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Chlorhexidine and its salts

Canada Hotlist: Chlorhexidine and its salts

Health Canada lists this ingredient as restricted; the listed conditions and warnings apply.

All Canada recordsOpen ingredient profileCompare all marketsOpen official source

Regulatory decision and full conditions

Status
Restricted
Legal role
Official guidance
Regulatory summary
Health Canada lists this ingredient as restricted; the listed conditions and warnings apply.
Conditions and restrictions
b) 0.19% calculated as chlorhexidine diacetate | c) 0.20% calculated as chlorhexidine digluconate | d) 0.16% calculated as chlorhexidine dihydrochloride · Maximum concentration: a) 0.14% calculated as chlorhexidine free base

Substance identity

Official source name
Chlorhexidine and its salts
CAS
55-56-1; 56-95-1; 18472-51-0; 3697-42-5
EC
Not supplied in this source row
Identity mapping
Exact CAS: 55-56-1
Linked ingredient
CHLORHEXIDINE
Search this identity across the siteCAS 55-56-1CAS 56-95-1CAS 18472-51-0CAS 3697-42-5

Linked CosIng identity data

Names and aliases

CHLORHEXIDINEchlorhexidine

CosIng description: 2,4,11,13-Tetraazatetradecanediimidamide, N,N''-bis(4-chlorophenyl)-3,12-diimino-; Biguanide, 1,1'-hexamethylenebis(5-(p-chlorophenyl)-

EU inventory restriction note: V/42

Recorded cosmetic function: ANTIMICROBIAL, ORAL CARE, PRESERVATIVE

Function pages:ANTIMICROBIAL, ORAL CARE, PRESERVATIVE

View the complete ingredient profile

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

7 market datasets

European Union

Positive-list entry with conditions

1 linked record · 1 with specific conditions

Open supporting record

Great Britain

Permitted list with conditions

1 linked record · 1 with specific conditions

Open supporting record
PubChem 2D chemical structure for CAS 18472-51-0
CAS 18472-51-0PubChem CID 9552081

Verified chemistry for CAS 18472-51-0

Chlorhexidine Gluconate

IUPAC name
(1E)-2-[6-[[amino-[(E)-[amino-(4-chloroanilino)methylidene]amino]methylidene]amino]hexyl]-1-[amino-(4-chloroanilino)methylidene]guanidine;bis((2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid)
Molecular formula
C34H54Cl2N10O14
Molecular weight
897.8 g/mol
Exact mass
896.3198018 Da
Monoisotopic mass
896.3198018 Da
Topological polar surface area
454.0 Ų
Molecular complexity
819.0
Formal charge
0
Hydrogen-bond donors
18
Hydrogen-bond acceptors
16
Rotatable bonds
23
Heavy atoms
60
Covalent units
3

Names and synonyms reported to PubChem

CHLORHEXIDINE DIGLUCONATEHibiclensDyna-hexBioscrubHibistatMicrodermPeriochipPeriogard
16 more reported names
ExidineChlorhexidine D-digluconateBrian CareSteri-StatCida-StatBacticlensCorsodylHibidilKleersightPrevacarePharmaseal Scrub CareCHG SCRUBFight bacPrevacare RChlorhexidine di-D-gluconateMOR84MUD8E
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
8
Undefined atom stereocentres
0
Defined bond stereocentres
2
Undefined bond stereocentres
0
3D conformers
0
Machine-readable structure identifiers
SMILES
C1=CC(=CC=C1N/C(=N/C(=NCCCCCCN=C(/N=C(/NC2=CC=C(C=C2)Cl)\N)N)N)/N)Cl.C(O)[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(=O)O.C(O)[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(=O)O
InChI
InChI=1S/C22H30Cl2N10.2C6H12O7/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18;2*7-1-2(8)3(9)4(10)5(11)6(12)13/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34);2*2-5,7-11H,1H2,(H,12,13)/t;2*2-,3-,4+,5-/m.11/s1
InChIKey
YZIYKJHYYHPJIB-UUPCJSQJSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 3697-42-5
CAS 3697-42-5PubChem CID 9571016

Verified chemistry for CAS 3697-42-5

Chlorhexidine Hydrochloride

IUPAC name
(1E)-2-[6-[[amino-[(E)-[amino-(4-chloroanilino)methylidene]amino]methylidene]amino]hexyl]-1-[amino-(4-chloroanilino)methylidene]guanidine;dihydrochloride
Molecular formula
C22H32Cl4N10
Molecular weight
578.4 g/mol
Exact mass
578.153602 Da
Monoisotopic mass
576.156552 Da
Topological polar surface area
178.0 Ų
Molecular complexity
648.0
Formal charge
0
Hydrogen-bond donors
8
Hydrogen-bond acceptors
2
Rotatable bonds
13
Heavy atoms
36
Covalent units
3

Names and synonyms reported to PubChem

Chlorhexidine dihydrochlorideChlorhexidine HClDantroche hibitaneAY-5312E64XL9U38KNSC-7566792,4,11,13-Tetraazatetradecanediimidamide, N,N''-bis(4-chlorophenyl)-3,12-diimino-, dihydrochlorideChlorhex hcl
16 more reported names
1,1'-Hexamethylenebis(5-(4-chlorophenyl)biguanide) dihydrochloride1,1'-Hexamethylenebis[5-(4-chlorophenyl)biguanide] DihydrochlorideNolvasan Cap-TabsNolvasan SuspensionRefChem:54790Hydrochloride, Chlorhexidine223-026-6Chlorhexidine 2HClArlacide HCaswell No. 481FChlorhexidine (dihydrochloride)Chlorhexidinium dichloride1,1'-Hexamethylenebis(5-(p-chlorophenyl)biguanide) dihydrochlorideEINECS 223-026-6EPA Pesticide Chemical Code 481700UNII-E64XL9U38K
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
2
Undefined bond stereocentres
0
3D conformers
0
Machine-readable structure identifiers
SMILES
C1=CC(=CC=C1N/C(=N/C(=NCCCCCCN=C(/N=C(/NC2=CC=C(C=C2)Cl)\N)N)N)/N)Cl.Cl.Cl
InChI
InChI=1S/C22H30Cl2N10.2ClH/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18;;/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34);2*1H
InChIKey
WJLVQTJZDCGNJN-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 55-56-1
CAS 55-56-1PubChem CID 9552079

Verified chemistry for CAS 55-56-1

Chlorhexidine

Chlorhexidine is a bisbiguanide compound with a structure consisting of two (p-chlorophenyl)guanide units linked by a hexamethylene bridge. It has a role as an antibacterial agent and an antiinfective agent. It is a member of biguanides and a member of monochlorobenzenes. It is functionally related to a biguanide. — ChEBI

IUPAC name
(1E)-2-[6-[[amino-[(E)-[amino-(4-chloroanilino)methylidene]amino]methylidene]amino]hexyl]-1-[amino-(4-chloroanilino)methylidene]guanidine
Molecular formula
C22H30Cl2N10
Molecular weight
505.4 g/mol
Exact mass
504.2031964 Da
Monoisotopic mass
504.2031964 Da
XLogP3
0.1
Topological polar surface area
178.0 Ų
Molecular complexity
648.0
Formal charge
0
Hydrogen-bond donors
6
Hydrogen-bond acceptors
2
Rotatable bonds
13
Heavy atoms
34
Covalent units
1

Names and synonyms reported to PubChem

HexadolSoretolFimeilSterilonTubulicidChlorhexidinumChlorhexidinClorhexidina
16 more reported names
CloresidinaNolvasanMerfen-incoloreChlorhexadineDentisept1,6-Bis(p-chlorophenyldiguanido)hexane1,6-Di(4'-chlorophenyldiguanido)hexane1,6-Bis(5-(p-chlorophenyl)biguandino)hexane1,1'-Hexamethylene bis(5-(p-chlorophenyl)biguanide)R4KO0DY52LCHEBI:36141,6-Di(N-p-chlorophenyldiguanido)hexane2,4,11,13-Tetraazatetradecanediimidamide, N,N''-bis(4-chlorophenyl)-3,12-diimino-N,N'-Bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamideN-(4-chlorophenyl)-1-3-(6-{N-[3-(4-chlorophenyl)carbamimidamidomethanimidoyl]amino}hexyl)carbamimidamidomethanimidamideclorexidina
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
2
Undefined bond stereocentres
0
3D pharmacophore features
13
3D rings
2
3D hydrophobes
1
3D acceptor features
0
3D donor features
6
3D anionic centres
0
3D cationic centres
4
3D conformers
10
Effective 3D rotors
13.0
Machine-readable structure identifiers
SMILES
C1=CC(=CC=C1N/C(=N/C(=NCCCCCCN=C(/N=C(/NC2=CC=C(C=C2)Cl)\N)N)N)/N)Cl
InChI
InChI=1S/C22H30Cl2N10/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34)
InChIKey
GHXZTYHSJHQHIJ-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 56-95-1
CAS 56-95-1PubChem CID 9562059

Verified chemistry for CAS 56-95-1

Chlorhexidine Acetate

Chlorhexidine acetate is the acetate salt of chlorhexidine. It is a disinfectant used for bacterial control in hospital, agricultural and domestic environments. It has a role as an antibacterial agent, an antiinfective agent, an antifungal agent and an antifouling biocide. It contains a chlorhexidine. — ChEBI

IUPAC name
acetic acid;(1E)-2-[6-[[amino-[(E)-[amino-(4-chloroanilino)methylidene]amino]methylidene]amino]hexyl]-1-[amino-(4-chloroanilino)methylidene]guanidine
Molecular formula
C26H38Cl2N10O4
Molecular weight
625.5 g/mol
Exact mass
624.2454551 Da
Monoisotopic mass
624.2454551 Da
Topological polar surface area
252.0 Ų
Molecular complexity
679.0
Formal charge
0
Hydrogen-bond donors
8
Hydrogen-bond acceptors
6
Rotatable bonds
13
Heavy atoms
42
Covalent units
3

Names and synonyms reported to PubChem

Chlorhexidine diacetateHibitane diacetateChlorohexidine diacetate10,040 DiacetateChlorhexidini diacetas5908ZUF22YNSC-526936Chlorhexidine acetate (USP)
16 more reported names
Chlorhexidine acetate [USP]1,1'-Hexamethylene bis(5-(p-chlorophenyl)biguanide) diacetateCHEBI:81711SerdaenGout OintmentBacteriostatic gelNail fungus creamanti-bacterial gelAntibacterialTabletsNail Fungus LiquidNail Fungus SolutionAcetate, ChlorhexidineFROST-PROOFNolvasan Surgical ScrubHOQU Nail fungus creamDisinfectant Fabric Wash
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
2
Undefined bond stereocentres
0
3D conformers
0
Machine-readable structure identifiers
SMILES
CC(=O)O.CC(=O)O.C1=CC(=CC=C1N/C(=N/C(=NCCCCCCN=C(/N=C(/NC2=CC=C(C=C2)Cl)\N)N)N)/N)Cl
InChI
InChI=1S/C22H30Cl2N10.2C2H4O2/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18;2*1-2(3)4/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34);2*1H3,(H,3,4)
InChIKey
WDRFFJWBUDTUCA-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
Health Canada Cosmetic Ingredient Hotlist
Source reference
Hotlist restricted entry 26
Source record ID
restricted:26
Source version
Health Canada Hotlist 2025-08-13
Source language
English
Translation status
Original is English
Source updated
2025-08-13
Snapshot checked
2026-08-30 04:07 UTC
Validation method
strict HTML tables t1=490 and t2=90
SHA-256
8b52ff573d08373ee90121f6a701b3607e4a3d6fc748a7d56171eb53510af91a

Registered dataset notes

Dataset coverage
Administrative prohibitions, restrictions, conditions and warning requirements
Authority note
Official Health Canada compliance indicator; not a complete safety clearance
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

580
current Canada records
90
records marked Restricted
580
records from this source version
516
market records with CAS identity

Status distribution

Prohibited: 490Restricted: 90

Condition text is present on 172 of 580 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

Canada market context

Complete Hotlist snapshot

Coverage version: Health Canada Cosmetic Ingredient Hotlist, 13 August 2025

All prohibited and restricted Hotlist entries, including conditions and warning requirements published in the official list.

Verification checklist

  1. Search English/French names and CAS identifiers.
  2. Apply every restriction, concentration and label warning.
  3. Check Food and Drugs Act/Cosmetic Regulations requirements.
  4. Recheck the current Hotlist before notification or sale.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “Chlorhexidine and its salts” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Search English/French names and CAS identifiers.
  3. Apply every restriction, concentration and label warning.
  4. Check Food and Drugs Act/Cosmetic Regulations requirements.
  5. Recheck the current Hotlist before notification or sale.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECNot supplied
  • Separate condition textAvailable
  • Effective dateNot supplied
  • Snapshot hash and methodAvailable

Questions this page answers

This substance is not unrestricted: cosmetic use is subject to the conditions in the cited official record. Check product type, body area, concentration, purity and warning requirements before deciding whether a formulation is compliant.

If this row does not reproduce conditions, open the cited official detail because omission does not mean unrestricted use. The Hotlist is an administrative compliance tool, not an exhaustive safety approval list.

The record cites Hotlist restricted entry 26, source version Health Canada Hotlist 2025-08-13. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

Chlorhexidine and its salts. Hotlist restricted entry 26. Canada. Source version Health Canada Hotlist 2025-08-13. CosIng Checker regulatory record: https://cosingchecker.com/regulations/ca/records/516/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for Canada

This substance is not unrestricted: cosmetic use is subject to the conditions in the cited official record.

Check product type, body area, concentration, purity and warning requirements before deciding whether a formulation is compliant.

How to interpret the legal role

The authority uses this source as compliance guidance; the underlying legislation remains controlling.

Evidence on this page

  • Recorded outcome: Restricted
  • Legal role: Official guidance
  • Source version: Health Canada Hotlist 2025-08-13

What it does not prove

The Hotlist is an administrative compliance tool, not an exhaustive safety approval list.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity at the source

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity at the source

US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source