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ProhibitedOfficial guidanceCAOriginal is EnglishOfficial-source import checked

4-Benzyloxyphenol

Canada Hotlist: 4-Benzyloxyphenol

Health Canada lists this ingredient as prohibited for use in cosmetic products.

All Canada recordsCompare all marketsOpen official source

Regulatory decision and full conditions

Status
Prohibited
Legal role
Official guidance
Regulatory summary
Health Canada lists this ingredient as prohibited for use in cosmetic products.
Conditions and restrictions
Synonyms or related compounds: Monobenzone

Substance identity

Official source name
4-Benzyloxyphenol
CAS
103-16-2
EC
Not supplied in this source row
Identity mapping
standalone:cas_number
Search this identity across the siteCAS 103-16-2

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

10 market datasets
PubChem 2D chemical structure for CAS 103-16-2
CAS 103-16-2PubChem CID 7638

Verified chemistry for CAS 103-16-2

Monobenzone

Monobenzone is the monobenzyl ether of hydroquinone. It is used as a topical drug for medical depigmentation. It has a role as a dermatologic drug, an allergen and a melanin synthesis inhibitor. It is functionally related to a hydroquinone. — ChEBI

IUPAC name
4-phenylmethoxyphenol
Molecular formula
C13H12O2
Molecular weight
200.23 g/mol
Exact mass
200.083729621 Da
Monoisotopic mass
200.083729621 Da
XLogP3
3.4
Topological polar surface area
29.5 Ų
Molecular complexity
167.0
Formal charge
0
Hydrogen-bond donors
1
Hydrogen-bond acceptors
2
Rotatable bonds
3
Heavy atoms
15
Covalent units
1

Names and synonyms reported to PubChem

4-(Benzyloxy)phenolHydroquinone monobenzyl etherBenoquinP-(BENZYLOXY)PHENOLBenzoquinDepigmanLeucodinineMonobenzon
16 more reported names
Monobenzyl hydroquinoneSuperlitePigmexAgerite alba4-(Phenylmethoxy)phenol4-(Benzyloxyl)phenolHydroquinone benzyl etherDermochinonaCarmifalp-Hydroxyphenyl benzyl etherAlba-DomePhenol, 4-(phenylmethoxy)-Benzyl p-hydroxyphenyl etherMonobenzyl ether hydroquinoneMonobenzonaMonobenzonum
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
4
3D rings
2
3D hydrophobes
0
3D acceptor features
1
3D donor features
1
3D anionic centres
0
3D cationic centres
0
3D conformers
10
Effective 3D rotors
3.0
Machine-readable structure identifiers
SMILES
C1=CC=C(C=C1)COC2=CC=C(C=C2)O
InChI
InChI=1S/C13H12O2/c14-12-6-8-13(9-7-12)15-10-11-4-2-1-3-5-11/h1-9,14H,10H2
InChIKey
VYQNWZOUAUKGHI-UHFFFAOYSA-N

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:34380

monobenzone

The monobenzyl ether of hydroquinone. It is used as a topical drug for medical depigmentation.

Formula
C13H12O2
Average mass
200.237 g/mol
Monoisotopic mass
200.08373 Da
Formal charge
0
  • benzyl ether — is a (CHEBI:59859)
  • dermatologic drug — has role (CHEBI:50177)
  • allergen — has role (CHEBI:50904)
  • melanin synthesis inhibitor — has role (CHEBI:64933)
  • hydroquinone — has functional parent (CHEBI:17594)
  • dermatologic drug — has role (CHEBI:50177)
  • allergen — has role (CHEBI:50904)
  • melanin synthesis inhibitor — has role (CHEBI:64933)
  • benzyl ether — is a (CHEBI:59859)
Additional curated names
4-(benzyloxy)phenol4-(Benzyloxyl)phenol4-Benzyloxy-phenol4-Benzyloxyphenol4-(Phenylmethoxy)phenolBenzyl p-hydroxyphenyl etherHydroquinone benzyl etherHydroquinone monobenzyl etherMONOBENZYL ETHER OF HYDROQUINONEMonobenzyl hydroquinoneNSC-2132p-(Benzyloxy)phenolp-Hydroxyphenyl benzyl ether
Cross-references from this source
  • CAS: 103-16-2 — ChemIDplus
  • CAS: 103-16-2 — KEGG COMPOUND
  • MANUAL_X_REF: 1834 — DrugCentral
  • MANUAL_X_REF: C14244 — KEGG COMPOUND
  • MANUAL_X_REF: D05072 — KEGG DRUG
  • MANUAL_X_REF: DB00600 — DrugBank
  • MANUAL_X_REF: EP0175701 — Patent
  • MANUAL_X_REF: LSM-5642 — LINCS
  • MANUAL_X_REF: Monobenzone — Wikipedia
  • MANUAL_X_REF: WO8504101 — Patent
  • REGISTRY_NUMBER: 1958305 — Reaxys

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2020-09-29. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match7638

Attributed physical-property, hazard, environmental and use annotations.

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
Health Canada Cosmetic Ingredient Hotlist
Source reference
Hotlist prohibited entry 35
Source record ID
prohibited:35
Source version
Health Canada Hotlist 2025-08-13
Source language
English
Translation status
Original is English
Source updated
2025-08-13
Snapshot checked
2026-08-30 04:07 UTC
Validation method
strict HTML tables t1=490 and t2=90
SHA-256
8b52ff573d08373ee90121f6a701b3607e4a3d6fc748a7d56171eb53510af91a

Registered dataset notes

Dataset coverage
Administrative prohibitions, restrictions, conditions and warning requirements
Authority note
Official Health Canada compliance indicator; not a complete safety clearance
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

580
current Canada records
490
records marked Prohibited
580
records from this source version
516
market records with CAS identity

Status distribution

Prohibited: 490Restricted: 90

Condition text is present on 172 of 580 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

Canada market context

Complete Hotlist snapshot

Coverage version: Health Canada Cosmetic Ingredient Hotlist, 13 August 2025

All prohibited and restricted Hotlist entries, including conditions and warning requirements published in the official list.

Verification checklist

  1. Search English/French names and CAS identifiers.
  2. Apply every restriction, concentration and label warning.
  3. Check Food and Drugs Act/Cosmetic Regulations requirements.
  4. Recheck the current Hotlist before notification or sale.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “4-Benzyloxyphenol” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Search English/French names and CAS identifiers.
  3. Apply every restriction, concentration and label warning.
  4. Check Food and Drugs Act/Cosmetic Regulations requirements.
  5. Recheck the current Hotlist before notification or sale.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECNot supplied
  • Separate condition textAvailable
  • Effective dateNot supplied
  • Snapshot hash and methodAvailable

Questions this page answers

This official record identifies the substance as prohibited for cosmetic use in the stated market scope. Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. The Hotlist is an administrative compliance tool, not an exhaustive safety approval list.

The record cites Hotlist prohibited entry 35, source version Health Canada Hotlist 2025-08-13. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

4-Benzyloxyphenol. Hotlist prohibited entry 35. Canada. Source version Health Canada Hotlist 2025-08-13. CosIng Checker regulatory record: https://cosingchecker.com/regulations/ca/records/35/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for Canada

This official record identifies the substance as prohibited for cosmetic use in the stated market scope.

Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

How to interpret the legal role

The authority uses this source as compliance guidance; the underlying legislation remains controlling.

Evidence on this page

  • Recorded outcome: Prohibited
  • Legal role: Official guidance
  • Source version: Health Canada Hotlist 2025-08-13

What it does not prove

The Hotlist is an administrative compliance tool, not an exhaustive safety approval list.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity at the source

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity at the source

US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source