ADIPIC ACID DIHYDRAZIDE
Hexanedioic Acid Dihydrazine
ADIPIC ACID DIHYDRAZIDE is linked to 2 EU annex records on this page. Inventory note: II/200.
Regulatory evidence by market
This matrix separates verified ingredient rules from sources that are mapped but not yet imported. No imported rule does not mean the ingredient is permitted.
Swipe or scroll horizontally to see every column.
| Market | Evidence status | Records | Source language |
|---|---|---|---|
| European Union | Evidence linked Prohibited entry found Open this evidence | 2 | English and EU languages |
| Great Britain | Source mapped Official source mapped; ingredient rule not imported | 0 | English |
| Canada | Evidence linked Prohibited Open this evidence | 1 | English and French |
| New Zealand | Source mapped Official source mapped; ingredient rule not imported | 0 | English |
| ASEAN | Source mapped Official source mapped; ingredient rule not imported | 0 | English and national languages |
| China | Source mapped Official source mapped; ingredient rule not imported | 0 | Chinese with selected English material |
| Japan | Source mapped Official source mapped; ingredient rule not imported | 0 | Japanese; official English translation available |
| South Korea | Source mapped Official source mapped; ingredient rule not imported | 0 | Korean with some English names |
| United States | Source mapped Official source mapped; ingredient rule not imported | 0 | English |
| Australia | Source mapped Official source mapped; ingredient rule not imported | 0 | English |
| Brazil | Source mapped Official source mapped; ingredient rule not imported | 0 | Portuguese with INCI crosswalks |
| India | Source mapped Official source mapped; ingredient rule not imported | 0 | English and Hindi |
| Saudi Arabia | Source mapped Official source mapped; ingredient rule not imported | 0 | Arabic and English |
Chemical identity and properties
Adipic Dihydrazide
The CIR Expert Panel concludes that the available data are insufficient to support the safety of Adipic Acid Dihydrazide as used in cosmetic products. — Cosmetic Ingredient Review (CIR)
- IUPAC name
- hexanedihydrazide
- Molecular formula
- C6H14N4O2
- Molecular weight
- 174.20 g/mol
- Exact mass
- 174.11167570 Da
- XLogP3
- -2.1
- Topological polar surface area
- 110.0 Ų
- Hydrogen-bond donors
- 4
- Hydrogen-bond acceptors
- 4
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
16 more reported names
External database identifiers
- ChEMBL:CHEMBL3185968
- EPA DTXSID:DTXSID0044361
- PubMed:22132154
- PubMed:17848981
Evidence from additional scientific databases
NIH PubChem PUG-View
Attributed physical-property, hazard, environmental and use annotations.
- Physical Description: Dry Powder; Dry Powder; Large Crystals; Liquid; Large Crystals; Liquid Source: EPA Chemical Data Reporting (CDR)
- Note: This chemical does not meet GHS hazard criteria for 4.2% (119 of 2828) of reports. Source: European Chemicals Agency (ECHA)
- Signal: Warning Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H317 (18.7%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H411 (86.5%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P261, P272, P273, P280, P302+P352, P321, P333+P317, P362+P364, P391, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 2828 reports by companies from 19 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 119 of 2828 reports by companies.; There are 18 notifications provided by 2709 of 2828 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Signal: Warning Source: NITE-CMC
- GHS Hazard Statements: H320: Causes eye irritation [Warning Serious eye damage/eye irritation]; H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
- Precautionary Statement Codes: P203, P264+P265, P273, P280, P305+P351+P338, P318, P337+P317, P391, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
- Cosmetic Ingredient Review Conclusion: The CIR Expert Panel concludes that the available data are insufficient to support the safety of Adipic Acid Dihydrazide as used in cosmetic products. Source: Cosmetic Ingredient Review (CIR)
- Cosmetic Ingredient Review Finding(s): The available data are insufficient to support safety, but the ingredient is not used Source: Cosmetic Ingredient Review (CIR)
- Consumer Uses: Hardener Source: EPA Chemical Data Reporting (CDR)
- Industry Uses: Monomers; Other; Binder; Hardener; Not Known or Reasonably Ascertainable Source: EPA Chemical Data Reporting (CDR)
- Cosmetic Ingredient Review Link: CIR ingredient: Adipic Acid Dihydrazide Source: Cosmetic Ingredient Review (CIR)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| EMBL-EBI ChEBI | No exact record | 2026-08-31 |
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Inventory details for ADIPIC ACID DIHYDRAZIDE
INCI name
ADIPIC ACID DIHYDRAZIDE
Description
Hexanedioic Acid Dihydrazine
Record provenance
- Inventory reference
- 54417
- Imported identity
- ADIPIC ACID DIHYDRAZIDE
- Source update
- 15/10/2010
Annex records for ADIPIC ACID DIHYDRAZIDE
Hydrazides and their salts e.g. Isoniazid (INN)
Hydrazine, its derivatives and their salts
Key data
- FRAGRANCE
- Imparting an odour or taste. Creating a perceivable pleasant smell and/or masking a bad smell.
- MOISTURISING
- Increasing the water content of the skin and keeping it soft and smooth.
Official EU ingredient-name evidence
The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.
Related inventory evidence
Ingredients with overlapping formulation functions
Additional official and scientific sources
11 external databases to check this identity in
Each link searches that source for this identity. What each source is, and its legal weight
How ADIPIC ACID DIHYDRAZIDE appears in the CosIng inventory
The CosIng inventory lists ADIPIC ACID DIHYDRAZIDE as a cosmetic ingredient and this page links it to 2 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.
ADIPIC ACID DIHYDRAZIDE is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.
Frequently asked questions
Source note for ADIPIC ACID DIHYDRAZIDE
This page combines the CosIng inventory entry for ADIPIC ACID DIHYDRAZIDE with 2 linked Annex II–VI records from the local dataset built from public European Commission cosmetic ingredient materials.
Use this inventory page to research ADIPIC ACID DIHYDRAZIDE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.
Tools & next steps
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