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4 – Benziloxifenol, 4 - metoxifenol e 4 – etoxifeno; 4-etoxifenol (4-ETHOXYPHENOL)

ANVISA lists this substance among materials that may not be used in personal-hygiene products, cosmetics or perfumes in Brazil.

All Brazil recordsOpen ingredient profileCompare all marketsOpen official source

Regulatory decision and full conditions

Status
Prohibited
Legal role
Binding rule
Regulatory summary
ANVISA lists this substance among materials that may not be used in personal-hygiene products, cosmetics or perfumes in Brazil.
Conditions and restrictions
4 – Benziloxifenol, 4 - metoxifenol e 4 – etoxifeno; 4-etoxifenol (4-ETHOXYPHENOL)

Substance identity

Official source name
4 – Benziloxifenol, 4 - metoxifenol e 4 – etoxifeno; 4-etoxifenol (4-ETHOXYPHENOL)
CAS
103-16-2; 150-76-5; 622-62-8
EC
203-083-3; 205-769-8; 210-748-1
Identity mapping
cas_number
Linked ingredient
P-HYDROXYANISOLE
Search this identity across the siteCAS 103-16-2CAS 150-76-5CAS 622-62-8EC 203-083-3EC 205-769-8EC 210-748-1

Linked CosIng identity data

Names and aliases

P-HYDROXYANISOLEmequinol

CosIng description: 4-Methoxyphenol

EU inventory restriction note: III/95

Recorded cosmetic function: ANTIOXIDANT, REDUCING

Function pages:ANTIOXIDANT, REDUCING

View the complete ingredient profile

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

10 market datasets
PubChem 2D chemical structure for CAS 103-16-2
CAS 103-16-2PubChem CID 7638

Verified chemistry for CAS 103-16-2

Monobenzone

Monobenzone is the monobenzyl ether of hydroquinone. It is used as a topical drug for medical depigmentation. It has a role as a dermatologic drug, an allergen and a melanin synthesis inhibitor. It is functionally related to a hydroquinone. — ChEBI

IUPAC name
4-phenylmethoxyphenol
Molecular formula
C13H12O2
Molecular weight
200.23 g/mol
Exact mass
200.083729621 Da
Monoisotopic mass
200.083729621 Da
XLogP3
3.4
Topological polar surface area
29.5 Ų
Molecular complexity
167.0
Formal charge
0
Hydrogen-bond donors
1
Hydrogen-bond acceptors
2
Rotatable bonds
3
Heavy atoms
15
Covalent units
1

Names and synonyms reported to PubChem

4-(Benzyloxy)phenolHydroquinone monobenzyl etherBenoquinP-(BENZYLOXY)PHENOLBenzoquinDepigmanLeucodinineMonobenzon
16 more reported names
Monobenzyl hydroquinoneSuperlitePigmexAgerite alba4-(Phenylmethoxy)phenol4-(Benzyloxyl)phenolHydroquinone benzyl etherDermochinonaCarmifalp-Hydroxyphenyl benzyl etherAlba-DomePhenol, 4-(phenylmethoxy)-Benzyl p-hydroxyphenyl etherMonobenzyl ether hydroquinoneMonobenzonaMonobenzonum
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
4
3D rings
2
3D hydrophobes
0
3D acceptor features
1
3D donor features
1
3D anionic centres
0
3D cationic centres
0
3D conformers
10
Effective 3D rotors
3.0
Machine-readable structure identifiers
SMILES
C1=CC=C(C=C1)COC2=CC=C(C=C2)O
InChI
InChI=1S/C13H12O2/c14-12-6-8-13(9-7-12)15-10-11-4-2-1-3-5-11/h1-9,14H,10H2
InChIKey
VYQNWZOUAUKGHI-UHFFFAOYSA-N

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:34380

monobenzone

The monobenzyl ether of hydroquinone. It is used as a topical drug for medical depigmentation.

Formula
C13H12O2
Average mass
200.237 g/mol
Monoisotopic mass
200.08373 Da
Formal charge
0
  • benzyl ether — is a (CHEBI:59859)
  • dermatologic drug — has role (CHEBI:50177)
  • allergen — has role (CHEBI:50904)
  • melanin synthesis inhibitor — has role (CHEBI:64933)
  • hydroquinone — has functional parent (CHEBI:17594)
  • dermatologic drug — has role (CHEBI:50177)
  • allergen — has role (CHEBI:50904)
  • melanin synthesis inhibitor — has role (CHEBI:64933)
  • benzyl ether — is a (CHEBI:59859)
Additional curated names
4-(benzyloxy)phenol4-(Benzyloxyl)phenol4-Benzyloxy-phenol4-Benzyloxyphenol4-(Phenylmethoxy)phenolBenzyl p-hydroxyphenyl etherHydroquinone benzyl etherHydroquinone monobenzyl etherMONOBENZYL ETHER OF HYDROQUINONEMonobenzyl hydroquinoneNSC-2132p-(Benzyloxy)phenolp-Hydroxyphenyl benzyl ether
Cross-references from this source
  • CAS: 103-16-2 — ChemIDplus
  • CAS: 103-16-2 — KEGG COMPOUND
  • MANUAL_X_REF: 1834 — DrugCentral
  • MANUAL_X_REF: C14244 — KEGG COMPOUND
  • MANUAL_X_REF: D05072 — KEGG DRUG
  • MANUAL_X_REF: DB00600 — DrugBank
  • MANUAL_X_REF: EP0175701 — Patent
  • MANUAL_X_REF: LSM-5642 — LINCS
  • MANUAL_X_REF: Monobenzone — Wikipedia
  • MANUAL_X_REF: WO8504101 — Patent
  • REGISTRY_NUMBER: 1958305 — Reaxys

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2020-09-29. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match7638

Attributed physical-property, hazard, environmental and use annotations.

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 150-76-5
CAS 150-76-5PubChem CID 9015

Verified chemistry for CAS 150-76-5

4-Methoxyphenol

IUPAC name
4-methoxyphenol
Molecular formula
C7H8O2
Molecular weight
124.14 g/mol
Exact mass
124.052429494 Da
Monoisotopic mass
124.052429494 Da
XLogP3
1.3
Topological polar surface area
29.5 Ų
Molecular complexity
75.0
Formal charge
0
Hydrogen-bond donors
1
Hydrogen-bond acceptors
2
Rotatable bonds
1
Heavy atoms
9
Covalent units
1

Names and synonyms reported to PubChem

Mequinol4-Hydroxyanisolep-Hydroxyanisolep-MethoxyphenolPhenol, 4-methoxy-HYDROQUINONE MONOMETHYL ETHERMEHQLeucobasal
16 more reported names
Leucodine BP-GuaiacolMechinolumNovo-DermoquinonaHydroquinone methyl etherHQMMEp-Hydroxymethoxybenzene1-Hydroxy-4-methoxybenzenepara-methoxyphenolMonomethyl ether hydroquinonePMF (antioxidant)USAF AN-7Mono methyl ether hydroquinoneMechinoloMequinolumBMS 181158
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
3
3D rings
1
3D hydrophobes
0
3D acceptor features
1
3D donor features
1
3D anionic centres
0
3D cationic centres
0
3D conformers
1
Effective 3D rotors
1.0
Machine-readable structure identifiers
SMILES
COC1=CC=C(C=C1)O
InChI
InChI=1S/C7H8O2/c1-9-7-4-2-6(8)3-5-7/h2-5,8H,1H3
InChIKey
NWVVVBRKAWDGAB-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 622-62-8
CAS 622-62-8PubChem CID 12150

Verified chemistry for CAS 622-62-8

4-Ethoxyphenol

4-Ethoxyphenol is a member of phenols and an aromatic ether. — ChEBI

IUPAC name
4-ethoxyphenol
Molecular formula
C8H10O2
Molecular weight
138.16 g/mol
Exact mass
138.068079557 Da
Monoisotopic mass
138.068079557 Da
XLogP3
1.8
Topological polar surface area
29.5 Ų
Molecular complexity
85.0
Formal charge
0
Hydrogen-bond donors
1
Hydrogen-bond acceptors
2
Rotatable bonds
2
Heavy atoms
10
Covalent units
1

Names and synonyms reported to PubChem

Phenol, 4-ethoxy-P-ETHOXYPHENOLHydroquinone monoethyl etherp-Hydroxyphenetole4-EthyloxyphenolPhenol, p-ethoxy-4-ethoxy-phenol1-Ethoxy-4-hydroxybenzene
16 more reported names
Ethoxyphenol, p-NSC 9885FEMA No. 3695Ether monoethylique de l'hydroquinonep-ethoxy-phenolEINECS 210-748-1BRN 1907114UNII-605352N8AQNSC-9885Ether monoethylique de l'hydroquinone [French]HYDROQUINONE MONO ETHYL ETHERHYDROQUINONE MONOETHYL ETHER [FHFI]FEMA 36954-06-00-05719 (Beilstein Handbook Reference)RefChem:98845210-748-1
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
3
3D rings
1
3D hydrophobes
0
3D acceptor features
1
3D donor features
1
3D anionic centres
0
3D cationic centres
0
3D conformers
6
Effective 3D rotors
2.0
Machine-readable structure identifiers
SMILES
CCOC1=CC=C(C=C1)O
InChI
InChI=1S/C8H10O2/c1-2-10-8-5-3-7(9)4-6-8/h3-6,9H,2H2,1H3
InChIKey
LKVFCSWBKOVHAH-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
Brazil ANVISA consolidated prohibited substances — RDC 529/2021 through RDC 1.030/2026
Source reference
RDC 529/2021 consolidated annex, entry 178 (through RDC 1.030/2026)
Source record ID
annex:178
Source version
RDC 529/2021 consolidated through RDC 1.030/2026
Source language
Portuguese with official English identity where published
Translation status
Official English translation · English translation
Effective date
2026-06-15
Source updated
2026-06-15
Snapshot checked
2026-08-31 15:26 UTC
Validation method
pdfplumber government baseline + 4 RDC 1.030 exclusions + 15 additions; 1,387 substantive rows
SHA-256
a212e85540a186a842664fbdd4f351af0b1b4baeeb0c4765b9b52c6ce91c1e84

Registered dataset notes

Dataset coverage
All 1,387 substantive current prohibited rows after applying RDC 1.030/2026 additions, amendments and exclusions to RDC 529/2021
Authority note
Binding consolidated prohibited list for personal-hygiene products, cosmetics and perfumes
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

1387
current Brazil records
1387
records marked Prohibited
1387
records from this source version
1335
market records with CAS identity

Status distribution

Prohibited: 1387

Condition text is present on 1387 of 1387 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

Brazil market context

Complete prohibited dataset plus current restricted-list workflow

Coverage version: ANVISA RDC 1.029/2026 and RDC 1.030/2026, published 15 June 2026

All 1,387 substantive current prohibited rows in RDC 529/2021 consolidated through RDC 1.030/2026, plus the current RDC 1.029 restricted-list and identity workflow.

Verification checklist

  1. Resolve Portuguese, INCI and CAS identity with the ANVISA crosswalk.
  2. Check the consolidated prohibited list including RDC 1.030/2026 changes.
  3. Apply RDC 1.029/2026 restrictions and the still-effective complementary rules.
  4. Verify Mercosur incorporation, regularisation, labelling and transition periods.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “4 – Benziloxifenol, 4 - metoxifenol e 4 – etoxifeno; 4-etoxifenol (4-ETHOXYPHENOL)” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Resolve Portuguese, INCI and CAS identity with the ANVISA crosswalk.
  3. Check the consolidated prohibited list including RDC 1.030/2026 changes.
  4. Apply RDC 1.029/2026 restrictions and the still-effective complementary rules.
  5. Verify Mercosur incorporation, regularisation, labelling and transition periods.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECAvailable
  • Separate condition textAvailable
  • Effective dateAvailable
  • Snapshot hash and methodAvailable

Questions this page answers

This official record identifies the substance as prohibited for cosmetic use in the stated market scope. Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. RDC 1.030/2026 amends rather than replaces the prohibited baseline, and the second restricted-list revision was still under consultation in July 2026.

The record cites RDC 529/2021 consolidated annex, entry 178 (through RDC 1.030/2026), source version RDC 529/2021 consolidated through RDC 1.030/2026. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

4 – Benziloxifenol, 4 - metoxifenol e 4 – etoxifeno; 4-etoxifenol (4-ETHOXYPHENOL). RDC 529/2021 consolidated annex, entry 178 (through RDC 1.030/2026). Brazil. Source version RDC 529/2021 consolidated through RDC 1.030/2026. CosIng Checker regulatory record: https://cosingchecker.com/regulations/br/records/13384/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for Brazil

This official record identifies the substance as prohibited for cosmetic use in the stated market scope.

Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

How to interpret the legal role

The cited row forms part of a binding rule or legally incorporated list for this market.

Evidence on this page

  • Recorded outcome: Prohibited
  • Legal role: Binding rule
  • Source version: RDC 529/2021 consolidated through RDC 1.030/2026
  • Effective date: 2026-06-15

What it does not prove

RDC 1.030/2026 amends rather than replaces the prohibited baseline, and the second restricted-list revision was still under consultation in July 2026.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity at the source

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity at the source

US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source