CAS 103-16-2PubChem CID 7638
Monobenzone
Monobenzone is the monobenzyl ether of hydroquinone. It is used as a topical drug for medical depigmentation. It has a role as a dermatologic drug, an allergen and a melanin synthesis inhibitor. It is functionally related to a hydroquinone. — ChEBI
- IUPAC name
- 4-phenylmethoxyphenol
- Molecular formula
- C13H12O2
- Molecular weight
- 200.23 g/mol
- Exact mass
- 200.083729621 Da
- XLogP3
- 3.4
- Topological polar surface area
- 29.5 Ų
- Hydrogen-bond donors
- 1
- Hydrogen-bond acceptors
- 2
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
4-(Benzyloxy)phenolHydroquinone monobenzyl etherBenoquinP-(BENZYLOXY)PHENOLBenzoquinDepigmanLeucodinineMonobenzon
16 more reported names
Monobenzyl hydroquinoneSuperlitePigmexAgerite alba4-(Phenylmethoxy)phenol4-(Benzyloxyl)phenolHydroquinone benzyl etherDermochinonaCarmifalp-Hydroxyphenyl benzyl etherAlba-DomePhenol, 4-(phenylmethoxy)-Benzyl p-hydroxyphenyl etherMonobenzyl ether hydroquinoneMonobenzonaMonobenzonum
External database identifiers
- ChEBI:CHEBI:34380
- ChEMBL:CHEMBL1388
- EPA DTXSID:DTXSID2020717
- PubMed:35435491
- PubMed:25455453
- PubMed:23013281
- PubMed:22566895
- PubMed:21911918
- PubMed:21754122
- PubMed:21716544
- PubMed:21689385
- PubMed:21599003
- PubMed:21566576
- PubMed:21429753
- PubMed:21326294
Evidence from additional scientific databases
EMBL-EBI ChEBI
Exact identifier matchCHEBI:34380
monobenzone
The monobenzyl ether of hydroquinone. It is used as a topical drug for medical depigmentation.
- Formula
- C13H12O2
- Average mass
- 200.237 g/mol
- Monoisotopic mass
- 200.08373 Da
- Formal charge
- 0
- benzyl ether — is a (CHEBI:59859)
- dermatologic drug — has role (CHEBI:50177)
- allergen — has role (CHEBI:50904)
- melanin synthesis inhibitor — has role (CHEBI:64933)
- hydroquinone — has functional parent (CHEBI:17594)
- dermatologic drug — has role (CHEBI:50177)
- allergen — has role (CHEBI:50904)
- melanin synthesis inhibitor — has role (CHEBI:64933)
- benzyl ether — is a (CHEBI:59859)
Additional curated names
4-(benzyloxy)phenol4-(Benzyloxyl)phenol4-Benzyloxy-phenol4-Benzyloxyphenol4-(Phenylmethoxy)phenolBenzyl p-hydroxyphenyl etherHydroquinone benzyl etherHydroquinone monobenzyl etherMONOBENZYL ETHER OF HYDROQUINONEMonobenzyl hydroquinoneNSC-2132p-(Benzyloxy)phenolp-Hydroxyphenyl benzyl ether
Cross-references from this source
- CAS: 103-16-2 — ChemIDplus
- CAS: 103-16-2 — KEGG COMPOUND
- MANUAL_X_REF: 1834 — DrugCentral
- MANUAL_X_REF: C14244 — KEGG COMPOUND
- MANUAL_X_REF: D05072 — KEGG DRUG
- MANUAL_X_REF: DB00600 — DrugBank
- MANUAL_X_REF: EP0175701 — Patent
- MANUAL_X_REF: LSM-5642 — LINCS
- MANUAL_X_REF: Monobenzone — Wikipedia
- MANUAL_X_REF: WO8504101 — Patent
- REGISTRY_NUMBER: 1958305 — Reaxys
Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2020-09-29. Retrieved: 2026-08-31. Open source record
NIH PubChem PUG-View
Exact identifier match7638
Attributed physical-property, hazard, environmental and use annotations.
- Color/Form: LUSTROUS LEAFLETS FROM WATER Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: WHITE CRYSTALLINE POWDER Source: Hazardous Substances Data Bank (HSDB)
- Density: 1.26 Source: Hazardous Substances Data Bank (HSDB)
- LogP: 3.2 Source: DrugBank
- LogP: 3.2 Source: Human Metabolome Database (HMDB)
- Melting Point: 122 °C Source: DrugBank
- Melting Point: 122.5 °C Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: 110 - 118 °C Source: Human Metabolome Database (HMDB)
- Odor: ODORLESS Source: Hazardous Substances Data Bank (HSDB)
- Physical Description: Tan solid; Insoluble in water; [Hawley] White powder; [Alfa Aesar MSDS] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Physical Description: Solid Source: Human Metabolome Database (HMDB)
- Solubility: 251 mg/L Source: DrugBank
- Solubility: SOLUBILITY IN BOILNG WATER ABOUT 1.0 G/100 ML; SOL IN ALC, ETHER, BENZENE Source: Hazardous Substances Data Bank (HSDB)
- Solubility: INSOL IN WATER Source: Hazardous Substances Data Bank (HSDB)
- Solubility: FREELY SOL IN ACETONE Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Practically insoluble in petroleum hydrocarbons, very soluble in benzene and alkalies. Source: Hazardous Substances Data Bank (HSDB)
- Solubility: 3.92e-02 g/L Source: Human Metabolome Database (HMDB)
- Vapor Pressure: 0.0000225 [mmHg] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Signal: Warning Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- GHS Hazard Statements: H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Precautionary Statement Codes: P261, P264+P265, P272, P280, P302+P352, P305+P351+P338, P321, P333+P317, P337+P317, P362+P364, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Signal: Warning Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P261, P264+P265, P272, P280, P302+P352, P305+P351+P338, P321, P333+P317, P337+P317, P362+P364, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 80 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: Not Classified Source: NITE-CMC
- Signal: Warning Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- GHS Hazard Statements: H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation] Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- Precautionary Statement Codes: P261, P264+P265, P272, P280, P302+P352, P305+P351+P338, P321, P333+P317, P337+P317, P362+P364, and P501 (click each P-code to see the statement) Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- Sources/Uses: Used as a solvent and in perfumes, soap, plastics, and pharmaceuticals; [Hawley] Used as an antioxidant (rubber, paraffins, and polyvinyl chloride), stabilizer, polymerization inhibitor, intermediate, and depigmentor to treat hyperpigmentation of the skin; [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Uses: ANTIOXIDANT FOR PARAFFINS AND POLYVINYL CHLORIDE, POLYPROPYLENE AND POLYPROPYLENE OXIDE; CHEM INT IN ORGANIC SYNTHESIS Source: Hazardous Substances Data Bank (HSDB)
- Uses: Rubber antioxidant, stabilizer, polymerization inhibitor, chemical intermediate. Source: Hazardous Substances Data Bank (HSDB)
- Uses: MEDICATION Source: Hazardous Substances Data Bank (HSDB)
- Uses: MEDICATION (VET) Source: Hazardous Substances Data Bank (HSDB)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| EMBL-EBI ChEBI | Exact match | 2026-08-31 |
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.