Is TAFLUPROST safe to use in EU cosmetics?

TAFLUPROST is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 209860-87-7?

CAS 209860-87-7 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 8688415/10/2010

TAFLUPROST

Isopropyl (5Z)-7-{(1R,2R,3R,5S)-2-((1E)-3,3-difluoro-4-phenoxybut-1- enyl)-3,5-dihydroxycyclopentyl}hept-5-enoate

TAFLUPROST is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

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Market	Evidence status	Records	Source language
European Union	Source mapped Inventory entry; no linked annex rule	0	English and EU languages
Great Britain	Source mapped Official source mapped; ingredient rule not imported	0	English
Canada	Evidence linked Prohibited Open this evidence	1	English and French
New Zealand	Source mapped Official source mapped; ingredient rule not imported	0	English
ASEAN	Source mapped Official source mapped; ingredient rule not imported	0	English and national languages
China	Source mapped Official source mapped; ingredient rule not imported	0	Chinese with selected English material
Japan	Source mapped Official source mapped; ingredient rule not imported	0	Japanese; official English translation available
South Korea	Source mapped Official source mapped; ingredient rule not imported	0	Korean with some English names
United States	Source mapped Official source mapped; ingredient rule not imported	0	English
Australia	Source mapped Official source mapped; ingredient rule not imported	0	English
Brazil	Source mapped Official source mapped; ingredient rule not imported	0	Portuguese with INCI crosswalks
India	Source mapped Official source mapped; ingredient rule not imported	0	English and Hindi
Saudi Arabia	Source mapped Official source mapped; ingredient rule not imported	0	Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 209860-87-7

CAS 209860-87-7PubChem CID 9868491

Tafluprost

Tafluprost is a prostaglandin Falpha that is prostaglandin F2alpha in which the carboxylic acid function has been converted to the corresponding isopropyl ester and the 3-hydroxy-1-octenyl side-chain is substituted by 3,3-difluoro-4-phenoxybut-1-enyl. Used for treatment of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. It has a role as a prostaglandin receptor agonist. It is an isopropyl ester, a prostaglandins Falpha and an organofluorine compound. It is functionally related to a prostaglandin F2alpha. — ChEBI

IUPAC name: propan-2-yl (Z)-7-[(1R,2R,3R,5S)-2-[(E)-3,3-difluoro-4-phenoxybut-1-enyl]-3,5-dihydroxycyclopentyl]hept-5-enoate

Molecular formula: C25H34F2O5
Molecular weight: 452.5 g/mol
Exact mass: 452.23743050 Da
XLogP3: 4.5
Topological polar surface area: 76.0 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 7
Covalent units: 1
Defined stereocentres: 4

Also known as

AFP-168TaflotanZioptanSaflutanMK-24521O6WQ6T7G3CHEBI:66899MK2452

16 more reported names

propan-2-yl (5Z)-7-[(1R,2R,3R,5S)-2-[(1E)-3,3-difluoro-4-phenoxybut-1-en-1-yl]-3,5-dihydroxycyclopentyl]hept-5-enoatetafluprostumtafluprost opthalmic5-Heptenoic acid, 7-[(1R,2R,3R,5S)-2-[(1E)-3,3-difluoro-4-phenoxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl]-, 1-methylethyl ester, (5Z)-ISOPROPYL (5Z)-7-((1R,2R,3R,5S)-2-((1E)-3,3-DIFLUORO-4-PHENOXYBUT-1-ENYL)-3,5-DIHYDROXYCYCLOPENTYL)HEPT-5-ENOATEIsopropyl (5Z)-7-{(1R,2R,3R,5S)-2-((1E)-3,3-difluoro-4-phenoxybut-1-enyl)-3,5-dihydroxycyclopentyl}hept-5-enoatepropan-2-yl (5Z)-7-((1R,2R,3R,5S)-2-((1E)-3,3-difluoro-4-phenoxybut-1-en-1-yl)-3,5-dihydroxycyclopentyl)hept-5-enoatepropan-2-yl (Z)-7-((1R,2R,3R,5S)-2-((E)-3,3-difluoro-4-(phenoxy)but-1-enyl)-3,5-dihydroxycyclopentyl)hept-5-enoatepropan-2-yl (Z)-7-[(1R,2R,3R,5S)-2-[(E)-3,3-difluoro-4-(phenoxy)but-1-enyl]-3,5-dihydroxycyclopentyl]hept-5-enoateTafluprost OphthalmicRefChem:57842S01EE055-Heptenoic acid, 7-((1R,2R,3R,5S)-2-((1E)-3,3-difluoro-4-phenoxy-1-buten-1-yl)-3,5-dihydroxycyclopentyl)-, 1-methylethyl ester, (5Z)-1-methylethyl (5Z)-7-((1R,2R, 3R,5S)-2-((1E)-3,3-difluoro-4-phenoxy-1-butenyl)-3,5-dihydroxycyclopentyl)-5-heptenoate(Z)-isopropyl 7-((1R,2R,3R,5S)-2-((E)-3,3-difluoro-4-phenoxybut-1-en-1-yl)-3,5-dihydroxycyclopentyl)hept-5-enoateC25H34F2O5

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:66899
ChEMBL:CHEMBL1963683
EPA DTXSID:DTXSID401021504
PubMed:21916788
PubMed:21858491
PubMed:19477946
PubMed:15037111

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for TAFLUPROST

INCI name

TAFLUPROST

INN name

tafluprost

Description

Isopropyl (5Z)-7-{(1R,2R,3R,5S)-2-((1E)-3,3-difluoro-4-phenoxybut-1- enyl)-3,5-dihydroxycyclopentyl}hept-5-enoate

Record provenance

Inventory reference: 86884
Imported identity: TAFLUPROST
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for TAFLUPROST

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Key data

CAS

209860-87-7

—

Restriction

—

Function

HAIR CONDITIONING: Enhancing the appearance and feel of hair. Leaving the hair easy to comb, supple, soft and shiny and/or imparting volume, lightness, gloss, texture, etc.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#28210 · TAFLUPROST

Ingredients with overlapping formulation functions

SYNEPHRINE HCLANTIOXIDANT, HAIR CONDITIONING, SKIN CONDITIONING

SYZYGIUM AQUEUM FRUIT WATERHAIR CONDITIONING, SKIN CONDITIONING

SYZYGIUM LUEHMANNII FRUIT EXTRACTANTIOXIDANT, HAIR CONDITIONING, HUMECTANT, SKIN CONDITIONING

SYZYGIUM LUEHMANNII FRUIT POWDERANTIOXIDANT, HAIR CONDITIONING, HUMECTANT, SKIN CONDITIONING

TALL OIL BENZYL HYDROXYETHYL IMIDAZOLINIUM CHLORIDEANTISTATIC, HAIR CONDITIONING

TALL OIL HYDROXYETHYL IMIDAZOLINEANTISTATIC, HAIR CONDITIONING

TALLOW BETAINEANTISTATIC, CLEANSING, HAIR CONDITIONING, SKIN CONDITIONING, SURFACTANT - CLEANSING, SURFACTANT - F…

TALLOW DIHYDROXYETHYL BETAINEANTISTATIC, CLEANSING, FOAMING, HAIR CONDITIONING, SKIN CONDITIONING, SURFACTANT - CLEANSING, VISCO…

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How TAFLUPROST appears in the CosIng inventory

The CosIng inventory lists TAFLUPROST as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

TAFLUPROST is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

TAFLUPROST is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, TAFLUPROST carries the following function designation(s):

HAIR CONDITIONING

CAS 209860-87-7 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for TAFLUPROST

This page reproduces the CosIng inventory entry for TAFLUPROST from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research TAFLUPROST and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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