Why does CAS 91-08-7 appear in more than one EU cosmetic annex?

A substance identified by CAS 91-08-7 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 91-08-7?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 91-08-7 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 91-08-7

Q: How do I use CAS 91-08-7 for compliance screening?

Cross-reference CAS 91-08-7 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 91-08-7 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 91-08-7

CAS 91-08-7PubChem CID 7040

Toluene 2,6-Diisocyanate

Toluene 2,6-diisocyanate is a toluene meta-diisocyanate in which the isocyanato groups are at positions 2 and 6 relative to the methyl group on the benzene ring. It has a role as an allergen and a hapten. — ChEBI

IUPAC name: 1,3-diisocyanato-2-methylbenzene

Molecular formula: C9H6N2O2
Molecular weight: 174.16 g/mol
Exact mass: 174.042927438 Da
XLogP3: 3.9
Topological polar surface area: 58.9 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 0

Also known as

2,6-DiisocyanatotolueneToluene-2,6-diisocyanate2,6-TOLUENE DIISOCYANATE2,6-TDIm-Tolylene diisocyanateBenzene, 1,3-diisocyanato-2-methyl-meta-Tolylene diisocyanate2,6-Diisocyanato-1-methylbenzene

16 more reported names

2-Methyl-meta-phenylene isocyanateTolylene 2,6-diisocyanateIsocyanic acid, 2-methyl-meta-phenylene esterBenzene, 2,6-diisocyanato-1-methyl-CHEBI:53557Isocyanic acid, 2-methyl-m-phenylene ester2-Methyl-m-phenylene isocyanate2,6-toluene-diisocyanateHylene ticRefChem:445869202-039-02-Methyl-m-phenylene diisocyanateTolylene-2,6-diisocyanate2,6-toluenediisocyanate1,3-diisocyanato-2-methyl-benzeneCCRIS 3741

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:53557
ChEMBL:CHEMBL1443390
EPA DTXSID:DTXSID2026157
PubMed:22952646
PubMed:21458408
PubMed:21447151
PubMed:20957106
PubMed:20933064
PubMed:20466021
PubMed:20085231
PubMed:20032816
PubMed:18291409
PubMed:18280204
PubMed:17431479
PubMed:16434466

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 91-08-7

1 total

Annex

Entry

1118

2-Methyl-m-phenylene diisocyanate (Toluene 2,6-diisocyanate)

202-039-0

CMR

How CAS 91-08-7 is used on this site

CAS 91-08-7 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 91-08-7 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 91-08-7 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.

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