2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid (Benzophenone-4) and its sodium salt (Benzophenone-5) Benzophenone-4 CAS No. 4065-45-6 Benzophenone-5 CAS No. 6628-37-1
ASEAN Annex VII lists this record among UV filters allowed for cosmetic use. Member-state transition rules and deviations still require local verification.
Regulatory decision and full conditions
- Status
- Permitted list with conditions
- Legal role
- Binding rule
- Regulatory summary
- ASEAN Annex VII lists this record among UV filters allowed for cosmetic use. Member-state transition rules and deviations still require local verification.
- Conditions and restrictions
- 5% (as acid)
Substance identity
- Official source name
- 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid (Benzophenone-4) and its sodium salt (Benzophenone-5) Benzophenone-4 CAS No. 4065-45-6 Benzophenone-5 CAS No. 6628-37-1
- CAS
- 4065-45-6; 6628-37-1
- EC
- 223-772-2
- Identity mapping
- cas_number
- Linked ingredient
- BENZOPHENONE-4
Linked CosIng identity data
Names and aliases
CosIng description: 5-Benzoyl-4-hydroxy-2-methoxybenzenesulfonic acid
EU inventory restriction note: VI/22
Recorded cosmetic function: LIGHT STABILIZER, UV ABSORBER, UV FILTER
Function pages:LIGHT STABILIZER, UV ABSORBER, UV FILTER
View the complete ingredient profileCross-market snapshot for this identity
Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.
European Union
1 linked record · 1 with specific conditions
Open supporting recordGreat Britain
1 linked record · 1 with specific conditions
Open supporting recordNew Zealand
1 linked record · 1 with specific conditions
Open supporting recordASEAN
Current record1 linked record · 1 with specific conditions
Open supporting recordSouth Korea
1 linked record · 1 with specific conditions
Open supporting recordVerified chemistry for CAS 4065-45-6
Sulisobenzone
Sulisobenzone is a member of benzophenones. — ChEBI
- IUPAC name
- 5-benzoyl-4-hydroxy-2-methoxybenzenesulfonic acid
- Molecular formula
- C14H12O6S
- Molecular weight
- 308.31 g/mol
- Exact mass
- 308.03545927 Da
- Monoisotopic mass
- 308.03545927 Da
- XLogP3
- 2.2
- Topological polar surface area
- 109.0 Ų
- Molecular complexity
- 462.0
- Formal charge
- 0
- Hydrogen-bond donors
- 2
- Hydrogen-bond acceptors
- 6
- Rotatable bonds
- 4
- Heavy atoms
- 21
- Covalent units
- 1
Names and synonyms reported to PubChem
16 more reported names
External database identifiers
- ChEBI:CHEBI:135312
- ChEMBL:CHEMBL2059073
- EPA DTXSID:DTXSID2042436
- PubMed:26016852
- PubMed:24407064
- PubMed:23815618
- PubMed:22189380
- PubMed:21807473
- PubMed:21272034
- PubMed:20937294
- PubMed:20363401
- PubMed:19854348
- PubMed:19645264
- PubMed:18498461
- PubMed:18455898
Advanced structure statistics
- Defined atom stereocentres
- 0
- Undefined atom stereocentres
- 0
- Defined bond stereocentres
- 0
- Undefined bond stereocentres
- 0
- 3D pharmacophore features
- 9
- 3D rings
- 2
- 3D hydrophobes
- 0
- 3D acceptor features
- 5
- 3D donor features
- 1
- 3D anionic centres
- 1
- 3D cationic centres
- 0
- 3D conformers
- 4
- Effective 3D rotors
- 4.0
Machine-readable structure identifiers
- SMILES
COC1=C(C=C(C(=C1)O)C(=O)C2=CC=CC=C2)S(=O)(=O)O- InChI
InChI=1S/C14H12O6S/c1-20-12-8-11(15)10(7-13(12)21(17,18)19)14(16)9-5-3-2-4-6-9/h2-8,15H,1H3,(H,17,18,19)- InChIKey
CXVGEDCSTKKODG-UHFFFAOYSA-N
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Verified chemistry for CAS 6628-37-1
Benzophenone-5
- IUPAC name
- sodium 5-benzoyl-4-hydroxy-2-methoxybenzenesulfonate
- Molecular formula
- C14H11NaO6S
- Molecular weight
- 330.29 g/mol
- Exact mass
- 330.01740352 Da
- Monoisotopic mass
- 330.01740352 Da
- Topological polar surface area
- 112.0 Ų
- Molecular complexity
- 468.0
- Formal charge
- 0
- Hydrogen-bond donors
- 1
- Hydrogen-bond acceptors
- 6
- Rotatable bonds
- 4
- Heavy atoms
- 22
- Covalent units
- 2
Names and synonyms reported to PubChem
16 more reported names
External database identifiers
- EPA DTXSID:DTXSID40216481
Advanced structure statistics
- Defined atom stereocentres
- 0
- Undefined atom stereocentres
- 0
- Defined bond stereocentres
- 0
- Undefined bond stereocentres
- 0
- 3D conformers
- 0
Machine-readable structure identifiers
- SMILES
COC1=C(C=C(C(=C1)O)C(=O)C2=CC=CC=C2)S(=O)(=O)[O-].[Na+]- InChI
InChI=1S/C14H12O6S.Na/c1-20-12-8-11(15)10(7-13(12)21(17,18)19)14(16)9-5-3-2-4-6-9;/h2-8,15H,1H3,(H,17,18,19);/q;+1/p-1- InChIKey
KJCLYACXIWMFCC-UHFFFAOYSA-M
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Official source and provenance
- Registered source
- ASEAN Cosmetic Directive annexes
- Source reference
- ASEAN Annex VII, reference 22
- Source record ID
VII-22- Source version
- 2026-1
- Source language
- English
- Translation status
- Original is English
- Source updated
- 2026-06-22
- Snapshot checked
- 2026-08-30 04:44 UTC
- Validation method
- pdfplumber ruled-table extraction with per-annex reviewed counts
- SHA-256
ffad59f6c01a92c82042c54203ee14969425c2a82bd04c2f4012ff82513e69f1
Registered dataset notes
- Dataset coverage
- Banned, restricted and positive-list substances under the harmonised ASEAN framework
- Authority note
- Regional directive; member-state transitions and deviations still require local verification
How this record fits the market dataset
Status distribution
Condition text is present on 462 of 2224 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.
ASEAN market context
Complete regional annex dataset
Coverage version: ASEAN Cosmetic Directive annexes 2026-1, 22 June 2026
Annexes II, III, IV, VI and VII covering prohibited, restricted and positive-list substances.
Verification checklist
- Search all ACD annexes by name and identifiers.
- Apply product type, maximum level and warning conditions.
- Confirm the target member state's adoption and transition date.
- Complete the local notification and responsible-company requirements.
Official market sources
- ASEAN Cosmetic Directive annexesRegional directive; member-state transitions and deviations still require local verification
Verification workflow and record completeness
Before using this result in a compliance decision
- Confirm that “2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid (Benzophenone-4) and its sodium salt (Benzophenone-5) Benzophenone-4 CAS No. 4065-45-6 Benzophenone-5 CAS No. 6628-37-1” and every CAS/EC identifier refer to the material in your supplier specification.
- Search all ACD annexes by name and identifiers.
- Apply product type, maximum level and warning conditions.
- Confirm the target member state's adoption and transition date.
- Complete the local notification and responsible-company requirements.
- Document the source version and recheck the regulator before manufacture, notification or market placement.
Fields available in this record
- Official substance nameAvailable
- CASAvailable
- ECAvailable
- Separate condition textAvailable
- Effective dateNot supplied
- Snapshot hash and methodAvailable
Questions this page answers
Stable citation
2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid (Benzophenone-4) and its sodium salt (Benzophenone-5) Benzophenone-4 CAS No. 4065-45-6 Benzophenone-5 CAS No. 6628-37-1. ASEAN Annex VII, reference 22. ASEAN. Source version 2026-1. CosIng Checker regulatory record: https://cosingchecker.com/regulations/asean/records/4344/
Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.
Interpretation and limits for ASEAN
This identity appears on a market positive list for the list function represented by the source record.
Confirm that the intended function and product use fall within the list scope and every stated condition.
How to interpret the legal role
The cited row forms part of a binding rule or legally incorporated list for this market.
Evidence on this page
- Recorded outcome: Permitted list with conditions
- Legal role: Binding rule
- Source version: 2026-1
What it does not prove
Regional annex coverage does not replace member-state implementation dates, notifications or national deviations.
Further authoritative substance research
These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.
Cosmetic Ingredient Review safety assessments
Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents
Independent expert review considered by FDA; not a government approval or binding market rule
Research this identity at the sourceFDA Global Substance Registration System
UNII identifiers, preferred names, substance types, codes and public substance relationships
Identity registry only; UNII availability does not imply FDA review or approval
Research this identity at the sourceILO/WHO International Chemical Safety Cards
Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals
International occupational chemical-safety reference; not cosmetic-use approval
Research this identity at the sourceJapan NITE-CHRIP
Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information
Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules
Research this identity at the sourceNIOSH Pocket Guide to Chemical Hazards
REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals
US occupational-health guidance and limits; not a cosmetic ingredient decision
Research this identity at the sourceOECD eChemPortal
Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records
Discovery gateway; each linked authority remains responsible for its data
Research this identity at the sourceUS EPA CompTox CTX APIs
API key required for importDTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data
Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality
Research this identity at the source