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ProhibitedOfficial guidanceCAOriginal is EnglishOfficial-source import checked

Prostaglandins, their salts and derivatives and their analogs

Canada Hotlist: Prostaglandins, their salts and derivatives and their analogs

Health Canada lists this ingredient as prohibited for use in cosmetic products.

All Canada recordsOpen ingredient profileCompare all marketsOpen official source

Regulatory decision and full conditions

Status
Prohibited
Legal role
Official guidance
Regulatory summary
Health Canada lists this ingredient as prohibited for use in cosmetic products.
Conditions and restrictions
Synonyms or related compounds: Alprostadil; Bimatoprost; Cloprostenol; Dinoprostone; Epoprostenol; Fluprostenol; Latanoprost; Misoprostol; Tafluprost; Travoprost; Treprostinil; Unoprostone; Dehydrolatanoprost; Ethyl Travoprostamide; Trifluoromethyl Dechloro Ethylprostenolamide; Isopropyl Phenylhydroxypentene Dihydroxycyclopentylheptenate; Isopropyl Cloprostenate

Substance identity

Official source name
Prostaglandins, their salts and derivatives and their analogs
CAS
745-65-3; 155206-00-1; 40665-92-7; 363-24-6; 35121-78-9; 40666-16-8; 130209-82-4; 59122-46-2; 209860-87-7; 157283-68-6; 81846-19-7; 120373-36-6; 130209-76-6; 1005193-64-5; 157283-66-4
EC
Not supplied in this source row
Identity mapping
Exact CAS: 209860-87-7
Linked ingredient
TAFLUPROST
Search this identity across the siteCAS 745-65-3CAS 155206-00-1CAS 40665-92-7CAS 363-24-6CAS 35121-78-9CAS 40666-16-8CAS 130209-82-4CAS 59122-46-2CAS 209860-87-7CAS 157283-68-6CAS 81846-19-7CAS 120373-36-6CAS 130209-76-6CAS 1005193-64-5CAS 157283-66-4

Linked CosIng identity data

Names and aliases

TAFLUPROSTtafluprost

CosIng description: Isopropyl (5Z)-7-{(1R,2R,3R,5S)-2-((1E)-3,3-difluoro-4-phenoxybut-1- enyl)-3,5-dihydroxycyclopentyl}hept-5-enoate

Recorded cosmetic function: HAIR CONDITIONING

Function pages:HAIR CONDITIONING

View the complete ingredient profile

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

3 market datasets
PubChem 2D chemical structure for CAS 1005193-64-5
CAS 1005193-64-5PubChem CID 50940350

Verified chemistry for CAS 1005193-64-5

TrifluoroMethyl Dechloro

IUPAC name
(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]cyclopentyl]-N-ethylhept-5-enamide
Molecular formula
C25H34F3NO5
Molecular weight
485.5 g/mol
Exact mass
485.23890767 Da
Monoisotopic mass
485.23890767 Da
XLogP3
3.0
Topological polar surface area
99.0 Ų
Molecular complexity
669.0
Formal charge
0
Hydrogen-bond donors
4
Hydrogen-bond acceptors
8
Rotatable bonds
12
Heavy atoms
34
Covalent units
1

Names and synonyms reported to PubChem

N-Ethyl Fluprostenol Carboxamide(5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]cyclopentyl]-N-ethyl-5-heptenamideTrifluoroMethylDechloroC25H34F3NO5Trifluoromethyl Dechloro Ethylcloprostenolamide(Z)-7-((1R,2R,3R,5S)-3,5-Dihydroxy-2-((R,E)-3-hydroxy-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)cyclopentyl)-N-ethylhept-5-enamide(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]cyclopentyl]-N-ethyl-hept-5-enamide
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
Advanced structure statistics
Defined atom stereocentres
5
Undefined atom stereocentres
0
Defined bond stereocentres
2
Undefined bond stereocentres
0
3D pharmacophore features
12
3D rings
2
3D hydrophobes
1
3D acceptor features
5
3D donor features
4
3D anionic centres
0
3D cationic centres
0
3D conformers
10
Effective 3D rotors
15.0
Machine-readable structure identifiers
SMILES
CCNC(=O)CCC/C=C\C[C@H]1[C@H](C[C@H]([C@@H]1/C=C/[C@H](COC2=CC=CC(=C2)C(F)(F)F)O)O)O
InChI
InChI=1S/C25H34F3NO5/c1-2-29-24(33)11-6-4-3-5-10-20-21(23(32)15-22(20)31)13-12-18(30)16-34-19-9-7-8-17(14-19)25(26,27)28/h3,5,7-9,12-14,18,20-23,30-32H,2,4,6,10-11,15-16H2,1H3,(H,29,33)/b5-3-,13-12+/t18-,20-,21-,22+,23-/m1/s1
InChIKey
GAAVJEMZITUZOC-XBUSSCQASA-N

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match50940350

Attributed physical-property, hazard, environmental and use annotations.

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBINo exact record2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 120373-36-6
CAS 120373-36-6PubChem CID 5311236

Verified chemistry for CAS 120373-36-6

Unoprostone

IUPAC name
(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-(3-oxodecyl)cyclopentyl]hept-5-enoic acid
Molecular formula
C22H38O5
Molecular weight
382.5 g/mol
Exact mass
382.27192431 Da
Monoisotopic mass
382.27192431 Da
XLogP3
3.7
Topological polar surface area
94.8 Ų
Molecular complexity
460.0
Formal charge
0
Hydrogen-bond donors
3
Hydrogen-bond acceptors
5
Rotatable bonds
15
Heavy atoms
27
Covalent units
1

Names and synonyms reported to PubChem

unoprostona13,14-dihydro-15-keto-20-ethyl PGF2alpha6X4F561V3W(5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-(3-oxodecyl)cyclopentyl]hept-5-enoic acidCHEBI:39455(+)-(Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-(3-oxodecyl)cyclopentyl)-5-heptenoic acid9,11-dihydroxy-15-oxo-20a,20b-dihomoprost-5Z-en-1-oic acid(5Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-(3-oxodecyl)cyclopentyl)hept-5-enoic acid
16 more reported names
unoprostonumRefChem:1100656S01EE02Unoprostone [MI]Unoprostone [INN]UnoprostaneUnoprostone (INN)13,14-Dihydro-15-keto-20-ethyl prostaglandin f2alphaUNII-6X4F561V3WUNOPROSTONE [VANDF]UNOPROSTONE [WHO-DD]HMS3648D22EBC-26874DA-68484HY-106916CS-0026907
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
4
Undefined atom stereocentres
0
Defined bond stereocentres
1
Undefined bond stereocentres
0
3D pharmacophore features
13
3D rings
1
3D hydrophobes
4
3D acceptor features
5
3D donor features
2
3D anionic centres
1
3D cationic centres
0
3D conformers
10
Effective 3D rotors
16.0
Machine-readable structure identifiers
SMILES
CCCCCCCC(=O)CC[C@H]1[C@@H](C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O
InChI
InChI=1S/C22H38O5/c1-2-3-4-5-8-11-17(23)14-15-19-18(20(24)16-21(19)25)12-9-6-7-10-13-22(26)27/h6,9,18-21,24-25H,2-5,7-8,10-16H2,1H3,(H,26,27)/b9-6-/t18-,19-,20+,21-/m1/s1
InChIKey
TVHAZVBUYQMHBC-SNHXEXRGSA-N

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match5311236

Attributed physical-property, hazard, environmental and use annotations.

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 130209-76-6
CAS 130209-76-6PubChem CID 5283107

Verified chemistry for CAS 130209-76-6

17-phenyl-trinor-PGF2alpha isopropyl ester

IUPAC name
propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxy-5-phenylpent-1-enyl]cyclopentyl]hept-5-enoate
Molecular formula
C26H38O5
Molecular weight
430.6 g/mol
Exact mass
430.27192431 Da
Monoisotopic mass
430.27192431 Da
XLogP3
3.8
Topological polar surface area
87.0 Ų
Molecular complexity
564.0
Formal charge
0
Hydrogen-bond donors
3
Hydrogen-bond acceptors
5
Rotatable bonds
13
Heavy atoms
31
Covalent units
1

Names and synonyms reported to PubChem

isopropyl 9S,11R,15S-trihydroxy-17-phenyl-18,19,20-trinor-5Z,13E-prostadienoateRefChem:1057638Bimatoprost isopropyl ester17-Phenyl trinor Pgf2alpha-IprdehydrolatanoprostPhDH 100A1IFH52MD8T17-Phenyl trinor PGF2|A isopropyl ester
16 more reported names
17-Phenyl-18,19,20-trinor-pgf2alpha-1-isopropyl ester17-phenyl trinor PGF2alpha isopropyl esterisopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-5-phenylpent-1-en-1-yl)cyclopentyl)hept-5-enoatePhdh100A5-Heptenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenyl-1-penten-1-yl]cyclopentyl]-, 1-methylethyl ester, (5Z)-UNII-1IFH52MD8TBimatoprost Acid Isopropyl Ester5-HEPTENOIC ACID, 7-((1R,2R,3R,5S)-3,5-DIHYDROXY-2-((1E,3S)-3-HYDROXY-5-PHENYL-1-PENTEN-1-YL)CYCLOPENTYL)-, 1-METHYLETHYL ESTER, (5Z)-PGF2Alpha,17-phenylCHEBI:137717JGZRPRSJSQLFBO-FWPUOYPASA-NHMS3648J1817-Phenyl-18,19,20-trinor-prostaglandin F2alpha-1-isopropyl esterFA 26:7;O3HY-116161A(1R-(1alpha(Z),2beta(1E,3S*),3alpha,5alpha))-1-Methylethyl 7-(3,5-dihydroxy-2-(3-hydroxy-5-phenyl-1-pentenyl)cyclopentyl)-5-heptenoate
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
5
Undefined atom stereocentres
0
Defined bond stereocentres
2
Undefined bond stereocentres
0
3D pharmacophore features
11
3D rings
2
3D hydrophobes
2
3D acceptor features
4
3D donor features
3
3D anionic centres
0
3D cationic centres
0
3D conformers
10
Effective 3D rotors
14.0
Machine-readable structure identifiers
SMILES
CC(C)OC(=O)CCC/C=C\C[C@H]1[C@H](C[C@H]([C@@H]1/C=C/[C@H](CCC2=CC=CC=C2)O)O)O
InChI
InChI=1S/C26H38O5/c1-19(2)31-26(30)13-9-4-3-8-12-22-23(25(29)18-24(22)28)17-16-21(27)15-14-20-10-6-5-7-11-20/h3,5-8,10-11,16-17,19,21-25,27-29H,4,9,12-15,18H2,1-2H3/b8-3-,17-16+/t21-,22+,23+,24-,25+/m0/s1
InChIKey
JGZRPRSJSQLFBO-FWPUOYPASA-N

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match5283107

Attributed physical-property, hazard, environmental and use annotations.

  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H302+H312+H332 (100%): Harmful if swallowed, in contact with skin or if inhaled [Warning Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]; H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]; H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]; H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation]; H360 (100%): May damage fertility or the unborn child [Danger Reproductive toxicity] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P261, P264, P270, P271, P280, P301+P317, P302+P352, P304+P340, P317, P318, P321, P330, P362+P364, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory. Source: European Chemicals Agency (ECHA)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 130209-82-4
CAS 130209-82-4PubChem CID 5311221

Verified chemistry for CAS 130209-82-4

Latanoprost

IUPAC name
propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoate
Molecular formula
C26H40O5
Molecular weight
432.6 g/mol
Exact mass
432.28757437 Da
Monoisotopic mass
432.28757437 Da
XLogP3
4.3
Topological polar surface area
87.0 Ų
Molecular complexity
526.0
Formal charge
0
Hydrogen-bond donors
3
Hydrogen-bond acceptors
5
Rotatable bonds
14
Heavy atoms
31
Covalent units
1

Names and synonyms reported to PubChem

XalatanPhXA41PHXA-41XA41PhXA 41XA-41IYUZEHlatanoprost (isopropyl ester)
16 more reported names
latanoprostum6Z5B6HVF6OXELPROSIsopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((3R)-3-hydroxy-5-phenylpentyl)cyclopentyl)-5-heptenoateT-2345CHEBI:6384propan-2-yl (5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}hept-5-enoateT2345XALACOM COMPONENT LATANOPROSTpropan-2-yl (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoateLatanoprost PF5-Heptenoic acid, 7-(3,5-dihydroxy-2-(3-hydroxy-5-phenylpentyl)cyclopentyl)-, 1-methylethyl ester, (1R-(1-alpha(Z),2-beta(R*),3-alpha,5-alpha))-Monopostisopropyl (z)-7-[(1r,2r,3r,5s)-3,5-dihydroxy-2-[(3r)-3-hydroxy-5-phenylpentyl]cyclopentyl]-5-heptenoatepropan-2-yl (5Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((3R)-3-hydroxy-5-phenylpentyl)cyclopentyl)hept-5-enoatepropan-2-yl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((3R)-3-hydroxy-5-phenylpentyl)cyclopentyl)hept-5-enoate
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
5
Undefined atom stereocentres
0
Defined bond stereocentres
1
Undefined bond stereocentres
0
3D pharmacophore features
11
3D rings
2
3D hydrophobes
2
3D acceptor features
4
3D donor features
3
3D anionic centres
0
3D cationic centres
0
3D conformers
10
Effective 3D rotors
15.0
Machine-readable structure identifiers
SMILES
CC(C)OC(=O)CCC/C=C\C[C@H]1[C@H](C[C@H]([C@@H]1CC[C@H](CCC2=CC=CC=C2)O)O)O
InChI
InChI=1S/C26H40O5/c1-19(2)31-26(30)13-9-4-3-8-12-22-23(25(29)18-24(22)28)17-16-21(27)15-14-20-10-6-5-7-11-20/h3,5-8,10-11,19,21-25,27-29H,4,9,12-18H2,1-2H3/b8-3-/t21-,22+,23+,24-,25+/m0/s1
InChIKey
GGXICVAJURFBLW-CEYXHVGTSA-N

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match5311221

Attributed physical-property, hazard, environmental and use annotations.

  • Note: This chemical does not meet GHS hazard criteria for 0.7% (1 of 145) of reports. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H300 (63.4%): Fatal if swallowed [Danger Acute toxicity, oral]; H301 (11%): Toxic if swallowed [Danger Acute toxicity, oral]; H361 (62.1%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P264, P270, P280, P301+P316, P318, P321, P330, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 145 reports by companies from 16 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 1 of 145 reports by companies.; There are 15 notifications provided by 144 of 145 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Toxicity Summary: Researchers found no carcinogenesis or mutagenesis with latanoprost, and the drug did not affect fertility in animal studies. However, latanoprost was noted to cause a chromosomal aberration in treated human lymphocytes. Intravenous infusion of 3 μg/kg of latanoprost in healthy volunteers produced plasma concentrations 200 times higher than during clinical treatment with latanoprost ophthalmic solution, and researchers identified no ADR. There is no evidence to establish a correlation between latanoprost administration and ocular or cutaneous melanoma.; Intravenous infusion of 5.5 to 10 μg/kg resulted in fatigue, sweating, dizziness, nausea, and abdominal pain. According to the manufacturer's labeling, treatment should be symptomatic if there is an overdosage with latanoprost ophthalmic solution. Source: StatPearls
  • Uses: Use (kg) in USA (2002): 1; Consumption (g per capita) in the USA (2002): 3.3e-06; Calculated removal (%): 100 Source: NORMAN Suspect List Exchange

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 155206-00-1
CAS 155206-00-1PubChem CID 5311027

Verified chemistry for CAS 155206-00-1

Bimatoprost

IUPAC name
(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxy-5-phenylpent-1-enyl]cyclopentyl]-N-ethylhept-5-enamide
Molecular formula
C25H37NO4
Molecular weight
415.6 g/mol
Exact mass
415.27225866 Da
Monoisotopic mass
415.27225866 Da
XLogP3
2.8
Topological polar surface area
89.8 Ų
Molecular complexity
541.0
Formal charge
0
Hydrogen-bond donors
4
Hydrogen-bond acceptors
4
Rotatable bonds
12
Heavy atoms
30
Covalent units
1

Names and synonyms reported to PubChem

LumiganLatisseAGN 192024ProstamideAGN-192024bimatoprostumDURYSTA(Z)-7-((1R,2R,3R,5S)-3,5-Dihydroxy-2-((1E,3S)-3-hydroxy-5-phenyl-1-pentenyl)cyclopentyl)-N-ethyl-5-heptenamide
16 more reported names
CHEBI:51230GANFORT COMPONENT BIMATOPROST5-Heptenamide, 7-(3,5-dihydroxy-2-(3-hydrdoxy-5-phenyl-1-pentenyl)cyclopentyl)-N-ethyl-, (1R-(1alpha(Z),2beta(1E,3S*),3alpha,5alpha))-(5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenylpent-1-en-1-yl]cyclopentyl]-N-ethylhept-5-enamide(5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenylpent-1-en-1-yl]cyclopentyl}-N-ethylhept-5-enamide(5Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((1E,3S)-3-hydroxy-5-phenylpent-1-en-1-yl)cyclopentyl)-N-ethylhept-5-enamide(Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((E,3S)-3-hydroxy-5-phenylpent-1-enyl)cyclopentyl)-N-ethylhept-5-enamide(Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenyl-1-pentenyl]cyclopentyl]-N-ethyl-5-heptenamide192024, AGNRefChem:54542S01EE035-Heptenamide, 7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((1E,3S)-3-hydroxy-5-phenyl-1-pentenyl)cyclopentyl)-N-ethyl-,(5Z)-(Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-5-phenylpent-1-en-1-yl)cyclopentyl)-N-ethylhept-5-enamide(E)-7-[3,5-dihydroxy-2-[(E)-3-hydroxy-5-phenylpent-1-enyl]cyclopentyl]-N-ethylhept-5-enamide5-Heptenamide, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenyl-1-penten-1-yl]cyclopentyl]-N-ethyl-, (5Z)-UNII-QXS94885MZ
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
5
Undefined atom stereocentres
0
Defined bond stereocentres
2
Undefined bond stereocentres
0
3D pharmacophore features
11
3D rings
2
3D hydrophobes
1
3D acceptor features
4
3D donor features
4
3D anionic centres
0
3D cationic centres
0
3D conformers
10
Effective 3D rotors
14.0
Machine-readable structure identifiers
SMILES
CCNC(=O)CCC/C=C\C[C@H]1[C@H](C[C@H]([C@@H]1/C=C/[C@H](CCC2=CC=CC=C2)O)O)O
InChI
InChI=1S/C25H37NO4/c1-2-26-25(30)13-9-4-3-8-12-21-22(24(29)18-23(21)28)17-16-20(27)15-14-19-10-6-5-7-11-19/h3,5-8,10-11,16-17,20-24,27-29H,2,4,9,12-15,18H2,1H3,(H,26,30)/b8-3-,17-16+/t20-,21+,22+,23-,24+/m0/s1
InChIKey
AQOKCDNYWBIDND-FTOWTWDKSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 157283-66-4
CAS 157283-66-4PubChem CID 59938277

Verified chemistry for CAS 157283-66-4

Isopropyl Cloprostenate

IUPAC name
propan-2-yl (Z)-7-[(1R,2R,3R,5S)-2-[(E,3R)-4-(3-chlorophenoxy)-3-hydroxybut-1-enyl]-3,5-dihydroxycyclopentyl]hept-5-enoate
Molecular formula
C25H35ClO6
Molecular weight
467.0 g/mol
Exact mass
466.2122165 Da
Monoisotopic mass
466.2122165 Da
XLogP3
3.8
Topological polar surface area
96.2 Ų
Molecular complexity
607.0
Formal charge
0
Hydrogen-bond donors
3
Hydrogen-bond acceptors
6
Rotatable bonds
13
Heavy atoms
32
Covalent units
1

Names and synonyms reported to PubChem

Cloprostenol isopropyl esterIsopropyl cloprostenolUNII-765298537GCPG-6112955-Heptenoic acid, 7-((1R,2R,3R,5S)-2-((1E,3R)-4-(3-chlorophenoxy)-3-hydroxy-1-buten-1-yl)-3,5-dihydroxycyclopentyl)-, 1-methylethyl ester, (5Z)-5-Heptenoic acid, 7-((1R,2R,3R,5S)-2-((1E,3R)-4-(3-chlorophenoxy)-3-hydroxy-1-butenyl)-3,5-dihydroxycyclopentyl)-, 1-methylethyl ester, (5Z)-CPG-6112-955-Heptenoic acid, 7-(2-(4-(3-chlorophenoxy)-3-hydroxy-1-butenyl)-3,5-dihydroxycyclopentyl)-, 1-methylethyl ester, (1R-(1alpha(Z),2beta(1E,3R*),3alpha,5alpha))-
16 more reported names
5-Heptenoic acid, 7-[(1R,2R,3R,5S)-2-[(1E,3R)-4-(3-chlorophenoxy)-3-hydroxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl]-, 1-methylethyl ester, (5Z)-RefChem:149814ISOPROPYL CLOPROSTENATE [INCI]5-Heptenoic acid, 7-[(1R,2R,3R,5S)-2-[(1E,3R)-4-(3-chlorophenoxy)-3-hydroxy-1-butenyl]-3,5-dihydroxycyclopentyl]-, 1-methylethyl ester, (5Z)-(9CI)682-025-2(+)-Cloprostenol isopropyl esterisopropyl (Z)-7-((1R,2R,3R,5S)-2-((R,E)-4-(3-chlorophenoxy)-3-hydroxybut-1-en-1-yl)-3,5-dihydroxycyclopentyl)hept-5-enoate(+)-16-m-chlorophenoxy tetranor Prostaglandin F2alpha isopropyl esterISOPROPYL CLOPROSTENATC25H35ClO6D-cloprostenol isopropyl ester(+)-CloprostenolisopropylesterMSK2978CPG 6112-95HY-100571CS-0019712
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
Advanced structure statistics
Defined atom stereocentres
5
Undefined atom stereocentres
0
Defined bond stereocentres
2
Undefined bond stereocentres
0
3D pharmacophore features
12
3D rings
2
3D hydrophobes
2
3D acceptor features
5
3D donor features
3
3D anionic centres
0
3D cationic centres
0
3D conformers
10
Effective 3D rotors
14.0
Machine-readable structure identifiers
SMILES
CC(C)OC(=O)CCC/C=C\C[C@H]1[C@H](C[C@H]([C@@H]1/C=C/[C@H](COC2=CC(=CC=C2)Cl)O)O)O
InChI
InChI=1S/C25H35ClO6/c1-17(2)32-25(30)11-6-4-3-5-10-21-22(24(29)15-23(21)28)13-12-19(27)16-31-20-9-7-8-18(26)14-20/h3,5,7-9,12-14,17,19,21-24,27-29H,4,6,10-11,15-16H2,1-2H3/b5-3-,13-12+/t19-,21-,22-,23+,24-/m1/s1
InChIKey
OCNSAYQJDKJOLH-AHTXBMBWSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 157283-68-6
CAS 157283-68-6PubChem CID 5282226

Verified chemistry for CAS 157283-68-6

Travoprost

IUPAC name
propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]cyclopentyl]hept-5-enoate
Molecular formula
C26H35F3O6
Molecular weight
500.5 g/mol
Exact mass
500.23857332 Da
Monoisotopic mass
500.23857332 Da
XLogP3
4.1
Topological polar surface area
96.2 Ų
Molecular complexity
693.0
Formal charge
0
Hydrogen-bond donors
3
Hydrogen-bond acceptors
9
Rotatable bonds
13
Heavy atoms
35
Covalent units
1

Names and synonyms reported to PubChem

TravatanTravatan ZIzbaAL-6221AL6221Otx-tptravoprostumIDOSE TR
16 more reported names
WJ68R08KX9CHEBI:746859NSC-760366DUOTRAV COMPONENT TRAVOPROSTpropan-2-yl (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-en-1-yl]cyclopentyl]hept-5-enoate5-Heptenoic acid, 7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((1E,3R)-3-hydroxy-4-(3-(trifluoromethyl)phenoxy)-1-butenyl)cyclopentyl)-, 1-methylethyl ester, (5Z)-isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[(alpha,alpha,alpha-trifluoro-m-tolyl)oxy]-1-butenyl}cyclopentyl)-5-heptenoatepropan-2-yl (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-en-1-yl}cyclopentyl]hept-5-enoateZ, TravatanAL 6221ISOPROPYL (Z)-7-((1R,2R,3R,5S)-3,5-DIHYDROXY-2-((1E,3R)-3-HYDROXY-4-((alpha,alpha,alpha-TRIFLUORO-M-TOLYL)OXY)-1-BUTENYL)CYCLOPENTYL)-5-HEPTENOATEpropan-2-yl (5Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((1E,3R)-3-hydroxy-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)cyclopentyl)hept-5-enoateTravoprost OphthalmicTravoprost IntracameralRefChem:56256Travoprost (Isomer Free)
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
5
Undefined atom stereocentres
0
Defined bond stereocentres
2
Undefined bond stereocentres
0
3D pharmacophore features
12
3D rings
2
3D hydrophobes
2
3D acceptor features
5
3D donor features
3
3D anionic centres
0
3D cationic centres
0
3D conformers
10
Effective 3D rotors
15.0
Machine-readable structure identifiers
SMILES
CC(C)OC(=O)CCC/C=C\C[C@H]1[C@H](C[C@H]([C@@H]1/C=C/[C@H](COC2=CC=CC(=C2)C(F)(F)F)O)O)O
InChI
InChI=1S/C26H35F3O6/c1-17(2)35-25(33)11-6-4-3-5-10-21-22(24(32)15-23(21)31)13-12-19(30)16-34-20-9-7-8-18(14-20)26(27,28)29/h3,5,7-9,12-14,17,19,21-24,30-32H,4,6,10-11,15-16H2,1-2H3/b5-3-,13-12+/t19-,21-,22-,23+,24-/m1/s1
InChIKey
MKPLKVHSHYCHOC-AHTXBMBWSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 209860-87-7
CAS 209860-87-7PubChem CID 9868491

Verified chemistry for CAS 209860-87-7

Tafluprost

IUPAC name
propan-2-yl (Z)-7-[(1R,2R,3R,5S)-2-[(E)-3,3-difluoro-4-phenoxybut-1-enyl]-3,5-dihydroxycyclopentyl]hept-5-enoate
Molecular formula
C25H34F2O5
Molecular weight
452.5 g/mol
Exact mass
452.23743050 Da
Monoisotopic mass
452.23743050 Da
XLogP3
4.5
Topological polar surface area
76.0 Ų
Molecular complexity
613.0
Formal charge
0
Hydrogen-bond donors
2
Hydrogen-bond acceptors
7
Rotatable bonds
13
Heavy atoms
32
Covalent units
1

Names and synonyms reported to PubChem

AFP-168TaflotanZioptanSaflutanMK-24521O6WQ6T7G3CHEBI:66899MK2452
16 more reported names
propan-2-yl (5Z)-7-[(1R,2R,3R,5S)-2-[(1E)-3,3-difluoro-4-phenoxybut-1-en-1-yl]-3,5-dihydroxycyclopentyl]hept-5-enoatetafluprostumtafluprost opthalmic5-Heptenoic acid, 7-[(1R,2R,3R,5S)-2-[(1E)-3,3-difluoro-4-phenoxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl]-, 1-methylethyl ester, (5Z)-ISOPROPYL (5Z)-7-((1R,2R,3R,5S)-2-((1E)-3,3-DIFLUORO-4-PHENOXYBUT-1-ENYL)-3,5-DIHYDROXYCYCLOPENTYL)HEPT-5-ENOATEIsopropyl (5Z)-7-{(1R,2R,3R,5S)-2-((1E)-3,3-difluoro-4-phenoxybut-1-enyl)-3,5-dihydroxycyclopentyl}hept-5-enoatepropan-2-yl (5Z)-7-((1R,2R,3R,5S)-2-((1E)-3,3-difluoro-4-phenoxybut-1-en-1-yl)-3,5-dihydroxycyclopentyl)hept-5-enoatepropan-2-yl (Z)-7-((1R,2R,3R,5S)-2-((E)-3,3-difluoro-4-(phenoxy)but-1-enyl)-3,5-dihydroxycyclopentyl)hept-5-enoatepropan-2-yl (Z)-7-[(1R,2R,3R,5S)-2-[(E)-3,3-difluoro-4-(phenoxy)but-1-enyl]-3,5-dihydroxycyclopentyl]hept-5-enoateTafluprost OphthalmicRefChem:57842S01EE055-Heptenoic acid, 7-((1R,2R,3R,5S)-2-((1E)-3,3-difluoro-4-phenoxy-1-buten-1-yl)-3,5-dihydroxycyclopentyl)-, 1-methylethyl ester, (5Z)-1-methylethyl (5Z)-7-((1R,2R, 3R,5S)-2-((1E)-3,3-difluoro-4-phenoxy-1-butenyl)-3,5-dihydroxycyclopentyl)-5-heptenoate(Z)-isopropyl 7-((1R,2R,3R,5S)-2-((E)-3,3-difluoro-4-phenoxybut-1-en-1-yl)-3,5-dihydroxycyclopentyl)hept-5-enoateC25H34F2O5
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
4
Undefined atom stereocentres
0
Defined bond stereocentres
2
Undefined bond stereocentres
0
3D pharmacophore features
10
3D rings
2
3D hydrophobes
2
3D acceptor features
4
3D donor features
2
3D anionic centres
0
3D cationic centres
0
3D conformers
10
Effective 3D rotors
14.0
Machine-readable structure identifiers
SMILES
CC(C)OC(=O)CCC/C=C\C[C@H]1[C@H](C[C@H]([C@@H]1/C=C/C(COC2=CC=CC=C2)(F)F)O)O
InChI
InChI=1S/C25H34F2O5/c1-18(2)32-24(30)13-9-4-3-8-12-20-21(23(29)16-22(20)28)14-15-25(26,27)17-31-19-10-6-5-7-11-19/h3,5-8,10-11,14-15,18,20-23,28-29H,4,9,12-13,16-17H2,1-2H3/b8-3-,15-14+/t20-,21-,22+,23-/m1/s1
InChIKey
WSNODXPBBALQOF-VEJSHDCNSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 35121-78-9
CAS 35121-78-9PubChem CID 5282411

Verified chemistry for CAS 35121-78-9

Prostacyclin

IUPAC name
(5Z)-5-[(3aR,4R,5R,6aS)-5-hydroxy-4-[(E,3S)-3-hydroxyoct-1-enyl]-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-2-ylidene]pentanoic acid
Molecular formula
C20H32O5
Molecular weight
352.5 g/mol
Exact mass
352.22497412 Da
Monoisotopic mass
352.22497412 Da
XLogP3
2.9
Topological polar surface area
87.0 Ų
Molecular complexity
484.0
Formal charge
0
Hydrogen-bond donors
3
Hydrogen-bond acceptors
5
Rotatable bonds
10
Heavy atoms
25
Covalent units
1

Names and synonyms reported to PubChem

epoprostenolprostaglandin I2PGI2VasocyclinProstaglandin XEpoprostenolumACT-385781ADCR9Z582X0
16 more reported names
U-53217(5Z,9alpha,11alpha,13E,15S)-6,9-epoxy-11,15-dihydroxyprosta-5,13-dien-1-oic acidU-53,217CHEBI:155526,9S-epoxy-11R,15S-dihydoxy-5Z,13E-prostadienoic acidEpoprostanol(5Z,13E)-(15S)-6,9alpha-Epoxy-11alpha,15-dihydroxyprosta-5,13-dienoateProsta-5,13-dien-1-oic acid, 6,9-epoxy-11,15-dihydroxy-, (5Z,9alpha,11alpha,13E,15S)-Prostaglandin I(2)epoprostenolo(5Z)-5-((3aR,4R,5R,6aS)-5-hydroxy-4-((E,3S)-3-hydroxyoct-1-enyl)-3,3a,4,5,6,6a-hexahydrocyclopenta(b)furan-2-ylidene)pentanoic acid(5Z)-5-((3aR,4R,5R,6aS)-5-hydroxy-4-((E,3S)-3-hydroxyoct-1-enyl)-3,3a,4,5,6,6a-hexahydrocyclopenta(d)furan-2-ylidene)pentanoic acid(5Z)-5-[(3aR,4R,5R,6aS)-5-hydroxy-4-[(E,3S)-3-hydroxyoct-1-enyl]-3,3a,4,5,6,6a-hexahydrocyclopenta[d]furan-2-ylidene]pentanoic acidRefChem:57239B01AC09Epoprostenol Sodium Salt, (5Z,9alpha,11alpha,13E,15S)-
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
5
Undefined atom stereocentres
0
Defined bond stereocentres
2
Undefined bond stereocentres
0
3D pharmacophore features
13
3D rings
2
3D hydrophobes
3
3D acceptor features
5
3D donor features
2
3D anionic centres
1
3D cationic centres
0
3D conformers
10
Effective 3D rotors
11.0
Machine-readable structure identifiers
SMILES
CCCCC[C@@H](/C=C/[C@H]1[C@@H](C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/O2)O)O
InChI
InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1
InChIKey
KAQKFAOMNZTLHT-OZUDYXHBSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 363-24-6
CAS 363-24-6PubChem CID 5280360

Verified chemistry for CAS 363-24-6

Prostaglandin E2

IUPAC name
(Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid
Molecular formula
C20H32O5
Molecular weight
352.5 g/mol
Exact mass
352.22497412 Da
Monoisotopic mass
352.22497412 Da
XLogP3
2.8
Topological polar surface area
94.8 Ų
Molecular complexity
469.0
Formal charge
0
Hydrogen-bond donors
3
Hydrogen-bond acceptors
5
Rotatable bonds
12
Heavy atoms
25
Covalent units
1

Names and synonyms reported to PubChem

DinoprostonePGE2Prostin E2PrepidilCervidilMinprostin E2PropessMinprositin E2
16 more reported names
DinoprostonDinoprostonumCerviprostDinoprostonaEnzaprost ECerviprimeProstenonePGE2alphaU-12062(5Z,11alpha,13E,15S)-11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acidProstaglandin E2alpha(E,Z)-(1R,2R,3R)-7-(3-Hydroxy-2-((3S)-(3-hydroxy-1-octenyl))-5-oxocyclopentyl)-5-heptenoic acidU 12062K7Q1JQR04MProstaglandin E(2)(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
4
Undefined atom stereocentres
0
Defined bond stereocentres
2
Undefined bond stereocentres
0
3D pharmacophore features
12
3D rings
1
3D hydrophobes
3
3D acceptor features
5
3D donor features
2
3D anionic centres
1
3D cationic centres
0
3D conformers
10
Effective 3D rotors
12.8
Machine-readable structure identifiers
SMILES
CCCCC[C@@H](/C=C/[C@H]1[C@@H](CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O)O
InChI
InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1
InChIKey
XEYBRNLFEZDVAW-ARSRFYASSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 40665-92-7
CAS 40665-92-7PubChem CID 5311053

Verified chemistry for CAS 40665-92-7

Cloprostenol

IUPAC name
(Z)-7-[(1R,2R,3R,5S)-2-[(E,3R)-4-(3-chlorophenoxy)-3-hydroxybut-1-enyl]-3,5-dihydroxycyclopentyl]hept-5-enoic acid
Molecular formula
C22H29ClO6
Molecular weight
424.9 g/mol
Exact mass
424.1652663 Da
Monoisotopic mass
424.1652663 Da
XLogP3
2.7
Topological polar surface area
107.0 Ų
Molecular complexity
551.0
Formal charge
0
Hydrogen-bond donors
4
Hydrogen-bond acceptors
6
Rotatable bonds
11
Heavy atoms
29
Covalent units
1

Names and synonyms reported to PubChem

CloprostenolumOestrophaneEstrofanEstrophanEstrophaneOestrophan5-Heptenoic acid, 7-((1R,2R,3R,5S)-2-((1E,3R)-4-(3-chlorophenoxy)-3-hydroxy-1-butenyl)-3,5-dihydroxycyclopentyl)-, (5Z)-rel-(5Z)-7-((1R,2R,3R,5S)-2-((1E,3R)-4-(3-chlorophenoxy)-3-hydroxybut-1-en-1-yl)-3,5-dihydroxycyclopentyl)hept-5-enoic acid
16 more reported names
(5Z)-7-{(1R,2R,3R,5S)-2-[(1E,3R)-4-(3-Chlorophenoxy)-3-hydroxybut-1-en-1-yl]-3,5-dihydroxycyclopentyl}hept-5-enoic acid(Z)-7-((1R,2R,3R,5S)-2-((E,3R)-4-(3-chlorophenoxy)-3-hydroxybut-1-enyl)-3,5-dihydroxycyclopentyl)hept-5-enoic acidSodium, CloprostenolRefChem:56481Cloprostenol Monosodium SaltMonosodium Salt, CloprostenolSalt, Cloprostenol MonosodiumICI80,966ICI 80,966(Z)-7-((1R*,2R*,3R*,5S*)-2-((E)-(3R*)-4-(3-Chlorophenoxy)-3-hydroxy-1-butenyl)-3,5-dihydroxycyclopentyl)-5-heptensaeure255-028-8(+)-CloprostenolDalmazinR-CloprostenolDalmaprost DD-Cloprostenol
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
5
Undefined atom stereocentres
0
Defined bond stereocentres
2
Undefined bond stereocentres
0
3D pharmacophore features
13
3D rings
2
3D hydrophobes
1
3D acceptor features
6
3D donor features
3
3D anionic centres
1
3D cationic centres
0
3D conformers
10
Effective 3D rotors
12.0
Machine-readable structure identifiers
SMILES
C1[C@@H]([C@@H]([C@H]([C@@H]1O)/C=C/[C@H](COC2=CC(=CC=C2)Cl)O)C/C=C\CCCC(=O)O)O
InChI
InChI=1S/C22H29ClO6/c23-15-6-5-7-17(12-15)29-14-16(24)10-11-19-18(20(25)13-21(19)26)8-3-1-2-4-9-22(27)28/h1,3,5-7,10-12,16,18-21,24-26H,2,4,8-9,13-14H2,(H,27,28)/b3-1-,11-10+/t16-,18-,19-,20+,21-/m1/s1
InChIKey
VJGGHXVGBSZVMZ-QIZQQNKQSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 40666-16-8
CAS 40666-16-8PubChem CID 5311100

Verified chemistry for CAS 40666-16-8

Fluprostenol

IUPAC name
(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]cyclopentyl]hept-5-enoic acid
Molecular formula
C23H29F3O6
Molecular weight
458.5 g/mol
Exact mass
458.19162313 Da
Monoisotopic mass
458.19162313 Da
XLogP3
2.9
Topological polar surface area
107.0 Ų
Molecular complexity
636.0
Formal charge
0
Hydrogen-bond donors
4
Hydrogen-bond acceptors
9
Rotatable bonds
11
Heavy atoms
32
Covalent units
1

Names and synonyms reported to PubChem

Fluprostenolumtravoprost free acidFluoprostenolICI 81,008358S7VUE5NCHEBI:60782ICI-80008 FREE ACIDICI 80,008 FREE ACID
16 more reported names
ICI 81008ICI-81008rac-(5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-en-1-yl}cyclopentyl]hept-5-enoic acid(Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((E,3R)-3-hydroxy-4-(3-(trifluoromethyl)phenoxy)but-1-enyl)cyclopentyl)hept-5-enoic acidrac-(5Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((1E,3R)-3-hydroxy-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)cyclopentyl)hept-5-enoic acidRefChem:921725255-029-3(+)-fluprostenoltravoprost acidFluprostenol, (+)-EINECS 255-029-3(+/-)-FluprostenolMEH3MCE8X1AL-58485-Heptenoic acid, 7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((1E,3R)-3-hydroxy-4-(3-(trifluoromethyl)phenoxy)-1-buten-1-yl)cyclopentyl)-, (5Z)-C23H29F3O6
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
5
Undefined atom stereocentres
0
Defined bond stereocentres
2
Undefined bond stereocentres
0
3D pharmacophore features
13
3D rings
2
3D hydrophobes
1
3D acceptor features
6
3D donor features
3
3D anionic centres
1
3D cationic centres
0
3D conformers
10
Effective 3D rotors
13.0
Machine-readable structure identifiers
SMILES
C1[C@@H]([C@@H]([C@H]([C@@H]1O)/C=C/[C@H](COC2=CC=CC(=C2)C(F)(F)F)O)C/C=C\CCCC(=O)O)O
InChI
InChI=1S/C23H29F3O6/c24-23(25,26)15-6-5-7-17(12-15)32-14-16(27)10-11-19-18(20(28)13-21(19)29)8-3-1-2-4-9-22(30)31/h1,3,5-7,10-12,16,18-21,27-29H,2,4,8-9,13-14H2,(H,30,31)/b3-1-,11-10+/t16-,18-,19-,20+,21-/m1/s1
InChIKey
WWSWYXNVCBLWNZ-QIZQQNKQSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 59122-46-2
CAS 59122-46-2PubChem CID 5282381

Verified chemistry for CAS 59122-46-2

Misoprostol

IUPAC name
methyl 7-[(1R,2R,3R)-3-hydroxy-2-[(E)-4-hydroxy-4-methyloct-1-enyl]-5-oxocyclopentyl]heptanoate
Molecular formula
C22H38O5
Molecular weight
382.5 g/mol
Exact mass
382.27192431 Da
Monoisotopic mass
382.27192431 Da
XLogP3
3.7
Topological polar surface area
83.8 Ų
Molecular complexity
487.0
Formal charge
0
Hydrogen-bond donors
2
Hydrogen-bond acceptors
5
Rotatable bonds
14
Heavy atoms
27
Covalent units
1

Names and synonyms reported to PubChem

CytotecMisoprostolumSC-29333SC 293330E43V0BB57ARTHROTEC COMPONENT MISOPROSTOLmethyl (11alpha,13E)-11,16-dihydroxy-16-methyl-9-oxoprost-13-en-1-oatemethyl 7-[(1R,2R,3R)-3-hydroxy-2-[(1E)-4-hydroxy-4-methyloct-1-en-1-yl]-5-oxocyclopentyl]heptanoate
16 more reported names
Apo MisoprostolProst-13-en-1-oic acid, 11,16-dihydroxy-16-methyl-9-oxo-, methyl ester, (11alpha,13E)-misoprostoloMysodelleTopogyneNovo MisoprostolMisoprostol 1%methyl 7-((1R,2R,3R)-3-hydroxy-2-((1E)-4-hydroxy-4-methyloct-1-en-1-yl)-5-oxocyclopentyl)heptanoateRefChem:55654Misoprostol 1% DispersionCHEBI:63610A02BB01G02AD06SC 30249664-288-5Isprelor
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
3
Undefined atom stereocentres
1
Defined bond stereocentres
1
Undefined bond stereocentres
0
3D pharmacophore features
10
3D rings
1
3D hydrophobes
3
3D acceptor features
4
3D donor features
2
3D anionic centres
0
3D cationic centres
0
3D conformers
10
Effective 3D rotors
14.8
Machine-readable structure identifiers
SMILES
CCCCC(C)(C/C=C/[C@H]1[C@@H](CC(=O)[C@@H]1CCCCCCC(=O)OC)O)O
InChI
InChI=1S/C22H38O5/c1-4-5-14-22(2,26)15-10-12-18-17(19(23)16-20(18)24)11-8-6-7-9-13-21(25)27-3/h10,12,17-18,20,24,26H,4-9,11,13-16H2,1-3H3/b12-10+/t17-,18-,20-,22?/m1/s1
InChIKey
OJLOPKGSLYJEMD-URPKTTJQSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 745-65-3
CAS 745-65-3PubChem CID 5280723

Verified chemistry for CAS 745-65-3

Alprostadil

IUPAC name
7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]heptanoic acid
Molecular formula
C20H34O5
Molecular weight
354.5 g/mol
Exact mass
354.24062418 Da
Monoisotopic mass
354.24062418 Da
XLogP3
3.2
Topological polar surface area
94.8 Ų
Molecular complexity
432.0
Formal charge
0
Hydrogen-bond donors
3
Hydrogen-bond acceptors
5
Rotatable bonds
13
Heavy atoms
25
Covalent units
1

Names and synonyms reported to PubChem

Prostaglandin E1PGE1CaverjectEdexMuseAlprostadilumBefarProstin VR Pediatric
16 more reported names
VitarosPrinkPGE-1Prostavasin(11alpha,13E,15S)-11,15-dihydroxy-9-oxoprost-13-en-1-oic acidCaverject ImpulsePGE1alphaLipo PGE1Prostaglandin E1alpha11alpha,15alpha-Dihydroxy-9-oxo-13-trans-prostenoic acid(13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprost-13-enoateU-101369-oxo-11R,15S-dihydroxy-13E-prostaenoic acidF5TD010360U-10,136CHEBI:15544
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
4
Undefined atom stereocentres
0
Defined bond stereocentres
1
Undefined bond stereocentres
0
3D pharmacophore features
13
3D rings
1
3D hydrophobes
4
3D acceptor features
5
3D donor features
2
3D anionic centres
1
3D cationic centres
0
3D conformers
10
Effective 3D rotors
13.8
Machine-readable structure identifiers
SMILES
CCCCC[C@@H](/C=C/[C@H]1[C@@H](CC(=O)[C@@H]1CCCCCCC(=O)O)O)O
InChI
InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,19+/m0/s1
InChIKey
GMVPRGQOIOIIMI-DWKJAMRDSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 81846-19-7
CAS 81846-19-7PubChem CID 6918140

Verified chemistry for CAS 81846-19-7

Treprostinil

IUPAC name
2-[[(1R,2R,3aS,9aS)-2-hydroxy-1-[(3S)-3-hydroxyoctyl]-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[g]naphthalen-5-yl]oxy]acetic acid
Molecular formula
C23H34O5
Molecular weight
390.5 g/mol
Exact mass
390.24062418 Da
Monoisotopic mass
390.24062418 Da
XLogP3
4.5
Topological polar surface area
87.0 Ų
Molecular complexity
495.0
Formal charge
0
Hydrogen-bond donors
3
Hydrogen-bond acceptors
5
Rotatable bonds
10
Heavy atoms
28
Covalent units
1

Names and synonyms reported to PubChem

UniprostRumodolinTyvasoUT-15LRX-15treprostinilo15AU81treprostinilum
16 more reported names
Tyvaso dpiRUM6K67ESG15-AU-81CHEBI:50861L-606((1R,2R,3aS,9aS)-2-hydroxy-1-((3S)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cylopent(b)naphthalen-5-yl)oxy)acetate2-{[(1R,2R,3aS,9aS)-2-hydroxy-1-[(3S)-3-hydroxyoctyl]-1H,2H,3H,3aH,4H,9H,9aH-cyclopenta[b]naphthalen-5-yl]oxy}acetic acid({(1R,2R,3aS,9aS)-2-hydroxy-1-[(3S)-3-hydroxyoctyl]-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-5-yl}oxy)acetic acidAcetic acid, ((2,3,3a,4,9,9a-hexahydro-2-hydroxy-1-(3-hydroxyoctyl)-1H-benz(f)inden-5-yl)oxy)-, (1R-(1alpha(S*),2beta,3aalpha,9aalpha))-trepostinil sodium(((1R,2R,3aS,9aS)-2-hydroxy-1-((3S)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta(b)naphthalen-5-yl)oxy)acetic acid[(1R,2R,3aS,9aS)-2-Hydroxy-1-((3S)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cylopent[b]naphthalen-5-yl]oxy]acetate2-(((1R,2R,3aS,9aS)-2-hydroxy-1-((3S)-3-hydroxyoctyl)-1H,2H,3H,3aH,4H,9H,9aH-cyclopenta(b)naphthalen-5-yl)oxy)acetic acid2-(((2R,3R,3aS,9aS)-2-hydroxy-3-((3S)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta(g)naphthalen-8-yl)oxy)acetic acid2-[[(2R,3R,3aS,9aS)-2-hydroxy-3-[(3S)-3-hydroxyoctyl]-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[g]naphthalen-8-yl]oxy]acetic acidRefChem:56257
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
5
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
13
3D rings
3
3D hydrophobes
2
3D acceptor features
5
3D donor features
2
3D anionic centres
1
3D cationic centres
0
3D conformers
10
Effective 3D rotors
11.0
Machine-readable structure identifiers
SMILES
CCCCC[C@@H](CC[C@H]1[C@@H](C[C@H]2[C@@H]1CC3=C(C2)C(=CC=C3)OCC(=O)O)O)O
InChI
InChI=1S/C23H34O5/c1-2-3-4-7-17(24)9-10-18-19-11-15-6-5-8-22(28-14-23(26)27)20(15)12-16(19)13-21(18)25/h5-6,8,16-19,21,24-25H,2-4,7,9-14H2,1H3,(H,26,27)/t16-,17-,18+,19-,21+/m0/s1
InChIKey
PAJMKGZZBBTTOY-ZFORQUDYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
Health Canada Cosmetic Ingredient Hotlist
Source reference
Hotlist prohibited entry 400
Source record ID
prohibited:400
Source version
Health Canada Hotlist 2025-08-13
Source language
English
Translation status
Original is English
Source updated
2025-08-13
Snapshot checked
2026-08-30 04:07 UTC
Validation method
strict HTML tables t1=490 and t2=90
SHA-256
8b52ff573d08373ee90121f6a701b3607e4a3d6fc748a7d56171eb53510af91a

Registered dataset notes

Dataset coverage
Administrative prohibitions, restrictions, conditions and warning requirements
Authority note
Official Health Canada compliance indicator; not a complete safety clearance
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

580
current Canada records
490
records marked Prohibited
580
records from this source version
516
market records with CAS identity

Status distribution

Prohibited: 490Restricted: 90

Condition text is present on 172 of 580 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

Canada market context

Complete Hotlist snapshot

Coverage version: Health Canada Cosmetic Ingredient Hotlist, 13 August 2025

All prohibited and restricted Hotlist entries, including conditions and warning requirements published in the official list.

Verification checklist

  1. Search English/French names and CAS identifiers.
  2. Apply every restriction, concentration and label warning.
  3. Check Food and Drugs Act/Cosmetic Regulations requirements.
  4. Recheck the current Hotlist before notification or sale.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “Prostaglandins, their salts and derivatives and their analogs” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Search English/French names and CAS identifiers.
  3. Apply every restriction, concentration and label warning.
  4. Check Food and Drugs Act/Cosmetic Regulations requirements.
  5. Recheck the current Hotlist before notification or sale.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECNot supplied
  • Separate condition textAvailable
  • Effective dateNot supplied
  • Snapshot hash and methodAvailable

Questions this page answers

This official record identifies the substance as prohibited for cosmetic use in the stated market scope. Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. The Hotlist is an administrative compliance tool, not an exhaustive safety approval list.

The record cites Hotlist prohibited entry 400, source version Health Canada Hotlist 2025-08-13. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

Prostaglandins, their salts and derivatives and their analogs. Hotlist prohibited entry 400. Canada. Source version Health Canada Hotlist 2025-08-13. CosIng Checker regulatory record: https://cosingchecker.com/regulations/ca/records/400/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for Canada

This official record identifies the substance as prohibited for cosmetic use in the stated market scope.

Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

How to interpret the legal role

The authority uses this source as compliance guidance; the underlying legislation remains controlling.

Evidence on this page

  • Recorded outcome: Prohibited
  • Legal role: Official guidance
  • Source version: Health Canada Hotlist 2025-08-13

What it does not prove

The Hotlist is an administrative compliance tool, not an exhaustive safety approval list.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity at the source

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity at the source

US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source