16745924 Da
XLogP3
6.5
Topological polar surface area
80.3 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
4
Covalent units
1
Defined stereocentres
0

Also known as

RefChem:411195EINECS 284-032-2Dipentyl phthalate, branched and linear284-032-2MSK1148YRWFRHKQYQHUTP-UHFFFAOYSA-LPhthalic acid, n-pentyl-isopentyl (mixture of branched and linear isomers)
Open full PubChem recordPubChem annotations3D structure image

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

1,2-Benzenedicarboxylic acid, dipentylester, branched and linear [1]; n-Pentyl-isopentylphthalate [2]; di-n-Pentyl phthalate [3]; Diisopentylphthalate [4]

Chemical / IUPAC name

1,2-Benzenedicarboxylic acid, dipentylester, branched and linear [1]; n-Pentyl-isopentylphthalate [2]; di-n-Pentyl phthalate [3]; Diisopentylphthalate [4]

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

SCCS opinions

CMR

CategoryCarcinogenicMutagenicReprotoxic
Cat. 1B——✓

Key data

CAS
84777-06-0 [1] / 776297-69-9 [2] / 131-18-0 [3] / 605-50-5 [4]
EC
284-032-2 [1] / 933-378-9 [2] / 205-017-9 [3] / 210-088-4 [4]
Annex
II
Entry number
1151

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 1157
Nearby record in the same annex

Azafenidin (ISO)

CAS: 68049-83-2
EC: 620-425-0

What Annex II means for 1,2-Benzenedicarboxylic acid, dipentylester, branched and linear [1]; n-Pentyl-isopentylphthalate [2]; di-n-Pentyl phthalate [3]; Diisopentylphthalate [4]

1,2-Benzenedicarboxylic acid, dipentylester, branched and linear [1]; n-Pentyl-isopentylphthalate [2]; di-n-Pentyl phthalate [3]; Diisopentylphthalate [4] is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).
  • This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.

Frequently asked questions

Yes. 1,2-Benzenedicarboxylic acid, dipentylester, branched and linear [1]; n-Pentyl-isopentylphthalate [2]; di-n-Pentyl phthalate [3]; Diisopentylphthalate [4] is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 84777-06-0 [1] / 776297-69-9 [2] / 131-18-0 [3] / 605-50-5 [4] is the unique numerical identifier assigned to 1,2-Benzenedicarboxylic acid, dipentylester, branched and linear [1]; n-Pentyl-isopentylphthalate [2]; di-n-Pentyl phthalate [3]; Diisopentylphthalate [4] by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

1,2-Benzenedicarboxylic acid, dipentylester, branched and linear [1]; n-Pentyl-isopentylphthalate [2]; di-n-Pentyl phthalate [3]; Diisopentylphthalate [4] has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record 1,2-Benzenedicarboxylic acid, dipentylester, branched and linear [1]; n-Pentyl-isopentylphthalate [2]; di-n-Pentyl phthalate [3]; Diisopentylphthalate [4]

This page summarizes one Annex II record for 1,2-Benzenedicarboxylic acid, dipentylester, branched and linear [1]; n-Pentyl-isopentylphthalate [2]; di-n-Pentyl phthalate [3]; Diisopentylphthalate [4] from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for 1,2-Benzenedicarboxylic acid, dipentylester, branched and linear [1]; n-Pentyl-isopentylphthalate [2]; di-n-Pentyl phthalate [3]; Diisopentylphthalate [4], but confirm any final regulatory decision against the current official annex wording and source files.

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