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ProhibitedOfficial guidanceCAOriginal is EnglishOfficial-source import checked

Hydrazides and their salts

Canada Hotlist: Hydrazides and their salts

Health Canada lists this ingredient as prohibited for use in cosmetic products.

All Canada recordsOpen ingredient profileCompare all marketsOpen official source

Regulatory decision and full conditions

Status
Prohibited
Legal role
Official guidance
Regulatory summary
Health Canada lists this ingredient as prohibited for use in cosmetic products.
Conditions and restrictions
A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. Open the cited source and apply the market-wide requirements below.

Substance identity

Official source name
Hydrazides and their salts
CAS
54-85-3; 1071-93-8; 123-33-1
EC
213-999-5
Identity mapping
cas_number
Linked ingredient
ADIPIC ACID DIHYDRAZIDE
Search this identity across the siteCAS 54-85-3CAS 1071-93-8CAS 123-33-1EC 213-999-5

Linked CosIng identity data

Names and aliases

ADIPIC ACID DIHYDRAZIDE

CosIng description: Hexanedioic Acid Dihydrazine

EU inventory restriction note: II/200

Recorded cosmetic function: FRAGRANCE, MOISTURISING

Function pages:FRAGRANCE, MOISTURISING

View the complete ingredient profile

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

10 market datasets
PubChem 2D chemical structure for CAS 1071-93-8
CAS 1071-93-8PubChem CID 66117

Verified chemistry for CAS 1071-93-8

Adipic Dihydrazide

IUPAC name
hexanedihydrazide
Molecular formula
C6H14N4O2
Molecular weight
174.20 g/mol
Exact mass
174.11167570 Da
Monoisotopic mass
174.11167570 Da
XLogP3
-2.1
Topological polar surface area
110.0 Ų
Molecular complexity
142.0
Formal charge
0
Hydrogen-bond donors
4
Hydrogen-bond acceptors
4
Rotatable bonds
5
Heavy atoms
12
Covalent units
1

Names and synonyms reported to PubChem

Adipic acid dihydrazideHexanedioic acid, dihydrazideadipic hydrazideVK98I9YW5MAJICURE ADHQUALIMER ADHNSC-3378ULTRALINK HYDRAZIDE
16 more reported names
NSC-29542NSC3378BK 1000ZBT 1000ZT 2210RefChem:553051213-999-5AdipohydrazideAdipodihydrazideAdipic acid, dihydrazideAdipoyldihydrazineadipoyl dihydrazideAdipyl hydrazideHexanedioic acid, 1,6-dihydrazideWLN: ZMV4VMZbutane-1,4-dicarbohydrazide
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
7
3D rings
0
3D hydrophobes
1
3D acceptor features
2
3D donor features
4
3D anionic centres
0
3D cationic centres
0
3D conformers
10
Effective 3D rotors
7.0
Machine-readable structure identifiers
SMILES
C(CCC(=O)NN)CC(=O)NN
InChI
InChI=1S/C6H14N4O2/c7-9-5(11)3-1-2-4-6(12)10-8/h1-4,7-8H2,(H,9,11)(H,10,12)
InChIKey
IBVAQQYNSHJXBV-UHFFFAOYSA-N

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match66117

Attributed physical-property, hazard, environmental and use annotations.

  • Note: This chemical does not meet GHS hazard criteria for 4.2% (119 of 2828) of reports. Source: European Chemicals Agency (ECHA)
  • Signal: Warning Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H317 (18.7%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H411 (86.5%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P261, P272, P273, P280, P302+P352, P321, P333+P317, P362+P364, P391, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 2828 reports by companies from 19 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 119 of 2828 reports by companies.; There are 18 notifications provided by 2709 of 2828 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Warning Source: NITE-CMC
  • GHS Hazard Statements: H320: Causes eye irritation [Warning Serious eye damage/eye irritation]; H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P264+P265, P273, P280, P305+P351+P338, P318, P337+P317, P391, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Cosmetic Ingredient Review Conclusion: The CIR Expert Panel concludes that the available data are insufficient to support the safety of Adipic Acid Dihydrazide as used in cosmetic products. Source: Cosmetic Ingredient Review (CIR)
  • Cosmetic Ingredient Review Finding(s): The available data are insufficient to support safety, but the ingredient is not used Source: Cosmetic Ingredient Review (CIR)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBINo exact record2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 123-33-1
CAS 123-33-1PubChem CID 21954

Verified chemistry for CAS 123-33-1

Maleic Hydrazide

IUPAC name
1,2-dihydropyridazine-3,6-dione
Molecular formula
C4H4N2O2
Molecular weight
112.09 g/mol
Exact mass
112.027277375 Da
Monoisotopic mass
112.027277375 Da
XLogP3
-0.8
Topological polar surface area
58.2 Ų
Molecular complexity
143.0
Formal charge
0
Hydrogen-bond donors
2
Hydrogen-bond acceptors
2
Rotatable bonds
0
Heavy atoms
8
Covalent units
1

Names and synonyms reported to PubChem

3,6-Dihydroxypyridazine3,6-Pyridazinediol3,6-Pyridazinedione, 1,2-dihydro-1,2-Dihydro-3,6-pyridazinedioneMaleic acid hydrazideStuntmanVondalhydeMalzid
16 more reported names
RetardSucker-StuffAntergonAntyrostMalazideReguloxVondraxRegulox 36Maleic hydrazineSprout/offDe-sproutSprout-StopSuper-de-sproutDe-cutMaintain 3Super sucker-stuff
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
5
3D rings
1
3D hydrophobes
0
3D acceptor features
2
3D donor features
2
3D anionic centres
0
3D cationic centres
0
3D conformers
1
Effective 3D rotors
0.0
Machine-readable structure identifiers
SMILES
C1=CC(=O)NNC1=O
InChI
InChI=1S/C4H4N2O2/c7-3-1-2-4(8)6-5-3/h1-2H,(H,5,7)(H,6,8)
InChIKey
BGRDGMRNKXEXQD-UHFFFAOYSA-N

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match21954

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) shou Source: CAMEO Chemicals
  • Note: This chemical does not meet GHS hazard criteria for 42.5% (34 of 80) of reports. Source: European Chemicals Agency (ECHA)
  • Signal: Warning Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H315 (57.5%): Causes skin irritation [Warning Skin corrosion/irritation]; H319 (57.5%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335 (56.2%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H341 (56.2%): Suspected of causing genetic defects [Warning Germ cell mutagenicity] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P318, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 80 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 34 of 80 reports by companies.; There are 6 notifications provided by 46 of 80 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]; H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]; H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory. Source: European Chemicals Agency (ECHA)
  • Environmental Bioconcentration: An estimated BCF of 3 was calculated for maleic hydrazide(SRC), using a log Kow of -1.96 (1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), measured Koc values of 264 for a clay soil, and 23 for a sandy loam(2), indicate that maleic hydrazide is expected to have very high to moderate mobility in soil. Maleic hydrazide exists in equilibrium with its tautomer 6-hydroxy-3(2H)-pyridazinone that has a pKa of 5.62(2), which indicates that this compound will primarily exist as an anion in moist soils and anions do not volatilize. The neutral species of maleic hydrazide is not expected to volatilize based on a Henry's Law constant of 8.1X10-9 atm-cu m/mole(2). Maleic hydrazide is not expected to volatilize from dry soils(SRC) based on a vapor pressure of 7.5X10-8 mm Hg at 25 °C(2). Biodegradation has been shown to be an important environmental fate process for maleic hydrazide in soils(2). The half-life of maleic hydrazide was reported as 2-3 days in a sandy loam used for growing potatoes, 6 days in a turfed sandy loam, and 7 days in a tobacco growing loam(2). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), measured Koc values of 264 for a clay soil, and 23 for a sandy loam(3), indicates that maleic hydrazide is not expected to adsorb to suspended solids and sediment(SRC). Maleic hydrazide exists in equilibrium with its tautomer 6-hydroxy-3(2H)-pyridazinone that has a pKa of 5.62(2), which indicates that this compound will primarily exist as an anion in water and anions do not volatilize. The neutral species of maleic hydrazide is not expected to volatilize based on a Henry's Law constant of 8.1X10-9 atm-cu m/mole(3). According to a classification scheme(4), an estimated BCF of 3(SRC), from a log Kow of -1.96(3) and a regression-derived equation(5), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Maleic hydrazide is stable to hydrolysis, but may undergo photochemical decomposition in sunlit surface waters(6). Maleic hydrazide (as the potassium salt) was irradiated with simulated sunlight in aqueous solutions at pH 5, 7 and 9 with calculated half-lives of 58, 58 and 34 days, respectively(6). The major product was maleate(6). Based on the rapid rate of biodegradation in soil(7), maleic hydrazide is expected Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), maleic hydrazide, which has a vapor pressure of 7.5X10-8 mm Hg at 25 °C(2), is expected to exist primarily in the particulate phase. Particulate-phase maleic hydrazide may be removed from the air by wet and dry deposition(SRC). Although maleic hydrazide absorbs light greater than 290 nm and photolyzes in aqueous solution(3), it exists primarily in the particulate phase in the atmosphere and it is unclear whether direct photolysis will be an important environmental fate process(SRC). Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 54-85-3
CAS 54-85-3PubChem CID 3767

Verified chemistry for CAS 54-85-3

Isoniazid

Isoniazide is a carbohydrazide obtained by formal condensation between pyridine-4-carboxylic acid and hydrazine. It has a role as an antitubercular agent and a drug allergen. It is functionally related to an isonicotinic acid. — ChEBI

IUPAC name
pyridine-4-carbohydrazide
Molecular formula
C6H7N3O
Molecular weight
137.14 g/mol
Exact mass
137.058911855 Da
Monoisotopic mass
137.058911855 Da
XLogP3
-0.7
Topological polar surface area
68.0 Ų
Molecular complexity
120.0
Formal charge
0
Hydrogen-bond donors
2
Hydrogen-bond acceptors
3
Rotatable bonds
1
Heavy atoms
10
Covalent units
1

Names and synonyms reported to PubChem

Isonicotinic acid hydrazideIsonicotinohydrazideIsoniazideRimifonNydrazidCotinazinDinacrinHydrazid
16 more reported names
IscotinMybasanCedinHidrasonilIsonicotanNicotibinaArmazideDitubinErtubanIsidrinaIsobicinaLaniazidNeumandinHyzydAtcotibineIsonidrin
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
5
3D rings
1
3D hydrophobes
0
3D acceptor features
2
3D donor features
2
3D anionic centres
0
3D cationic centres
0
3D conformers
3
Effective 3D rotors
2.0
Machine-readable structure identifiers
SMILES
C1=CN=CC=C1C(=O)NN
InChI
InChI=1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10)
InChIKey
QRXWMOHMRWLFEY-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
Health Canada Cosmetic Ingredient Hotlist
Source reference
Hotlist prohibited entry 266
Source record ID
prohibited:266
Source version
Health Canada Hotlist 2025-08-13
Source language
English
Translation status
Original is English
Source updated
2025-08-13
Snapshot checked
2026-08-30 04:07 UTC
Validation method
strict HTML tables t1=490 and t2=90
SHA-256
8b52ff573d08373ee90121f6a701b3607e4a3d6fc748a7d56171eb53510af91a

Registered dataset notes

Dataset coverage
Administrative prohibitions, restrictions, conditions and warning requirements
Authority note
Official Health Canada compliance indicator; not a complete safety clearance
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

580
current Canada records
490
records marked Prohibited
580
records from this source version
516
market records with CAS identity

Status distribution

Prohibited: 490Restricted: 90

Condition text is present on 172 of 580 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

Canada market context

Complete Hotlist snapshot

Coverage version: Health Canada Cosmetic Ingredient Hotlist, 13 August 2025

All prohibited and restricted Hotlist entries, including conditions and warning requirements published in the official list.

Verification checklist

  1. Search English/French names and CAS identifiers.
  2. Apply every restriction, concentration and label warning.
  3. Check Food and Drugs Act/Cosmetic Regulations requirements.
  4. Recheck the current Hotlist before notification or sale.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “Hydrazides and their salts” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Search English/French names and CAS identifiers.
  3. Apply every restriction, concentration and label warning.
  4. Check Food and Drugs Act/Cosmetic Regulations requirements.
  5. Recheck the current Hotlist before notification or sale.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECAvailable
  • Separate condition textNot present in source row
  • Effective dateNot supplied
  • Snapshot hash and methodAvailable

Questions this page answers

This official record identifies the substance as prohibited for cosmetic use in the stated market scope. Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. The Hotlist is an administrative compliance tool, not an exhaustive safety approval list.

The record cites Hotlist prohibited entry 266, source version Health Canada Hotlist 2025-08-13. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

Hydrazides and their salts. Hotlist prohibited entry 266. Canada. Source version Health Canada Hotlist 2025-08-13. CosIng Checker regulatory record: https://cosingchecker.com/regulations/ca/records/266/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for Canada

This official record identifies the substance as prohibited for cosmetic use in the stated market scope.

Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

How to interpret the legal role

The authority uses this source as compliance guidance; the underlying legislation remains controlling.

Evidence on this page

  • Recorded outcome: Prohibited
  • Legal role: Official guidance
  • Source version: Health Canada Hotlist 2025-08-13

What it does not prove

The Hotlist is an administrative compliance tool, not an exhaustive safety approval list.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity at the source

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity at the source

US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source