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Toluene Diisocyanates

Canada Hotlist: Toluene Diisocyanates

Health Canada lists this ingredient as prohibited for use in cosmetic products.

All Canada recordsOpen ingredient profileCompare all marketsOpen official source

Regulatory decision and full conditions

Status
Prohibited
Legal role
Official guidance
Regulatory summary
Health Canada lists this ingredient as prohibited for use in cosmetic products.
Conditions and restrictions
Synonyms or related compounds: TDIs; 2,4-diisocyanato-1-methyl-benzene (2,4-toluene diisocyanate); 2,6-diisocyanato-1-methyl-benzene (2,6 toluene diisocyanate); 1,3-diisocyanatomethyl-benzene (mixed isomers of toluene diisocyanate)

Substance identity

Official source name
Toluene Diisocyanates
CAS
584-84-9; 91-08-7; 26471-62-5
EC
247-722-4 [1] / 209-544-5 [2] / 202-039-0 [3]
Identity mapping
cas_number
Linked ingredient
TOLUENE DIISOCYANATE
Search this identity across the siteCAS 584-84-9CAS 91-08-7CAS 26471-62-5EC 247-722-4EC 209-544-5EC 202-039-0

Linked CosIng identity data

Names and aliases

TOLUENE DIISOCYANATE

CosIng description: m-tolylidene diisocyanate [1]; 4-methyl-m-phenylene diisocyanate [2]; 2-methyl-m-phenylene diisocyanate [3]

EU inventory restriction note: CMR2 II/1118, II/1119, II/1120

Recorded cosmetic function: NOT REPORTED

Function pages:NOT REPORTED

View the complete ingredient profile

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

10 market datasets
PubChem 2D chemical structure for CAS 584-84-9
CAS 584-84-9PubChem CID 11443

Verified chemistry for CAS 584-84-9

Toluene 2,4-Diisocyanate

Toluene 2,4-diisocyanate is a toluene meta-diisocyanate in which the isocyanato groups are at positions 2 and 4 relative to the methyl group on the benzene ring. It has a role as an allergen and a hapten. — ChEBI

IUPAC name
2,4-diisocyanato-1-methylbenzene
Molecular formula
C9H6N2O2
Molecular weight
174.16 g/mol
Exact mass
174.042927438 Da
Monoisotopic mass
174.042927438 Da
XLogP3
3.9
Topological polar surface area
58.9 Ų
Molecular complexity
265.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
4
Rotatable bonds
2
Heavy atoms
13
Covalent units
1

Names and synonyms reported to PubChem

2,4-Toluene diisocyanate2,4-DiisocyanatotolueneTolylene-2,4-diisocyanateToluene-2,4-diisocyanate2,4-Tolylene diisocyanate2,4-TDIHylene tlcBenzene, 2,4-diisocyanato-1-methyl-
16 more reported names
Di-iso-cyanatolueneToluylene-2,4-diisocyanate2,4-ToluenediisocyanateHylene TDiisocyanat-toluolMondur TDToluen-disocianatoTuluylendiisocyanatMondur TDSDesmodur T80Tolueen-diisocyanaatToluilenodwuizocyjanianMondur TD-80Nacconate IOOCresorcinol diisocyanateTolyene 2,4-diisocyanate
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
3
3D rings
1
3D hydrophobes
0
3D acceptor features
2
3D donor features
0
3D anionic centres
0
3D cationic centres
0
3D conformers
10
Effective 3D rotors
2.0
Machine-readable structure identifiers
SMILES
CC1=C(C=C(C=C1)N=C=O)N=C=O
InChI
InChI=1S/C9H6N2O2/c1-7-2-3-8(10-5-12)4-9(7)11-6-13/h2-4H,1H3
InChIKey
DVKJHBMWWAPEIU-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 91-08-7
CAS 91-08-7PubChem CID 7040

Verified chemistry for CAS 91-08-7

Toluene 2,6-Diisocyanate

Toluene 2,6-diisocyanate is a toluene meta-diisocyanate in which the isocyanato groups are at positions 2 and 6 relative to the methyl group on the benzene ring. It has a role as an allergen and a hapten. — ChEBI

IUPAC name
1,3-diisocyanato-2-methylbenzene
Molecular formula
C9H6N2O2
Molecular weight
174.16 g/mol
Exact mass
174.042927438 Da
Monoisotopic mass
174.042927438 Da
XLogP3
3.9
Topological polar surface area
58.9 Ų
Molecular complexity
239.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
4
Rotatable bonds
2
Heavy atoms
13
Covalent units
1

Names and synonyms reported to PubChem

2,6-DiisocyanatotolueneToluene-2,6-diisocyanate2,6-TOLUENE DIISOCYANATE2,6-TDIm-Tolylene diisocyanateBenzene, 1,3-diisocyanato-2-methyl-meta-Tolylene diisocyanate2,6-Diisocyanato-1-methylbenzene
16 more reported names
2-Methyl-meta-phenylene isocyanateTolylene 2,6-diisocyanateIsocyanic acid, 2-methyl-meta-phenylene esterBenzene, 2,6-diisocyanato-1-methyl-CHEBI:53557Isocyanic acid, 2-methyl-m-phenylene ester2-Methyl-m-phenylene isocyanate2,6-toluene-diisocyanateHylene ticRefChem:445869202-039-02-Methyl-m-phenylene diisocyanateTolylene-2,6-diisocyanate2,6-toluenediisocyanate1,3-diisocyanato-2-methyl-benzeneCCRIS 3741
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
3
3D rings
1
3D hydrophobes
0
3D acceptor features
2
3D donor features
0
3D anionic centres
0
3D cationic centres
0
3D conformers
6
Effective 3D rotors
2.0
Machine-readable structure identifiers
SMILES
CC1=C(C=CC=C1N=C=O)N=C=O
InChI
InChI=1S/C9H6N2O2/c1-7-8(10-5-12)3-2-4-9(7)11-6-13/h2-4H,1H3
InChIKey
RUELTTOHQODFPA-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
Health Canada Cosmetic Ingredient Hotlist
Source reference
Hotlist prohibited entry 458
Source record ID
prohibited:458
Source version
Health Canada Hotlist 2025-08-13
Source language
English
Translation status
Original is English
Source updated
2025-08-13
Snapshot checked
2026-08-30 04:07 UTC
Validation method
strict HTML tables t1=490 and t2=90
SHA-256
8b52ff573d08373ee90121f6a701b3607e4a3d6fc748a7d56171eb53510af91a

Registered dataset notes

Dataset coverage
Administrative prohibitions, restrictions, conditions and warning requirements
Authority note
Official Health Canada compliance indicator; not a complete safety clearance
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

580
current Canada records
490
records marked Prohibited
580
records from this source version
516
market records with CAS identity

Status distribution

Prohibited: 490Restricted: 90

Condition text is present on 172 of 580 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

Canada market context

Complete Hotlist snapshot

Coverage version: Health Canada Cosmetic Ingredient Hotlist, 13 August 2025

All prohibited and restricted Hotlist entries, including conditions and warning requirements published in the official list.

Verification checklist

  1. Search English/French names and CAS identifiers.
  2. Apply every restriction, concentration and label warning.
  3. Check Food and Drugs Act/Cosmetic Regulations requirements.
  4. Recheck the current Hotlist before notification or sale.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “Toluene Diisocyanates” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Search English/French names and CAS identifiers.
  3. Apply every restriction, concentration and label warning.
  4. Check Food and Drugs Act/Cosmetic Regulations requirements.
  5. Recheck the current Hotlist before notification or sale.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECAvailable
  • Separate condition textAvailable
  • Effective dateNot supplied
  • Snapshot hash and methodAvailable

Questions this page answers

This official record identifies the substance as prohibited for cosmetic use in the stated market scope. Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. The Hotlist is an administrative compliance tool, not an exhaustive safety approval list.

The record cites Hotlist prohibited entry 458, source version Health Canada Hotlist 2025-08-13. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

Toluene Diisocyanates. Hotlist prohibited entry 458. Canada. Source version Health Canada Hotlist 2025-08-13. CosIng Checker regulatory record: https://cosingchecker.com/regulations/ca/records/458/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for Canada

This official record identifies the substance as prohibited for cosmetic use in the stated market scope.

Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

How to interpret the legal role

The authority uses this source as compliance guidance; the underlying legislation remains controlling.

Evidence on this page

  • Recorded outcome: Prohibited
  • Legal role: Official guidance
  • Source version: Health Canada Hotlist 2025-08-13

What it does not prove

The Hotlist is an administrative compliance tool, not an exhaustive safety approval list.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity at the source

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity at the source

US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source