CAS 1071-93-8PubChem CID 66117
Adipic Dihydrazide
The CIR Expert Panel concludes that the available data are insufficient to support the safety of Adipic Acid Dihydrazide as used in cosmetic products. — Cosmetic Ingredient Review (CIR)
- IUPAC name
- hexanedihydrazide
- Molecular formula
- C6H14N4O2
- Molecular weight
- 174.20 g/mol
- Exact mass
- 174.11167570 Da
- XLogP3
- -2.1
- Topological polar surface area
- 110.0 Ų
- Hydrogen-bond donors
- 4
- Hydrogen-bond acceptors
- 4
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
Adipic acid dihydrazideHexanedioic acid, dihydrazideadipic hydrazideVK98I9YW5MAJICURE ADHQUALIMER ADHNSC-3378ULTRALINK HYDRAZIDE
16 more reported names
NSC-29542NSC3378BK 1000ZBT 1000ZT 2210RefChem:553051213-999-5AdipohydrazideAdipodihydrazideAdipic acid, dihydrazideAdipoyldihydrazineadipoyl dihydrazideAdipyl hydrazideHexanedioic acid, 1,6-dihydrazideWLN: ZMV4VMZbutane-1,4-dicarbohydrazide
External database identifiers
- ChEMBL:CHEMBL3185968
- EPA DTXSID:DTXSID0044361
- PubMed:22132154
- PubMed:17848981
Evidence from additional scientific databases
NIH PubChem PUG-View
Exact identifier match66117
Attributed physical-property, hazard, environmental and use annotations.
- Physical Description: Dry Powder; Dry Powder; Large Crystals; Liquid; Large Crystals; Liquid Source: EPA Chemical Data Reporting (CDR)
- Note: This chemical does not meet GHS hazard criteria for 4.2% (119 of 2828) of reports. Source: European Chemicals Agency (ECHA)
- Signal: Warning Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H317 (18.7%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H411 (86.5%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P261, P272, P273, P280, P302+P352, P321, P333+P317, P362+P364, P391, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 2828 reports by companies from 19 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 119 of 2828 reports by companies.; There are 18 notifications provided by 2709 of 2828 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Signal: Warning Source: NITE-CMC
- GHS Hazard Statements: H320: Causes eye irritation [Warning Serious eye damage/eye irritation]; H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
- Precautionary Statement Codes: P203, P264+P265, P273, P280, P305+P351+P338, P318, P337+P317, P391, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
- Cosmetic Ingredient Review Conclusion: The CIR Expert Panel concludes that the available data are insufficient to support the safety of Adipic Acid Dihydrazide as used in cosmetic products. Source: Cosmetic Ingredient Review (CIR)
- Cosmetic Ingredient Review Finding(s): The available data are insufficient to support safety, but the ingredient is not used Source: Cosmetic Ingredient Review (CIR)
- Consumer Uses: Hardener Source: EPA Chemical Data Reporting (CDR)
- Industry Uses: Monomers; Other; Binder; Hardener; Not Known or Reasonably Ascertainable Source: EPA Chemical Data Reporting (CDR)
- Cosmetic Ingredient Review Link: CIR ingredient: Adipic Acid Dihydrazide Source: Cosmetic Ingredient Review (CIR)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| EMBL-EBI ChEBI | No exact record | 2026-08-31 |
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.