RestrictedOfficial guidanceCAOriginal is EnglishOfficial-source import checked
Azelaic acid and its salts
Canada Hotlist: Azelaic acid and its salts
Health Canada lists this ingredient as restricted; the listed conditions and warnings apply.
Regulatory decision and full conditions
- Status
- Restricted
- Legal role
- Official guidance
- Regulatory summary
- Health Canada lists this ingredient as restricted; the listed conditions and warnings apply.
- Conditions and restrictions
- Synonyms or related compounds: Nonanedioic acid; Disodium Azelate; Dipotassium Azelate · Maximum concentration: 14%
Substance identity
- Official source name
- Azelaic acid and its salts
- CAS
- 123-99-9; 52457-54-2; 132499-85-5; 17265-13-3; 27825-99-6
- EC
- Not supplied in this source row
- Identity mapping
- Exact CAS: 123-99-9
- Linked ingredient
- AZELAIC ACID
Linked CosIng identity data
Names and aliases
AZELAIC ACID
CosIng description: Nonanedioic acid
Recorded cosmetic function: BUFFERING, FRAGRANCE
Function pages:BUFFERING, FRAGRANCE
View the complete ingredient profileCross-market snapshot for this identity
Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.
Canada
Current recordRestricted
1 linked record · 1 with specific conditions
Open supporting recordASEAN
Prohibited
1 linked record
Open supporting recordSouth Korea
Prohibited
1 linked record · 1 with specific conditions
Open supporting recordSaudi Arabia
Restricted
1 linked record
Open supporting recordCAS 123-99-9PubChem CID 2266
Verified chemistry for CAS 123-99-9
Azelaic Acid
Nonanedioic acid is an alpha,-dicarboxylic acid that is heptane substituted at positions 1 and 7 by carboxy groups. It has a role as an antibacterial agent, an antineoplastic agent, a dermatologic drug and a plant metabolite. It is a dicarboxylic fatty acid and an alpha,omega-dicarboxylic acid. It is a conjugate acid of an azelaate and an azelaate(2-). — ChEBI
- IUPAC name
- nonanedioic acid
- Molecular formula
- C9H16O4
- Molecular weight
- 188.22 g/mol
- Exact mass
- 188.10485899 Da
- Monoisotopic mass
- 188.10485899 Da
- XLogP3
- 1.6
- Topological polar surface area
- 74.6 Ų
- Molecular complexity
- 147.0
- Formal charge
- 0
- Hydrogen-bond donors
- 2
- Hydrogen-bond acceptors
- 4
- Rotatable bonds
- 8
- Heavy atoms
- 13
- Covalent units
- 1
Names and synonyms reported to PubChem
FinaceaAnchoic acidLepargylic acid1,7-Heptanedicarboxylic acidAzelexSkinorenHeptanedicarboxylic acidEmerox 1110
16 more reported names
1,9-Nonanedioic acidEmerox 1144n-Nonanedioic acidAcido azelaicoacide azelaiqueacidum azelaicumAzelaic acid, technical grade1,7-DicarboxyheptaneZK 62498ZK-62498Finacea FoamF2VW3D43YTNSC-19493CHEBI:481314-02-00-02055 (Beilstein Handbook Reference)hydron;nonanedioate
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
- ChEBI:CHEBI:48131
- ChEMBL:CHEMBL1238
- EPA DTXSID:DTXSID8021640
- PubMed:22920095
- PubMed:22849351
- PubMed:22822212
- PubMed:22779176
- PubMed:22777226
- PubMed:22772611
- PubMed:22747347
- PubMed:22693913
- PubMed:22675394
- PubMed:22675387
- PubMed:22675033
- PubMed:22645576
Advanced structure statistics
- Defined atom stereocentres
- 0
- Undefined atom stereocentres
- 0
- Defined bond stereocentres
- 0
- Undefined bond stereocentres
- 0
- 3D pharmacophore features
- 6
- 3D rings
- 0
- 3D hydrophobes
- 0
- 3D acceptor features
- 4
- 3D donor features
- 0
- 3D anionic centres
- 2
- 3D cationic centres
- 0
- 3D conformers
- 10
- Effective 3D rotors
- 8.0
Machine-readable structure identifiers
- SMILES
C(CCCC(=O)O)CCCC(=O)O- InChI
InChI=1S/C9H16O4/c10-8(11)6-4-2-1-3-5-7-9(12)13/h1-7H2,(H,10,11)(H,12,13)- InChIKey
BDJRBEYXGGNYIS-UHFFFAOYSA-N
Evidence from additional scientific databases
NIH PubChem PUG-View
Exact identifier match2266
Attributed physical-property, hazard, environmental and use annotations.
- Boiling Point: 286.5 °C at 1.00E+02 mm Hg Source: DrugBank
- Boiling Point: 357.1 °C; 287 °C at 100 mm Hg Source: Hazardous Substances Data Bank (HSDB)
- Boiling Point: BP: 365 °C (decomposes) Source: Hazardous Substances Data Bank (HSDB)
- Boiling Point: Distills above 360 °C with partial anhydride formation. BP: 286.5 °C at 100 mm Hg; 265 °C at 50 mm Hg; 237 °C at 15 mm Hg; 225 dg C at 10 mm Hg Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: Monoclinic prismatic needles Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: Yellowish to white crystalline powder Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: Leaflets or needles Source: Hazardous Substances Data Bank (HSDB)
- Density: 1.225 g/cu cm at 25 °C Source: Hazardous Substances Data Bank (HSDB)
- pKa: 4.55 (at 25 °C) Source: DrugBank
- Dissociation Constants: pKa = 4.55 Source: Hazardous Substances Data Bank (HSDB)
- Flash Point: 210 °C (closed cup) Source: Hazardous Substances Data Bank (HSDB)
- LogP: 1.57 Source: DrugBank
- LogP: log Kow = 1.57 Source: Hazardous Substances Data Bank (HSDB)
- LogP: 1.57 Source: Human Metabolome Database (HMDB)
- Melting Point: 106.5 °C Source: DrugBank
- Melting Point: 160.5 °C Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: 106.5 °C Source: Human Metabolome Database (HMDB)
- Physical Description: Dry Powder; Other Solid; Large Crystals Source: EPA Chemical Data Reporting (CDR)
- Physical Description: Yellowish to white solid; [HSDB] White flakes; [Acros Organics MSDS] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Physical Description: Solid Source: Human Metabolome Database (HMDB)
- Refractive Index: Index of refraction = 1.4303 at 111 °C Source: Hazardous Substances Data Bank (HSDB)
- Solubility: 2400 mg/L (at 20 °C) Source: DrugBank
- Solubility: Slightly soluble in ethy ether, benzene, DMSO; soluble in ethanol Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Soluble in hot water, alcohol and organic solvents Source: Hazardous Substances Data Bank (HSDB)
- Solubility: One liter of water dissolves 1.0 g at 1.0 °C; 2.4 g at 20 °C; 8.2 g at 50 °C; 22 g at 50 °C ... 1000 g ether dissolves 18.8 g at 11 °C and 26.8 g at 15 °C Source: Hazardous Substances Data Bank (HSDB)
- Solubility: In water, 2.40X10+3 mg/L at 20 °C Source: Hazardous Substances Data Bank (HSDB)
- Solubility: 2.4 mg/mL Source: Human Metabolome Database (HMDB)
- Vapor Pressure: 0.00000001 [mmHg] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Vapor Pressure: 1.07X10-8 mm Hg at 25 °C Source: Hazardous Substances Data Bank (HSDB)
- Carcinogen Classification: No indication of carcinogenicity to humans (not listed by IARC). Source: Toxin and Toxin Target Database (T3DB)
- Exposure Routes: Approximately 4% of the topically applied azelaic acid is systemically absorbed. Source: Toxin and Toxin Target Database (T3DB)
- Note: This chemical does not meet GHS hazard criteria for 6.5% (71 of 1087) of reports. Source: European Chemicals Agency (ECHA)
- Signal: Warning Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H315 (40.2%): Causes skin irritation [Warning Skin corrosion/irritation]; H319 (93.4%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P264, P264+P265, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, and P362+P364 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 1087 reports by companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 71 of 1087 reports by companies.; There are 11 notifications provided by 1016 of 1087 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Cosmetic Ingredient Review Finding(s): Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org Source: Cosmetic Ingredient Review (CIR)
- Toxicity Summary: The exact mechanism of action of azelaic acid is not known. It is thought that azelaic acid manifests its antibacterial effects by inhibiting the synthesis of cellular protein in anaerobic and aerobic bacteria, especially Staphylococcus epidermidis and Propionibacterium acnes. In aerobic bacteria, azelaic acid reversibly inhibits several oxidoreductive enzymes including tyrosinase, mitochondrial enzymes of the respiratory chain, thioredoxin reductase, 5-alpha-reductase, and DNA polymerases. In anaerobic bacteria, azelaic acid impedes glycolysis. Along with these actions, azelaic acid also improves acne vulgaris by normalizing the keratin process and decreasing microcomedo formation. Azelaic acid may be effective against both inflamed and noninflamed lesions. Specifically, azelaic acid reduces the thickness of the stratum corneum, shrinks keratohyalin granules by reducing the amount and distribution of filaggrin (a component of keratohyalin) in epidermal layers, and lowers the number of keratohyalin granules. Source: Toxin and Toxin Target Database (T3DB)
- Environmental Bioconcentration: An estimated BCF of 3 was calculated in fish for 1,7-heptanecarboxylic acid(SRC), using a log Kow of 1.57(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 170(SRC), determined from a log Kow of 1.57(2) and a regression-derived equation(3), indicates that 1,7-heptanecarboxylic acid is expected to have moderate mobility in soil(SRC). The pKa of 1,7-heptanecarboxylic acid is 4.55(4), indicating that this compound will exist almost entirely in the anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5). Volatilization from moist soil is not expected because the acid exists as an anion and anions do not volatilize. 1,7-Heptanecarboxylic acid is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 1.07X10-8 mm Hg(6). Biodegradation data were not available(SRC, 2008) but straight chain carboxylic acids are expected to readily biodergade(7). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 170(SRC), determined from a log Kow of 1.57(2) and a regression-derived equation(3), indicates that 1,7-heptanecarboxylic acid is expected to adsorb to suspended solids and sediment(SRC). A pKa of 4.55(4) indicates 1,7-heptanecarboxylic acid will exist almost entirely in the anion form at pH values of 5 to 9 and therefore volatilization from water surfaces is not expected to be an important fate process(5). According to a classification scheme(6), an estimated BCF of 3(SRC), from its log Kow(2) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Biodegradation data were not available(SRC, 2008) but straight chain carboxylic acids are expected to readily biodergade(8). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1,7-heptanecarboxylic acid, which has a vapor pressure of 1.07X10-8 mm Hg at 25 °C(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase 1,7-heptanecarboxylic acid is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 40 hrs(SRC), calculated from its rate constant of 9.8X10-12 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Particulate-phase 1,7-heptanecarboxylic acid may be removed from the air by wet or dry deposition(SRC). 1,7-Heptanecarboxylic acid does not contain chromophores that absorb at wavelengths >290 nm(4) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Consumer Uses: Not Known or Reasonably Ascertainable Source: EPA Chemical Data Reporting (CDR)
- Industry Uses: Monomers; Lubricating agent; Wetting agent (non-aqueous); Binder; Intermediate; Not Known or Reasonably Ascertainable; Corrosion inhibitor; Plasticizer Source: EPA Chemical Data Reporting (CDR)
- Cosmetic Ingredient Review Link: CIR ingredient: Azelaic Acid Source: Cosmetic Ingredient Review (CIR)
- Sources/Uses: Found in rancid oleic acid; [Merck Index] Used in organic syntheses, lacquers, alkyd resins, low-temperature plasticizers, adhesives, polyamides, urethane elastomers, and for the treatment of acne; [HSDB] Natural component of foods such as whole grain cereals and animal products; [REPROTOX] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Industrial Processes with risk of exposure: Painting (Pigments, Binders, and Biocides) [Category: Paint]; Working with Glues and Adhesives [Category: Other]; Plastic Composites Manufacturing [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Uses: Azelaic acid is used in lacquers, alkyd resins, plasticizers, adhesives, polyamides, urethane elastomers, and organic syntheses. Azelaic acid is also used in treating of acne. Source: Hazardous Substances Data Bank (HSDB)
- Uses: Organic synthesis, lacquers, product of hydrotropic salts, alkyd resins, polyamides, polyester adhesives, low-temperature plasticizers, urethane elastomers Source: Hazardous Substances Data Bank (HSDB)
- Uses: Use (kg; approx.) in Germany (2009): >1000; Consumption (g per capita; approx.) in Germany (2009): 0.0122; Calculated removal (%): 92.2 Source: NORMAN Suspect List Exchange
- Uses: For the topical treatment of mild-to-moderate inflammatory acne vulgaris. Source: Toxin and Toxin Target Database (T3DB)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
CAS 132499-85-5PubChem CID 159815
Verified chemistry for CAS 132499-85-5
Azelaic acid, disodium salt
- IUPAC name
- disodium;nonanedioate
- Molecular formula
- C9H14Na2O4
- Molecular weight
- 232.18 g/mol
- Exact mass
- 232.06874749 Da
- Monoisotopic mass
- 232.06874749 Da
- Topological polar surface area
- 80.3 Ų
- Molecular complexity
- 136.0
- Formal charge
- 0
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 4
- Rotatable bonds
- 6
- Heavy atoms
- 15
- Covalent units
- 3
Names and synonyms reported to PubChem
RefChem:135012Disodium azelateNonanedioic acid, disodium saltdisodium nonanedioateNonanedioic acid, sodium salt (1:2)0P4H8NH3UJUNII-0P4H8NH3UJsodium azelate
3 more reported names
EINECS 241-298-4SODIUM AZELATE (2:1)DB-254558
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
- EPA DTXSID:DTXSID40889659
Advanced structure statistics
- Defined atom stereocentres
- 0
- Undefined atom stereocentres
- 0
- Defined bond stereocentres
- 0
- Undefined bond stereocentres
- 0
- 3D conformers
- 0
Machine-readable structure identifiers
- SMILES
C(CCCC(=O)[O-])CCCC(=O)[O-].[Na+].[Na+]- InChI
InChI=1S/C9H16O4.2Na/c10-8(11)6-4-2-1-3-5-7-9(12)13;;/h1-7H2,(H,10,11)(H,12,13);;/q;2*+1/p-2- InChIKey
QFYNUCAKHMSPCY-UHFFFAOYSA-L
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
CAS 17265-13-3PubChem CID 159815
Verified chemistry for CAS 17265-13-3
Azelaic acid, disodium salt
- IUPAC name
- disodium;nonanedioate
- Molecular formula
- C9H14Na2O4
- Molecular weight
- 232.18 g/mol
- Exact mass
- 232.06874749 Da
- Monoisotopic mass
- 232.06874749 Da
- Topological polar surface area
- 80.3 Ų
- Molecular complexity
- 136.0
- Formal charge
- 0
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 4
- Rotatable bonds
- 6
- Heavy atoms
- 15
- Covalent units
- 3
Names and synonyms reported to PubChem
RefChem:135012Disodium azelateNonanedioic acid, disodium saltdisodium nonanedioateNonanedioic acid, sodium salt (1:2)0P4H8NH3UJUNII-0P4H8NH3UJsodium azelate
3 more reported names
EINECS 241-298-4SODIUM AZELATE (2:1)DB-254558
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
- EPA DTXSID:DTXSID40889659
Advanced structure statistics
- Defined atom stereocentres
- 0
- Undefined atom stereocentres
- 0
- Defined bond stereocentres
- 0
- Undefined bond stereocentres
- 0
- 3D conformers
- 0
Machine-readable structure identifiers
- SMILES
C(CCCC(=O)[O-])CCCC(=O)[O-].[Na+].[Na+]- InChI
InChI=1S/C9H16O4.2Na/c10-8(11)6-4-2-1-3-5-7-9(12)13;;/h1-7H2,(H,10,11)(H,12,13);;/q;2*+1/p-2- InChIKey
QFYNUCAKHMSPCY-UHFFFAOYSA-L
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
CAS 52457-54-2PubChem CID 162680
Verified chemistry for CAS 52457-54-2
Azelaic acid, dipotassium salt
- IUPAC name
- dipotassium;nonanedioate
- Molecular formula
- C9H14K2O4
- Molecular weight
- 264.40 g/mol
- Exact mass
- 264.01662189 Da
- Monoisotopic mass
- 264.01662189 Da
- Topological polar surface area
- 80.3 Ų
- Molecular complexity
- 136.0
- Formal charge
- 0
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 4
- Rotatable bonds
- 6
- Heavy atoms
- 15
- Covalent units
- 3
Names and synonyms reported to PubChem
RefChem:589030Dipotassium azelateAzelaic acid, potassium saltDipotassium nonanedioateNonanedioic acid, dipotassium saltNonanedioic acid, potassium salt (1:2)Nonanedioic acid, potassium saltPotassium nonanedioate
5 more reported names
Potassium azelateEINECS 257-931-2UNII-C98170693JEINECS 243-190-2RTMGQVSGXYZVTE-UHFFFAOYSA-L
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
- EPA DTXSID:DTXSID501014948
Advanced structure statistics
- Defined atom stereocentres
- 0
- Undefined atom stereocentres
- 0
- Defined bond stereocentres
- 0
- Undefined bond stereocentres
- 0
- 3D conformers
- 0
Machine-readable structure identifiers
- SMILES
C(CCCC(=O)[O-])CCCC(=O)[O-].[K+].[K+]- InChI
InChI=1S/C9H16O4.2K/c10-8(11)6-4-2-1-3-5-7-9(12)13;;/h1-7H2,(H,10,11)(H,12,13);;/q;2*+1/p-2- InChIKey
RTMGQVSGXYZVTE-UHFFFAOYSA-L
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Official source and provenance
- Registered source
- Health Canada Cosmetic Ingredient Hotlist
- Source reference
- Hotlist restricted entry 12
- Source record ID
restricted:12- Source version
- Health Canada Hotlist 2025-08-13
- Source language
- English
- Translation status
- Original is English
- Source updated
- 2025-08-13
- Snapshot checked
- 2026-08-30 04:07 UTC
- Validation method
- strict HTML tables t1=490 and t2=90
- SHA-256
8b52ff573d08373ee90121f6a701b3607e4a3d6fc748a7d56171eb53510af91a
Registered dataset notes
- Dataset coverage
- Administrative prohibitions, restrictions, conditions and warning requirements
- Authority note
- Official Health Canada compliance indicator; not a complete safety clearance
How this record fits the market dataset
580
current Canada records
90
records marked Restricted
580
records from this source version
516
market records with CAS identity
Status distribution
Condition text is present on 172 of 580 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.
Canada market context
Complete Hotlist snapshot
Coverage version: Health Canada Cosmetic Ingredient Hotlist, 13 August 2025
All prohibited and restricted Hotlist entries, including conditions and warning requirements published in the official list.
Verification checklist
- Search English/French names and CAS identifiers.
- Apply every restriction, concentration and label warning.
- Check Food and Drugs Act/Cosmetic Regulations requirements.
- Recheck the current Hotlist before notification or sale.
Official market sources
- Health Canada Cosmetic Ingredient HotlistOfficial Health Canada compliance indicator; not a complete safety clearance
Verification workflow and record completeness
Before using this result in a compliance decision
- Confirm that “Azelaic acid and its salts” and every CAS/EC identifier refer to the material in your supplier specification.
- Search English/French names and CAS identifiers.
- Apply every restriction, concentration and label warning.
- Check Food and Drugs Act/Cosmetic Regulations requirements.
- Recheck the current Hotlist before notification or sale.
- Document the source version and recheck the regulator before manufacture, notification or market placement.
Fields available in this record
- Official substance nameAvailable
- CASAvailable
- ECNot supplied
- Separate condition textAvailable
- Effective dateNot supplied
- Snapshot hash and methodAvailable
Questions this page answers
This substance is not unrestricted: cosmetic use is subject to the conditions in the cited official record. Check product type, body area, concentration, purity and warning requirements before deciding whether a formulation is compliant.
If this row does not reproduce conditions, open the cited official detail because omission does not mean unrestricted use. The Hotlist is an administrative compliance tool, not an exhaustive safety approval list.
The record cites Hotlist restricted entry 12, source version Health Canada Hotlist 2025-08-13. Open the official source.
No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.
Stable citation
Azelaic acid and its salts. Hotlist restricted entry 12. Canada. Source version Health Canada Hotlist 2025-08-13. CosIng Checker regulatory record: https://cosingchecker.com/regulations/ca/records/502/
Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.
Interpretation and limits for Canada
This substance is not unrestricted: cosmetic use is subject to the conditions in the cited official record.
Check product type, body area, concentration, purity and warning requirements before deciding whether a formulation is compliant.
How to interpret the legal role
The authority uses this source as compliance guidance; the underlying legislation remains controlling.
Evidence on this page
- Recorded outcome: Restricted
- Legal role: Official guidance
- Source version: Health Canada Hotlist 2025-08-13
What it does not prove
The Hotlist is an administrative compliance tool, not an exhaustive safety approval list.
Further authoritative substance research
These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.
Cosmetic Ingredient Review safety assessments
Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents
Independent expert review considered by FDA; not a government approval or binding market rule
Research this identity at the sourceFDA Global Substance Registration System
UNII identifiers, preferred names, substance types, codes and public substance relationships
Identity registry only; UNII availability does not imply FDA review or approval
Research this identity at the sourceILO/WHO International Chemical Safety Cards
Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals
International occupational chemical-safety reference; not cosmetic-use approval
Research this identity at the sourceJapan NITE-CHRIP
Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information
Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules
Research this identity at the sourceNIOSH Pocket Guide to Chemical Hazards
REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals
US occupational-health guidance and limits; not a cosmetic ingredient decision
Research this identity at the sourceOECD eChemPortal
Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records
Discovery gateway; each linked authority remains responsible for its data
Research this identity at the sourceUS EPA CompTox CTX APIs
API key required for importDTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data
Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality
Research this identity at the source